Titration device for drug analysis

Abstract

The invention relates to the technical field of drug analysis, in particular to a drug analysis titration device which comprises a fixed base and a titration base, the fixed base is of a C-shaped structure, two symmetrically-arranged moving grooves are formed in the top of the inner wall of the fixed base, and a plurality of solution bins which are linearly and evenly distributed are arranged below the fixed base; the solution bins are fixedly connected with one another, the tops of the solution bins are slidably connected with the corresponding moving grooves, and burettes are fixedly mounted at the bottoms of the solution bins. The titration base and the burette are designed, accurate titration of a standard solution can be achieved through cooperation of the movable support on the titration base and the burette, the accuracy of drug analysis is improved, meanwhile, high automation is achieved, analysts can conveniently pay attention to the solution reaction in the test tube, accurate operation is facilitated, and the accuracy of drug analysis is improved. The problem of poor drug analysis efficiency in the prior art is solved.

Description

Technical Field

[0001] The invention relates to the technical field of drug analysis, in particular to a drug analysis titration device. Background Art

[0002] Drug analysis is a discipline that uses chemical, physical, biological and microbiological methods and techniques to study the chemical testing of drugs, drug stability, bioavailability, drug clinical monitoring and the qualitative and quantitative analysis of active ingredients in Chinese herbal medicines.

[0003] In drug analysis, various equipment are used, the most common of which is the titration device. When using the titration device, the drug to be analyzed is usually placed in a glass test tube, and then the standard solution is dripped into the test tube through the titration device to fully blend the standard solution and the drug to be analyzed. Finally, the content of the drug to be analyzed is calculated by the consumed volume of the standard solution. However, the existing drug analysis titration device has the following problems when used: 1. The existing titration device can usually only titrate one standard solution. When different standard solutions need to be dripped into the test tube, it usually needs to be replaced manually. This method is relatively primitive and inefficient, and it is easy to delay the mixing time of the solution and the drug; 2. In order to improve the accuracy, the existing titration device will be equipped with a quantitative structure, but these quantitative structures usually come into contact with the standard solution. Therefore, multiple standard solutions require multiple quantitative structures, which undoubtedly increases the cost of drug analysis. Summary of the invention

[0004] The purpose of the present invention is to solve the problems in the background technology and to propose a drug analysis titration device.

[0005] In order to achieve the above-mentioned object, the present invention adopts the following technical scheme: a drug analysis titration device, comprising a fixed base and a titration base, wherein the fixed base is in a C-shaped structure, two symmetrically arranged moving grooves are provided on the top of the inner wall of the fixed base, a plurality of solution tanks evenly distributed in a straight line are arranged below the fixed base, the plurality of solution tanks are fixedly connected to each other, the tops of the plurality of solution tanks are respectively slidably connected to the corresponding moving grooves, and a burette is fixedly installed at the bottom of the solution tank; The titration base is an L-shaped structure, one end of the titration base is fixedly connected to the top of the inner wall of the fixed base, a movable track is provided on the titration base, a movable bracket is slidably installed on the movable track, a connecting shaft is rotatably installed on the movable bracket, and a C-shaped test tube rack is fixedly installed on the end of the connecting shaft away from the movable bracket.

[0006] In the above-mentioned drug analysis titration device, hollow grooves are provided on both sides of the burette, and an isolation layer made of a flexible plastic material is fixedly installed on the inner wall of the hollow groove.

[0007] In the above-mentioned drug analysis titration device, an adjustment groove is provided on the side wall of the titration base, and an adjustment bracket is slidably installed in the adjustment groove. The end of the adjustment bracket away from the adjustment groove is rotatably connected to two symmetrically arranged movable brackets through a rotating shaft. The two movable brackets are arranged facing each other, and telescopic plates are provided on the sides of the two movable brackets close to each other. A telescopic rod 1 is fixedly installed in the movable bracket, and the telescopic end of the telescopic rod 1 penetrates the movable bracket and is fixedly connected to the corresponding telescopic plate. A positioning pressure rod is fixedly installed on the side of the telescopic plate away from the corresponding telescopic rod 1, and a lifting frame is provided below the positioning pressure rod, and a movable pressure rod is fixedly installed on the lifting frame. The distribution positions of the positioning pressure rods and the movable pressure rods on the two movable brackets respectively correspond to the installation positions of the isolation layers on both sides of the burette.

[0008] In the above-mentioned drug analysis titration device, the positioning pressure rod and the movable pressure rod are both semi-cylindrical structures and are in contact with each other.

[0009] In the above-mentioned drug analysis titration device, two symmetrically arranged lifting screws are fixedly installed on the bottom of the movable bracket, and the lifting screws pass through the corresponding lifting frame and are threadedly connected thereto.

[0010] In the above-mentioned drug analysis titration device, an adjusting screw is threadedly connected in the adjusting groove, the adjusting screw passes through the adjusting bracket and is threadedly connected thereto, and the top of the adjusting screw passes through the titration base and the fixed base and is fixedly mounted with an adjusting handle.

[0011] In the above-mentioned drug analysis titration device, a liquid outlet is opened at the bottom of the burette, a sealing bead is inserted in the burette, the sealing bead covers the liquid outlet, a stirring wire is inserted in the burette, the stirring wire passes through the liquid outlet, and both ends of the stirring wire pass through the burette and are fixedly connected in the corresponding solution tank.

[0012] In the above-mentioned drug analysis titration device, a groove is provided on the top of the fixed base, the groove runs through the fixed base, and a liquid adding port is provided on the top of the solution tank.

[0013] In the above-mentioned drug analysis titration device, a drug test tube is inserted on the test tube rack, a sealing ring is inserted in the drug test tube, the outer ring wall of the sealing ring is in contact with the inner wall of the drug test tube, the top of the sealing ring is clamped on the top edge of the drug test tube by two symmetrically arranged hooks, and two symmetrically arranged sealing plates are fixedly installed on the inner ring wall of the sealing ring. The two sealing plates are arranged facing each other, and the sealing plates are fan-shaped. The sides of the two sealing plates close to each other are inclined along the center point of the sealing ring.

[0014] In the above-mentioned drug analysis titration device, inclined pressure rods are fixedly installed on the top of the two sealing plates, the top of the pressure rods extends out of the drug test tube and has an inclined surface, and two symmetrically arranged extrusion rods are fixedly installed on the side wall of the titration base, and the end of the extrusion rod away from the titration base has an inclined surface.

[0015] Compared with the existing technology, the advantages of the drug analysis titration device are as follows: the present invention designs a titration base and a burette, and the movable bracket on the titration base cooperates with the burette to achieve accurate titration of the standard solution, thereby improving the accuracy of drug analysis. At the same time, it is highly automated, which makes it convenient for analysts to pay attention to the solution reaction in the test tube, facilitates accurate operation, and solves the problem of poor drug analysis efficiency in the existing technology. At the same time, the titration of several different standard solutions can be achieved by adjusting the structure on the bracket alone, thereby further improving the efficiency of drug analysis and reducing the cost of drug analysis under the premise of long-term use. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic diagram of the three-dimensional structure of the fixed base and the titration base in the present invention.

[0017] Figure 2 It is a schematic diagram of the three-dimensional structure of the adjustment groove in the present invention.

[0018] Figure 3 It is a schematic diagram of the three-dimensional structure of the titration base in the present invention.

[0019] Figure 4 The present invention Figure 3 Schematic diagram of the local enlarged structure at point A in the middle.

[0020] Figure 5 It is a schematic diagram of the three-dimensional cross-section structure of the drug test tube of the present invention.

[0021] Figure 6 It is a schematic diagram of the cross-sectional structure of the movable bracket in the present invention.

[0022] Figure 7 It is a schematic diagram of the cross-sectional structure of the burette in the present invention.

[0023] Figure 8 The present invention Figure 7 Schematic diagram of the local enlarged structure at point B in the middle.

[0024] In the figure: 1. fixed base; 2. titration base; 101. movable groove; 3. solution tank; 301. burette; 201. movable track; 202. movable bracket; 203. connecting shaft; 204. test tube rack; 302. hollow groove; 303. isolation layer; 205. adjustment groove; 206. adjustment bracket; 207. movable bracket; 208. telescopic plate; 209. telescopic rod 1; 210. positioning pressure rod; 211. lifting frame; 212. movable pressure rod; 213. lifting screw; 214. adjusting screw; 304. liquid outlet; 305. sealing bead; 306. moving thread; 102. groove; 4. drug test tube; 401. sealing ring; 402. sealing plate; 403. pressure rod; 215. squeezing rod. DETAILED DESCRIPTION

[0025] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0026] In the description of the present invention, it is necessary to understand that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0027] Reference Figure 1-Figure 8 A drug analysis titration device comprises a fixed base 1 and a titration base 2. The fixed base 1 is in a C-shaped structure. Two symmetrically arranged moving grooves 101 are provided on the top of the inner wall of the fixed base 1. A plurality of solution tanks 3 evenly distributed in a straight line are arranged below the fixed base 1. The plurality of solution tanks 3 are fixedly connected to each other. The tops of the plurality of solution tanks 3 are respectively slidably connected to the corresponding moving grooves 101. A burette 301 is fixedly installed at the bottom of the solution tank 3. The fixed base 1 is used to be placed on a desktop for fixing and supporting. The titration base 2 is used to realize quantitative titration. An electric slider is slidably installed in the moving groove 101. The electric slider drives the plurality of solution tanks 3 to move back and forth, and can quickly switch between a variety of standard solutions. The burette 301 is used to realize the titration operation.

[0028] The titration base 2 is an L-shaped structure, one end of the titration base 2 is fixedly connected to the top of the inner wall of the fixed base 1, a movable track 201 is provided on the titration base 2, a movable bracket 202 is slidably installed on the movable track 201, a connecting shaft 203 is rotatably installed on the movable bracket 202, a C-shaped test tube rack 204 is fixedly installed on one end of the connecting shaft 203 away from the movable bracket 202, the movable bracket 202 is reciprocated on the movable track 201 by electric drive, a driving motor with forward and reverse functions is fixedly installed in the movable bracket 202, the output shaft of the driving motor is fixedly connected to the connecting shaft 203, and the driving motor can drive the test tube rack 204 to swing back and forth.

[0029] Hollow grooves 302 are provided on both sides of the burette 301 , and an isolation layer 303 made of flexible plastic material is fixedly installed on the inner wall of the hollow groove 302 . The flexible isolation layer 303 on the burette 301 can conveniently squeeze out the solution in the burette 301 to achieve titration.

[0030] An adjusting groove 205 is provided on the side wall of the titration base 2, and an adjusting bracket 206 is slidably installed in the adjusting groove 205. One end of the adjusting bracket 206 away from the adjusting groove 205 is rotatably connected to two symmetrically arranged movable brackets 207 through a rotating shaft. The two movable brackets 207 are arranged facing each other, and a telescopic plate 208 is provided on the side where the two movable brackets 207 are close to each other. A telescopic rod 209 is fixedly installed in the movable bracket 207. The telescopic end of the telescopic rod 209 passes through the movable bracket 207 and is fixedly connected to the corresponding telescopic plate 208. The telescopic plate A positioning pressure rod 210 is fixedly installed on one side of 208 away from the corresponding telescopic rod 209, a lifting frame 211 is arranged below the positioning pressure rod 210, and a movable pressure rod 212 is fixedly installed on the lifting frame 211. The distribution positions of the positioning pressure rod 210 and the movable pressure rod 212 on the two movable brackets 207 correspond to the installation positions of the isolation layers 303 on both sides of the burette 301, respectively. The adjustment groove 205 is used to adjust the adjustment bracket 206. A scale is engraved on the outer wall of the adjustment groove 205 for reference during adjustment. The adjustment bracket 206 Two symmetrically arranged rotating motors are fixedly installed inside, and the two rotating motors have forward and reverse functions. The two rotating motors can drive the two movable brackets 207 to rotate back and forth. When the solution tank 3 needs to be moved, the two movable brackets 207 are operated to move away from each other. At this time, the movable brackets 207 will not block the burette 301. When the solution tank 3 is moved, the two movable brackets 207 are operated to move closer to each other. At this time, the two movable brackets 207 are flush with each other and are respectively distributed on both sides of the burette 301 on the corresponding solution tank 3. 09 is electrically driven, and the telescopic plate 208 can be driven to move horizontally by the extension and retraction of the telescopic rod 209. When titration is required, the telescopic plate 208 is pushed toward the burette 301 by the telescopic rod 209. At this time, the positioning pressure rod 210 and the movable pressure rod 212 will squeeze the isolation layer 303 on the burette 301, and the squeezed burette 301 will be divided into two parts. The solution above the positioning pressure rod 210 will be blocked, and the solution below the positioning pressure rod 210 will be squeezed out by the movable pressure rod 212 under the drive of the lifting frame 211 to achieve titration.

[0031] The positioning pressure rod 210 and the movable pressure rod 212 are both semi-cylindrical structures and contact each other. The positioning pressure rod 210 and the movable pressure rod 212 contact each other to form a cylindrical structure, which is convenient for fully squeezing the burette 301.

[0032] Two symmetrically arranged lifting screws 213 are fixedly installed at the bottom of the movable bracket 207. The lifting screws 213 pass through the corresponding lifting frame 211 and are threadedly connected thereto. Two symmetrically arranged lifting motors are also installed in the movable bracket 207. The lifting motor drives the lifting screws 213 to rotate, and the lifting screws 213 can drive the lifting frame 211 to reciprocate.

[0033] The adjusting groove 205 is internally threadedly connected with an adjusting screw 214, which passes through the adjusting bracket 206 and is threadedly connected thereto, and the top of the adjusting screw 214 passes through the titration base 2 and the fixed base 1 and is fixedly installed with an adjusting handle. The adjusting screw 214 cooperates with the adjusting handle to adjust the height of the adjusting bracket 206, which is convenient for adjustment according to the scale to achieve quantitative titration.

[0034] A liquid outlet 304 is provided at the bottom of the burette 301, a sealing bead 305 is inserted in the burette 301, and the sealing bead 305 covers the liquid outlet 304. A toggle thread 306 is inserted in the burette 301, and the toggle thread 306 runs through the liquid outlet 304. Both ends of the toggle thread 306 run through the burette 301 and are fixedly connected to the corresponding solution tank 3. The liquid outlet 304 is used to discharge the solution. The sealing bead 305 will cover the liquid outlet 304 under the action of its own weight to achieve blocking of the liquid outlet 304 and prevent the solution from dripping out. The toggle thread 306 is in a relaxed state when not squeezed. At this time, the sealing bead 305 will squeeze the corresponding position on the moving wire 306 to make it bent. When the positioning pressure rods 210 and the movable pressure rod 212 on both sides of the burette 301 squeeze the isolation layer 303 on the burette 301, the moving wire 306 will be squeezed at the same time. The squeezed moving wire 306 will be in a taut state. At this time, the moving wire 306 in the liquid outlet 304 will be in a taut state at the same time. The taut moving wire 306 will lift the sealing bead 305. At this time, the liquid outlet 304 is in an open state, and the solution can be dripped out under the squeezing of the movable pressure rod 212.

[0035] A groove 102 is provided on the top of the fixed base 1 , and the groove 102 passes through the fixed base 1 . A liquid filling port is provided on the top of the solution tank 3 , and the groove 102 is used to facilitate the filling of liquid into the solution tank 3 .

[0036] A drug test tube 4 is inserted on the test tube rack 204, and a sealing ring 401 is inserted in the drug test tube 4. The outer ring wall of the sealing ring 401 is in contact with the inner wall of the drug test tube 4, and the top of the sealing ring 401 is clamped on the top edge of the drug test tube 4 by two symmetrically arranged hooks. Two symmetrically arranged sealing plates 402 are fixedly installed on the inner ring wall of the sealing ring 401. The two sealing plates 402 are arranged facing each other, and the sealing plates 402 are fan-shaped. The side where the two sealing plates 402 are close to each other is inclined along the center point of the sealing ring 401. The sealing ring 401 cooperates with the sealing plate 402 to seal the drug test tube 4 to prevent the solution from being splashed out of the drug test tube 4 during shaking.

[0037] The tops of the two sealing plates 402 are fixedly mounted with inclined pressure rods 403, the tops of the pressure rods 403 extend out of the drug test tube 4 and are provided with an inclined surface, and the side walls of the titration base 2 are fixedly mounted with two symmetrically arranged squeezing rods 215, one end of the squeezing rods 215 away from the titration base 2 is provided with an inclined surface, when the drug test tube 4 on the test tube rack 204 moves to the right below the corresponding burette 301 driven by the mobile bracket 202, the pressure rods 403 will contact the squeezing rods 215, and the two pressure rods 403 will be moved to the inclined surfaces on the squeezing rods 215 and the pressure rods 403. The two pressure rods 403 squeezed down will open the two sealing plates 402 to facilitate titration. At the same time, the sealing plates 402 can prevent the solution from splashing during titration. After the titration is completed, driven by the movable bracket 202, the drug test tube 4 will be separated from the corresponding burette 301. At this time, the pressure rod 403 is separated from the squeezing rod 215. The sealing plate 402 and the pressure rod 403 are reset under the action of the elasticity of the sealing plate 402 itself. At this time, the sealing plate 402 can seal the drug test tube 4 to a certain extent to prevent the drug test tube 4 from splashing the solution during shaking.

[0038] It is further explained that the above-mentioned fixed connection should be understood in a broad sense unless otherwise clearly specified and limited. For example, it can be welding, gluing, or one-piece molding, etc., which are conventional means well known to those skilled in the art.

[0039] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A drug analysis titration device, comprising a fixed base (1) and a titration base (2), characterized in that: The fixed base (1) is of a C-shaped structure, and two symmetrically arranged movable grooves (101) are provided on the top of the inner wall of the fixed base (1). A plurality of solution bins (3) evenly distributed in a straight line are provided below the fixed base (1), the plurality of solution bins (3) are fixedly connected to each other, the tops of the plurality of solution bins (3) are respectively slidably connected to the corresponding movable grooves (101), and a burette (301) is fixedly installed at the bottom of the solution bin (3); The titration base (2) is an L-shaped structure. One end of the titration base (2) is fixedly connected to the top of the inner wall of the fixed base (1). A movable track (201) is provided on the titration base (2). A movable bracket (202) is slidably mounted on the movable track (201). A connecting shaft (203) is rotatably mounted on the movable bracket (202). A test tube rack (204) of a C-shaped structure is fixedly mounted on one end of the connecting shaft (203) away from the movable bracket (202).

2. A drug analysis titration device according to claim 1, characterized in that: Hollow grooves (302) are provided on both sides of the burette (301), and an isolation layer (303) made of a flexible plastic material is fixedly mounted on the inner wall of the hollow groove (302).

3. A drug analysis titration device according to claim 2, characterized in that: An adjustment groove (205) is provided on the side wall of the titration base (2), an adjustment bracket (206) is slidably installed in the adjustment groove (205), one end of the adjustment bracket (206) away from the adjustment groove (205) is rotatably connected to two symmetrically arranged movable brackets (207) via a rotating shaft, the two movable brackets (207) are arranged facing each other, and a telescopic plate (208) is provided on the side of the two movable brackets (207) close to each other, and a telescopic rod (209) is fixedly installed in the movable bracket (207), and the telescopic end of the telescopic rod (209) is The movable bracket (207) passes through the movable bracket (207) and is fixedly connected to the corresponding telescopic plate (208). A positioning pressure rod (210) is fixedly installed on one side of the telescopic plate (208) away from the corresponding telescopic rod 1 (209). A lifting frame (211) is provided below the positioning pressure rod (210). A movable pressure rod (212) is fixedly installed on the lifting frame (211). The distribution positions of the positioning pressure rod (210) and the movable pressure rod (212) on the two movable brackets (207) respectively correspond to the installation positions of the isolation layers (303) on both sides of the burette (301).

4. A drug analysis titration device according to claim 3, characterized in that: The positioning pressure rod (210) and the movable pressure rod (212) are both semi-cylindrical structures and are in contact with each other.

5. A drug analysis titration device according to claim 3, characterized in that: Two symmetrically arranged lifting screws (213) are fixedly mounted on the bottom of the movable bracket (207), and the lifting screws (213) penetrate the corresponding lifting frame (211) and are threadedly connected thereto.

6. A drug analysis titration device according to claim 3, characterized in that: The adjusting groove (205) is internally threadedly connected with an adjusting screw (214), the adjusting screw (214) passes through the adjusting bracket (206) and is threadedly connected thereto, and the top of the adjusting screw (214) passes through the titration base (2) and the fixed base (1) and is fixedly mounted with an adjusting handle.

7. A drug analysis titration device according to claim 1, characterized in that: The bottom of the burette (301) is provided with a liquid outlet (304), a sealing bead (305) is inserted into the burette (301), the sealing bead (305) covers the liquid outlet (304), a moving wire (306) is inserted into the burette (301), the moving wire (306) passes through the liquid outlet (304), and both ends of the moving wire (306) pass through the burette (301) and are fixedly connected to the corresponding solution tank (3).

8. A drug analysis titration device according to claim 1, characterized in that: The top of the fixed base (1) is provided with a groove (102), the groove (102) passes through the fixed base (1), and the top of the solution tank (3) is provided with a liquid filling port.

9. A drug analysis titration device according to claim 1, characterized in that: A drug test tube (4) is inserted into the test tube rack (204), a sealing ring (401) is inserted into the drug test tube (4), the outer ring wall of the sealing ring (401) contacts the inner wall of the drug test tube (4), the top of the sealing ring (401) is clamped to the top edge of the drug test tube (4) via two symmetrically arranged hooks, and two symmetrically arranged sealing plates (402) are fixedly mounted on the inner ring wall of the sealing ring (401), the two sealing plates (402) are arranged facing each other, the sealing plates (402) are in a fan-shaped structure, and the sides of the two sealing plates (402) that are close to each other are inclined along the center point of the sealing ring (401).

10. A drug analysis titration device according to claim 9, characterized in that: The tops of the two sealing plates (402) are both fixedly mounted with inclined pressure rods (403), the tops of the pressure rods (403) extending out of the drug test tube (4) and having inclined surfaces, and the side walls of the titration base (2) are fixedly mounted with two symmetrically arranged squeezing rods (215), and the ends of the squeezing rods (215) away from the titration base (2) have inclined surfaces.

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