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Application of dimethyl fumarate in the preparation of drugs for treating early brain injury after subarachnoid hemorrhage

A technology of dimethyl fumarate and subarachnoid space, applied in the field of medicine, can solve the problems of EBI treatment without DMF and lack of effective drug treatment, so as to improve cortical cell apoptosis, weaken the development of EBI, and reduce brain damage Effect

Inactive Publication Date: 2015-10-07
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Abstract
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Problems solved by technology

[0004] At present, for the early brain injury EBI after SAH, there is still a lack of effective drug treatment, and there is no report on the treatment of EBI with DMF

Method used

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  • Application of dimethyl fumarate in the preparation of drugs for treating early brain injury after subarachnoid hemorrhage
  • Application of dimethyl fumarate in the preparation of drugs for treating early brain injury after subarachnoid hemorrhage
  • Application of dimethyl fumarate in the preparation of drugs for treating early brain injury after subarachnoid hemorrhage

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Embodiment Construction

[0031] The present invention can be better understood from the following examples. However, it is easily understood by those skilled in the art that the examples are only for illustrating the present invention, and should not and will not limit the present invention described in detail in the claims.

[0032] 1. Materials and instruments

[0033]Heme oxygenase-1 was purchased from Santa Cruz Company (diluted 1:200); the primary antibody was purchased from Santa Cruz Biotechnology Company, the IgG antibody was purchased from Santa Cruz Biotechnology Company, and the Fluoro-jade B staining kit was purchased from Histo -Chem Company; EMSA gel shift detection kit was purchased from Promega Company of the United States; DeadEnd Fluorometric kit was purchased from Promega Company of the United States; GAPDH was purchased from Sigma Company; Glycopeptide peroxidase detection kit was purchased from Northwest Life Sciences Company of the United States; TNF-α was purchased from DIACLON...

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Abstract

The invention discloses application of dimethyl fumarate to preparation of medicine for treating early brain injury (EBI) after subarachnoid hemorrhage (SAH). The dimethyl fumarate can activate a Keap1-Nrf2-ARE signal pathway, so that the EBI after SAH is reduced, and EBI development is weakened, in addition, the situations of cortex cell apoptosis, nervous necrosis, encephaledema, and blood-brain barrier damage are improved, and a novel method for clinically treating the EBI after the SAH is provided.

Description

technical field [0001] The invention belongs to the technical field of medicine, specifically relates to a new medicine application, in particular to the application of DMF in treating early brain injury after subarachnoid hemorrhage. Background technique [0002] Subarachnoid hemorrhage (experimental subarachnoid hemorrhage, SAH) is a cerebrovascular disease with high mortality and high disability rate. The clinical syndrome, also known as primary subarachnoid hemorrhage, accounts for approximately 10% of acute strokes. Subarachnoid hemorrhage (SAH) is often accompanied by many interrelated complications, such as acute / delayed cerebral vasospasm, cerebral edema, obstructive / communicating hydrocephalus, diffuse / focal cerebral ischemia or infarction , and persistent cognitive deficits. In China, about 137,200 people suffer from subarachnoid hemorrhage due to intracranial aneurysm rupture every year. Despite the new development of microsurgery and endovascular surgery techni...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/225A61P9/00A61P25/00
Inventor 王中陈罡刘一之邱教学
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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