Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Bulk freezing of biopharmaceuticals

A bulk, container technology that is used in the field of bulk freezing of biopharmaceuticals to solve problems such as inability to scale up, no processing control provided, and loss of biopharmaceutical yields

Inactive Publication Date: 2014-10-01
PRAXAIR TECH INC
View PDF6 Cites 20 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The lack of this control can lead to yield losses for biopharmaceuticals on the order of about 5% to 50%
Also, the systems described above cannot be easily scaled up for larger volumes and do not provide proper handling control for the product during freezing, storage and delivery

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bulk freezing of biopharmaceuticals
  • Bulk freezing of biopharmaceuticals
  • Bulk freezing of biopharmaceuticals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0026] It is to be understood that aspects of the invention are described herein with reference to the drawings, which show illustrative embodiments in accordance with aspects of the invention. The illustrative embodiments described herein are not necessarily intended to show all aspects of the invention, but rather are used to describe a small number of illustrative embodiments. Accordingly, aspects of the invention are not intended to be interpreted narrowly in consideration of the illustrative embodiments. It should then be appreciated that the various concepts and embodiments introduced above and discussed in greater detail below may be implemented in any of numerous ways, as the disclosed concepts and embodiments are not limited to any particular method of execution. In addition, it should be appreciated that aspects of the invention may be used alone or in any suitable combination with other aspects of the invention.

[0027] In one possible embodiment, the parallel fl...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A system and method for bulk freezing is provided. In one embodiment, the system and method for bulk freezing includes a bulk freezing container adapted to hold at least one and preferably a plurality of bags holding a biopharmaceutical liquid. The bulk freezing container includes at least a first and second shelf having corrugations, wherein the second shelf is vertically arranged above the first shelf with the bags disposed between the shelves. The bags and the corrugations of the first and second shelves define a plurality of substantially parallel flow channels through which a cryogenic cold fluid or a warming fluid is passed to freeze and / or thaw the biopharmaceutical fluid. In another embodiment, the bulk freezing system and method includes a bulk freezing container with a plurality of adjacent elongated chambers adapted for holding the biopharmaceutical fluid.

Description

technical field [0001] The present invention relates to systems and methods for bulk freezing / thawing of biopharmaceutical materials, and more particularly to systems and methods for bulk freezing employing bulk freezing containers having A plurality of racks defining a plurality of parallel flow channels adapted to convey a heat exchange medium through the plurality of flow channels for freezing / thaw. Background technique [0002] Biopharmaceuticals are often frozen multiple times in bulk to stabilize the product and build inventory. When biopharmaceuticals are required, frozen product is transferred to fill and finish operations for subsequent thawing and distribution. [0003] Current bulk freezing systems provide for freezing of materials in a variety of ways. In one approach, the bottle or container is simply filled and placed in the freezer. Such approaches are labor intensive and offer little scalability and control of the freezing and thawing process. In anothe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): F25D31/00
CPCF25D31/00F25D3/10A01N1/0252A23L3/364F25D15/00F25D17/06F25D2400/38
Inventor Y.周A.程N.格林特Z.富勒R.塞弗R.伯萨克
Owner PRAXAIR TECH INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com