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Traditional Chinese medicine preparation for treating helicobacter pylori related gastropathy and preparation method

A technology of Helicobacter pylori and traditional Chinese medicine preparations, which can be applied to antibacterial drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve problems such as reduced effects, limited use, and life-threatening

Active Publication Date: 2013-04-24
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the side effects are large and the cost is high. Whether it is PPI, RBC, or antibiotics, it is a kind of damage to liver and kidney functions. If the patient is allergic to antibiotics, it will also cause his life-threatening
Recent studies have found that the drug resistance rate of Helicobacter pylori is also increasing. With incomplete statistics, the drug resistance of HP has increased from 5% ten years ago to 12% now; once the first triple therapy fails, the second Use of this therapy is 50% less effective
These reasons limit the use of

Method used

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  • Traditional Chinese medicine preparation for treating helicobacter pylori related gastropathy and preparation method
  • Traditional Chinese medicine preparation for treating helicobacter pylori related gastropathy and preparation method
  • Traditional Chinese medicine preparation for treating helicobacter pylori related gastropathy and preparation method

Examples

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Effect test

Embodiment 1

[0153] A traditional Chinese medicine composition for treating Helicobacter pylori-associated stomach disease. The traditional Chinese medicine composition is as follows according to weight ratio: 2 parts of Coptidis Rhizoma; 5 parts of Dandelion; 2 parts of Panax notoginseng; 5 parts of cuttlefish bone;

[0154] Its preparation method is:

[0155] (1) Take the green skin, add 5-10 times the amount of water to soak for 1-2 hours, extract the volatile oil for 2-5 hours, collect the volatile oil, filter the medicinal solution, and set aside;

[0156] (2) Add 60-90% ethanol to medicinal dregs and other raw materials, soak for 0.5-1.5 hours, extract twice, each time for 1-2 hours, add 5-10 times the amount for the first time, and add 5-10 times for the second time Double the amount, combine the extracts, and filter; the above two filtrates are combined and filtered, and the filtrate is concentrated under reduced pressure to a relative density of 80 ° C. When the relative density i...

Embodiment 2

[0160] A traditional Chinese medicine composition for treating Helicobacter pylori-associated stomach disease. The traditional Chinese medicine composition is as follows according to the weight ratio: 15 parts of Coptidis Rhizoma; 30 parts of Dandelion; 25 parts of Sanqi; 30 parts of cuttlefish bone;

[0161] Its preparation method is:

[0162] (1) Take the green skin, add 5-10 times the amount of water to soak for 1-2 hours, extract the volatile oil for 2-5 hours, collect the volatile oil, filter the medicinal solution, and set aside;

[0163] (2) Add 60-90% ethanol to medicinal dregs and other raw materials, soak for 0.5-1.5 hours, extract twice, each time for 1-2 hours, add 5-10 times the amount for the first time, and add 5-10 times for the second time Double the amount, combine the extracts, and filter; the above two filtrates are combined and filtered, and the filtrate is concentrated under reduced pressure to a relative density of 80 ° C. When the relative density is 1....

Embodiment 3

[0167] A traditional Chinese medicine composition for treating Helicobacter pylori-associated stomach disease. The traditional Chinese medicine composition is as follows according to the weight ratio: 5 parts of Coptidis Rhizoma; 15 parts of Dandelion; 5 parts of Panax notoginseng; 15 parts of cuttlefish bone;

[0168] Its preparation method is:

[0169] (1) Take the green skin, add 5-10 times the amount of water to soak for 1-2 hours, extract the volatile oil for 2-5 hours, collect the volatile oil, filter the medicinal solution, and set aside;

[0170] (2) Add 60-90% ethanol to medicinal dregs and other raw materials, soak for 0.5-1.5 hours, extract twice, each time for 1-2 hours, add 5-10 times the amount for the first time, and add 5-10 times for the second time Double the amount, combine the extracts, and filter; the above two filtrates are combined and filtered, and the filtrate is concentrated under reduced pressure to a relative density of 80 ° C. When the relative den...

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Abstract

The invention relates to a traditional Chinese medicine preparation for treating helicobacter pylori related gastropathy and a preparation method thereof, and the traditional Chinese medicine in the invention comprises the following components by weight: 2-15 parts of coptis; 5-30 parts of dandelions; 2-25 parts of pseudo-ginseng; 5-30 parts of cuttlefish bones; and 5-25 parts of green tangerine peel. An extract is prepared by green tangerine peel volatile oil, herb residues obtained after volatile oil extraction of the green tangerine peel, and other raw material herbs; proper amounts of theextract and plant oil are mixed, and are grinded by a colloid grinder so as to obtain a medicament which can be prepared into various preparations. The preparation of the invention has the effect of clearing heat and draining dampness, moving qi and relieving pain, can treat diseases with a traditional Chinese medicine syndrome type of dampness-heat in the spleen and stomach, and can treat acute and chronic gastritis, gastric ulcer, duodenitis, and duodenal ulcer with helicobacter pylori infection. The formula and the preparation method of the invention have the advantages of definite therapeutic effect, simple operation, low price, and less toxic or side effect for the treatment of helicobacter pylori related gastropathy.

Description

technical field [0001] The invention relates to a medicinal composition and a preparation method for treating stomach diseases, in particular to a traditional Chinese medicine preparation and a preparation method for treating Helicobacter pylori-associated stomach diseases. Background technique [0002] Helicobacter pylori infection (HP) is an important cause of chronic gastropathy (chronic gastropathy, peptic ulcer and gastric cancer), and poses a serious hazard to human health. HP infection causes gastric mucosal congestion, edema, and neutrophil infiltration, leading to acute gastric mucosal inflammation, and then develops into chronic gastropathy, with lymphocyte and plasma cell infiltration, gastric mucosal atrophy, intestinal metaplasia, and epithelial dysplasia. Adenocarcinogenic formation. The multi-center HP epidemiological survey organized by the National Helicobacter pylori Scientific Research Collaboration Group shows that the average HP infection rate of the po...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P1/04A61P31/04A61K35/56A61K35/618
Inventor 王小娟郭建生郭璇徐寅
Owner HUNAN UNIV OF CHINESE MEDICINE
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