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Traditional Chinese medicine composition with effect of improving cognition, preparation method thereof, and traditional Chinese medicine preparation

A technology for improving cognition and traditional Chinese medicine preparations, which is applied in the direction of drug combinations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as incomplete medicinal ingredients, and achieve improved brain cognition, Effects of improving Alzheimer's disease and improving brain cognition

Active Publication Date: 2020-02-04
甘肃琛蓝生物科技有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extraction of medicinal ingredients in this prescription is not complete enough, and other public technologies rarely mix the volatile oil with the Chinese medicine extract after inclusion

Method used

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  • Traditional Chinese medicine composition with effect of improving cognition, preparation method thereof, and traditional Chinese medicine preparation
  • Traditional Chinese medicine composition with effect of improving cognition, preparation method thereof, and traditional Chinese medicine preparation
  • Traditional Chinese medicine composition with effect of improving cognition, preparation method thereof, and traditional Chinese medicine preparation

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Experimental program
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Effect test

Embodiment 1

[0042] Embodiment 1 Chinese medicine composition and preparation method thereof

[0043] 1, the present embodiment formula is:

[0044] Gastrodia elata 180g, polygala 120g, calamus 180g, cistanche 60g, rehmannia glutinosa 60g, curcumin 1g.

[0045] 2. The preparation method is:

[0046] (1) Gastrodia elata and polygala plus 10 times the amount of 70% ethanol were heated and refluxed for 3 times, each time for 1 hour, and the medicinal liquid and dregs were collected respectively;

[0047] (2) add 14 times the amount of water to Acorus calamus, heat and reflux once for 5 hours, and collect the medicinal liquid, medicinal residues and volatile oil respectively;

[0048] (3) add Cistanche deserticola, rehmannia glutinosa and the traditional Chinese medicine dregs collected in steps (1) and (2) to 10 times the amount of water, heat and reflux twice, each time for 1.5 hours, and collect the liquid medicine respectively;

[0049] (4) filtering and concentrating all the medicinal ...

Embodiment approach

[0101] Implementation method: The test program includes two parts: directional navigation and space exploration. A total of 5 days of continuous testing. The first part is the positioning and navigation experiment, and the mice are tested for 4 days, and the second part is the space exploration experiment, which is tested for 1 day. Rinse the black veggie toner with warm water to hide the platform and make it contrast sharply with the color of the mice for easy tracking. The platform is located 0.8cm below the water surface, the water depth is 21cm high, and it is located in the NW quadrant. The water temperature in the water maze is kept at a constant temperature of 22-24°C with heating rods.

[0102] Orientation navigation experiment: each mouse was trained 4 times / d, and the time interval between each training was 15-20min. During the test, the water entry point was selected in a semi-random manner each time. The experimenter held the mouse with his hand so that it faced ...

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Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition with an effect of improving cognition, a preparation method thereof, and a traditional Chinese medicine preparation. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-20 parts of gastrodia elata, 1-15parts of polygala amflra, 1-30 parts of acorus tatarinowii, 0.1-10 parts of cistanche salsa, 0.1-10 parts of prepared rehmannia root, and 0.01-1 part of curcumin. A prescription is extracted througha composite extraction method, and pharmacodynamic substances of the gastrodia elata, the polygala amflra, the acorus tatarinowii, the cistanche salsa and the prepared rehmannia root are completely extracted as many as possible, concentrated and dried; acorus tatarinowii volatile oil and the curcumin are included and dried through a volatile oil inclusion technology, traditional Chinese medicine compound extract dry powder and a volatile oil inclusion compound are evenly mixed, and then the final traditional Chinese medicine composition is obtained; and through pharmacological experiments, itis proved that compound traditional Chinese medicine has the effect of improving brain cognition.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition capable of improving cognition, a preparation method thereof and a traditional Chinese medicine preparation. Background technique [0002] As the world's aging trend increases year by year, mild cognitive impairment (mild cognitive impairment, MCI) and vascular cognitive impairment (Vascular cognitive impairment, VCI), which are transitional states from normal aging to dementia, are becoming more and more popular. focus on. In developed countries, the mortality rate of senile dementia ranks fourth after heart disease, tumor and stroke. As the world's population ages, the disease has become one of the most serious problems facing geriatric medicine today. Mild cognitive impairment in the early stages of Alzheimer's is recognized as a highly prevalent and preventable syndrome. Currently, there is no specific treatm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61P25/00A61K31/12
CPCA61K36/8988A61K36/69A61K36/888A61K36/64A61K36/804A61K31/12A61P25/00A61K2300/00A61K36/882A61K47/6951A61K2236/331A61K2236/333A61K2236/37A61K2236/53A61K36/9066A61K9/5036A61K9/0053
Inventor 张曾亮王尚龙李鑫宗磊宗建成邹圣灿
Owner 甘肃琛蓝生物科技有限公司
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