Screening method for highly contributing pathogenic genes in rheumatoid arthritis

A rheumatoid and arthritis technology, applied in the field of screening high-contribution pathogenic genes for rheumatoid arthritis, can solve problems such as destruction of joint organs, affecting joints and joints of the whole body, abnormal gene expression, etc., and achieve early treatment and prevention. Effect
CN107475351BActive Publication Date: 2021-02-05戴勇 +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
戴勇
Publication Date
2021-02-05

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Abstract

A method for screening pathogenic genes with high contribution to rheumatoid arthritis, comprising the following steps: setting a rheumatoid arthritis patient group and a healthy control group, each group including several peripheral blood samples from different human bodies that have been separated from the human body; extracting DNA in peripheral blood samples; prepare the DNA pool of the rheumatoid arthritis patient group and the DNA pool of the healthy control group; measure the content, quality and integrity of the DNA pool, and if it is available, proceed to the next step; construct a DNA library; The genome resequencing method is used to sequence the rheumatoid arthritis patient group and the healthy control group respectively to obtain the sequencing results of the rheumatoid arthritis patient group and the healthy control group; the sequencing results of the rheumatoid arthritis patient group Compared with the sequencing results of the healthy control group, high-contributing gene variation sites were screened out. The above-mentioned screening method can screen out the mutation sites of highly contributing pathogenic genes, which is beneficial to the early treatment and prevention of the inflammation.
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Description

technical field

[0001] The invention relates to a method for obtaining high-contribution pathogenic gene information of rheumatoid arthritis as an intermediate result, in particular to a screening method for high-contribution pathogenic genes of rheumatoid arthritis. Background technique

[0002] Rheumatoid Arthritis (RA) is an autoimmune disease with a high incidence in the world. Among them, the incidence in my country remains high, and the incidence of women is much higher than that of men. It has always been the biggest and most common problem that plagues people's normal life. It is one of the most common diseases, which is characterized by joint symmetry and destruction, eroding the bones and joints of the human body, mild cases of temporary pain, inconvenience of movement, inflexibility of limbs, etc., severe cases of walking difficulties, skeletal deformities, It is accompanied by painful and irreversible pathological features, and causes multiple inflammations of vari...

Claims

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