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External connection fixing device for manufacturing rat spine subluxation animal model

A technology of external connection and fixing device, applied in the direction of animal restraint equipment, applications, veterinary instruments, etc., can solve the problems of different modeling methods and observation indicators, and the stability and repeatability of the model need to be further improved, and achieve a comprehensive The effect of biomechanical properties

Active Publication Date: 2012-05-02
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the different selection of animals, modeling methods and observation indicators, the stability and repeatability of the model need to be further improved. At present, there is no generally accepted animal model of vertebral subluxation.

Method used

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  • External connection fixing device for manufacturing rat spine subluxation animal model
  • External connection fixing device for manufacturing rat spine subluxation animal model
  • External connection fixing device for manufacturing rat spine subluxation animal model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0081] Objective: To observe the effect of implantation of external connection fixation device on the spinal function of rats.

[0082] 1. Experimental animals

[0083] 36 male SD rats (clean grade), weighing 350g-450g.

[0084] 2. Grouping of experimental animals

[0085] 36 male SD rats (clean grade) weighing 350g-450g were randomly divided into experimental group (group F, implanted with external connection fixation device) and control group (group C, implanted with spinous process plate, but the The straight part is not connected to the connecting plate), the sham operation group (group K, no external connection fixation device implanted)

[0086] The experimental group was randomly divided into the one-week observation group (F1) according to the designed observation time, and the three observation units in the group were F11, F12, and F13; the two-week observation group (F2), and the three observation units in the group were F21 and F22. , F23; four-week observation g...

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Abstract

The invention discloses an external connection fixing device for manufacturing a rat spine subluxation animal model. In the device, the oblique part of a first pair of spinal steel plates is clamped and fixed with the fourth lumbar spinal segment of the rat; the oblique part of a second pair of spinal steel plates is clamped and fixed with the fifth lumbar spinal segment of the rat; the oblique part of a third pair of spinal steel plates is clamped and fixed with the sixth lumbar spinal segment of the rat; and straight parts of the spinal steel plates are fixed and connected together by bolts and nuts through a connecting steel plate. The device can be used for manufacturing a fixing model for preparing L4-L6 segments from the fourth to the sixth lumbar spine of the rat, and can objectively and comprehensively reflect the biomechanical characteristics of a living spine (after the spine is fixed).

Description

technical field [0001] The invention relates to a device for making an animal model, in particular to an external connection and fixation device for making a rat spinal subluxation animal model. Background technique [0002] Spinal injury is a common ailment that plagues human beings. Traditional Chinese medicine has a long history and rich accumulation of clinical practice in the use of spinal manipulation. Evidence-based medical research shows that spinal manipulation has obvious clinical advantages such as mature operation technology, definite curative effect, low recurrence rate, and high cost-effectiveness, and is a safe and effective method. Spinal manipulation has become the preferred physical therapy recommended in clinical practice guidelines for low back pain. [0003] Traditional Chinese medicine often uses terms such as "vertebral dislocation", "dislocation", and "displacement" to describe spinal disorders. Western manual medicine calls it "subluxation". For a l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B19/00A61B17/60A61B90/00A61D3/00
Inventor 詹红生程英武何天翔阴涛田伟陈博元唯安
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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