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Pancreatic cancer diagnosis marker and application thereof

A pancreatic cancer, selected technology, applied in the field of pancreatic cancer diagnostic markers, can solve the problems of pancreatic cancer patients with a 5-year survival rate of less than 10%, rapid occurrence and development, and difficulty in early diagnosis.

Inactive Publication Date: 2019-12-10
CENT FOR EXCELLENCE IN MOLECULAR CELL SCI CHINESE ACAD OF SCI +1
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Problems solved by technology

[0003] Although the five-year survival rate of pancreatic cancer patients in the United States increased from 3.0% to 8.5% from 1975 to 2017, the current five-year survival rate of pancreatic cancer patients is still less than 10%, which is not optimistic
Early diagnosis is difficult, the prognosis is poor, and the occurrence and development are rapid. Most of the patients diagnosed with pancreatic cancer are in the advanced stage. Surgical resection is currently the only effective way to completely cure pancreatic cancer, but the recurrence rate of pancreatic cancer in patients with surgical resection is very high

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  • Pancreatic cancer diagnosis marker and application thereof
  • Pancreatic cancer diagnosis marker and application thereof
  • Pancreatic cancer diagnosis marker and application thereof

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[0025] It should be understood that within the scope of the present invention, the above-mentioned technical features of the present invention and the technical features specifically described in the following (such as embodiments) can be combined with each other to form a preferred technical solution.

[0026] In this paper, a quantitative proteomics strategy based on TMT markers was used to study the differentially expressed proteins in cancer tissues and paracancerous tissues of 32 pancreatic cancer patients; at the same time, patients were divided into survival groups according to their 9-15 month survival and dead groups, the differentially expressed proteins in cancer tissues of living and dead patients were studied. Finally, 540 differentially expressed proteins were found in cancer tissues and para-cancer tissues, 540 proteins were significantly enriched in the ECM-receptor interaction pathway, and 22 proteins were more significantly expressed in cancer tissues and para...

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Abstract

The invention relates to a pancreatic cancer diagnostic marker and an application thereof. The pancreas cancer diagnosis marker comprises any one or more of protein of HLA-G, POSTN, COL12A1, THBS2, MUC5AC, AGR2, GPRC5A, USP44, CPEB2, DDX19B, CAMP, DUS1L, SLC16A3, ZNF236, TPM4, CHGA, S100P, CEACAM6, S100A12, HTRA3, COL10A1 and LAMC2. The invention also relates to a kit for detecting the expressionlevel of any one or more of these proteins.

Description

technical field [0001] The invention relates to the diagnosis of pancreatic cancer, in particular to a pancreatic cancer diagnostic marker and its application. Background technique [0002] Pancreatic cancer is currently the twelfth most common cancer in the world and the seventh most common cause of death. The prognosis of pancreatic cancer is extremely poor, and the annual incidence and death toll are close to 1:1. According to the statistics of the World Health Organization in 2012, pancreatic cancer is currently the twelfth most common cancer in the world and the seventh leading cause of death. There are 330,000 new pancreatic cancer patients and 330,000 deaths each year worldwide. In humans, the ratio of the incidence of pancreatic cancer to the number of deaths is close to 1:1. Pancreatic cancer includes endocrine pancreatic cancer and exocrine pancreatic cancer. Most pancreatic cancer patients belong to exocrine pancreatic cancer, and pancreatic ductal adenocarcinoma...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N30/88
CPCG01N30/88G01N33/57438G01N33/57484
Inventor 曾嵘吴家睿金钢李辰郭世伟袁亚俊
Owner CENT FOR EXCELLENCE IN MOLECULAR CELL SCI CHINESE ACAD OF SCI
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