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System and method for predicting new change age limit of ovarian reserve of subject

An ovarian reserve and subject technology, applied in biological testing, inoculation and ovulation diagnosis, medical science, etc., can solve the problems of inability to improve fertility, low fertility, and loss of reproductive opportunities for women of childbearing age.

Active Publication Date: 2020-10-16
GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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  • Description
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Problems solved by technology

People often do not realize that their fertility may be declining until menstrual irregularities or menopause, but when these signs appear, their fertility is already extremely low, and it is no longer possible to improve fertility through assisted reproductive technology
Early fertility decline caused by ovarian reserve decline usually occurs earlier, but due to the long-term lack of clear ovarian reserve assessment methods, a large number of women of childbearing age have lost the best time to give birth

Method used

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  • System and method for predicting new change age limit of ovarian reserve of subject
  • System and method for predicting new change age limit of ovarian reserve of subject
  • System and method for predicting new change age limit of ovarian reserve of subject

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0178] Construction of an optimized three-index ovarian reserve assessment system model

[0179] In the examples of this application, the applicants of this application received the subjects treated with the above-mentioned GnRH antagonists between 2017 and 2018, among which the data of 1523 subjects in 2017 met the above criteria and were accepted Included in this example, the data of 3273 subjects in 2018 meeting the above criteria were included in this example. Used to build the system involved in this application.

[0180] Cases were selected for subsequent studies according to the following inclusion and exclusion criteria.

[0181] The inclusion criteria were: women aged 20-45 years, body mass index (BMI) ≤ 30, six consecutive menstrual cycles of 25-45 days, normal bilateral ovarian morphology assessed by transvaginal ultrasonography, previous IVF / ICSI- ET cycle number ≤ 2.

[0182] The exclusion criteria were: hydrosalpinx, unilateral ovary AFC>20, polycystic ovary s...

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Abstract

The invention relates to a system for predicting new change age limit of ovarian reserve of a subject. The system comprises a data collection module which is used for obtaining the data of the age, anti-mullerian hormone level and follicle stimulating hormone level of the subject, a module for calculating an ovarian reserve function, wherein the module calculates a current ovarian hyporesponse probability (p0) of the subject using a multi-taxonomic variable that is obtained by conversion of the data of subject age, subject anti-mullerian hormone (AMH) level, subject follicle stimulating hormone (FSH) level, and a module for calculating the age limit of the ovarian reserve decline of the subject to a certain extent, wherein the module is used for calculating the age limit of the new changeof the ovarian reserve of the subject by using the current ovarian reserve of the subject, namely the ovarian hyporesponse probability (p0).

Description

technical field [0001] The present invention relates to an optimized system for evaluating the ovarian reserve function of a subject, which can be used to evaluate the condition of the subject's own ovarian reserve function, and to evaluate the subject according to the current ovarian reserve condition of the subject Reaching a specific ovarian reserve state, such as ovarian reserve close to depletion, early fertility decline caused by ovarian reserve decline, and the number of years required for a significant decline in fertility due to ovarian reserve decline (or the number of years that can be used to predict the above-mentioned ovarian reserve status in different individuals age). Background technique [0002] A large percentage of women around the world choose to delay having their first child in search of opportunities to improve their education and the value of their workforce. Female fertility (the ability to establish a clinical pregnancy) is known to decrease as w...

Claims

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Application Information

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IPC IPC(8): A61B10/00G01N33/74
CPCA61B10/00A61B10/0012G01N33/74
Inventor 徐慧玉李蓉乔杰冯国双韩勇
Owner GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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