GABA agonists and antagonists to affect differentiation of hematopoietic stem cells and megakaryocyte progenitors

A technology of hematopoietic stem cells and progenitor cells, applied in animal cells, vertebrate cells, receptors/cell surface antigens/cell surface determinants, etc. Issues such as anatomical distribution and functional properties

Pending Publication Date: 2022-03-11
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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However, to date, neither the cell type-specific expression of GABA receptors nor their anatomical dist

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  • GABA agonists and antagonists to affect differentiation of hematopoietic stem cells and megakaryocyte progenitors
  • GABA agonists and antagonists to affect differentiation of hematopoietic stem cells and megakaryocyte progenitors
  • GABA agonists and antagonists to affect differentiation of hematopoietic stem cells and megakaryocyte progenitors

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Embodiment Construction

[0019] To facilitate understanding of the present disclosure, certain terms and phrases are defined below and throughout the specification. The definitions provided herein are non-limiting and should be interpreted based on what was known to those skilled in the art at the time of publication of the invention.

[0020] Before the methods and compositions of the present invention are described, it is to be understood that this invention is not limited to the particular methods or compositions described, as actual practice will necessarily vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the inventive concept, the scope of which will be defined only by the appended claims.

[0021] Where a range of values ​​is provided, it is understood that every intervening value between the upper and lower limit of that range is expressly disclosed. Unless the context clearly dictates ...

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Abstract

It has been demonstrated that GABRR1 is expressed on a subset of hematopoietic stem cells (HSC) and megakaryotic progenitor cells (MkP). MkP differentiation and reduction of the number of platelets in blood can be inhibited by inhibiting the GABRR1. GABRR1 overexpression or agonist treatment can significantly promote the generation of MkP and the growth of megakaryocytes.

Description

[0001] Cross References to Related Applications [0002] This patent application claims priority to U.S. Provisional Patent Application No. 62 / 846,865, filed March 13, 2019, which is hereby incorporated by reference in its entirety. Background technique [0003] γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the vertebrate central nervous system and plays a role in neurogenesis. In addition, GABA is also present in various peripheral tissues and organs, such as intestine, stomach, etc. However, to date, neither the cell type-specific expression of GABA receptors nor their anatomical distribution and functional properties in hematopoietic stem and progenitor cells (HSPCs) have been reported. [0004] HSCs are capable of stepwise giving rise to a variety of different cell types. HSC-derived megakaryoline-erythroid progenitors (MEPs) are bipotent progenitors that can differentiate into MkP (platelet-producing) or erythroid progenitors (EP; erythroid-prod...

Claims

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Application Information

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IPC IPC(8): C07K14/715C07K14/705C07K14/475G01N33/00G01N33/48G01N33/94
CPCC07K14/475C07K14/705C12N5/0644C12N15/907C12N2506/11C12N2310/20A61K35/19A61K35/18C12N2740/16043C12N15/1138
Inventor 朱芳芳欧文·L·唔斯曼
Owner THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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