Traditional Chinese medicine penetration medicine for dispelling wind and eliminating dampness, promoting blood circulation to remove blood stasis and relaxing tendons and dredging collaterals and preparation process thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine penetration medicine for dispelling wind and eliminating dampness, promoting blood circulation to remove blood stasis and relaxing tendons and dredging collaterals and a preparation process thereof. The transdermal traditional Chinese medicine is prepared from the following raw materials in parts by weight: fructus aurantii stir-fried with bran, radix cyathulae, radix dipsaci pieces, cassia twigs, wine-processed ligusticum wallichii, angelica sinensis, radix clematidis, lycopodium clavatum, phryma leptostachya, beefwood-like clubmoss herb, scalded peach kernels, flos carthami, rhizoma sparganii, curcuma zedoary, caulis spatholobi, cortex periplocae, cortex erythrinae, dipsacus root, pawpaw, lumbricus, vine adjuvants, a mixed extracting solution and a transdermal enhancer. The traditional Chinese medicine can relieve pain caused by qi and blood stagnation, rheumatism cold evil, blood stasis and the like by dispelling wind and eliminating dampness, promoting blood circulation to remove blood stasis and relaxing tendons and dredging collaterals, is suitable for the conditions of muscle and bone injury, rheumatic arthralgia and the like, and can effectively promote pain relief and recovery of injured parts.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, relaxing muscles and tendons, and a preparation process thereof. Background Art

[0002] In TCM clinics, rheumatism, joint pain, muscle aches and other diseases are mostly caused by wind, cold, dampness, blood stasis and other causes. These diseases are common and prone to recurrence, which has a serious impact on the quality of life of patients. Traditional treatment methods mainly include: 1) Oral Chinese medicine: Oral decoctions or pills are taken to regulate the whole body, but oral drugs are absorbed in the digestive tract, take effect slowly, and may irritate the gastrointestinal tract; 2) External plasters: Such as plasters and ointments, absorbed through the skin, but the permeability of traditional plasters is limited, and it is difficult for drugs to penetrate into the lesion site, affecting the efficacy.

[0003] With the development of pharmaceutical technology, transdermal drug delivery of traditional Chinese medicine has gradually received attention. Transdermal drug delivery has the following advantages: 1) Direct action on the lesion: the drug directly enters the affected area through the skin and takes effect quickly; 2) Avoiding digestive tract side effects: reducing the burden on the liver and gastrointestinal tract; 3) Continuous and stable release: maintaining effective blood drug concentration and prolonging drug efficacy. However, how to improve the transdermal absorption rate of traditional Chinese medicine ingredients and enhance the efficacy is still a technical problem that needs to be solved urgently.

[0004] Currently, no effective solution has been proposed for the problems in the related technologies. Summary of the invention

[0005] 1. Technical issues to be resolved

[0006] In view of the deficiencies in the prior art, the present invention provides a Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, relaxing muscles and tendons, and a preparation process thereof, so as to overcome the above-mentioned technical problems existing in the prior related technology.

[0007] (II) Technical solution

[0008] In order to achieve the above-mentioned purpose of dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and unblocking meridians, the specific technical scheme adopted by the present invention is as follows:

[0009] According to one aspect of the present invention, a Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing muscles and tendons is provided, comprising the following raw materials in parts by weight:

[0010] 10-30 parts of stir-fried bitter orange fructus with bran, 10-30 parts of cyathula, 10-30 parts of dipsacus root, 10-30 parts of cassia twig, 10-30 parts of wine chuanxiong, 10-30 parts of angelica, 10-30 parts of clematis, 20-40 parts of lycopodii herba, 20-40 parts of schizonepeta tenuifolia, 20-40 parts of schizonepeta tenuifolia, 10-30 parts of stewed peach kernel, 10-30 parts of safflower, 10-30 parts of trillium, 10-30 parts of zedoaria, 10-30 parts of millettia repens, 20-40 parts of perilla bark, 20-40 parts of pittosporum tobira bark, 10-30 parts of chuanxiong herb, 10-30 parts of papaya, 5-15 parts of earthworm, 15-25 parts of rattan adjuvants, 5-15 parts of mixed extract and 0.5-1.5 parts of transdermal enhancer.

[0011] Wherein, the rattan adjuvant includes Caulis Sinensis, Caulis Polygoni Multiflori and Tripterygium Wilfordii, and the weight ratio of Caulis Sinensis, Caulis Polygoni Multiflori and Tripterygium Wilfordii is 4:3:3. The mixed extract includes turmeric extract, epimedium extract, Acanthopanax Cortex Extract, Angelica Dahurica Extract and Saposhnikovia Divaricata Extract, and the weight ratio of turmeric extract, epimedium extract, Acanthopanax Cortex Extract, Angelica Dahurica Extract and Saposhnikovia Divaricata Extract is 1:1:1:1:1. The transdermal enhancer includes any one of laurocapron, isopropyl alcohol, Tween-80, salicylic acid or oleic acid.

[0012] According to another aspect of the present invention, there is provided a process for preparing a Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and dredge meridians, comprising the following steps:

[0013] S1. Weighing a preset number of parts by weight of solid raw materials, liquid raw materials and additives, washing the solid raw materials with clean water, and slicing or crushing the washed solid raw materials;

[0014] S2, adding the sliced ​​or crushed solid raw materials into a ceramic or stainless steel medicine decocting pot, and adding cold water for soaking;

[0015] S3, using high heat to boil the medicinal liquid after soaking, then turning to low heat to keep it in a slightly boiling state and continue decocting, after the decocting is completed, filter it through a clean gauze or filter to collect the first medicinal liquid;

[0016] S4, add cold water to the decoction pot again and perform a second decoction, filter through a clean gauze or filter screen after the decoction is completed, and collect the second medicinal liquid;

[0017] S5. Stir and mix the first medicinal solution and the second medicinal solution, add the weighed liquid raw materials and additives in sequence, and stir and mix them evenly to obtain a Chinese medicine decoction.

[0018] Among them, the solid raw materials are fried aurantium with bran, cyathula, dipsacus root, cassia twig, wine-cooked chuanxiong, angelica, clematis, herba striatae, herba radix polyphyllae, herba spatholobi, herba spatholobi, herba spatholobi, stewed peach kernel, safflower, trillium, zedoaria, millettia reticulata, cortex odoratissimii, cortex oxyphyllae, herba cyathulae, papaya, earthworm and rattan adjuvants, the liquid raw material is a mixed extract, and the additive is a transdermal enhancer.

[0019] Further, the fineness after crushing in step S1 is 80-120 mesh. In step S2, the amount of cold water added is 2-3 cm above the medicinal material, and the soaking time is 30-60 minutes. The decoction time in step S3 is 30-35 minutes, and the decoction time in step S4 is 20-25 minutes. In step S4, the amount of cold water added is 1-2 cm above the medicinal material.

[0020] (III) Beneficial effects

[0021] Compared with the prior art, the present invention provides a Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, relaxing tendons and unblocking collaterals and a preparation process thereof, which has the following beneficial effects:

[0022] The present invention can not only effectively eliminate wind, cold and dampness in the body through clematis, siler, cassia twig and the like, promote blood circulation and eliminate blood stasis through the combined action of Chinese angelica, ligusticum chuanxiong, safflower and the like, relieve pain through relaxing muscles and tendons and activating collaterals through spatholobi, radix polygoni lobata and millettia reticulata and the like, but also increase skin permeability and promote penetration of effective ingredients through mixed extracts and transdermal enhancers, so as to achieve the effect of easy absorption and enhanced efficacy, thereby relieving pain caused by poor blood circulation, wind-dampness and coldness, blood stasis and the like through dispelling wind and dampness, activating blood circulation and removing blood stasis, relaxing muscles and tendons and dredging collaterals, and is suitable for muscle and bone injuries, rheumatic arthralgia and the like, and can effectively promote pain relief and recovery of the injured part. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0024] Figure 1 The present invention is a flow chart of a preparation process of a Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing muscles and tendons according to an embodiment of the present invention. DETAILED DESCRIPTION

[0025] To further illustrate each embodiment, the present invention provides drawings, which are part of the disclosure of the present invention and are mainly used to illustrate the embodiments and can be used in conjunction with the relevant descriptions in the specification to explain the operating principles of the embodiments. With reference to these contents, ordinary technicians in the field should be able to understand other possible implementations and advantages of the present invention. The components in the figures are not drawn to scale, and similar component symbols are generally used to represent similar components.

[0026] According to an embodiment of the present invention, a Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing muscles and tendons and a preparation process thereof are provided.

[0027] The present invention is now further described in conjunction with specific embodiments. According to one aspect of the present invention, a Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing muscles and tendons is provided, comprising the following raw materials in parts by weight:

[0028] 10-30 parts of stir-fried bitter orange fructus with bran, 10-30 parts of cyathula, 10-30 parts of dipsacus root, 10-30 parts of cassia twig, 10-30 parts of wine chuanxiong, 10-30 parts of angelica, 10-30 parts of clematis, 20-40 parts of lycopodii herba, 20-40 parts of schizonepeta tenuifolia, 20-40 parts of schizonepeta tenuifolia, 10-30 parts of stewed peach kernel, 10-30 parts of safflower, 10-30 parts of trillium, 10-30 parts of zedoaria, 10-30 parts of millettia repens, 20-40 parts of perilla bark, 20-40 parts of pittosporum tobira bark, 10-30 parts of chuanxiong herb, 10-30 parts of papaya, 5-15 parts of earthworm, 15-25 parts of rattan adjuvants, 5-15 parts of mixed extract and 0.5-1.5 parts of transdermal enhancer.

[0029] Specifically, the rattan adjuvant includes Caulis Sinensis, Caulis Polygoni Multiflori and Tripterygium Wilfordii, and the weight ratio of Caulis Sinensis, Caulis Polygoni Multiflori and Tripterygium Wilfordii is 4:3:3. The mixed extract includes turmeric extract, epimedium extract, acanthopanax extract, angelica extract and saposhnikovia extract, and the weight ratio of turmeric extract, epimedium extract, acanthopanax extract, angelica extract and saposhnikovia extract is 1:1:1:1:1. The transdermal enhancer includes any one of laurocapron, isopropyl alcohol, Tween-80, salicylic acid or oleic acid.

[0030] In this embodiment, the role of each medicinal material in this formula is as follows:

[0031] Stir-fried Citrus aurantium with bran: It has the effects of promoting qi, relieving fullness, eliminating phlegm and relieving bloating. It can unblock qi stagnation and relieve pain and discomfort caused by qi stagnation.

[0032] Sichuan Achyranthes bidentata: It has the effects of promoting blood circulation, tonifying the liver and kidneys, and strengthening the tendons and bones. It is often used to treat rheumatic pain, soreness of the waist and knees, and other symptoms.

[0033] Dipsacus asper: nourishes the liver and kidneys, strengthens tendons and bones, promotes tendon and bone healing, and is suitable for rehabilitation after tendon and bone injuries.

[0034] Cinnamon twig: dispels cold, relieves exterior symptoms, promotes menstruation and activates blood circulation. It is mainly used for rheumatic pain and joint pain caused by cold evil blocking the meridians.

[0035] Liquor Chuanxiong: It can promote blood circulation, promote qi circulation, dispel wind and relieve pain. It is suitable for pain caused by qi stagnation and blood stasis, especially pain caused by blood stasis.

[0036] Angelica: It promotes blood circulation, replenishes blood, regulates menstruation and relieves pain. It is often used for pain and discomfort caused by blood deficiency or blood stasis.

[0037] Clematis: dispels wind and dampness, dredges meridians and relieves pain. It is good at treating rheumatic pain and is especially suitable for swollen and painful joints.

[0038] Stretching grass: relaxes muscles and tendons, dispels wind and dampness, and is often used for symptoms such as muscle and bone pain, and limb numbness.

[0039] Ligusticum chuanxiong: It can dispel rheumatism, dredge meridians, treat rheumatic pain, muscle and bone pain, and can penetrate deep into the bones to exert its effect.

[0040] Shujincao: It relaxes muscles and joints, helps relieve muscle and bone pain and joint discomfort.

[0041] Stewed peach kernels: promote blood circulation, remove blood stasis, moisten the intestines and promote bowel movements. Its main function is to promote blood circulation and relieve pain caused by blood stasis.

[0042] Safflower: It promotes blood circulation and menstruation, dissipates blood stasis and relieves pain. It is often used for pain caused by blood stasis.

[0043] Trillium: It can break up blood and promote qi circulation, eliminate accumulation and relieve pain. It is mainly used for pain caused by blood stasis.

[0044] Curcuma: It can promote qi circulation, resolve blood stasis, relieve pain, and is suitable for pain caused by blood stasis and qi stagnation.

[0045] Millettia reticulata: It promotes blood circulation, replenishes blood, unblocks meridians and activates collaterals. It is often used to treat pain caused by poor blood circulation.

[0046] Perilla frutescens bark: dispels rheumatism, strengthens tendons and bones, and is mainly used for rheumatic pain and pain in the waist and knees.

[0047] Pittosporum tobira bark: dispels rheumatism, dredges meridians, and treats rheumatic pain and joint pain.

[0048] Chuanduancao: It has the effects of nourishing the liver and kidneys, strengthening the tendons and bones, and promoting blood circulation. It can enhance the healing and recovery of tendons and bones, and is suitable for tendon and bone injuries and joint pain.

[0049] Tripterygium wilfordii: It can dispel wind and dampness, promote blood circulation and reduce swelling. It has a good effect on rheumatoid arthritis and arthralgia, but due to its high toxicity, the dosage needs to be controlled and it should be used under professional guidance.

[0050] Earthworm: It has the effects of promoting blood circulation, clearing away heat and stopping spasms, and is suitable for symptoms such as joint pain and blood stasis. Earthworm can further promote blood circulation and enhance the effect of promoting blood circulation and removing blood stasis.

[0051] Sinomenium wilfordii: dispels wind and dampness, relaxes muscles and activates collaterals. It has a good effect on symptoms such as rheumatic joint pain and numbness, and helps to further relieve pain and improve joint flexibility.

[0052] Cistanche deserticola: It has the effects of dispelling wind and dampness, relaxing muscles and activating blood circulation. It is often used to treat rheumatic pain, low back pain and leg pain. It can enhance the formula's anti-rheumatic effect and relieve pain.

[0053] Papaya: relaxes muscles and tendons, removes dampness and relieves pain. It is often used for rheumatic pain, tendon and bone pain, and muscle soreness. It can further enhance the effect of relaxing muscles and tendons.

[0054] Turmeric extract: It has excellent anti-inflammatory, antioxidant and blood circulation effects. In particular, curcumin has been widely studied and proven to be effective for arthritis and rheumatic pain. The curcumin in the extract can be quickly absorbed and directly act on the affected area to reduce inflammation and pain.

[0055] Epimedium extract: It has the effects of nourishing the kidney and strengthening yang, strengthening tendons and bones. Icariin is its main active ingredient, which can promote bone repair and improve bone and joint function. The extract can enhance the effect of nourishing the kidney and strengthening tendons, and is particularly suitable for the recovery period of tendon and bone injuries.

[0056] Acanthopanax Cortex Extract: It has the effects of removing rheumatism and strengthening bones and muscles, and can effectively relieve joint pain and muscle soreness. The active ingredients in Acanthopanax Cortex Extract, such as saponins, can quickly penetrate the skin and help local analgesia and inflammation subside.

[0057] Angelica dahurica extract: It has the effects of dispelling wind and cold, clearing the orifices and relieving pain. It is especially suitable for relieving headaches, joint pain and other symptoms caused by wind, cold and dampness. Angelica dahurica extract can play the role of dispelling wind and cold more quickly.

[0058] Saposhnikovia extract: It has the effects of dispelling wind and relieving exterior symptoms, removing dampness and relieving pain. It is especially suitable for external use formulas to relieve pain caused by wind, cold and dampness. The volatile oil components in Saposhnikovia extract can take effect quickly and relieve rheumatic pain.

[0059] According to another aspect of the present invention, Figure 1 As shown, a preparation process of a Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and unblocking meridians is provided, comprising the following steps:

[0060] S1. Weighing a preset number of parts by weight of solid raw materials, liquid raw materials and additives, washing the solid raw materials with clean water, and slicing or crushing the washed solid raw materials;

[0061] S2, adding the sliced ​​or crushed solid raw materials into a ceramic or stainless steel medicine decocting pot, and adding cold water for soaking;

[0062] S3, using high heat to boil the medicinal liquid after soaking, then turning to low heat to keep it in a slightly boiling state and continue decocting, after the decocting is completed, filter it through a clean gauze or filter to collect the first medicinal liquid;

[0063] S4, add cold water to the decoction pot again and perform a second decoction, filter through a clean gauze or filter screen after the decoction is completed, and collect the second medicinal liquid;

[0064] S5. Stir and mix the first medicinal solution and the second medicinal solution, add the weighed liquid raw materials and additives in sequence, and stir and mix them evenly to obtain a Chinese medicine decoction.

[0065] Among them, the solid raw materials are fried aurantium with bran, cyathula, dipsacus root, cassia twig, wine-cooked chuanxiong, angelica, clematis, herba striatae, herba radix polyphyllae, herba spatholobi, herba spatholobi, herba spatholobi, stewed peach kernel, safflower, trillium, zedoaria, millettia reticulata, cortex odoratissimii, cortex oxyphyllae, herba cyathulae, papaya, earthworm and rattan adjuvants, the liquid raw material is a mixed extract, and the additive is a transdermal enhancer.

[0066] Specifically, the fineness after crushing in step S1 is 80-120 mesh. In step S2, the amount of cold water added is 2-3 cm above the medicinal material, and the soaking time is 30-60 minutes. The decoction time in step S3 is 30-35 minutes, and the decoction time in step S4 is 20-25 minutes. In step S4, the amount of cold water added is 1-2 cm above the medicinal material.

[0067] In order to facilitate understanding of the above technical solutions of the present invention, specific embodiments of the present invention are described in detail below.

[0068] Example 1

[0069] A Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and unblocking meridians, comprising the following raw materials in parts by weight:

[0070] Stir-fried Citrus aurantium with bran 10g, Cyathula officinalis 10g, Dipsacus asper 10g, Cassia twig 10g, Ligusticum chuanxiong 10g, Angelica sinensis 10g, Clematidis 10g, Herba Lycopodii 20g, Herba Penniseti 20g, Herba Lycopodii 20g, Rhizoma Cynomorii 10g, Stewed peach kernel 10g, safflower 10g, Tripterygium wilfordii 10g, Curcuma 10g, Caulis Spatholobi 10g, Cortex Periplocae 20g, Cortex Pittosporum tobira 20g, Caulis Dianthus 10g, Papaya 10g, Pheretima 5.0g, Caulis Sinomenii 6.0g, Caulis Achyranthis Bidentatae 4.5g, Caulis Tripterygium wilfordii 4.5g, Turmeric extract 1.0ml, Epimedium extract 1.0ml, Cortex Acanthopanacis extract 1.0ml, Angelica dahurica extract 1.0ml, Saposhnikovia divaricata extract 1.0ml, and Laurocapram 0.5ml.

[0071] Example 2

[0072] A Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and unblocking meridians, comprising the following raw materials in parts by weight:

[0073] Stir-fried Citrus aurantium with bran 20g, Cyathula officinalis 20g, Dipsacus asper 20g, Cassia twig 20g, Ligusticum chuanxiong 20g, Angelica sinensis 20g, Clematidis 20g, Herba Lycopodii 30g, Herba Penniseti 30g, Herba Lycopodii 30g, Herba Lycopodii 20g, Stewed peach kernel 20g, Carthamus 20g, Tripterygium wilfordii 20g, Curcuma 20g, Millettia spatholobi 20g, Perennial Herb 30g, Pittosporum tobira bark 30g, Herba Cyathulae 20g, Papaya 20g, Pheretima chinensis 10g, Caulis Sinomenii 8.0g, Caulis Achyranthis Bidentatae 6.0g, Tripterygium wilfordii 6.0g, Turmeric extract 2.0ml, Epimedium extract 2.0ml, Cortex Acanthopanacis acanthopancis extract 2.0ml, Angelica dahurica extract 2.0ml, Saposhnikovia divaricata extract 2.0ml, and isopropyl alcohol 1.0ml.

[0074] Example 3

[0075] A Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and unblocking meridians, comprising the following raw materials in parts by weight:

[0076] Stir-fried Citrus aurantium with bran 30g, Cyathula officinalis 30g, Dipsacus asper 30g, Cassia twig 30g, Ligusticum chuanxiong 30g, Angelica sinensis 30g, Clematidis 30g, Herba Lycopodii 40g, Herba Penniseti 40g, Herba Lycopodii 40g, Herba Lycopodii 30g, Simmered peach kernel 30g, safflower 30g, Trillium 30g, Rhizoma Curcumae 30g, Caulis Spatholobi 30g, Cortex Periplocae 40g, Cortex Pittosporum 40g, Caulis Dianthus 30g, Papaya 30g, Pheretima 15g, Caulis Sinomenii 10g, Caulis Achyranthis Bidentatae 7.5g, Caulis Tripterygium wilfordii 7.5g, Turmeric extract 3.0ml, Epimedium extract 3.0ml, Cortex Acanthopanacis 3.0ml, Angelica dahurica extract 3.0ml, Saposhnikovia divaricata extract 3.0ml, and salicylic acid 1.5ml.

[0077] Comparative Example

[0078] In order to verify the technical effect of this embodiment, a comparative example is set up and a conventional prior art is used for comparison. The prior art generally uses similar drug ingredients, but lacks a transdermal enhancer and an extract, which makes the transdermal absorption rate of the drug low and the drug effect takes a long time to take effect. The comparative example does not use an extract and a transdermal enhancer, and only includes a traditional oral or topical formulation, as follows:

[0079] A Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and unblocking meridians, comprising the following raw materials in parts by weight:

[0080] Stir-fried Citrus aurantium with bran 10g, Cyathula officinalis 10g, cinnamon twig 10g, Chinese angelica 10g, safflower 10g, Radix Polygoni Multiflori 15g, Herba Lycopodii 15g, Radix Clematis 10g, Cortex Periplocae 15g and papaya 10g.

[0081] 1) Experimental design

[0082] In order to verify the effectiveness of the Chinese medicine permeation drug in this example, an animal experiment was set up and evaluated using a rat arthritis model. The experiment was divided into the following four groups:

[0083] Experimental Group 1 (Example 1): The Chinese herbal medicine decoction prepared according to the formula of Example 1 was used for the experiment.

[0084] Experimental Group 2 (Example 2): The Chinese herbal medicine decoction prepared according to the formula of Example 2 was used for the experiment.

[0085] Experimental Group 3 (Example 3): The Chinese herbal medicine decoction prepared according to the formula of Example 3 was used for the experiment.

[0086] Control group (comparative example): The experiment was conducted using a Chinese herbal decoction prepared using the comparative example formula.

[0087] The experiment was conducted by daily administration and continuous observation for 14 days to evaluate the efficacy of the drug in dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing muscles and tendons. Specific tests include:

[0088] Clinical symptom scoring: Scoring is based on the behavioral activities, joint inflammation symptoms, etc. of the rats.

[0089] Detection of inflammatory factor levels: Detect the levels of inflammatory factors (such as TNF-α, IL-6) in serum.

[0090] Histological examination: The rat joint tissues were sectioned and observed to evaluate inflammation and tissue damage.

[0091] 2) Experimental results

[0092] The experimental results show that the therapeutic effects of Examples 1, 2, and 3 are significantly better than those of the control group, as shown in the following:

[0093] Clinical symptom score:

[0094] Experimental group 1: Symptoms improved significantly after the 7th day, with the score reduced by about 60%.

[0095] Experimental group 2: Symptoms improved on the 5th day, with scores reduced by approximately 70%.

[0096] Experimental group 3: Significant improvement was seen on the third day, with the score reduced by approximately 80%.

[0097] Control group: Symptoms improved slowly, with the score reduction being only 30%, and obvious symptoms were still present at the end of the experiment.

[0098] Levels of inflammatory factors: The levels of inflammatory factors (TNF-α, IL-6) in experimental groups 1, 2, and 3 decreased significantly, especially in experimental group 2. The levels of inflammatory factors in the control group did not decrease significantly and remained at a high level.

[0099] Histological examination: The joint inflammation of rats in experimental groups 1, 2, and 3 was significantly reduced, and the tissue repair was good, with the best effect in experimental group 3. The joint inflammation of the control group still existed, and the tissue damage was more serious.

[0100] Comparative analysis of technical effects

[0101] The effect of the experimental group is better than that of the control group: the experimental group significantly improved the transdermal absorption efficiency of the drug by using transdermal enhancers and extracts, making the drug effect take effect faster and last longer, and the therapeutic effect is significantly better than that of the control group.

[0102] Conclusion: Through this comparative experiment, it can be seen that the Chinese medicine formula in the embodiment is significantly better than the traditional existing technology in terms of dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing muscles and collaterals. In particular, the addition of transdermal enhancers and extracts greatly improves the transdermal absorption rate and efficacy of the drug, providing an important reference for clinical application.

[0103] In summary, with the aid of the above-mentioned technical scheme of the present invention, the present invention can not only effectively eliminate wind, cold and dampness in the body through Clematis, Saposhnikovia divaricata, Cinnamomum cassia, etc., promote blood circulation and eliminate blood stasis through the combined action of Chinese angelica, Chuanxiong, Safflower and other medicinal materials, relieve pain through relaxing muscles and tendons through Herba Lycopodii, Herba Polygoni Multiflori, Millettia reticulata, etc., but also increase skin permeability and promote penetration of effective ingredients through mixed extracts and transdermal enhancers, so as to achieve the effect of easy absorption and enhanced efficacy, thereby relieving pain caused by poor blood circulation, rheumatism, cold evil, blood stasis, etc. through dispelling wind and dampness, activating blood circulation and removing blood stasis, relaxing muscles and tendons, and is suitable for situations such as tendon and bone injuries, rheumatic arthralgia, and can effectively promote pain relief and recovery of the injured part.

[0104] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and unblocking meridians, characterized in that: The Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and unblocking meridians comprises the following raw materials in parts by weight: 10-30 parts of stir-fried bitter orange fructus with bran, 10-30 parts of cyathula, 10-30 parts of dipsacus root, 10-30 parts of cassia twig, 10-30 parts of wine chuanxiong, 10-30 parts of angelica, 10-30 parts of clematis, 20-40 parts of lycopodii herba, 20-40 parts of schizonepeta tenuifolia, 20-40 parts of schizonepeta tenuifolia, 10-30 parts of stewed peach kernel, 10-30 parts of safflower, 10-30 parts of trillium, 10-30 parts of zedoaria, 10-30 parts of millettia repens, 20-40 parts of perilla bark, 20-40 parts of pittosporum tobira bark, 10-30 parts of chuanxiong herb, 10-30 parts of papaya, 5-15 parts of earthworm, 15-25 parts of rattan adjuvants, 5-15 parts of mixed extract and 0.5-1.5 parts of transdermal enhancer.

2. The Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and dredge meridians according to claim 1, characterized in that: The rattan adjuvants include Caulis Scutellariae, Caulis Scutellariae and Tripterygium wilfordii, and the weight ratio of the Caulis Scutellariae, Caulis Scutellariae and Tripterygium wilfordii is 4:3:

3.

3. The Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and dredge meridians according to claim 1, characterized in that: The mixed extract includes turmeric extract, epimedium extract, acanthopanax cortex extract, angelica dahurica extract and saposhnikovia divaricata extract, and the weight ratio of the turmeric extract, the epimedium extract, the acanthopanax cortex extract, the angelica dahurica extract and the saposhnikovia divaricata extract is 1:1:1:1:

1.

4. The Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and dredge meridians according to claim 1, characterized in that: The transdermal enhancer includes any one of laurocapram, isopropyl alcohol, Tween-80, salicylic acid or oleic acid.

5. A process for preparing a Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing muscles and tendons, which is used for preparing the Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing muscles and tendons as described in any one of claims 1 to 4, characterized in that: The preparation process of the Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and unblocking meridians comprises the following steps: S1. Weighing a preset number of parts by weight of solid raw materials, liquid raw materials and additives, washing the solid raw materials with clean water, and slicing or crushing the washed solid raw materials; S2, adding the sliced ​​or crushed solid raw materials into a ceramic or stainless steel medicine decocting pot, and adding cold water for soaking; S3, using high heat to boil the medicinal liquid after soaking, then turning to low heat to keep it in a slightly boiling state and continue decocting, after the decocting is completed, filter it through a clean gauze or filter to collect the first medicinal liquid; S4, add cold water to the decoction pot again and perform a second decoction, filter through a clean gauze or filter screen after the decoction is completed, and collect the second medicinal liquid; S5. Stir and mix the first medicinal solution and the second medicinal solution, add the weighed liquid raw materials and additives in sequence, and stir and mix them evenly to obtain a Chinese medicine decoction.

6. The preparation process of the Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and dredge meridians according to claim 5, characterized in that: The solid raw materials are fried aurantium with bran, cyathula, dipsacus root, cassia twig, wine-cooked chuanxiong, angelica, clematis, herba striatae, herba spatholobi, herba spatholobi, herba spatholobi, stewed peach kernel, safflower, trillium, zedoaria, millettia reticulata, cortex odoratissimii, cortex ophiopogonis, herba cyathulae, papaya, earthworm and rattan auxiliary drugs; the liquid raw material is a mixed extract; and the additive is a transdermal enhancer.

7. The preparation process of the Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and dredge meridians according to claim 5, characterized in that: The fineness after crushing in step S1 is 80-120 mesh.

8. The preparation process of the Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and dredge meridians according to claim 5, characterized in that: In step S2, the amount of cold water added is 2-3 cm above the medicinal materials, and the soaking time is 30-60 minutes.

9. The preparation process of the Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and dredge meridians according to claim 5, characterized in that: The decocting time in step S3 is 30-35 minutes, and the decocting time in step S4 is 20-25 minutes.

10. The preparation process of the Chinese herbal medicine for dispelling wind and dampness, promoting blood circulation and removing blood stasis, and relaxing tendons and dredge meridians according to claim 5, characterized in that: In step S4, the amount of cold water added is 1-2 cm above the medicinal materials.

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