Next generation sequencing based coronary heart disease genetic risk evaluation method

A genetic risk assessment and next-generation sequencing technology, applied in the field of coronary heart disease risk assessment based on next-generation sequencing, can solve problems such as the lack of a good genetic risk assessment method for coronary heart disease.

Inactive Publication Date: 2016-01-27
SUZHOU GENEWORKS TECH CO LTD
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  • Abstract
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  • Claims
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Problems solved by technology

At present, there is no good genetic risk assessment method for coronary heart disease. In view of t...

Method used

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  • Next generation sequencing based coronary heart disease genetic risk evaluation method
  • Next generation sequencing based coronary heart disease genetic risk evaluation method
  • Next generation sequencing based coronary heart disease genetic risk evaluation method

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Embodiment Construction

[0028] The above solution will be further described below in conjunction with specific embodiments. It should be understood that these examples are used to illustrate the present invention and not to limit the scope of the present invention. The implementation conditions used in the examples can be further adjusted according to the conditions required by specific applications, and the unspecified implementation conditions are usually the conditions in routine experiments.

[0029] The concrete method of a kind of coronary heart disease risk assessment method of the present invention is as follows:

[0030](1) Selection and weighting of risk SNPs. 风险SNPs位点有两个来源:第一,已知风险SNPs位点,包括rs646776,rs17114036,rs11206510,rs17465637,rs6725887,rs9818870,rs17609940,rs9349379,rs12190287,rs3798220,rs10455872,rs11556924,rs4977574,rs9411489,rs1746048, rs12413409, rs964184, rs2259816, rs3184504, rs4773144, rs2895811, rs3825807, rs12936587, rs216172, rs46522, rs1122608, rs9982601; Second, deep minin...

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Abstract

The invention discloses a next generation sequencing based coronary heart disease genetic risk evaluation method. Particularly, the invention relates to screening of coronary heart disease genetic risk loci and establishment of a coronary heart disease genetic risk evaluation model based on the risk loci. Depending on the model, an individual genome is subjected to targeted sequencing to finally obtain coronary heart disease genetic risk of an individual.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the field of molecular biology, and relates to a method for assessing the risk of coronary heart disease based on next-generation sequencing. Background technique [0002] Predicting disease risk through genome sequencing technology is one of the important scientific research directions in the era of genome big data, and it also provides a strategy for personalized health management. In the past decade, with the development of high-throughput molecular detection technologies, including expression profiling microchips and SNP typing chips, especially the genome-wide association technology, many disease risk loci have been discovered for common complex diseases in humans. This knowledge is based on Individual genome sequencing offers the possibility to predict disease risk. At present, the general process of disease risk prediction based on next-generation sequencing is as follows: fi...

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Application Information

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IPC IPC(8): G06F19/00
Inventor 张鑫磊朱文杰袁骁
Owner SUZHOU GENEWORKS TECH CO LTD
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