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A kind of pharmaceutical composition for treating psoriasis

A composition and technology for psoriasis, applied in the directions of drug combinations, skin diseases, pharmaceutical formulations, etc., can solve the problems of severe symptoms, inducing acute pustular psoriasis or erythrodermic psoriasis, etc.

Active Publication Date: 2018-05-01
CHANGSHA BAISHUN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the ointments for the treatment of psoriasis have added glucocorticoids. Although the effect is good, the symptoms are worse than before after stopping the medicine, and can even induce acute pustular psoriasis or erythrodermic psoriasis sick

Method used

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  • A kind of pharmaceutical composition for treating psoriasis
  • A kind of pharmaceutical composition for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Calcipotriol 2g, Hydroxyurea 1.5g, Glyceryl Monostearate 10g, Liquid Paraffin 9g, White Petrolatum 6g, Azone 2g, Span-80 6g, Sodium Lauryl Sulfate 2g, Glycerin 16g, Purified Water 50g

[0022] Preparation:

[0023] 1) Grind the prescribed amount of calcipotriol and hydroxyurea through an 80-mesh sieve, add glycerin and grind evenly, and set aside.

[0024] 2) Dissolve liquid paraffin, white petrolatum, glyceryl monostearate, Span-80, and azone in a water bath at 80°C.

[0025] 3) Add sodium lauryl sulfate to purified water and dissolve in a 78°C water bath.

[0026] 4) Under the condition of 500r / min, slowly add 2) into 3), stir for 10min, then cool down to 40-60℃, add 1) and continue stirring for 8min, then cool to room temperature.

Embodiment 2

[0028] Calcipotriol 2g, Hydroxyurea 1.5g, Glyceryl Monostearate 10g, Liquid Paraffin 7g, White Petrolatum 8g, Azone 2g, Span-80 5g, Sodium Lauryl Sulfate 3g, Glycerin 16g, Purified Water 50g

[0029] Preparation:

[0030] 1) Grind the prescribed amount of calcipotriol and hydroxyurea through an 80-mesh sieve, add glycerin and grind evenly, and set aside.

[0031] 2) Dissolve liquid paraffin, white petrolatum, glyceryl monostearate, Span-80, and azone in a water bath at 80°C.

[0032] 3) Add sodium lauryl sulfate to purified water and dissolve in a 78°C water bath.

[0033] 4) Under the condition of 500r / min, slowly add 2) into 3), stir for 10min, then cool down to 40-60℃, add 1) and continue stirring for 8min, then cool to room temperature.

Embodiment 3

[0035] Calcipotriol 2g, Hydroxyurea 1.5g, Glyceryl Monostearate 10g, Liquid Paraffin 5g, White Petrolatum 10g, Azone 2g, Span-80 7g, Sodium Lauryl Sulfate 1g, Glycerin 16g, Purified Water 50g

[0036] Preparation:

[0037] 1) Grind the prescribed amount of calcipotriol and hydroxyurea through an 80-mesh sieve, add glycerin and grind evenly, and set aside.

[0038] 2) Dissolve liquid paraffin, white petrolatum, glyceryl monostearate, Span-80, and azone in a water bath at 80°C.

[0039] 3) Add sodium lauryl sulfate to purified water and dissolve in a 78°C water bath.

[0040] 4) Under the condition of 500r / min, slowly add 2) into 3), stir for 10min, then cool down to 40-60℃, add 1) and continue stirring for 8min, then cool to room temperature.

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PUM

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Abstract

The invention discloses a medicine composition for treating psoriasis. The medicine composition is characterized by being prepared from, by weight, 1-10 parts of calcipotriol, 1-10 parts of hydroxyurea, 1-20 parts of glycerol monostearate, 1-20 parts of fat-soluble matrix, 1-20 parts of an emulsifier, 5-20 parts of a moisturizing agent, 1-8 parts of a transdermal absorbent and 20-70 parts of purified water. The medicine composition is scientific in formula and simple in preparation technology and has the remarkable treatment curative effect on psoriasis vulgaris and psoriasis inveterate.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating psoriasis. Background technique [0002] Psoriasis, commonly known as psoriasis, commonly known as "undead cancer", is a common skin disease characterized by hyperplasia of the epidermis and chronic inflammatory response of the dermis. The prevalence rate of the natural population is about 2%, and it has a tendency to increase year by year. The disease has a higher incidence rate and a longer course of disease, and the onset is mainly in young adults, which has a greater impact on the patient's physical health and mental status. The clinical manifestations are mainly erythema and scales, and the disease can occur all over the body. The scalp and the extensor sides of the limbs are more common, and it usually aggravates in winter. At present, most of the ointments for the treatment of psoriasis have added glucocorticoids. Althou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/593A61P17/06A61K31/17
CPCA61K9/06A61K31/17A61K31/593A61K47/14A61K2300/00
Inventor 不公告发明人
Owner CHANGSHA BAISHUN BIOTECH
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