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Applications of Promethazine in preparing anti-liver cancer and/or colorectal carcinoma and/or lung cancer products

A technology for colon cancer and liver cancer inhibition, applied in the biological field, can solve the problems of long cycle, unknown side effects, and large genetic variation of individual tumors.

Active Publication Date: 2015-11-11
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the rapid development of tumor genomics and molecular pharmacology, the research and development of new anti-tumor drugs has achieved good results, but due to the large investment in new drug research and development, the bottlenecks such as long cycle cannot be overcome, and the genetic variation of individual tumors is large, etc. characteristics, leading to the ineffectiveness of many traditional antineoplastic drugs, expensive new drugs, and unknown side effects

Method used

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  • Applications of Promethazine in preparing anti-liver cancer and/or colorectal carcinoma and/or lung cancer products
  • Applications of Promethazine in preparing anti-liver cancer and/or colorectal carcinoma and/or lung cancer products
  • Applications of Promethazine in preparing anti-liver cancer and/or colorectal carcinoma and/or lung cancer products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1, CELLTITER-GLO detects that Promethazine resists liver cancer and / or colon cancer

[0046] 1. Preparation of orifice plate to be tested

[0047] 1. Cell plating

[0048] a) Prepare the complete medium required for each cell.

[0049] b) Before the start of the experiment, confirm the drug screening cell name, medium, subculture time, generation and other information marked on the 100mm culture dish to ensure that the experiment is correct.

[0050] c) For the operation of adherent cells, refer to steps d) to i), for the operation of suspension cells, refer to steps j) to l).

[0051] d) Use a vacuum pump to suck up the cell culture medium during aseptic operation.

[0052] e) Rinse the cell surface with 2 ml of sterile PBS solution, and then suck out the PBS waste liquid with a vacuum pump.

[0053] f) Gently add 1ml of 0.25% (w / v) Trypsin-0.038% (w / v) EDTA solution to the culture dish to digest the cells, mix gently for a few times, the solution covers th...

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Abstract

The invention discloses applications of Promethazine in preparing anti-liver cancer and / or colorectal carcinoma and / or lung cancer products. Medicine Promethazine approved by FDA and CFDA is subjected to tumor drug repositioning, drugs with indication not including tumor are subjected to screening based on different cell lines (tissue types) and mutation sites of tumor, the novel application of Promethazine in resisting liver cancer and / or colorectal carcinoma and / or lung cancer is discovered, and new use for approved drug is realized.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the application of Promethazine in the preparation of products against liver cancer and / or colon cancer and / or lung cancer. Background technique [0002] Tumor is the most common and serious disease that threatens human health, and the development of highly effective anti-tumor drugs is crucial to prolonging the survival period of patients. In recent years, with the rapid development of tumor genomics and molecular pharmacology, the research and development of new anti-tumor drugs has achieved good results, but due to the large investment in new drug research and development, the bottlenecks such as long cycle cannot be overcome, and the genetic variation of individual tumors is large, etc. Many traditional antineoplastic drugs are ineffective, new drugs are expensive, and side effects are unknown. [0003] Researchers such as BarabasiAL pointed out in a paper published in "Nature R...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5415A61P35/00
Inventor 师咏勇宋智健
Owner SHANGHAI JIAO TONG UNIV
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