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Methods for monitoring CD4+ T-helper type 1 response in cancer and immune restoration

A cancer and cell technology, applied in the direction of blood/immune system cells, animal cells, vertebrate cells, etc., can solve problems such as unclear effects

Inactive Publication Date: 2018-01-02
布莱恩 J 赫尔尼奇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, systemic anti-HER2 CD4 + The role of the Th1 response is unclear

Method used

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  • Methods for monitoring CD4+ T-helper type 1 response in cancer and immune restoration
  • Methods for monitoring CD4+ T-helper type 1 response in cancer and immune restoration
  • Methods for monitoring CD4+ T-helper type 1 response in cancer and immune restoration

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[0183] Preferred embodiments are further described in detail with reference to the following experimental examples. These examples are provided for purposes of illustration only and are not intended to be limiting unless otherwise specified. Accordingly, the preferred embodiments should in no way be construed as limited to the examples below, but rather should be construed to encompass any and all variations that become apparent as a result of the teaching provided herein.

[0184] Without further description, one skilled in the art is believed to be able, using the preceding description and the following illustration, to make and use the present embodiments and practice the claimed methods. The following working examples thus point specifically to preferred embodiments and are not to be construed in any way as limiting the remainder of the disclosure.

[0185] The following reference example includes Methods, Results and Discussion sections.

[0186] Reference example

[0...

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Abstract

A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprises: generating a circulating anti-cancer CD4+ Th1 response from antigen presenting cells or their precursors and CD4+ T-cells from a sample of the subject's blood which causes secretion of interferon-gamma ('IFN-[gamma]'); and detecting the anti-cancer CD4+ Th1 response to determine if the response is depressed. A method for restoring HER2-specific CD4+ Th1 immune response in a HER2-positive breast cancer patient in need thereof, comprises: administering to the patient a therapeutically effective amount of a dendritic cell ('DC') vaccine comprising autologous DCs pulsed with HER2-derived MHC class II binding peptides ('DC vaccination') to elevate the patient's anti-HER2 CD4+ Th1 response; and measuring said anti-HER2 Th1 response of the patient pre- and post-DC vaccination to determine the amount of increase in the response.

Description

[0001] This application is a continuation-in-part of Serial No. 14 / 985,303 filed December 30, 2015, which in turn is a continuation-in-part of Serial No. 14 / 658,095 filed March 13, 2015, which in turn claims priority To and benefit from U.S. Provisional Application Serial No. 61 / 953,726 filed March 14, 2014, the entire contents of each such application are hereby incorporated by reference. This application also claims priority and benefits from International Application No. PCT / US 15 / 20613 filed March 13, 2015 under the Patent Cooperation Treaty, which in turn claims priority and benefits from March 14, 2014 US Provisional Patent Application Serial No. 61 / 953,726 filed, the entire contents of each such application are incorporated herein by reference. [0002] thank you [0003] This application was developed with support in part under grant number R01CA096997 awarded by the National Institutes of Health. The government has certain rights in this application. technical field...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/569G01N33/574C12N5/078C12N5/0784A61K35/12A61K35/17A61K38/19A61K38/20A61P35/00
CPCA61K38/20A61K35/12G01N33/5091G01N33/57419G01N2333/57G01N2800/52G01N2800/54A61P15/00A61P35/00A61P37/04A61K39/4622A61K39/4615A61K39/464406A61K39/001106
Inventor 布莱恩·J·赫尔尼奇加里·K·科斯基乔休德普·达塔
Owner 布莱恩 J 赫尔尼奇
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