Application of desogestrel in the preparation of anti-colon cancer/er-negative ah receptor-positive breast cancer products

A breast cancer and colon cancer technology, applied in the biological field, can solve the problems of ineffective anti-tumor drugs, long cycle, and expensive new drugs

Active Publication Date: 2017-08-25
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the rapid development of tumor genomics and molecular pharmacology, the research and development of new anti-tumor drugs has achieved good results, but due to the large investment in new drug research and development, the bottlenecks such as long cycle cannot be overcome, and the genetic variation of individual tumors is large, etc. characteristics, leading to the ineffectiveness of many traditional antineoplastic drugs, expensive new drugs, and unknown side effects

Method used

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  • Application of desogestrel in the preparation of anti-colon cancer/er-negative ah receptor-positive breast cancer products
  • Application of desogestrel in the preparation of anti-colon cancer/er-negative ah receptor-positive breast cancer products
  • Application of desogestrel in the preparation of anti-colon cancer/er-negative ah receptor-positive breast cancer products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1, CELLTITER-GLO detects Desogestrel anti-colon cancer

[0051] 1. Preparation of orifice plate to be tested

[0052] 1. Cell plating

[0053] a) Prepare the complete medium required for each cell.

[0054] b) Before the start of the experiment, confirm the drug screening cell name, medium, subculture time, generation and other information marked on the 100mm culture dish to ensure that the experiment is correct.

[0055] c) For the operation of adherent cells, refer to steps d) to i), for the operation of suspension cells, refer to steps j) to l).

[0056] d) Use a vacuum pump to suck up the cell culture medium during aseptic operation.

[0057] e) Rinse the cell surface with 2 ml of sterile PBS solution, and then suck out the PBS waste liquid with a vacuum pump.

[0058] f) Gently add 1ml 0.25% (w / v) Trypsin-0.038% (w / v) EDTA solution to the culture dish to digest the cells, mix gently for a few times, the solution covers the cell surface, and observe the ce...

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Abstract

The invention discloses the application of Desogestrel in the preparation of anti-colon cancer / ER-negative Ah receptor-positive breast cancer products. The invention provides the application of Desogestrel in the preparation of products for treating colon cancer and / or breast cancer. Experiments of the present invention prove that the present invention repositions the drug Desogestrel, which has been approved by FDA and CFDA, and screens drugs whose indications are not anti-tumor according to different cell lines (tissue types) and mutation sites of the tumor, and finds that The new use of Desogestrel against colon cancer realizes the new use of old drugs.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to an application of Desogestrel in the preparation of anti-colon cancer / ER-negative Ah receptor-positive breast cancer products. Background technique [0002] Tumor is the most common and serious disease that threatens human health, and the development of highly effective anti-tumor drugs is crucial to prolonging the survival period of patients. In recent years, with the rapid development of tumor genomics and molecular pharmacology, the research and development of new anti-tumor drugs has achieved good results, but due to the large investment in new drug research and development, the bottlenecks such as long cycle cannot be overcome, and the genetic variation of individual tumors is large, etc. Many traditional antineoplastic drugs are ineffective, new drugs are expensive, and side effects are unknown. [0003] Barabasi AL and other researchers pointed out in a paper published in "Na...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/59A61P35/00
Inventor 师咏勇宋智健
Owner SHANGHAI JIAOTONG UNIV
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