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Systems and methods for predicting the number of years a subject will experience new changes in ovarian reserve

A technology for ovarian reserve and subjects, applied in medical data mining, medical informatics, health index calculation, etc., can solve the problems of lack of ovarian reserve evaluation methods, low fertility, and inability to improve fertility, etc.

Active Publication Date: 2021-10-19
GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

People often do not realize that their fertility may be declining until menstrual irregularities or menopause, but when these signs appear, their fertility is already extremely low, and it is no longer possible to improve fertility through assisted reproductive technology
Early fertility decline caused by ovarian reserve decline usually occurs earlier, but due to the long-term lack of clear ovarian reserve assessment methods, a large number of women of childbearing age have lost the best time to give birth

Method used

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  • Systems and methods for predicting the number of years a subject will experience new changes in ovarian reserve
  • Systems and methods for predicting the number of years a subject will experience new changes in ovarian reserve
  • Systems and methods for predicting the number of years a subject will experience new changes in ovarian reserve

Examples

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Effect test

Embodiment

[0128] From January 2017 to December 2018, a total of 16,280 subjects were selected who received fresh cycles of in vitro fertilization / intracytoplasmic sperm injection-embryo transfer (IVF / ICSI-ET) at the Reproductive Medicine Center of Peking University Third Hospital. The inclusion criteria of the subjects are as follows: 1) females aged between 20 and 50; 2) all hormone levels were tested in the endocrine laboratory of Peking University Third Hospital Reproductive Medicine Center.

[0129] In this example, the inventors collected the medical records of the subjects, and obtained information including age, body mass index (BMI), duration of infertility, previous IVF / ICSI-ET attempts, serum basal estradiol (E 2 ), basal luteinizing hormone (LH), follicle-stimulating hormone (FSH) and anti-Müllerian hormone (AMH) levels, antral follicle count (AFC) of the left and right ovaries, and record the causes of infertility.

[0130] Obtaining samples and endocrine assays

[0131] On...

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Abstract

The present invention relates to a system for calculating the age of a subject with new changes in ovarian reserve, which includes: a data acquisition module for acquiring the subject's age, anti-Müllerian hormone level, follicle-stimulating hormone level, and antral follicle count The data; the module for calculating ovarian reserve function, using the receiver operating characteristic curve to detect the cut-off of the subject's age, anti-Müllerian hormone level, follicle stimulating hormone level, and antral follicle count obtained in the data acquisition module point, and convert age, anti-Müllerian hormone level, follicle-stimulating hormone level, and antral follicle count into binary variables according to the cut-off value of the cut-off point, thereby using the binary variables as predictor variables to calculate the affected The current probability of ovarian hyporesponse (p 0 ); calculate the subject's ovarian reserve decline to a certain level of years, using the subject's current ovarian reserve, that is, the probability of ovarian hyporesponse (p 0 ) to calculate the number of years the subjects had new changes in ovarian reserve.

Description

technical field [0001] The present invention relates to an optimized system for evaluating the ovarian reserve function of a subject, which can be used to evaluate the condition of the subject's own ovarian reserve function, and to evaluate the subject according to the current ovarian reserve condition of the subject Reaching a specific ovarian reserve state, such as ovarian reserve close to depletion, early fertility decline caused by ovarian reserve decline, and the number of years required for a significant decline in fertility due to ovarian reserve decline (or the number of years that can be used to predict the above-mentioned ovarian reserve status in different individuals age). Background technique [0002] A large percentage of women around the world choose to delay having their first child in search of opportunities to improve their education and the value of their workforce. Female fertility (the ability to establish a clinical pregnancy) is known to decrease as w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16H50/70G16H50/30
CPCG16H50/70G16H50/30
Inventor 徐慧玉李蓉乔杰冯国双韩勇史莉
Owner GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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