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Micro-droplet preparation system, micro-fluidic chip and design method thereof

A microfluidic chip and chip technology, applied in chemical instruments and methods, measuring tubes/pipettes, laboratory utensils, etc., can solve problems such as poor stability

Pending Publication Date: 2020-11-20
GUANGDONG SHUNDE IND DESIGN INST GUANGDONG SHUNDE INNOVATIVE DESIGN INST
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, the stability of droplets generated by traditional microfluidic chips is poor

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  • Micro-droplet preparation system, micro-fluidic chip and design method thereof
  • Micro-droplet preparation system, micro-fluidic chip and design method thereof
  • Micro-droplet preparation system, micro-fluidic chip and design method thereof

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[0023] In order to make the above objects, features and advantages of the present invention more comprehensible, specific implementations of the present invention will be described in detail below in conjunction with the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, the present invention can be implemented in many other ways different from those described here, and those skilled in the art can make similar improvements without departing from the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.

[0024] refer to Figure 1 to Figure 3 , figure 1 Schematic diagram showing the structure of the chip board 11 of the microfluidic chip 10 according to an embodiment of the present invention; figure 2 showed figure 1 Schematic diagram of the enlarged structure at A; image 3 A schemat...

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Abstract

The invention relates to a micro-droplet preparation system, a micro-fluidic chip and a design method thereof. The micro-fluidic chip comprises a chip board. The chip board is provided with a continuous phase hole, a discrete phase hole, a micro-droplet liquid outlet hole, a first flow channel and a second flow channel. The continuous phase hole is communicated with the middle part of the second flow channel through the first flow channel; the discrete phase hole is communicated with the micro-drop liquid outlet hole through the second flow channel; the first flow channel is provided with a first circuitous channel section; and a second circuitous channel section is arranged from the end, connected with the discrete phase hole, of the second flow channel to the middle of the second flow channel. On one hand, the first circuitous channel section is beneficial to sufficient and uniform mixing of continuous phase fluid and can play a role in flow stabilization, and the second circuitous channel section is also beneficial to sufficient and uniform mixing of discrete phase fluid and plays a role in flow stabilization; and on the other hand, the shear stress during two-phase contact canbe controlled through control, and it is guaranteed that after the dispersed phase fluid enters the micro-channel, under the shear stress effect of the continuous phase fluid, micro-droplets with theuniform size can be stably generated at the intersection.

Description

technical field [0001] The invention relates to the technical field of droplet preparation, in particular to a droplet preparation system, a microfluidic chip and a design method thereof. Background technique [0002] Traditionally, droplet microfluidics is a technology that injects immiscible liquids into microfluidic chips to generate uniform droplets that meet various size requirements at an extremely fast speed. The basic operation units such as sample preparation, reaction, separation, and detection are integrated into micron-scale chips to automatically complete the entire analysis process. Macroscopic samples can undergo various chemical and physical reactions in tens of thousands of microfluidic chips (the volume of a single droplet ranges from nanosonic to picoliter levels). By measuring and analyzing these droplets, the precision and sensitivity of sample detection and analysis can be greatly improved. However, the stability of droplets generated by traditional m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00B01L3/02
CPCB01L3/502707B01L3/0213
Inventor 王帅超梁帅曾杰生王哲
Owner GUANGDONG SHUNDE IND DESIGN INST GUANGDONG SHUNDE INNOVATIVE DESIGN INST
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