Methods of using potassium channel inhibiting compounds
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A channel and inhibitor technology, applied in the field of potassium channel inhibitory compounds, can solve the problem of increasing peripheral insulin sensitivity
Inactive Publication Date: 2008-07-30
SOLVAY PHARMA GMBH
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In addition, potassium K v1.3 Inhibition of increases peripheral insulin sensitivity
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[0021] Although the present invention can be implemented in different forms, the following description of several embodiments is made based on the following understanding: the disclosed content is regarded as an example of the present invention, and the present invention is not intended to be limited to the specific embodiments explained. . The titles used in this specification are provided for convenience only, and should not be construed as limiting the present invention in any way. The specific embodiment explained under any heading can be combined with the specific embodiment explained under any other heading.
[0022] Not only have their potassium K v1.3 Channel inhibitory property, also has CB x Regulatory properties and / or potassium K (atp) Channel-opening compound, such CB x Regulatory properties are selected from: CB 1 Antagonistic properties, CB 1 Exciting nature and / or CB 2 Exciting nature.
[0023] Inhibition of potassium K v1.3 A compound having a channel of at least ...
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Abstract
The present invention relates to the use of an effective amount of at least one potassium KvI.3 channel inhibitor or of an effective amount of at least one compound having in addition to its potassium KvI.3 channel inhibiting properties also CBx modulating properties and / or potassium K(atp) channel opening properties for the manufacture of a medicament for the prophylaxis, treatment, delayed progression, delayed onset and / or inhibition of various medical conditions in subjects in need thereof . The diseases are obesity, diabetes mellitus, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulemic hypoglycemia, male pattern baldness, detrusor hyperreactivity , asthma, glucose metabolism - in particular, insulin resistance, hyperglycaem ea and / or glucose intolerance - neuroprotection, epilepsy, analgesia, cardioprotection, angina, cardioplegia, arrhythmia, coronary spasm, peripher al vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration , pain - including neuropathic pain and chronic pain - and impotence. The compounds are a.o. 4, 5-dihydropyrazole derivatives, imidazole derivatives, diazoxide, NN414, R(+) -WIN55212-2, HU-308, Rimonaband, SR-147778.
Description
Invention field [0001] The present invention involves administering an effective amount of at least one potassium K to a subject in need v1.3 Channel inhibitors are methods of treating, preventing or inhibiting a variety of medical conditions, such as type I and type II diabetes. Optionally, potassium K v1.3 Channel inhibitor not only has its potassium K v1.3 Channel inhibitory property, also has CB x Regulatory properties and / or potassium K (atp) The channel is open in nature. Background of the invention [0002] Insulin is a key regulator of glucose and liposome homeostasis and cell proliferation. It is secreted into the bloodstream by pancreatic β-cells that respond to increases in serum glucose and amino acids, for example, after a meal, but also as part of the cephalic phase before the absorption of a meal. This insulin binds to specific insulin receptors (IR) at the plasma membrane of insulin-responsive tissues such as skeletal muscle, fat, and liver. It is believed that IR...
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