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Correction information acquisition method for performing attenuation correction on pet activity distribution images
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A technology for activity distribution and attenuation correction, which is applied in the field of medical imaging and can solve the problems of inability to provide a large enough scanning range and truncation of attenuation images.
Active Publication Date: 2021-05-07
JIANGSU SINOGRAM MEDICAL TECH CO LTD
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Problems solved by technology
When scanning heavy patients, imaging with other modalities will likely not provide a large enough scan field, resulting in truncated attenuation images
This incomplete attenuation information can also produce attenuation artifacts in PET reconstructions
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Embodiment 1
[0073]Embodiments of the present invention provide a correction information acquisition method for attenuating correction of the PET activity distribution image, such asfigure 1 withfigure 2 As shown, the method includes the following steps:
[0074]S0, get PET probing data with flight time information and other modal images when the PET system scan is scanned.
[0075]For example, other modal images can include: CT images or MR images.
[0076]S1, based on the PET detection data suit from the Poisson distribution, the PET detection data is modeled, and the alignment likelihood functions L (X, μ, Y) of the formula (1);
[0077]
[0078]Where Y = [Y1tY2t, ..., yNT ]TIndicates the detection data, n is expressed as the size of the sinusoidal map, T represents the dimension of the flight time TOF; x = [x1, X2, ..., xM]TIndicates unknown PET radioactive activity distribution, and m is expressed as the size of the PET image space; μ = [μ1μ2, ..., μK]TIndicates unknown linear attenuation coefficient; A =...
Embodiment 2
[0119]The present invention also provides a PET image reconstruction method including:
[0120]M01, using any of the above-described embodiments, any one of the corrected information acquisition methods, acquisition of the output value of the PET radioactivity distribution X and the linear attenuation coefficient distribution μ;
[0121]M02, based on the output value of the PET radioactivity distribution μ, the PET system scanned PET activity distribution image reconstruction is applied.
[0122]It should be noted that the output value of the X and μ acquired in the first embodiment is indicated by an array, which is used to indicate the value of the PET radioactivity distribution and the linear attenuation coefficient distribution of each pixel point.
[0123]In practical applications, the PET active distribution image reconstruction is reconstructed with a single bed, and then spliced into a PET activity distribution image of the entire scanning space;
[0124]Alternatively, the PET activity d...
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Abstract
The invention discloses a correction information acquisition method for performing attenuation correction on PET activity distribution images. The method includes: S0 acquiring PET detection data with time-of-flight information and other modal images during PET system scanning; S1 performing PET detection data Perform modeling processing to obtain L(x, μ, y); S2. According to other modal images, obtain the linear attenuation coefficient distribution image μ 0 ; S3. If there are artifacts in the linear attenuation coefficient distribution image, then obtain the complete linear attenuation coefficient distribution R(μ); S4. Based on μ 0 , using an iterative algorithm to optimize L(x,μ,y), and during the optimization process, use R(μ) to update the μ value of each iteration, and obtain the correction information of x and μ when the iteration termination condition is satisfied estimated value. In a specific implementation, applying the final estimated values x and μ to PET image reconstruction can solve the problem of attenuation artifacts in PET image reconstruction in the prior art, and can ensure accurate quantification of attenuation correction.
Description
Technical field[0001]The present invention relates to the field of medical imaging, and more particularly to a correction information acquisition method, a PET activity distribution image reconstruction method, and a PET system that performs attenuation correction method, PET activity distribution image reconstruction method.Background technique[0002]Positron Emiss Tomography, PET is a high-end nuclear medical imaging diagnostic device. Use radioactivity (eg, in practice)18F,11C, etc.) Mark the metabolic substance and inject the metabolic material marked with a nucleate into the human body, and then perform functional metabolism imaging through the PET system, reflecting the situation of life metabolic activities, thereby achieving the purpose of diagnosis.[0003]When the PET system is acquired, the photon reaches the PET system, which is attenuated in the human body, and the inventory of the object is in the event of an event in the surface of the object, which has a greater detecti...
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