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Ultrasound and MRI combined contrast medium and preparation method thereof

A magnetic resonance contrast agent and contrast agent technology, applied in echo/ultrasonic imaging agents, etc., can solve the problems of lack of enhanced information, uncertain diagnosis, and inconspicuous ultrasound image contrast.

Inactive Publication Date: 2009-12-02
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Contrast-enhanced ultrasonography may lack enhancement information due to the contrast part being covered by tissue or the contrast of the ultrasound image is not obvious, making the diagnosis uncertain

Method used

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  • Ultrasound and MRI combined contrast medium and preparation method thereof
  • Ultrasound and MRI combined contrast medium and preparation method thereof
  • Ultrasound and MRI combined contrast medium and preparation method thereof

Examples

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specific Embodiment 1

[0029] Specific implementation example 1: the composition of the prescription of the combined contrast agent

[0030] Recipe composition 1 (upper limit composition)

[0031] Carboxymethyl starch modified superparamagnetic Fe 3 o 4 Nanoparticles 1g

[0032] Polyethylene glycol (PEG) 100g

[0033] Tween 80 30g

[0034] Span 80 30g

[0035] Rb40.34 anti-P-selective protein antibody 10μg

[0036] Biotin 5.5μg

[0037] Avidin 5.5μg

[0038]Perfluoropentane 5g

[0039] Deionized water total 1000ml

[0040] Formula composition 2 (lower limit composition)

[0041] Carboxymethyl starch modified superparamagnetic Fe 3 o 4 Nanoparticles 0.4g

[0042] Polyethylene glycol (PEG) 30g

[0043] Tween 80 10g

[0044] Span 80 10g

[0045] Rb40.34 anti-P-selective protein antibody 5μg

[0046] Biotin 1.5μg

[0047] Avidin 1.5μg

[0048] Perfluoropentane 1g

[0049] Deionized water total 1000ml

[0050] Recipe Composition 3 (Best Point Composition)

[0051] Carboxymethyl star...

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Abstract

The ultrasonic-magnetic-resonance combined contrast agent and its preparation method relate to ultrasound and magnetic resonance contrast agents, in particular to a combined contrast agent composed of a modified high molecular polymer capsule shell and a magnetic contrast agent and biologically active gas, and a preparation method thereof. The contrast agent is composed of a modified high molecular polymer capsule shell material wrapped magnetic resonance contrast agent and bioactive gas, wherein the capsule shell material mainly includes high molecular polymer, targeting antibody, surfactant; the combined contrast agent Among them, by weight percentage, the proportion of high molecular polymer is 10-30%, polyethylene glycol is 1-10%, surfactant is 0.01-5%, targeting antibody is 5-10%, magnetic resonance imaging The agent is 0.4-1%, the bioactive gas perfluoropentane is 1-5%, and the rest is solvent. Through the invention, the stability and effectiveness of the ultrasound contrast agent can be improved and the magnetic resonance imaging can be completed at the same time, which not only improves the patient's compliance but also improves the accuracy of diagnosis.

Description

technical field [0001] The invention relates to ultrasound and magnetic resonance contrast agents, in particular to a combined contrast agent composed of modified high molecular polymer capsule shells and wrapped magnetic contrast agents and bioactive gases and a preparation method thereof. Background technique [0002] Ultrasound contrast agent (UCA) is a class of diagnostic agents that can significantly enhance medical ultrasound detection signals. In the detection and imaging of human microvascular and tissue perfusion, the use of UCA has good imaging effects, real-time, convenient operation, and ion-free Radiation, non-destructive, wide application and other advantages. The basic point of ultrasound contrast agents is to use gas as a reflection-enhancing medium. After the first generation of free microbubble contrast agent and the second generation of air-encapsulated microbubble contrast agent, the third generation of new acoustic contrast agent uses polymer fluorocarb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22A61K49/16
Inventor 顾宁杨芳吉民张宇
Owner SOUTHEAST UNIV
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