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Preparation method of liposome of medicine composition of ceftriaxone sodium and sulbactam sodium

A technology of ceftriaxone sodium and sulbactam sodium, which can be used in liposome delivery, pharmaceutical formulations, active ingredients of heterocyclic compounds, etc., and can solve problems such as poor absorption

Active Publication Date: 2014-08-27
JIANGSU SKYRUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poor absorption of sulbactam sodium after oral administration

Method used

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  • Preparation method of liposome of medicine composition of ceftriaxone sodium and sulbactam sodium
  • Preparation method of liposome of medicine composition of ceftriaxone sodium and sulbactam sodium
  • Preparation method of liposome of medicine composition of ceftriaxone sodium and sulbactam sodium

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Embodiment Construction

[0019] Set forth the present invention with example below:

[0020] Case number one:

[0021] Ceftriaxone Sodium 100g Sulbactam Sodium 50g Soy Lecithin 100 cholesterol 33g Sodium dihydrogen phosphate 1.6g Disodium phosphate 0.3g production 100 bottles

[0022] Preparation process: Take the prescribed amount of soybean lecithin and cholesterol and dissolve them completely in 230ml of absolute ethanol. or mixed.) Remove absolute ethanol on a rotary evaporator to obtain a phospholipid film.

[0023] Weigh 0.3 g of disodium hydrogen phosphate and 1.6 g of sodium dihydrogen phosphate and add it to 800 ml of water to dissolve completely, prepare a phosphate buffer solution (PBS) with a pH of about 5.8, add it to the phospholipid membrane for hydration, and use a high-pressure homogenizer to prepare a blank lipid body.

[0024] Weigh ceftriaxone sodium and dissolve it in 800ml of water, filter it at 0.45um after dissolving complet...

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Abstract

The invention relates to a preparation method of liposome of a medicine composition of ceftriaxone sodium and sulbactam sodium. According to the method, the liposome is prepared in a combining form of medicines, and the specification proportion of the ceftriaxone sodium to the sulbactam sodium is equal to (1-4):1. The preparation method comprises the following main steps of: preparing blank liposome from phospholipid and cholesterol, preparing the liposome from the ceftriaxone sodium and the sulbactam sodium which are respectively subjected to passive loading, and performing freeze drying on the prepared liposome to obtain a finished product; or dissolving the ceftriaxone sodium and the sulbactam sodium in phosphate buffer with the pH ranging from 6.0 to 6.5, and adding phospholipid cholesterol and a freeze-dried support agent to the solution in an active loading manner to prepare a freeze-drying preparation of the liposome.

Description

technical field [0001] The invention relates to a preparation method of a liposome related to ceftriaxone sodium sulbactam sodium pharmaceutical composition, and belongs to the field of pharmaceutical preparations. Background technique [0002] Ceftriaxone sodium is a third-generation cephalosporin antibiotic with strong activity against Enterobacteriaceae. The MIC90 for Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter freundii, indole-positive Proteus, Pruvidenella and Serratia is between 0.12 and 0.25mg / Between L. Enterobacter cloacae, Acinetobacter and Pseudomonas aeruginosa were less sensitive to the drug. It has strong antibacterial effect on Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis, and also has good effect on hemolytic streptococcus and pneumococcus. The MIC for Staphylococcus aureus is 2-4mg / L. Methicillin-resistant staphylococci and enterococci were resistant to this drug. Most Bacteroides fragilis ar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K31/43A61K9/127A61P31/04
Inventor 燕立波王丽赵晖程思
Owner JIANGSU SKYRUN PHARMA CO LTD
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