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Quality control method in extraction process of Salvia miltiorrhiza, and method for extracting salvianolic acid B

A quality control method and extraction process technology, applied in the field of traditional Chinese medicine production technology, can solve the problems of difficult product quality control, high labor intensity, complex components, etc., and achieve the effects of inhibiting degradation and oxidation, improving accuracy, and reducing interference

Inactive Publication Date: 2018-11-06
GUIZHOU JINGFENG INJECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the prior art, in the extraction method of salvianolic acid B: most of them use high-temperature decoction and reflux extraction to obtain the phenolic acid components in the medicinal material of Danshen. In this way, salvianolic acid B is easily degraded and oxidized after being heated for a long time. The transfer rate is very low; Salvia miltiorrhiza has many components, complex components, and dynamic transformation between components, it is difficult to maximize the extr

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  • Quality control method in extraction process of Salvia miltiorrhiza, and method for extracting salvianolic acid B
  • Quality control method in extraction process of Salvia miltiorrhiza, and method for extracting salvianolic acid B
  • Quality control method in extraction process of Salvia miltiorrhiza, and method for extracting salvianolic acid B

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Embodiment 1

[0033] The present embodiment provides a kind of quality control method in the salvia miltiorrhiza extraction process, and it comprises the following steps:

[0034] S1. Add 300L of purified water to the extraction tank, start stirring, heat the water to 90°C with steam, and add an appropriate amount of acid to maintain the pH of the liquid at 3.5. Put 15kg of medicinal materials that have been weighed into the extraction tank, extract at a temperature of 85°C, and keep stirring during the extraction process.

[0035] S2. After 30 minutes of the extraction, the first sampling was carried out, and then the samples were taken every 1 minute. The above samples were measured by near-infrared spectroscopy, and the content of salvianolic acid B in the samples was calculated.

[0036] S3. After the test, the sample is sealed and stored at 4°C until use.

Embodiment 2

[0038] The present embodiment provides a kind of quality control method in the salvia miltiorrhiza extraction process, and it comprises the following steps:

[0039] S1. Add 270L of purified water to the extraction tank, start stirring, heat the water to 95°C with steam, and add an appropriate amount of acid to maintain the pH of the liquid at 4.5. Put the weighed 15kg medicinal material into the extraction tank, extract at a temperature of 90°C, and keep stirring during the extraction process.

[0040] S2. After 30 minutes of the extraction, the first sampling was carried out, and then the samples were taken every 1 minute. The above samples were measured by near-infrared spectroscopy, and the content of salvianolic acid B in the samples was calculated.

[0041] S3. After the test, the sample is sealed and stored at 4°C until use.

Embodiment 3

[0043] The present embodiment provides a kind of quality control method in the salvia miltiorrhiza extraction process, and it comprises the following steps:

[0044] S1. Add 225L of purified water to the extraction tank, start stirring, heat the water to 85°C with steam, and add an appropriate amount of acid to maintain the pH of the liquid at 5.0. Put 15kg of medicinal materials that have been weighed into the extraction tank, extract at a temperature of 80°C, and keep stirring during the extraction process.

[0045]S2. After 30 minutes of the extraction, the first sampling was carried out, and then the samples were taken every 1 minute. The above samples were measured by near-infrared spectroscopy, and the content of salvianolic acid B in the samples was calculated.

[0046] S3. After the test, the sample is sealed and stored at 4°C until use.

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Abstract

A quality control method in the extraction process of Salvia miltiorrhiza relates to the field of traditional Chinese medicine production technologies. The method adopts near-infrared spectroscopy tocarry out online monitoring of an extract liquid, so the change of salvianolic acid B in the extract liquid is monitored in real time, and a basis is provided for further adjusting the extraction scheme, thereby the quality of a final product is improved. The method further limits extraction conditions, so the degradation and the oxidation of the salvianolic acid B re effectively inhibited, the interference of byproducts to the near-infrared spectrum of the salvianolic acid B is reduced as much as possible, and the accuracy of a monitoring result is improved. A method for extracting salvianolic acid B is characterized in that the main product salvianolic acid B is accurately monitored in real time in the extraction process, so maximum extraction of the salvianolic acid B is achieved, and high quality and high purity salvianolic acid B is obtained.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine production technology, in particular to a quality control method in the extraction process of salvia miltiorrhiza and a method for extracting salvianolic acid B. Background technique [0002] Salvianolic acid B (Lithospermic acid B) is one of the main components of phenolic acids in Danshen medicinal materials, and its content ranks first in Danshen medicinal materials. Salvianolic acid B has: protection to the heart (protective effect on myocardial ischemia-reperfusion injury, delayed protective effect on cardiac microvascular endothelial cells), protection to the brain (protective effect on cerebral ischemic injury) and anti-tumor , the prevention and treatment of atherosclerosis, the effect on cell apoptosis and so on. [0003] The structure of salvianolic acid B is formed by condensation of 3 molecules of danshensu and 1 molecule of caffeic acid, and has two carboxyl groups. Its s...

Claims

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Application Information

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IPC IPC(8): G01N21/359B01D11/02
CPCG01N21/359B01D11/02B01D11/0207
Inventor 冯世明毕昌琼
Owner GUIZHOU JINGFENG INJECTION