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A kind of dressing for promoting wound healing and preparation method thereof

A wound healing and mixed solution technology, applied in the field of biomedical engineering, can solve problems such as poor wound healing effect, poor barrier effect, and exogenous infection

Active Publication Date: 2021-09-10
江苏奥普莱医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional dressings also have obvious disadvantages. For example, the dressing has poor barrier function after being penetrated by wound fluid, which is easy to cause exogenous infection and has poor wound healing effect.

Method used

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  • A kind of dressing for promoting wound healing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] alpha 2 Method for preparing M crude tissue:

[0022] Fresh pig plasma was added to a 0.1% (w / v) soy trypsin inhibitor under -5 ° C, and EDTA (ethylenediamine tetracetate) solution was added to a final concentration to 10 mmol / L, after 5% - The 18% polyethylene glycol 6000 was graded, stirred with stirring for 60 min, 40 mm / min at 4 ° C for 30 min, 5 times mass 50 mmol / L Tris-HCl (pH 7.4) solution dissolved precipitation, 50 mmol / L Tris-HCl (pH7 .4) The buffer is fully dialyzed, that is, α 2 M rough.

Embodiment 1

[0024] 1, take α 2 M crude extract was concentrated and subjected to Sephacryl S-300 gel chromatography column, the eluate was a 100 mmol / l Tris-HCl (pH 8.0) buffer containing 0.5 mol / l NaCl, and the flow out of the absorption peak was detected. The first peak outflow is collected and the ultrafiltration membrane ultrafiltration of 400 kDa is used. 2 Gully globulin solution, its protein concentration is measured to 90 μg / L using a BCA protein quantitative kit;

[0025] 2, 0.42 g of blue copper wins, 0.12 g of copper sulfate, 2.2 g of bright peptide, 5 g of a total molecular weight of 5.0 × 10 5 , The deacetylacetin is 82.5% of the carboxymethyl chitosan and 15g average molecular weight of 1.0 × 10 6 The polyoxyethylene is dissolved in 1 L of water, stirred and uniformly prepared, then the α obtained by 1.25 ml of step 1 2 Gully globulin solution to obtain spinning fluid;

[0026] 3, use the spinning liquid for electrospinning, the syringe specification is 10ml, the needle sp...

Embodiment 2

[0028] 1, take α 2 M crude extract was concentrated and subjected to Sephacryl S-300 gel chromatography column, the eluate was a 100 mmol / l Tris-HCl (pH 8.0) buffer containing 0.5 mol / l NaCl, and the flow out of the absorption peak was detected. The first peak outflow was collected and the ultrafiltration membrane ultrafiltration was concentrated by ultrafiltration membrane ultrafiltration of 300 kDa. 2 Gully globulin solution, its protein concentration was measured by a BCA protein quantitative kit was 80 μg / L;

[0029] 2, 0.17 g of blue copper wins, 0.08 g of copper sulfate, 1.1 g of bright peptide, 5 g of a bonded molecular weight of 5.0 × 10 5 , The deacetylatin is 80% of the carboxymethyl chitosan and 5g average molecular weight of 1.0 × 10 6 The polyoxyethylene is dissolved in 1 L of water, stirred and uniformly prepared, then the alpha obtained by 1 ml of step 1 was added. 2 Gully globulin solution to obtain spinning fluid;

[0030] 3, use the spinning liquid for elec...

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Abstract

The invention relates to the field of biomedical engineering, and discloses a dressing for promoting wound healing and a preparation method thereof, comprising (1)α 2 Purification of macroglobulin; (2) dissolving blue copper peptide, copper sulfate, leupeptin, carboxymethyl chitosan and polyethylene oxide in water, stirring evenly, adding α 2 The macroglobulin solution is used to obtain a spinning solution; (3) the spinning solution is used for electrospinning to obtain a dressing for promoting wound healing. The dressing for promoting wound healing prepared by the invention is a medical material capable of inducing wound healing for a long time, can accelerate wound healing, and is very effective in treating wounds and skin damage.

Description

Technical field [0001] The present invention relates to the field of biomedical engineering, and more particularly to an inkwound healing dressing and a preparation method thereof. Background technique [0002] Skin injury usually requires medical dressing to protect wounds, prevent wound infections and severe dehydration, and provide environmental environment that is conducive to wound healing, promoting wound healing. At present, traditional dressings such as medical skim cotton gauze, cotton pads and Vaseline gauze, etc. are the most widely used dressings for clinical wound applications. The traditional dressing has a mesh woven structure, which is low, the production process is relatively simple, the raw material source is wide, soft, strong absorption ability, can prevent the accumulation of seepage from the wound, and a certain degree of protective effect on the wounds, still Widely used in skin trauma. However, traditional dressings also have a significant disadvantage, su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/18A61L15/26A61L15/28A61L15/32A61L15/42A61L15/44
CPCA61L15/18A61L15/26A61L15/28A61L15/32A61L15/42A61L15/44A61L2300/102A61L2300/252A61L2300/412C08L89/00C08L5/08C08L71/02
Inventor 汤佳鹏吴小梅葛彦朱俐万峥
Owner 江苏奥普莱医疗用品有限公司
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