A continuous flow reactor for pharmaceutical production

Abstract

This utility model discloses a continuous flow reactor for pharmaceutical production, relating to the field of pharmaceutical production technology. The utility model includes a reactor outer cylinder, a continuous flow transfer device, an outlet pipe, and a continuous flow reaction assembly. The continuous flow transfer device is fixedly installed outside the reactor outer cylinder, and the outlet pipe is fixedly installed outside the reactor outer cylinder. The continuous flow reaction assembly includes a heated water outlet pipe, a sealing ring, a circular ring fixing block, and a heated water inlet pipe. By setting up the continuous flow reaction assembly, this device allows the reactor outer cylinder to continue adding reaction materials through the first water inlet pipe while the internal reaction is taking place. The continuous flow reactor allows raw materials to continuously enter the reaction system, thus avoiding the intermittent nature of secondary reactions. Furthermore, by designing a circulating heating pipe, the reactor can be circulatedly heated, providing a stable temperature for the reactor.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical production technology, specifically a continuous flow reactor for pharmaceutical production. Background Technology

[0002] A continuous flow reactor for pharmaceutical manufacturing is a device used in chemical reactions, synthesis, or pharmaceutical processes. It continuously feeds raw materials into the reactor and reacts them in a continuous flow state to produce the final product. Because the raw materials need to be cleaned, prepared, and loaded after each reaction, the reaction cycle is long. This intermittent operation mode leads to low production efficiency, especially in large-scale production. As the conditions in each reaction process fluctuate, it leads to inconsistent product quality.

[0003] Traditional batch reactors require cleaning, preparation, and loading of raw materials after each reaction, resulting in long reaction cycles. This intermittent operation mode leads to low production efficiency, especially in large-scale production. To address these issues, the inventors have proposed a continuous flow reactor for pharmaceutical production. Utility Model Content

[0004] To address the problem of low production efficiency caused by the long reaction cycle of traditional batch reactors, which require cleaning, preparation, and loading of raw materials after each reaction, especially in large-scale production where fluctuating conditions during each reaction lead to inconsistent product quality, this invention aims to provide a continuous flow reactor for pharmaceutical production. By incorporating a continuous flow reaction assembly, the reactor's outer cylinder can continue to receive reactants through a primary water inlet pipe while the internal reaction is underway. The continuous flow reactor allows for a continuous inflow of raw materials into the reaction system, thus avoiding the intermittent nature of batch reactions. Furthermore, the design of a circulating heating pipe enables cyclic heating of the reactor, providing a stable temperature.

[0005] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: a continuous flow reactor for pharmaceutical production, comprising a reactor outer cylinder, a continuous flow transmission device and an outlet pipe, wherein the continuous flow transmission device is fixedly installed outside the reactor outer cylinder, an outlet pipe is fixedly installed outside the reactor outer cylinder, and a continuous flow reaction assembly is fixedly installed outside the continuous flow transmission device, wherein the continuous flow reaction assembly comprises a heated water outlet pipe, a sealing and fixing ring, a circular ring fixing block and a heated water inlet pipe.

[0006] Preferably, a No. 1 motor is fixedly installed on the outside of the continuous flow transmission device, and a No. 1 rotating shaft is rotatably connected to the outside of the No. 1 motor. A turbine spiral fan blade is fixedly installed on the outside of the No. 1 rotating shaft, and the turbine spiral fan blade is in contact with the outer cylinder of the reactor.

[0007] Preferably, a circulating fan blade is fixedly installed on the outside of the first rotating shaft, the annular fixing block is fixedly installed on the outside of the outer cylinder of the reactor, a supporting fixing block is fixedly installed on the outside of the annular fixing block, and the first rotating shaft is rotatably connected to the supporting fixing block.

[0008] Preferably, a first discharge port is fixedly installed outside the outlet pipe, a second fixing block is fixedly installed outside the outer cylinder of the reactor, a water outlet pipe is opened outside the second fixing block, and the first discharge port is connected to the water outlet pipe.

[0009] Preferably, a circulating heating pipe is fixedly installed on the outside of the outer cylinder of the reactor, a heating outlet pipe is fixedly installed on the outside of the circulating heating pipe, the end of the circulating heating pipe away from the heating outlet pipe is fixedly connected to the heating inlet pipe, and both the heating outlet pipe and the heating inlet pipe are fixedly connected to the annular fixing block.

[0010] Preferably, a first pipe is fixedly installed outside the continuous flow transmission device, a first inlet pipe is fixedly installed outside the first pipe, and a secondary inlet pipe is fixedly installed outside the first pipe, with the first inlet pipe and the secondary inlet pipe communicating with each other.

[0011] Preferably, a waste outlet is fixedly installed on the outside of the outlet pipe, and the waste outlet is connected to the first water inlet pipe and the auxiliary water inlet pipe.

[0012] Preferably, the sealing ring is fixedly installed on the outside of the circular ring fixing block, and the number of the sealing rings is two sets and they are symmetrically distributed.

[0013] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0014] In this invention, by setting up a continuous flow reaction assembly, the outer cylinder of the reactor can continue to add reactants through the No. 1 water inlet pipe while the internal reaction is taking place. The continuous flow reactor allows raw materials to continuously enter the reaction system, thereby avoiding the intermittent nature of batch reactions. The continuous addition of reactants can keep the reaction in a stable state, thereby achieving a stable production process and improving overall production efficiency. Through continuous feeding, the reactants continuously react with catalysts or other substances in the reactor, which helps to maintain a high reaction rate and prevents the reaction efficiency from decreasing due to too much or too little reactant.

[0015] In this invention, by designing a circulating heating pipe, the reactor can be circulated and heated to provide a stable temperature. Through circulating heating, sufficient energy can be provided for the reaction, avoiding a slowdown in the reaction rate due to a drop in temperature, thereby improving the overall efficiency of the reaction. A large amount of heat may be released during the reaction. If the heat cannot be removed or controlled in time, it may lead to overheating and runaway. The circulating heating system can help ensure that the temperature of the reactor is maintained within a safe range by effectively controlling the heating temperature, thus avoiding the risk of thermal runaway. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0018] Figure 2 This is a cross-sectional view of the outer cylinder structure of the reactor of this utility model.

[0019] Figure 3 This is a cross-sectional view of the continuous flow transmission device of this utility model.

[0020] Figure 4 This is a cross-sectional view of the outlet pipeline structure of this utility model.

[0021] Figure 5 This utility model Figure 2 Enlarged schematic diagram of the structure at point A in the middle.

[0022] Figure 6 This utility model Figure 3 Enlarged schematic diagram of the structure at point B.

[0023] In the diagram: 1. Reactor outer cylinder; 101. Circulating heating pipe; 102. No. 1 water inlet pipe; 103. No. 1 pipe; 104. Secondary water inlet pipe; 105. Heated water outlet pipe; 106. Sealing ring; 107. Heated water inlet pipe; 108. Circular ring fixing block; 2. Continuous flow transmission device; 201. No. 1 motor; 202. No. 1 rotating shaft; 203. Turbine spiral fan blade; 204. Circulating fan blade; 3. Outlet pipe; 301. Support fixing block; 302. No. 2 fixing block; 303. Water outlet pipe; 304. Waste outlet; 305. No. 1 discharge port. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0025] Example: Figure 1-6 As shown, this utility model provides a continuous flow reactor for pharmaceutical production, including a reactor outer cylinder 1, a continuous flow transfer device 2, and an outlet pipe 3. The continuous flow transfer device 2 is fixedly installed outside the reactor outer cylinder 1, and the outlet pipe 3 is fixedly installed outside the reactor outer cylinder 1. A continuous flow reaction assembly is fixedly installed outside the continuous flow transfer device 2, and the continuous flow reaction assembly includes a heated water outlet pipe 105, a sealing and fixing ring 106, a circular ring fixing block 108, and a heated water inlet pipe 107.

[0026] A No. 1 motor 201 is fixedly installed on the outside of the continuous flow transmission device 2. A No. 1 rotating shaft 202 is rotatably connected to the outside of the No. 1 rotating shaft 202. A turbine spiral fan blade 203 is fixedly installed on the outside of the No. 1 rotating shaft 202. The turbine spiral fan blade 203 is in contact with the outer cylinder 1 of the reactor.

[0027] By adopting the above technical solution, and by having the turbine spiral fan blade 203 fit in close contact with the outer cylinder 1 of the reactor, the rotation of the turbine spiral fan blade 203 can make the reaction inside the outer cylinder 1 of the reactor more rapid.

[0028] A circulating fan blade 204 is fixedly installed on the outside of the first rotating shaft 202. A circular fixing block 108 is fixedly installed on the outside of the outer cylinder 1 of the reactor. A support fixing block 301 is fixedly installed on the outside of the circular fixing block 108. The first rotating shaft 202 is rotatably connected to the support fixing block 301.

[0029] By adopting the above technical solution, the first rotating shaft 202 is rotatably connected to the support fixing block 301, and the rotation of the first rotating shaft 202 can drive the turbine spiral fan blade 203 to rotate.

[0030] The outlet pipe 3 has a first discharge port 305 fixedly installed on its exterior. The outer cylinder 1 of the reactor has a second fixing block 302 fixedly installed on its exterior. The second fixing block 302 has a water outlet pipe 303 on its exterior. The first discharge port 305 is connected to the water outlet pipe 303.

[0031] By adopting the above technical solution, the No. 1 discharge port 305 is connected to the water outlet pipe 303, so that the reaction material can pass from the No. 2 fixed block 302 through the No. 1 discharge port 305 and drive the circulating fan blade 204 to rotate.

[0032] A circulating heating pipe 101 is fixedly installed on the outside of the outer cylinder 1 of the reactor. A heating outlet pipe 105 is fixedly installed on the outside of the circulating heating pipe 101. The end of the circulating heating pipe 101 away from the heating outlet pipe 105 is fixedly connected to the heating inlet pipe 107. Both the heating outlet pipe 105 and the heating inlet pipe 107 are fixedly connected to the circular fixing block 108.

[0033] By adopting the above technical solution, the reactor can be circulated and heated by connecting the end of the circulating heating pipe 101 away from the heating outlet pipe 105 to the heating inlet pipe 107, thus providing a stable temperature for the reactor and providing sufficient energy for the reaction through circulating heating.

[0034] The continuous flow transmission device 2 has a first pipe 103 fixedly installed on its exterior. A first water inlet pipe 102 is fixedly installed on the exterior of the first pipe 103. A secondary water inlet pipe 104 is fixedly installed on the exterior of the first pipe 103. The first water inlet pipe 102 and the secondary water inlet pipe 104 are connected.

[0035] By adopting the above technical solution, the reactor can be continuously added through a dual-channel system by connecting the No. 1 water inlet pipe 102 with the auxiliary water inlet pipe 104.

[0036] Waste outlet 304 is fixedly installed on the outside of outlet pipe 3. Waste outlet 304 is connected to the first water inlet pipe 102 and the auxiliary water inlet pipe 104.

[0037] By adopting the above technical solution, the waste outlet 304 is connected to the first water inlet pipe 102 and the auxiliary water inlet pipe 104, so that the material can be added into the outer cylinder 1 of the reactor from the first water inlet pipe 102 and the auxiliary water inlet pipe 104, and the waste can be discharged from the waste outlet 304.

[0038] The sealing ring 106 is fixedly installed on the outside of the circular ring fixing block 108. There are two sets of sealing rings 106, which are symmetrically distributed.

[0039] By adopting the above technical solution, and by using two sets of sealing rings 106 that are symmetrically distributed, the outer cylinder 1 of the reactor can be sealed by the sealing rings 106, thereby improving the sealing performance of the reactor.

[0040] Working principle: When a continuous flow reactor for pharmaceutical production is required, the materials to be reacted are introduced into the outer cylinder 1 of the reactor through the primary water inlet pipe 102 and the secondary water inlet pipe 104. Furthermore, the primary motor 201 drives the primary rotating shaft 202 to rotate, which in turn drives the turbine spiral fan blades 203 to rotate, thus stirring the materials in the outer cylinder 1. This allows the outer cylinder 1 to continue to receive reactants while the internal reaction is taking place, through the primary water inlet pipe 102. The continuous flow reactor allows raw materials to continuously enter the reaction system, thereby avoiding the intermittent nature of batch reactions. Continuous addition of reactants keeps the reaction in a stable state, thus achieving a stable production process and improving overall production efficiency. Through continuous feeding, the reactants continuously react with catalysts or other substances in the reactor, which helps to maintain a high reaction rate.

[0041] At the same time, hot water is introduced from the heating inlet pipe 107 into the circulating heating pipe 101 and out through the heating outlet pipe 105 to circulate and heat the reactor, providing a stable temperature for the reactor. Through circulating heating, sufficient energy can be provided for the reaction, avoiding a slowdown in the reaction rate due to a drop in temperature, thereby improving the overall efficiency of the reaction.

[0042] Obviously, those skilled in the art can make various modifications and variations to this utility model without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this utility model and their equivalents, this utility model also intends to include these modifications and variations.

Claims

1. A continuous flow reactor for pharmaceutical production, comprising a reactor outer cylinder (1), a continuous flow conveying device (2), and an outlet pipe (3), characterized in that: The continuous flow transmission device (2) is fixedly installed outside the outer cylinder (1) of the reactor. An outlet pipe (3) is fixedly installed outside the outer cylinder (1) of the reactor. A continuous flow reaction assembly is fixedly installed outside the continuous flow transmission device (2). The continuous flow reaction assembly includes a heated water outlet pipe (105), a sealing ring (106), a circular ring fixing block (108), and a heated water inlet pipe (107).

2. The continuous flow reactor for pharmaceutical production as described in claim 1, characterized in that, The continuous flow transmission device (2) has a No. 1 motor (201) fixedly installed on its exterior. The No. 1 motor (201) is rotatably connected to a No. 1 rotating shaft (202). The No. 1 rotating shaft (202) has a turbine spiral fan blade (203) fixedly installed on its exterior. The turbine spiral fan blade (203) is in contact with the outer cylinder (1) of the reactor.

3. The continuous flow reactor for pharmaceutical production as described in claim 2, characterized in that, The first rotating shaft (202) is fixedly mounted with a circulating fan blade (204), the annular fixing block (108) is fixedly mounted on the outside of the outer cylinder (1) of the reactor, and a support fixing block (301) is fixedly mounted on the outside of the annular fixing block (108). The first rotating shaft (202) is rotatably connected to the support fixing block (301).

4. A continuous flow reactor for pharmaceutical production as described in claim 3, characterized in that, The outlet pipe (3) has a first discharge port (305) fixedly installed on its exterior. The outer cylinder (1) of the reactor has a second fixing block (302) fixedly installed on its exterior. The second fixing block (302) has a water outlet pipe (303) on its exterior. The first discharge port (305) is connected to the water outlet pipe (303).

5. A continuous flow reactor for pharmaceutical production as described in claim 1, characterized in that, A circulating heating pipe (101) is fixedly installed on the outside of the outer cylinder (1) of the reactor. A heating outlet pipe (105) is fixedly installed on the outside of the circulating heating pipe (101). The end of the circulating heating pipe (101) away from the heating outlet pipe (105) is fixedly connected to the heating inlet pipe (107). Both the heating outlet pipe (105) and the heating inlet pipe (107) are fixedly connected to the annular fixing block (108).

6. A continuous flow reactor for pharmaceutical production as described in claim 1, characterized in that, The continuous flow transmission device (2) has a first pipe (103) fixedly installed on its exterior. The first pipe (103) has a first water inlet pipe (102) fixedly installed on its exterior. The first pipe (103) has a second water inlet pipe (104) fixedly installed on its exterior. The first water inlet pipe (102) and the second water inlet pipe (104) are connected.

7. A continuous flow reactor for pharmaceutical production as described in claim 6, characterized in that, The outlet pipe (3) is fixedly installed with a waste outlet (304) on the outside, and the waste outlet (304) is connected to the first water inlet pipe (102) and the auxiliary water inlet pipe (104).

8. A continuous flow reactor for pharmaceutical production as described in claim 1, characterized in that, The sealing ring (106) is fixedly installed on the outside of the circular ring fixing block (108), and there are two sets of the sealing ring (106) in a symmetrical distribution.

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