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Preparation of Chinese traditional medicine in use for hepatic disease and preparation method

A technology for traditional Chinese medicine preparations and liver diseases, which is applied in the direction of antiviral agents, medical formulas, and medical preparations containing active ingredients. The effect of increasing stability

Active Publication Date: 2010-05-12
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on the good clinical basis of the drug, but due to the large volume of the original dosage form of pills, inconvenient taking, and cumbersome manufacturing process, we further studied it and changed its dosage to tablets. The preparation process of this dosage form is simple, and it is easy to take, transport, and It is more convenient to carry, etc. After searching, the preparation is still a blank in China

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Example 1: According to the number of raw materials in Qianggan Tablets, the following prescription amounts of raw materials were taken:

[0081] Angelica 75g White Peony 75g Salvia 187.5g Turmeric 75g Astragalus 187.5g Codonopsis 75g Alisma 75g Polygonatum 75g Rehmannia 56.3g Yam 75g Hawthorn 93.8g Shenqu 112.5g Yinchen 75g Isatis Root 56.3g Gentiana 37.5g Licorice 37.5g

[0082] The above sixteen flavors, dangshen, white peony root, and Shenqu are crushed into coarse powder, and the remaining 13 flavors such as angelica are decocted twice with 10 times the amount of water for 2 hours each time. The decoction is combined, filtered, and the filtrate is concentrated to a relative density to 1.34 (25℃) thick paste, add the above coarse powder, mix well, dry, pulverize into fine powder, about 445g, add 25g povidone K30 and appropriate amount of starch, mix well, granulate with 90% ethanol, dry, Then add 5 g of magnesium stearate, mix evenly, press to make 1000 tablets, and coat...

Embodiment 2

[0083] Example 2: According to the number of parts of each raw material in Qianggan Tablets, take the following prescription amount of raw materials:

[0084] Angelica 75g White Peony 75g Salvia 187.5g Turmeric 75g Astragalus 187.5g Codonopsis 75g Alisma 75g Polygonatum 75g Rehmannia 56.3g Yam 75g Hawthorn 93.8g Shenqu 112.5g Yinchen 75g Isatis Root 56.3g Gentiana 37.5g Licorice 37.5g

[0085] The above sixteen flavors, dangshen, white peony root, and Shenqu are crushed into coarse powder, and the remaining 13 flavors such as angelica are decocted twice with 12 times the amount of water for 2 hours each time. The decoction is combined, filtered, and the filtrate is concentrated to a relative density. 1.34 (25℃) thick paste, add the above coarse powder, mix, dry, pulverize into a fine powder, weighing about 450g, add 25g of mannitol and appropriate amount of dextrin, mix well, granulate with 85% ethanol, dry, and then Add 7.5 g of finely powdered silica gel, mix well, press to make ...

Embodiment 3

[0086] Example 3: According to the number of parts of each raw material in Qianggan Tablets, take the following prescription amount of raw materials:

[0087] Angelica 75g White Peony 75g Danshen 187.5g Turmeric 75g Astragalus 187.5g Codonopsis 75g Alisma 75g Polygonatum 75g Rehmannia 56.3g Yam 75g Hawthorn 93.8g Shenqu 112.5g Yinchen 75g Isatis Root 56.3g Gentiana sylvestris 37.5g Licorice 37.5g

[0088] The above sixteen flavors, dangshen, white peony, and Shenqu are crushed into coarse powder, and the remaining 13 flavors such as angelica are decocted twice with 8 times the amount of water for 2 hours each time. The decoction is combined, filtered, and the filtrate is concentrated to a relative density to 1.34 (25℃) thick paste, add the above coarse powder, mix, dry, pulverize into a fine powder, weighing about 400g, add 100g lactose, mix, granulate with 80% ethanol, dry, mix, press to make 1000 Pieces are available.

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PUM

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Abstract

A Chinese medicine in the form of tablet for treating hepatism is prepared from 7 Chinese-medicinal materials including red sage root, astragalus root, orientle wormwood, Chinese angelica root, etc. Its preparing process is also disclosed.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine preparation for liver disease and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. technical background [0002] Acute hepatitis is persistent and does not heal, and the course of the disease exceeds six months, it is called chronic hepatitis. Some hepatitis has an insidious onset and becomes chronic when the disease is discovered clinically. Chronic hepatitis has various causes, mainly caused by hepatitis B or non-A, non-B hepatitis virus infection; certain drugs (isoniazid, aspirin, methyldopa, etc.), alcoholism and chronic intestinal inflammation can also Cause this disease. In addition, hemochromatosis caused by excessive iron storage, hepatolenticular degeneration caused by excessive copper storage, and autoimmune diseases (such as thyroiditis, glomerulonephritis, Sjogren’s syndrome, etc.) can all cause chronic hepatitis. Although various drugs h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K36/8969A61K36/8945A61K36/884A61K36/804A61K36/734A61K36/65A61K36/53A61K36/51A61K36/484A61K36/481A61K36/344A61K36/315A61K36/28A61K36/232A61K36/19A61K36/00A61K9/20A61P31/12A61P1/16
Inventor 张保献
Owner BEIJING INCREASEPHARM CORP LTD
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