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Application of Estrone in preparation of ovarian cancer resistant and/or breast cancer resistant product

A technology for breast cancer and ovarian cancer, applied in the application field of Estrone in the preparation of anti-ovarian cancer and/or breast cancer products, which can solve the problems of ineffective anti-tumor drugs, long cycle time, and expensive new drugs

Active Publication Date: 2015-10-21
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the rapid development of tumor genomics and molecular pharmacology, the research and development of new anti-tumor drugs has achieved good results, but due to the large investment in new drug research and development, the bottlenecks such as long cycle cannot be overcome, and the genetic variation of individual tumors is large, etc. characteristics, leading to the ineffectiveness of many traditional antineoplastic drugs, expensive new drugs, and unknown side effects

Method used

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  • Application of Estrone in preparation of ovarian cancer resistant and/or breast cancer resistant product
  • Application of Estrone in preparation of ovarian cancer resistant and/or breast cancer resistant product
  • Application of Estrone in preparation of ovarian cancer resistant and/or breast cancer resistant product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1, CELLTITER-GLO detects Estrone against ovarian cancer and / or breast cancer

[0048] 1. Preparation of orifice plate to be tested

[0049] 1. Cell plating

[0050] a) Prepare the complete medium required for each cell.

[0051] b) Before the start of the experiment, confirm the drug screening cell name, medium, subculture time, generation and other information marked on the 100mm culture dish to ensure that the experiment is correct.

[0052] c) For the operation of adherent cells, refer to steps d) to i), for the operation of suspension cells, refer to steps j) to l).

[0053] d) Use a vacuum pump to suck up the cell culture medium during aseptic operation.

[0054] e) Rinse the cell surface with 2 ml of sterile PBS solution, and then suck out the PBS waste liquid with a vacuum pump.

[0055] f) Gently add 1ml 0.25% (w / v) Trypsin-0.038% (w / v) EDTA solution to the culture dish to digest the cells, mix gently for a few times, the solution covers the cell sur...

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Abstract

The invention discloses an application of Estrone in preparation of an ovarian cancer resistant and / or breast cancer resistant product, and provides an application of the Estrone in preparation of an ovarian cancer curing and / or breast cancer curing product. An experiment of the application proves that relocation of an anti-tumor drug is carried out on the Estrone which is approved by the FDA and the CFDA, according to different cell lines (histopathological types) and mutation sites of a tumor, screening is carried out to screen out drugs showing indications which are not resistant to tumors, novel uses / a novel use of being resistant to ovarian cancer and / or resistant to breast cancer of the Estrone are / is found, and the novel uses / the novel use for the approved drug are / is achieved.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to an application of Estrone in the preparation of anti-ovarian and / or breast cancer products. Background technique [0002] Tumor is the most common and serious disease that threatens human health, and the development of highly effective anti-tumor drugs is crucial to prolonging the survival period of patients. In recent years, with the rapid development of tumor genomics and molecular pharmacology, the research and development of new anti-tumor drugs has achieved good results, but due to the large investment in new drug research and development, the bottlenecks such as long cycle cannot be overcome, and the genetic variation of individual tumors is large, etc. Many traditional antineoplastic drugs are ineffective, new drugs are expensive, and side effects are unknown. [0003] Barabasi AL and other researchers pointed out in a paper published in "Nature Reviews Genetics" in 2011 that...

Claims

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Application Information

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IPC IPC(8): A61K31/566A61P35/00A61P15/00
Inventor 师咏勇宋智健
Owner SHANGHAI JIAO TONG UNIV
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