Formulation of galantamine and carnitine and method of fatty acid mobilization

Abstract

A method of reducing abdominal and subcutaneous fat in the subject as disclosed whereby the subject is administered a formulation comprised of a combination of galantamine and L-carnitine on a daily basis of a period of days.

Description

FIELD OF THE INVENTION

[0001] The present invention relates to a formulation and its use in a method for enhancing metabolism in general and specifically fat mobilization. The formulation is useful in metabolic fitness, to reduce abdominal and subcutaneous fat and is administered as a dietary supplement containing an herbal extract or other preparation containing galantamine and a source of L-carnitine.BACKGROUND OF THE INVENTION

[0002] Galantamine is an alkaloid that is obtained from the bulbs and flowers of Galanthus nivalis (also known as Galanthus caucasicus, Caucasian or Voronov's snowdrop), Leucojum aestivum (snowflake), Lycoris radiata (Red Spider Lily), Galanthus woronowii (Amaryllidaceae), Narcissus (Daffodil) and related species. It also can be prepared synthetically. Regardless of the source, in practice the usual active ingredient is the salt galantamine hydrobromide.

[0003] Galantamine belongs to a class of compounds known as cholinesterase inhibitors. These compounds, both n...

Examples

example 1

[0048]Tablets were made with the following formula:

L-carnitine fumarate2,000 mgGlycine propionyl-L-carnitine HCl1,000 mgGalantamine hydrobromide 7.5 mg

[0049]Seven athletically trained test subjects participated in a 4-week trial. The above formula was taken once a day with a small meal approximately 2 hours prior to working out. Two of the test subjects reported slight tiredness for the first week, but improved strength, stamina and recovery thereafter. In total, 4 out of 7 reported improved strength, 6 out of 7 reported improved stamina, and 7 out of 7 reported better recovery, including not being as sore the next day after extreme workouts. One subject, although reporting a greatly improved rate of recovery from excessive physical training, nevertheless dropped out of the trial due to tightness in the lower back, a development likely related to increased muscle tonus linked to cholinesterase activity. These findings were within the expected parameters. Quite unexpected was the fin...

example 2

[0050]The following formula adds a choline component as a substrate for other functions of galantamine.

Glycine propionyl-L-carnitine HCl2,000 mgCholine bitartrate1,000 mgGalantamine hydrobromide   7 mg

[0051]This formula can be delivered via two large tablets or smaller tablets in greater number. Intake can be doubled by those not sensitive to cholinesterase inhibitors. The subject may be treated by the administration of a larger number of smaller capsules. In addition, it is possible to create a dry powder of the formulation, and keep the dry powder in separate individual dosing packages which contain all of the formulation such as the formulation described in the examples below. The dry powder is then added to a liquid such as water just prior to consumption. The dry powder and water or other flavored and or colored liquid may be sold together with the individual dry powder packets.

example 3

[0052]The following formula adds a choline component as a substrate for other functions of galantamine while utilizing a lower dosage to avoid side effects in individuals who are especially sensitive to galantamine.

Glycine propionyl-L-carnitine HCl2,000 mgCholine bitartrate1,000 mgGalantamine hydrobromide   4 mg

[0053]This formula can be delivered via two large tablets or smaller tablets in greater number. The dosage can be doubled. As indicated above, different variations of the formulation can be created using different numbers of smaller tablets, dry powder packets including the whole dose which can be added to a liquid, as well as other variations. This is true with respect to each of the formulation examples provided here.

FIELD OF THE INVENTION

[0001] The present invention relates to a formulation and its use in a method for enhancing metabolism in general and specifically fat mobilization. The formulation is useful in metabolic fitness, to reduce abdominal and subcutaneous fat and is administered as a dietary supplement containing an herbal extract or other preparation containing galantamine and a source of L-carnitine.BACKGROUND OF THE INVENTION

[0002] Galantamine is an alkaloid that is obtained from the bulbs and flowers of Galanthus nivalis (also known as Galanthus caucasicus, Caucasian or Voronov's snowdrop), Leucojum aestivum (snowflake), Lycoris radiata (Red Spider Lily), Galanthus woronowii (Amaryllidaceae), Narcissus (Daffodil) and related species. It also can be prepared synthetically. Regardless of the source, in practice the usual active ingredient is the salt galantamine hydrobromide.

[0003] Galantamine belongs to a class of compounds known as cholinesterase inhibitors. These compounds, both n...

Examples

example 1

[0048]Tablets were made with the following formula:

L-carnitine fumarate2,000 mgGlycine propionyl-L-carnitine HCl1,000 mgGalantamine hydrobromide 7.5 mg

[0049]Seven athletically trained test subjects participated in a 4-week trial. The above formula was taken once a day with a small meal approximately 2 hours prior to working out. Two of the test subjects reported slight tiredness for the first week, but improved strength, stamina and recovery thereafter. In total, 4 out of 7 reported improved strength, 6 out of 7 reported improved stamina, and 7 out of 7 reported better recovery, including not being as sore the next day after extreme workouts. One subject, although reporting a greatly improved rate of recovery from excessive physical training, nevertheless dropped out of the trial due to tightness in the lower back, a development likely related to increased muscle tonus linked to cholinesterase activity. These findings were within the expected parameters. Quite unexpected was the fin...

example 2

[0050]The following formula adds a choline component as a substrate for other functions of galantamine.

Glycine propionyl-L-carnitine HCl2,000 mgCholine bitartrate1,000 mgGalantamine hydrobromide   7 mg

[0051]This formula can be delivered via two large tablets or smaller tablets in greater number. Intake can be doubled by those not sensitive to cholinesterase inhibitors. The subject may be treated by the administration of a larger number of smaller capsules. In addition, it is possible to create a dry powder of the formulation, and keep the dry powder in separate individual dosing packages which contain all of the formulation such as the formulation described in the examples below. The dry powder is then added to a liquid such as water just prior to consumption. The dry powder and water or other flavored and or colored liquid may be sold together with the individual dry powder packets.

example 3

[0052]The following formula adds a choline component as a substrate for other functions of galantamine while utilizing a lower dosage to avoid side effects in individuals who are especially sensitive to galantamine.

Glycine propionyl-L-carnitine HCl2,000 mgCholine bitartrate1,000 mgGalantamine hydrobromide   4 mg

[0053]This formula can be delivered via two large tablets or smaller tablets in greater number. The dosage can be doubled. As indicated above, different variations of the formulation can be created using different numbers of smaller tablets, dry powder packets including the whole dose which can be added to a liquid, as well as other variations. This is true with respect to each of the formulation examples provided here.

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