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Systems and methods for predicting the number of years a subject will experience new changes in ovarian reserve

An ovarian reserve and subject technology, applied in biological testing, inoculation and ovulation diagnosis, medical science, etc., can solve problems such as failure to improve fertility, low fertility, and loss of reproductive opportunities for women of childbearing age.

Active Publication Date: 2021-08-13
GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

People often do not realize that their fertility may be declining until menstrual irregularities or menopause, but when these signs appear, their fertility is already extremely low, and it is no longer possible to improve fertility through assisted reproductive technology
Early fertility decline caused by ovarian reserve decline usually occurs earlier, but due to the long-term lack of clear ovarian reserve assessment methods, a large number of women of childbearing age have lost the best time to give birth

Method used

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  • Systems and methods for predicting the number of years a subject will experience new changes in ovarian reserve
  • Systems and methods for predicting the number of years a subject will experience new changes in ovarian reserve
  • Systems and methods for predicting the number of years a subject will experience new changes in ovarian reserve

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0178] Construction of an optimized three-index ovarian reserve assessment system model

[0179] In the examples of this application, the applicants of this application received the subjects treated with the above-mentioned GnRH antagonists between 2017 and 2018, among which the data of 1523 subjects in 2017 met the above criteria and were accepted Included in this example, the data of 3273 subjects in 2018 meeting the above criteria were included in this example. Used to build the system involved in this application.

[0180] Cases were selected for subsequent studies according to the following inclusion and exclusion criteria.

[0181] The inclusion criteria were: women aged 20-45 years, body mass index (BMI) ≤ 30, six consecutive menstrual cycles of 25-45 days, normal bilateral ovarian morphology assessed by transvaginal ultrasonography, previous IVF / ICSI- ET cycle number ≤ 2.

[0182] The exclusion criteria were: hydrosalpinx, unilateral ovary AFC>20, polycystic ovary s...

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Abstract

This application relates to a system for predicting the age of a subject with new changes in ovarian reserve, which includes: a data collection module, which is used to obtain the age, anti-Müllerian hormone level, and follicle-stimulating hormone level of the subject. Data; a module for calculating ovarian reserve using multi-categorical variables transformed from data of subject's age, subject's anti-Müllerian hormone (AMH) level, subject's follicle stimulating hormone (FSH) level into Calculate the subject's current ovarian hyporesponse probability (p 0 ); calculate the subject's ovarian reserve decline to a certain level of years, which uses the subject's current ovarian reserve, that is, the probability of ovarian hyporesponse (p 0 ) to calculate the number of years the subjects had new changes in ovarian reserve.

Description

technical field [0001] The present invention relates to an optimized system for evaluating the ovarian reserve function of a subject, which can be used to evaluate the condition of the subject's own ovarian reserve function, and to evaluate the subject according to the current ovarian reserve condition of the subject Reaching a specific ovarian reserve state, such as ovarian reserve close to depletion, early fertility decline caused by ovarian reserve decline, and the number of years required for a significant decline in fertility due to ovarian reserve decline (or the number of years that can be used to predict the above-mentioned ovarian reserve status in different individuals age). Background technique [0002] A large percentage of women around the world choose to delay having their first child in search of opportunities to improve their education and the value of their workforce. Female fertility (the ability to establish a clinical pregnancy) is known to decrease as w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B10/00G01N33/74
CPCA61B10/00A61B10/0012G01N33/74
Inventor 徐慧玉李蓉乔杰冯国双韩勇
Owner GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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