Purification equipment in amifostine production process

Abstract

The invention relates to the technical field of amifostine preparation, in particular to purification equipment in an amifostine production process, which comprises a rack and a support seat arranged on the rack, the mixing mechanism is used for dissolving an amifostine crude product, and is mounted on the supporting seat; during use, the high point and the low point of the inclined surface base plate are intermittently matched with the gear, so that the lifting column rotates and intermittently vibrates in a reciprocating lifting manner at the same time, and the mounting seat on the material placing platform is driven to synchronously act along with the action of the lifting column, so that mixed liquid in the material storage tank is self-vibrated and mixed in the material storage tank; meanwhile, the driving mechanism also drives the matching plate to synchronously perform lifting action, so that the mixed liquid in the storage tank can rotate while being subjected to self-oscillation, automatic stirring is further kept in the purification process, the mixing uniformity is improved, and the recrystallization purification improvement effect is ensured.

Description

Technical Field

[0001] The invention relates to the technical field of amifostine preparation, in particular to a purification device in the amifostine production process. Background Art

[0002] Amifostine is a protective agent used in radiotherapy and chemotherapy. The purification of amifostine is one of the key steps to ensure that it meets pharmaceutical standards. Its purification process usually includes several key steps, namely filtration, extraction, concentration, and crystallization to obtain crude amifostine, and finally ethanol recrystallization is used to remove by-products and unreacted raw materials to ensure the purity and quality of the final product.

[0003] For example, the Chinese patent with application number CN201110431844.8 discloses a method for preparing amifostine, which uses N-(2-hydroxyethyl) 1,3-propylenediamine as the basic raw material, drips concentrated hydrochloric acid for reaction, concentrates, crystallizes, and dries to obtain its ammonium salt after the reaction is completed; sodium thiophosphate and purified water are added to a reaction vessel, and potassium iodide is added for stirring, and stirred into a suspension for standby use; chloride is dissolved in purified water to obtain a chloride solution, which is loaded into a constant pressure titration funnel, and dripped into a reaction vessel containing a standby suspension for reaction, and treated after the reaction is completed, and finally the product amifostine is obtained, which has a high yield, a short reaction time, and low cost, is easy to control, and is suitable for industrial-scale production. However, in the actual preparation process of amifostine, uniform mixing is completed by stirring before recrystallization, and continuous stirring cannot be performed in the precipitation stage, and the distillation of the static concentrated solution in the lower layer is affected, and the precipitated amifostine will polymerize with the corresponding byproducts or unreacted raw materials, thereby resulting in poor effect of recrystallization purification and promotion. Summary of the invention

[0004] In view of this, the purpose of the present invention is to propose a purification equipment in the production process of amifostine to solve the technical problem that the existing technology cannot continuously stir during the precipitation stage, the distillation of the static concentrated liquid in the lower layer is affected, and the by-products and unreacted raw materials are precipitated together with amifostine, which leads to poor recrystallization purification and improvement effect.

[0005] Based on the above purpose, the present invention provides a purification device in the production process of amifostine, including a frame and a support base arranged on the frame; the purification device also includes:

[0006] A mixing mechanism for dissolving crude amifostine, wherein the mixing mechanism is installed on the support seat;

[0007] A material placing platform, the material placing platform is installed on the mixing mechanism, a mounting groove is arranged around the material placing platform, and a clamping groove is arranged at a side end of the mounting groove;

[0008] A purification mechanism for recrystallizing the crude amifostine product, wherein the purification mechanism is installed on the material placement platform;

[0009] A liquid extraction top seat, the liquid extraction top seat is arranged on the top of the purification mechanism;

[0010] A matching plate, the matching plate is installed between the material placement platform and the liquid extraction top seat;

[0011] A driving mechanism for driving the mating plate to rise and fall.

[0012] Furthermore, the mixing mechanism comprises:

[0013] A driving motor mounted on the support base, wherein a gear is mounted on the output end of the driving motor;

[0014] A lifting column, wherein the lifting column is slidably disposed on the support seat, and the material placing platform is fixedly connected to the lifting column;

[0015] An inclined surface base plate, the inclined surface base plate is fixedly mounted on the lifting column, a push head is provided around the side end of the inclined surface base plate, and the push head is meshed with the gear;

[0016] There are several guide columns, and several of the guide columns are installed on the material placement platform. The liquid extraction top seat is slidably arranged on the several guide columns.

[0017] Further, the purification mechanism comprises:

[0018] A temperature control plate, the temperature control plate is installed on the material placement platform;

[0019] A mounting seat, the mounting seat is arranged in the mounting groove and positioned by the clamping groove;

[0020] A material storage tank, the material storage tank is rotatably mounted on the mounting seat, a hollow threaded tube is provided on the top cover of the material storage tank, the hollow threaded tube is threadably matched with the matching plate, and the temperature control plate is placed on the side of the material storage tank;

[0021] A connecting pipe is connected to the hollow threaded pipe and the liquid extraction top seat.

[0022] Furthermore, the height difference between the highest point and the lowest point of the inclined substrate is consistent with the height of the storage tank.

[0023] Furthermore, a liquid collecting pump is provided on the top ring of the liquid pumping seat, and the liquid collecting pump is connected with the connecting pipe.

[0024] Furthermore, a plurality of the guide columns are sleeved with springs, and the lower ends of the springs abut against the upper end of the liquid extraction top seat.

[0025] Furthermore, a mounting opening is provided on the liquid extraction top seat, and a mounting frame is detachably provided on the outside of the mounting opening on the liquid extraction top seat.

[0026] Furthermore, the driving mechanism comprises:

[0027] A cylinder, wherein the cylinder is mounted on the mounting frame, and an output end of the cylinder passes through the mounting opening;

[0028] A reinforcing plate, wherein the middle portion of the reinforcing plate is mounted on the output end of the cylinder, and both ends of the reinforcing plate are mounted on the lower end surface of the matching plate and are fixedly connected.

[0029] The beneficial effects of the present invention are as follows: when using the purification equipment in the amifostine production process of the present invention, the intermittent cooperation between the high and low points of the inclined substrate and the gears enables the lifting column to perform intermittent vibration of reciprocating lifting and lowering while rotating, and the movement of the lifting column will drive the mounting seat on the material placement platform to perform synchronous movement, so that the mixed liquid in the storage tank can be self-oscillated and mixed in the storage tank, and at the same time, the driving mechanism also drives the matching plate to perform synchronous lifting and lowering movements, so that the mixed liquid in the storage tank can be self-oscillated and rotated at the same time, and further maintain automatic stirring during the purification process, improve the uniformity of mixing, and ensure the effect of recrystallization purification enhancement. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are only for the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0031] Figure 1 It is a structural schematic diagram of the present invention;

[0032] Figure 2 It is a schematic diagram of the assembly of the mixing mechanism and the purification mechanism in the present invention;

[0033] Figure 3 It is a structural schematic diagram of the material placement platform in the present invention;

[0034] Figure 4 It is a schematic diagram of the assembly of the liquid extraction top seat and the purification mechanism in the present invention;

[0035] Figure 5 It is a schematic diagram of the assembly of the driving mechanism and the matching plate in the present invention.

[0036] The markings in the figure are:

[0037] 1. Frame; 2. Support seat; 3. Material placement platform; 4. Mounting slot; 5. Liquid extraction seat; 6. Matching plate; 7. Drive motor; 8. Gear; 9. Lifting column; 10. Inclined substrate; 11. Pushing head; 12. Guide column; 13. Temperature control board; 14. Mounting seat; 15. Storage tank; 16. Hollow threaded pipe; 17. Connecting pipe; 18. Liquid collecting pump; 19. Spring; 20. Installation opening; 21. Mounting frame; 22. Cylinder; 23. Reinforcement plate. DETAILED DESCRIPTION

[0038] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with specific embodiments.

[0039] It should be noted that, unless otherwise defined, the technical terms or scientific terms used in the present invention should be understood by people with ordinary skills in the field to which the present invention belongs. The "first", "second" and similar words used in the present invention do not indicate any order, quantity or importance, but are only used to distinguish different components. "Include" or "comprise" and similar words mean that the elements or objects appearing before the word include the elements or objects listed after the word and their equivalents, without excluding other elements or objects. "Connect" or "connected" and similar words are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0040] The embodiment of the present invention provides a purification device in the production process of amifostine, such as Figure 1-5 As shown, it includes a frame 1 and a support base 2 arranged on the frame 1; the purification equipment also includes:

[0041] A mixing mechanism for dissolving crude amifostine, the mixing mechanism being mounted on the support seat 2;

[0042] A material placing platform 3 is installed on the mixing mechanism, a mounting groove 4 is provided on the material placing platform 3, and a clamping groove is provided at the side end of the mounting groove 4;

[0043] A purification mechanism for recrystallizing the crude amifostine product, the purification mechanism being installed on the loading platform 3;

[0044] The liquid extraction top seat 5 is arranged on the top of the purification mechanism;

[0045] A matching plate 6, which is installed between the material placement platform 3 and the liquid extraction top seat 5;

[0046] A driving mechanism for driving the mating plate 6 to rise and fall.

[0047] In this embodiment, the mixing mechanism includes:

[0048] A drive motor 7 is mounted on the support base 2, and a gear 8 is mounted on the output end of the drive motor 7;

[0049] A lifting column 9 is slidably disposed on the support seat 2, and the material placing platform 3 is fixedly connected to the lifting column 9;

[0050] The inclined substrate 10 is fixedly mounted on the lifting column 9. A push head 11 is provided around the side end of the inclined substrate 10, and the push head 11 is meshed with the gear 8;

[0051] There are several guide pillars 12 , and the several guide pillars 12 are installed on the material placing platform 3 , and the liquid extraction top seat 5 is slidably arranged on the several guide pillars 12 .

[0052] In this embodiment, the purification mechanism includes:

[0053] A temperature control plate 13, which is installed on the material placement platform 3;

[0054] A mounting seat 14, the mounting seat 14 is disposed in the mounting groove 4 and positioned by a card slot;

[0055] The material storage tank 15 is rotatably mounted on the mounting seat 14. A hollow threaded tube 16 is provided on the top cover of the material storage tank 15. The hollow threaded tube 16 is threadably matched with the matching plate 6. The temperature control plate 13 is placed on the side of the material storage tank 15.

[0056] The connecting pipe 17 connects the hollow threaded pipe 16 and the liquid extraction top seat 5 .

[0057] It should be noted that the height difference between the highest point and the lowest point of the inclined substrate 10 is consistent with the height of the storage tank 15 .

[0058] In this embodiment, if Figure 1 , Figure 2 , Figure 5 As shown, when in use, a mixed solution containing crude amifostine and an organic solvent is placed in each storage tank 15, and the driving motor 7 is started so that its output end drives the gear 8 to rotate, and then drives the inclined substrate 10 to rotate through the push head 11. As the high and low points of the inclined substrate 10 intermittently cooperate with the gear 8, the lifting column 9 is rotated and intermittently lifted and lowered. As the lifting column 9 moves, the mounting seat 14 on the material placement platform 3 is driven to move synchronously, so that the mixed liquid in the storage tank 15 is self-oscillated and mixed in the storage tank 15, avoiding mechanical stirring and mixing before purification;

[0059] At this time, the driving mechanism drives the matching plate 6 to synchronously perform lifting and lowering movements. In this process, the matching plate 6 drives the hollow threaded tube 16 threadedly connected to it to rotate, and then drives the storage tank 15 at the lower end to rotate on the mounting seat 14, so as to realize the self-oscillation of the mixed liquid in the storage tank 15 while also rotating, and further maintain automatic stirring during the purification process to improve the uniformity of mixing. The temperature control plate 13 provides a suitable temperature environment for the mixed liquid in the storage tank 15, and the amifostine in the mixed liquid in the storage tank 15 is quickly precipitated, and the liquid solvent is collected into the corresponding liquid collecting pump 18 through the hollow threaded tube 16 and the connecting tube 17 to avoid polymerization effect, so as to ensure the improvement of recrystallization purification effect.

[0060] In this embodiment, if Figure 4 As shown, a liquid collecting pump 18 is provided on the top seat 5 for pumping liquid, and the liquid collecting pump 18 is connected with the connecting pipe 17, and the amifostine in the storage tank 15 is crystallized and precipitated, and the solid material and the liquid solvent are automatically separated.

[0061] In this embodiment, if Figure 1 As shown, a plurality of guide columns 12 are sleeved with springs 19, the lower end of the spring 19 abuts against the upper end of the liquid extraction top seat 5, so as to achieve a stable lifting effect and avoid excessive amplitude causing the precipitated amifostine to be extracted together with the organic solvent.

[0062] In this embodiment, if Figure 1 , Figure 2 As shown, a mounting opening 20 is provided on the top base 5 for pumping liquid, and a mounting frame 21 is detachably provided on the top base 5 at the outer side of the mounting opening 20, and the driving mechanism includes:

[0063] The cylinder 22 is mounted on the mounting frame 21, and the output end of the cylinder 22 passes through the mounting opening 20;

[0064] The reinforcing plate 23 has its middle portion mounted on the output end of the cylinder 22, and both ends of the reinforcing plate 23 are mounted on the lower end surface of the matching plate 6 and fixedly connected thereto. The output end of the cylinder 22 drives the matching plate 6 to reciprocate and rise and fall through the reinforcing plate 23.

[0065] Those skilled in the art should understand that the discussion of any of the above embodiments is merely illustrative and is not intended to imply that the scope of the present invention (including the claims) is limited to these examples. Under the concept of the present invention, the technical features in the above embodiments or different embodiments may be combined, the steps may be implemented in any order, and there are many other variations of the different aspects of the present invention as described above, which are not provided in detail for the sake of simplicity.

[0066] The present invention is intended to cover all such substitutions, modifications and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A purification device in an amifostine production process, comprising a frame (1) and a support base (2) arranged on the frame (1); characterized in that: The purification equipment also includes: A mixing mechanism for dissolving crude amifostine, the mixing mechanism being mounted on the support seat (2); A material placing platform (3), the material placing platform (3) being installed on the mixing mechanism, a mounting groove (4) being provided around the material placing platform (3), and a clamping groove being provided at a side end of the mounting groove (4); A purification mechanism for recrystallizing the crude amifostine product, wherein the purification mechanism is installed on the material placement platform (3); A liquid extraction top seat (5), the liquid extraction top seat (5) being arranged on the top of the purification mechanism; A matching plate (6), the matching plate (6) being installed between the material placement platform (3) and the liquid extraction top seat (5); A driving mechanism for driving the matching plate (6) to rise and fall.

2. The purification device in the amifostine production process according to claim 1, characterized in that: The mixing mechanism comprises: A drive motor (7) mounted on the support seat (2), wherein a gear (8) is mounted on the output end of the drive motor (7); A lifting column (9), wherein the lifting column (9) is slidably disposed on the support seat (2), and the material placement platform (3) is fixedly connected to the lifting column (9); An inclined surface base plate (10), the inclined surface base plate (10) being fixedly mounted on the lifting column (9), a push head (11) being provided around the side end of the inclined surface base plate (10), the push head (11) being meshed with the gear (8); There are a plurality of guide columns (12), and the plurality of guide columns (12) are installed on the material placing platform (3). The liquid extraction top seat (5) is slidably arranged on the plurality of guide columns (12).

3. The purification device in the amifostine production process according to claim 1 or 2, characterized in that: The purification mechanism comprises: A temperature control plate (13), wherein the temperature control plate (13) is installed on the material placement platform (3); A mounting seat (14), the mounting seat (14) being arranged in the mounting groove (4) and positioned by the clamping groove; A material storage tank (15), the material storage tank (15) is rotatably mounted on the mounting seat (14), a hollow threaded tube (16) is provided on the top cover of the material storage tank (15), the hollow threaded tube (16) is threadably matched with the matching plate (6), and the temperature control plate (13) is placed on the side of the material storage tank (15); A connecting pipe (17), wherein the connecting pipe (17) connects the hollow threaded pipe (16) and the liquid extraction top seat (5).

4. The purification equipment in the amifostine production process according to claim 3, characterized in that: The height difference between the highest point and the lowest point of the inclined substrate (10) is consistent with the height of the storage tank (15).

5. The purification equipment in the amifostine production process according to claim 3, characterized in that: A liquid collecting pump (18) is provided on the upper ring of the liquid pumping top seat (5), and the liquid collecting pump (18) is connected to the connecting pipe (17).

6. The purification equipment in the amifostine production process according to claim 2, characterized in that: A plurality of the guide columns (12) are sleeved with springs (19), and the lower ends of the springs (19) abut against the upper ends of the liquid extraction top seats (5).

7. The purification equipment in the amifostine production process according to claim 1, characterized in that: The liquid extraction top seat (5) is provided with a mounting opening (20), and the liquid extraction top seat (5) is detachably provided with a mounting frame (21) outside the mounting opening (20).

8. The purification equipment in the amifostine production process according to claim 7, characterized in that: The driving mechanism comprises: A cylinder (22), wherein the cylinder (22) is mounted on the mounting frame (21), and an output end of the cylinder (22) passes through the mounting opening (20); A reinforcing plate (23), wherein the middle portion of the reinforcing plate (23) is mounted on the output end of the cylinder (22), and both ends of the reinforcing plate (23) are mounted on the lower end surface of the matching plate (6) and are fixedly connected to each other.

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