Facial injection filler for cosmetic and plastic surgery and preparation method of facial injection filler

Abstract

The invention discloses a facial injection filler for cosmetic and plastic surgery and a preparation method thereof, and relates to the technical field of cosmetic and plastic surgery. The preparation method comprises the following steps: firstly, preparing raw materials including hyaluronic acid, PCL microspheres, CMC gel, collagen powder, L-polylactic acid, beta tricalcium phosphate, vitamin powder, an excipient and water for injection; the preparation method comprises the following steps: taking hyaluronic acid and water for injection, dissolving the hyaluronic acid in the water for injection, and uniformly mixing for 30 seconds to obtain a hyaluronic acid solution; adding PCL microspheres, L-polylactic acid and beta tricalcium phosphate into the obtained hyaluronic acid solution, and continuously mixing for 2-3 minutes to obtain a mixed solution; and continuing to add collagen powder and vitamin powder into the mixed solution, mixing for 5-8 minutes, and the like. The facial injection filler for cosmetic and plastic surgery is safe in use components and free of toxic and side effects, can play a good repairing and filling effect on the face when acting on the face, and is excellent in overall cosmetic effect.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetic surgery, and in particular to a facial injection filler for cosmetic surgery and a preparation method thereof. Background Art

[0002] Facial filler cosmetic surgery is a medical cosmetic technique that uses fillers to improve facial contours, reduce wrinkles and increase skin elasticity. This technique can help people achieve a younger, more natural and more beautiful appearance. The principle of facial filler cosmetic surgery is to inject fillers into the subcutaneous tissue of the face to increase the volume and elasticity of the skin. The advantages of facial filler cosmetic surgery include non-surgical, short recovery time, and significant results.

[0003] The effects of current fillers for facial cosmetic surgery are unstable. Since different people have different adaptability to each component, unified fillers will affect the cosmetic effect to a certain extent. At the same time, the preparation process of fillers is complicated under the current unified ingredients, and its preparation cost and efficiency are adversely affected. For this reason, this scheme proposes a facial injection filler for cosmetic surgery and a preparation method thereof. Summary of the invention

[0004] The purpose of the present invention is to provide a facial injection filler for cosmetic surgery and a preparation method thereof, so as to solve the problems raised in the background technology by optimizing the ingredients and improving the preparation process.

[0005] The present invention is achieved through the following technical solutions:

[0006] The invention discloses a facial injection filler for cosmetic surgery, which comprises, by weight, 55-65 parts of hyaluronic acid, 10-15 parts of PCL microspheres, 5-8 parts of CMC gel, 3-5 parts of collagen powder, 4-6 parts of L-polylactic acid, 8-10 parts of beta tricalcium phosphate, 0.5-1.5 parts of vitamin powder, 2-3 parts of excipients and 12-18 parts of water for injection.

[0007] Preferably, the composition comprises, by weight, 58-62 parts of hyaluronic acid, 12-14 parts of PCL microspheres, 6-7 parts of CMC gel, 3.5-4.5 parts of collagen powder, 4.5-5.5 parts of poly(L-lactic acid), 8.5-9.5 parts of β-tricalcium phosphate, 0.8-1.2 parts of vitamin powder, 2.2-2.8 parts of excipients and 14-16 parts of water for injection.

[0008] Preferably, the PCL microspheres are composed of artificially synthesized polycaprolactone microspheres, glycerol, hydroxymethyl cellulose and phosphate buffer solution, and the usage ratio is 1.5:0.4:0.8:1.

[0009] Preferably, the excipients include a stabilizer, a buffer and a preservative, the stabilizer is dextran, the buffer is an acid-base buffer, the preservative is methanol, and the usage ratio of the dextran, the acid-base buffer and the methanol is 1:1.5:0.8.

[0010] Preferably, the water for injection uses sterile distilled water to improve safety of use.

[0011] A method for preparing a facial injection filler for cosmetic surgery comprises the following steps:

[0012] S1, prepare raw materials, including hyaluronic acid, PCL microspheres, CMC gel, collagen powder, poly-L-lactic acid, β-tricalcium phosphate, vitamin powder, excipients and water for injection;

[0013] S2, taking hyaluronic acid and water for injection, dissolving the hyaluronic acid in the water for injection, and mixing them evenly for 30 seconds to obtain a hyaluronic acid solution;

[0014] S3, adding PCL microspheres, poly(L-lactic acid) and β-tricalcium phosphate to the hyaluronic acid solution obtained in S2, and continuing to mix for 2-3 minutes to obtain a mixed solution;

[0015] S4, continue to add collagen powder and vitamin powder to the mixed solution of S3, mix for 5-8 minutes, and obtain a further mixed solution after mixing evenly;

[0016] S5, adding excipients to the mixed solution of S4, mixing at 55-65° C. for 10 min, maintaining the mixing speed at 180 rpm / min, mixing evenly to obtain a mixed solution, so as to adjust the physical and chemical properties of the filler;

[0017] S6, finally adding CMC gel to the mixed solution in S5 and mixing evenly to increase the viscosity and stability of the filler to obtain a filler;

[0018] S7, filtering the filler prepared in S6 through a sterile filter to remove impurities and particulate matter in the filler, and then packaging the filler into sterile containers to obtain the desired facial injection filler for cosmetic surgery.

[0019] Preferably, the mixing speed in S2 is maintained at 80 rpm / min, the mixing speed in S3 is maintained at 120 rpm / min, the mixing speed in S4 is maintained at 150 rpm / min, and the mixing speed in S6 is maintained at 100 rpm / min.

[0020] Preferably, the S7 then dispenses the filler into sterile containers, with the dispensing specifications including 5 ml, 10 ml and 50 ml.

[0021] The present invention has the following beneficial effects:

[0022] 1. The facial injection filler for cosmetic surgery of the present invention has safe ingredients with no toxic side effects, is highly adaptable to people of all ages, can have a good repair and filling effect on the face when applied to the face, and has an excellent overall cosmetic effect. At the same time, the filling ingredients are conventionally easy to obtain, the use cost is controllable, and the promotion value is high.

[0023] 2. The preparation method of the facial injection filler for cosmetic surgery of the present invention is simple and quick in preparation. By improving the ingredient ratio and updating the preparation process of the filler, the overall preparation efficiency is improved and each link is highly controllable.

[0024] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for describing the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.

[0026] Figure 1 The present invention is a flow chart of the preparation method of the facial injection filler for cosmetic surgery. DETAILED DESCRIPTION

[0027] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0028] See also Figure 1 As shown: The present invention is a facial injection filler for cosmetic surgery, which comprises, by weight, 58-62 parts of hyaluronic acid, 12-14 parts of PCL microspheres, 6-7 parts of CMC gel, 3.5-4.5 parts of collagen powder, 4.5-5.5 parts of polylactic acid, 8.5-9.5 parts of beta tricalcium phosphate, 0.8-1.2 parts of vitamin powder, 2.2-2.8 parts of excipients and 14-16 parts of water for injection.

[0029] PCL microspheres are composed of artificially synthesized polycaprolactone microspheres, glycerol, hydroxymethyl cellulose and phosphate buffer solution, and the usage ratio is 1.5:0.4:0.8:1; excipients include stabilizers, buffers and preservatives, the stabilizer is dextran, the buffer is an acid-base buffer, and the preservative is methanol. The usage ratio of dextran, acid-base buffer and methanol is 1:1.5:0.8; sterile distilled water is used for injection.

[0030] Embodiment 1:

[0031] The present invention is a facial injection filler for cosmetic surgery, which comprises, by weight, 58 parts of hyaluronic acid, 12 parts of PCL microspheres, 6 parts of CMC gel, 3.5 parts of collagen powder, 4.5 parts of L-polylactic acid, 8.5 parts of beta tricalcium phosphate, 0.8 parts of vitamin powder, 2.2 parts of excipients and 14 parts of water for injection.

[0032] PCL microspheres are composed of artificially synthesized polycaprolactone microspheres, glycerol, hydroxymethyl cellulose and phosphate buffer solution, and the usage ratio is 1.5:0.4:0.8:1; excipients include stabilizers, buffers and preservatives, the stabilizer is dextran, the buffer is an acid-base buffer, and the preservative is methanol. The usage ratio of dextran, acid-base buffer and methanol is 1:1.5:0.8; sterile distilled water is used for injection.

[0033] A method for preparing a facial injection filler for cosmetic surgery comprises the following steps:

[0034] S1, prepare raw materials, including hyaluronic acid, PCL microspheres, CMC gel, collagen powder, poly-L-lactic acid, β-tricalcium phosphate, vitamin powder, excipients and water for injection;

[0035] S2, taking hyaluronic acid and water for injection, dissolving the hyaluronic acid in the water for injection, and mixing evenly for 30 seconds at a mixing speed of 80 rpm / min to obtain a hyaluronic acid solution;

[0036] S3, adding PCL microspheres, L-polylactic acid and β-tricalcium phosphate to the hyaluronic acid solution obtained in S2, and continuing to mix for 2-3 minutes at a mixing speed of 120 rpm / min to obtain a mixed solution;

[0037] S4, continue to add collagen powder and vitamin powder to the mixed solution of S3, mix for 5-8 minutes, keep the mixing speed at 150 rpm / min, and obtain a further mixed solution after mixing evenly;

[0038] S5, adding excipients to the mixed solution of S4, mixing at 55-65° C. for 10 min, maintaining the mixing speed at 180 rpm / min, mixing evenly to obtain a mixed solution, so as to adjust the physical and chemical properties of the filler;

[0039] S6, finally adding CMC gel to the mixed solution in S5, mixing evenly, and maintaining the mixing speed at 100 rpm / min to increase the viscosity and stability of the filler, thereby obtaining a filler;

[0040] S7, filtering the filler prepared in the above S6 through a sterile filter to remove impurities and particulate matter in the filler, and then packaging the filler into sterile containers (packaging specifications include 5ml, 10ml and 50ml), to obtain the desired facial injection filler for cosmetic surgery.

[0041] Embodiment 2:

[0042] The present invention is a facial injection filler for cosmetic surgery, which comprises, by weight, 58 parts of hyaluronic acid, 13 parts of PCL microspheres, 7 parts of CMC gel, 4 parts of collagen powder, 5 parts of L-polylactic acid, 9 parts of beta-tricalcium phosphate, 1 part of vitamin powder, 2.5 parts of excipients and 15 parts of water for injection.

[0043] PCL microspheres are composed of artificially synthesized polycaprolactone microspheres, glycerol, hydroxymethyl cellulose and phosphate buffer solution, and the usage ratio is 1.5:0.4:0.8:1; excipients include stabilizers, buffers and preservatives, the stabilizer is dextran, the buffer is an acid-base buffer, and the preservative is methanol. The usage ratio of dextran, acid-base buffer and methanol is 1:1.5:0.8; sterile distilled water is used for injection.

[0044] The preparation method is the same as Example 1.

[0045] Embodiment 3:

[0046] The present invention discloses a facial injection filler for cosmetic surgery, which comprises, by weight, 60 parts of hyaluronic acid, 14 parts of PCL microspheres, 6.5 parts of CMC gel, 4 parts of collagen powder, 5.5 parts of L-polylactic acid, 8.8 parts of beta-tricalcium phosphate, 0.9 parts of vitamin powder, 2.6 parts of excipients and 15 parts of water for injection.

[0047] PCL microspheres are composed of artificially synthesized polycaprolactone microspheres, glycerol, hydroxymethyl cellulose and phosphate buffer solution, and the usage ratio is 1.5:0.4:0.8:1; excipients include stabilizers, buffers and preservatives, the stabilizer is dextran, the buffer is an acid-base buffer, and the preservative is methanol. The usage ratio of dextran, acid-base buffer and methanol is 1:1.5:0.8; sterile distilled water is used for injection.

[0048] The preparation method is the same as Example 1.

[0049] Embodiment 4:

[0050] The present invention is a facial injection filler for cosmetic surgery, which comprises, by weight, 62 parts of hyaluronic acid, 14 parts of PCL microspheres, 7 parts of CMC gel, 4.5 parts of collagen powder, 5.5 parts of L-polylactic acid, 9.5 parts of beta-tricalcium phosphate, 1.2 parts of vitamin powder, 2.8 parts of excipients and 16 parts of water for injection.

[0051] PCL microspheres are composed of artificially synthesized polycaprolactone microspheres, glycerol, hydroxymethyl cellulose and phosphate buffer solution, and the usage ratio is 1.5:0.4:0.8:1; excipients include stabilizers, buffers and preservatives, the stabilizer is dextran, the buffer is an acid-base buffer, and the preservative is methanol. The usage ratio of dextran, acid-base buffer and methanol is 1:1.5:0.8; sterile distilled water is used for injection.

[0052] The preparation method is the same as Example 1.

[0053] In the present invention, hyaluronic acid is widely used as a tissue filler in the field of micro-plastic surgery, which can play a supporting and filling role, thereby achieving the purpose of wrinkle removal. At the same time, it has an excellent moisturizing effect, can absorb and retain a large amount of water, and keep the skin hydrated and smooth; β-tricalcium phosphate has an excellent moisturizing effect, can absorb and retain a large amount of water, and keep the skin hydrated and smooth; collagen powder plays a key role in maintaining skin elasticity, and collagen powder is used in facial fillers to enhance the biocompatibility and skin repair ability of the filler; L-polylactic acid stimulates the host's immune response and attracts a large number of subcutaneous macrophages and other immune cells. These cells can produce chemokines and cytokines, leading to the proliferation of fibroblasts and the differentiation of myofibroblasts, synthesizing a large amount of collagen, thereby restoring subcutaneous capacity and compensating for the loss of collagen.

[0054] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0055] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A facial injection filler for cosmetic surgery, characterized in that: By weight, it comprises 55-65 parts of hyaluronic acid, 10-15 parts of PCL microspheres, 5-8 parts of CMC gel, 3-5 parts of collagen powder, 4-6 parts of poly(L-lactic acid), 8-10 parts of beta-tricalcium phosphate, 0.5-1.5 parts of vitamin powder, 2-3 parts of excipients and 12-18 parts of water for injection.

2. A facial injection filler for cosmetic surgery according to claim 1, characterized in that: By weight, it includes 58-62 parts of hyaluronic acid, 12-14 parts of PCL microspheres, 6-7 parts of CMC gel, 3.5-4.5 parts of collagen powder, 4.5-5.5 parts of poly(L-lactic acid), 8.5-9.5 parts of beta-tricalcium phosphate, 0.8-1.2 parts of vitamin powder, 2.2-2.8 parts of excipients and 14-16 parts of water for injection.

3. A facial injection filler for cosmetic surgery according to claim 2, characterized in that: The PCL microspheres are composed of artificially synthesized polycaprolactone microspheres, glycerol, hydroxymethyl cellulose and phosphate buffer solution, and the usage ratio is 1.5:0.4:0.8:

1.

4. A facial injection filler for cosmetic surgery according to claim 2, characterized in that: The excipients include a stabilizer, a buffer and a preservative, wherein the stabilizer is dextran, the buffer is an acid-base buffer, and the preservative is methanol. The ratio of the dextran, the acid-base buffer and the methanol is 1:1.5:0.

8.

5. The facial injection filler for cosmetic surgery according to claim 2, characterized in that: The water for injection uses sterile distilled water.

6. A method for preparing a facial injection filler for cosmetic surgery, characterized in that: The steps include: S1, prepare raw materials, including hyaluronic acid, PCL microspheres, CMC gel, collagen powder, poly-L-lactic acid, β-tricalcium phosphate, vitamin powder, excipients and water for injection; S2, taking hyaluronic acid and water for injection, dissolving the hyaluronic acid in the water for injection, and mixing them evenly for 30 seconds to obtain a hyaluronic acid solution; S3, adding PCL microspheres, poly(L-lactic acid) and β-tricalcium phosphate to the hyaluronic acid solution obtained in S2, and continuing to mix for 2-3 minutes to obtain a mixed solution; S4, continue to add collagen powder and vitamin powder to the mixed solution of S3, mix for 5-8 minutes, and obtain a further mixed solution after mixing evenly; S5, adding excipients to the mixed solution of S4, mixing at 55-65° C. for 10 min, maintaining the mixing speed at 180 rpm / min, mixing evenly to obtain a mixed solution, so as to adjust the physical and chemical properties of the filler; S6, finally adding CMC gel to the mixed solution in S5 and mixing evenly to increase the viscosity and stability of the filler to obtain a filler; S7, filtering the filler prepared in S6 through a sterile filter to remove impurities and particulate matter in the filler, and then packaging the filler into sterile containers to obtain the desired facial injection filler for cosmetic surgery.

7. The method for preparing a facial injection filler for cosmetic surgery according to claim 6, characterized in that: The mixing speed in S2 is maintained at 80 rpm / min, the mixing speed in S3 is maintained at 120 rpm / min, the mixing speed in S4 is maintained at 150 rpm / min, and the mixing speed in S6 is maintained at 100 rpm / min.

8. The method for preparing a facial injection filler for cosmetic surgery according to claim 6, characterized in that: The S7 then dispenses the filler into sterile containers, with the dispensing specifications including 5 ml, 10 ml and 50 ml.

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