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System and method for calculating age limit of new change of ovarian reserve of subject

A technology for ovarian reserve and subjects, applied in medical data mining, health index calculation, medical informatics, etc., can solve problems such as low fertility, lack of ovarian reserve assessment methods, and women of childbearing age losing their fertility opportunities

Active Publication Date: 2020-10-16
GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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AI Technical Summary

Problems solved by technology

People often do not realize that their fertility may be declining until menstrual irregularities or menopause, but when these signs appear, their fertility is already extremely low, and it is no longer possible to improve fertility through assisted reproductive technology
Early fertility decline caused by ovarian reserve decline usually occurs earlier, but due to the long-term lack of clear ovarian reserve assessment methods, a large number of women of childbearing age have lost the best time to give birth

Method used

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  • System and method for calculating age limit of new change of ovarian reserve of subject
  • System and method for calculating age limit of new change of ovarian reserve of subject
  • System and method for calculating age limit of new change of ovarian reserve of subject

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Embodiment

[0128] From January 2017 to December 2018, a total of 16,280 subjects were selected who received fresh cycles of in vitro fertilization / intracytoplasmic sperm injection-embryo transfer (IVF / ICSI-ET) at the Reproductive Medicine Center of Peking University Third Hospital. The inclusion criteria of the subjects are as follows: 1) females aged between 20 and 50; 2) all hormone levels were tested in the endocrine laboratory of Peking University Third Hospital Reproductive Medicine Center.

[0129] In this example, the inventors collected the medical records of the subjects, and obtained information including age, body mass index (BMI), duration of infertility, previous IVF / ICSI-ET attempts, serum basal estradiol (E 2 ), basal luteinizing hormone (LH), follicle-stimulating hormone (FSH) and anti-Müllerian hormone (AMH) levels, antral follicle count (AFC) of the left and right ovaries, and record the causes of infertility.

[0130] Obtaining samples and endocrine assays

[0131] On...

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Abstract

The invention relates to a system for calculating the age limit of new change of ovarian reserve of a subject, and the system comprises a data acquisition module which is used for obtaining the age, anti-mullerian hormone level, follicle-stimulating hormone level and sinus follicle counting data of the subject; a module for calculating an ovarian reserve function which uses a subject working characteristic curve for detecting the demarcation points of the age, the anti-mullerian hormone level, the follicle-stimulating hormone level and the sinus follicle counting of the subject acquired in thedata acquisition module, converts the age, the anti-mullerian hormone level, the follicle-stimulating hormone level and the sinus follicle count into dichotomy variables according to the tangent point value of the demarcation point and calculates the current low ovarian response probability (p0) of the subject by using the dichotomy variables as prediction variables; and a module for calculatingthe age limit of the subject when the ovarian reserve of the subject is reduced to a certain degree, which is used for calculating the age limit of the subject when the ovarian reserve of the subjectis newly changed by utilizing the current ovarian reserve, namely the ovarian low-response probability (p0).

Description

technical field [0001] The present invention relates to an optimized system for evaluating the ovarian reserve function of a subject, which can be used to evaluate the condition of the subject's own ovarian reserve function, and to evaluate the subject according to the current ovarian reserve condition of the subject Reaching a specific ovarian reserve state, such as ovarian reserve close to depletion, early fertility decline caused by ovarian reserve decline, and the number of years required for a significant decline in fertility due to ovarian reserve decline (or the number of years that can be used to predict the above-mentioned ovarian reserve status in different individuals age). Background technique [0002] A large percentage of women around the world choose to delay having their first child in search of opportunities to improve their education and the value of their workforce. Female fertility (the ability to establish a clinical pregnancy) is known to decrease as w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/70G16H50/30
CPCG16H50/70G16H50/30
Inventor 徐慧玉李蓉乔杰冯国双韩勇史莉
Owner GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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