Visual microfluidic test device for multiphase fluid flow-mass transfer-heat transfer coupling process

Abstract

The invention discloses a visual microfluidic test device for a multiphase fluid flow-mass transfer-heat transfer coupling process. The device comprises a multiphase fluid generation and injection unit, a microfluidic unit and a data acquisition unit, the micro-fluidic unit is connected with the multi-phase fluid generation and injection unit through a pipeline and a valve, a micro-machining structure is arranged in the micro-fluidic chip, and the data acquisition unit observes and acquires related data to the computer. According to the method, through a high-precision visual micro-fluidic technology, the size and apparent velocity of a single foam injected into a multi-phase fluid in a flow channel can be controlled, and control over parameters such as the foam fluid proportion, the foam size and the circulation density is achieved; and the processes of foam volume, foam proportion, density and multi-phase fluid flowing, heat transfer, mass transfer, reaction, erosion precipitation and the like of gas-water-oil-solid-green multi-phase fluid and multi-component are realized in the test, and high-precision control and observation of complex physical and chemical processes of the multi-phase and multi-component fluid are realized.

Description

Technical Field

[0001] The present invention relates to the technical field of visualization test devices for microfluidic bubble preparation and complex processes such as multiphase fluid flow-mass transfer-heat transfer-precipitation-erosion, and more specifically to a visualization microfluidic test device for multiphase fluid flow-mass transfer-heat transfer coupled processes. Background Art

[0002] Multiphase flow is a phenomenon in fluid dynamics, where two or more different phases, such as gas, liquid or solid, flow simultaneously in a system. The interactions between different phases are very complex and vary depending on the characteristics of any phase and environmental conditions. Multiphase flow has a wide range of applications. For example, in the fields of energy, water conservancy, chemical industry, metallurgy, etc., the flow of oil, gas and water mixtures during oil extraction and transportation is a typical multiphase flow problem; in the fields of life sciences, environmental protection, aerospace, etc., microfluidics technology can be used to achieve cell separation, culture and detection, all of which involve multiphase flow problems.

[0003] Microfluidics refers to the technology that integrates sample preparation, reaction, separation, detection, cell manipulation and other operation units involved in the field of chemistry and biology into a small chip, forming a network of microchannels and microvalves, and controlling the flow of fluids between channels, thereby realizing the multiple functions of chemical and biological laboratories. Microfluidics has the characteristics of miniaturization and integration, and its devices are usually called microfluidic chips, also known as chip laboratories (Lab on a Chip). After years of development, microfluidics has covered multiple disciplines such as chemistry, biology, medicine, materials, and optics, becoming an important interdisciplinary subject.

[0004] Foam flow refers to a flow pattern in which bubbles are dispersed in a liquid phase and flow through a conduit or container. This flow pattern is commonly seen in various industrial processes, such as chemical reactors, wastewater treatment systems, and bubble towers for gas-liquid reactions. In bubbly flow, the size, shape, and distribution of bubbles in the liquid phase will change, affecting the overall flow characteristics and mixing efficiency. The behavior of bubbles in liquids affects the heat and mass transfer rates, reaction kinetics, and the overall performance of the system. Bubble flow has a wide range of applications in the fields of pharmaceuticals, food, and environmental engineering. In chemical production, pharmaceutical testing, and seawater sampling, for example, solid catalysts, biological cells, and marine biological matrices will inevitably block the flow channel. Foam fluid is a flow type known to have a good carrying capacity, so it is important to consider the effects of foam size and foam flow rate on the carrying of solid particles and other phase fluids. Summary of the invention

[0005] In view of this, the present invention overcomes the shortcomings of the prior art and provides a visualized indoor experimental device for complex processes such as multi-phase and multi-component microfluid flow-mass transfer-heat transfer-precipitation-erosion. The method realizes the flow behavior of bubbles of different sizes during the injection of multi-phase fluids through high-precision visualized microfluidics, and can control the flow rate and proportion of multi-phase fluids at different injection temperatures. It can provide a theoretical basis for the migration of solid catalysts in chemical production, the migration of biological matrices in seawater sampling, and the movement laws of cells in biomedicine.

[0006] In order to achieve the above object, the present invention adopts the following scheme:

[0007] A visualized microfluidic experimental device for a multiphase fluid flow-mass transfer-heat transfer coupling process, comprising: a multiphase fluid generation and injection unit, a microfluidic unit, and a data acquisition unit;

[0008] The multiphase fluid generation and injection unit comprises an injection pump, an intermediate container and a temperature control device which are connected in sequence through an injection pipeline, and a plurality of the injection pump, the intermediate container, the temperature control device and the flow dividing device are provided;

[0009] The microfluidic unit includes a microfluidic chip and a micro-machined structure arranged in the microfluidic chip; the liquid inlet of the microfluidic chip is connected to the end of the injection pipe;

[0010] The data acquisition unit comprises an observation and imaging device and a computer connected to the observation and imaging device and the multi-spectral imaging device.

[0011] Preferably, the temperature control device comprises a temperature control stirring kettle and a temperature control box, and the intermediate container is arranged in the temperature control box.

[0012] Preferably, it further comprises a flow dividing device, wherein the inlet end of the flow dividing device is connected to the end of the injection pipe, and the outlet end of the flow dividing device is connected to the liquid inlet of the microfluidic chip.

[0013] Preferably, it further comprises a valve, wherein the valve is arranged on the injection pipe.

[0014] Preferably, it further comprises a microfluidic chip fixing device, the microfluidic chip fixing device comprises a base and a clamping plate, and the microfluidic chip is detachably mounted on the clamping plate.

[0015] Preferably, it further comprises a recovery unit, wherein the recovery unit comprises a liquid recovery device and an exhaust gas treatment device which are connected in sequence, and the liquid recovery device is connected to the liquid outlet of the microfluidic chip.

[0016] Preferably, the micro-machined structure is arranged at the junction of microfluidic channels in the microfluidic chip.

[0017] Furthermore, the micro-machined structure includes a structural body and a through hole arranged on the structural body.

[0018] Preferably, the observation and imaging device includes a Raman spectrometer and an infrared imaging temperature measuring device.

[0019] To achieve the above object, the present invention adopts the following technical solution:

[0020] It can be seen from the above technical solutions that, compared with the prior art, the present invention discloses a visualized microfluidic test device for multiphase fluid flow-mass transfer-heat transfer coupling process, which has the following beneficial effects:

[0021] The present invention uses multiple injection pumps to inject multiple sample reagents of different proportions into the microfluidic chip to form a multi-phase and multi-component foam microfluid containing solid particles, and then outputs the multi-phase and multi-component foam microfluid through a circulation tube. With the help of a Raman spectrometer and an infrared imaging temperature measuring device, the mass transfer-heat transfer visualization process of the multi-phase and multi-component foam microfluid can be realized. The present invention has a simple structure, does not require complex processing technology and expensive equipment, and can realize the control of the size and rate of a single foam injected into the foam flow channel through high-precision visualized microfluidic technology, and realize the control of parameters such as the foam fluid ratio and the foam size, flow density, etc., so as to dynamically adjust the proportion of the multi-phase foam fluid and the ability to carry solid particles and other phase fluids; and realize the foam volume, foam ratio, density of gas-water-oil-solid-bio and multi-component multi-phase fluids and multi-components in the experiment, as well as the multi-phase fluid flow-heat transfer-mass transfer-reaction-erosion precipitation and other processes of the components, so as to realize the high-precision control and observation of the complex physical and chemical processes of the multi-phase and multi-component fluids. The present device can provide a theoretical basis for the research of chemical engineering, biology, medicine and marine microorganisms. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0023] Figure 1 This is an overall structural diagram of Embodiment 1 of the present invention;

[0024] Figure 2 Schematic diagram of the geometric structure of the microfluidic chip in the present invention;

[0025] Figure 3 Schematic diagram of the location of the micro-machining structure;

[0026] Figure 4 Schematic diagram of the geometry of the micro-machined structure;

[0027] Figure 5 This is the layout diagram of the infrared imaging temperature measurement device;

[0028] In the figure, 1-injection pump A; 2-injection pump B; 3-injection pump C; 4-injection pump D; 5-valve A; 6-valve B; 7-valve C; 8-valve D; 9-temperature-controlled stirring kettle; 10-intermediate container A; 11-intermediate container B; 12-intermediate container C; 13-temperature control box A; 14-temperature control box B; 15-temperature control box C; 16-valve E; 17-valve F; 18-valve G; 19-valve H; 20-diversion device; 21-Raman spectrum Instrument; 22-infrared imaging temperature measuring device; 23-microfluidic chip; 24-plywood; 25-base; 26-liquid flow recovery device; 27-exhaust treatment bottle; 28-computer; 29-continuous phase flow channel liquid inlet containing solid particles; 30-continuous phase flow channel liquid inlet A; 31-gas phase flow channel liquid inlet; 32-continuous phase flow channel liquid inlet B; 33-dispersed phase flow channel liquid inlet; 34-micro-machined structure; 35-mixing flow channel; 36-mixing flow channel liquid outlet. DETAILED DESCRIPTION

[0029] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] A visualized microfluidic experimental device for multiphase fluid flow-mass transfer-heat transfer coupling process, comprising: a multiphase fluid generation and injection unit, a microfluidic unit and a data acquisition unit;

[0031] Among them, the multiphase fluid generation and injection unit includes an injection pump, an intermediate container and a temperature control device connected in sequence through an injection pipe, and the injection pump, the intermediate container, the temperature control device and the diversion device are each provided in plurality; the microfluidic unit includes a microfluidic chip and a micro-machined structure arranged in the microfluidic chip; the liquid inlet of the microfluidic chip is connected to the end of the injection pipe; the data acquisition unit includes an observation and imaging device and a computer connected to the observation and imaging device and the multi-spectral imaging device.

[0032] In some specific solutions, the temperature control device includes a temperature-controlled stirring kettle and a temperature-controlled box, and the intermediate container is arranged in the temperature-controlled box.

[0033] Some specific solutions further include a flow dividing device, wherein the inlet end of the flow dividing device is connected to the end of the injection pipe, and the outlet end of the flow dividing device is connected to the liquid inlet of the microfluidic chip.

[0034] Some specific solutions further include a valve, which is arranged on the injection pipe.

[0035] Some specific solutions further include a microfluidic chip fixing device, which includes a base and a clamping plate, and the microfluidic chip is detachably mounted on the clamping plate.

[0036] Some specific schemes further include a recovery unit, which includes a liquid recovery device and an exhaust gas treatment device connected in sequence, and the liquid recovery device is connected to the liquid outlet of the microfluidic chip.

[0037] In some specific solutions, the micro-machined structure is arranged at the junction of the microfluidic channels in the microfluidic chip, and the micro-machined structure includes a structural body and a through hole arranged on the structural body.

[0038] In some specific schemes, the observation and imaging device includes a Raman spectrometer and an infrared imaging temperature measurement device.

[0039] The device of the present invention will be further described below using specific embodiments.

[0040] Example 1

[0041] As attached Figure 1-5 As shown, in this embodiment, four injection pumps are provided, including injection pump A1, injection pump B2, injection pump C3, and injection pump D4; the microfluidic chip 23 is multi-channel, and is provided with multiple liquid inlets, including a continuous phase flow channel liquid inlet 29 containing solid particles, a continuous phase flow channel liquid inlet A30, a gas phase flow channel liquid inlet 31, a continuous phase flow channel liquid inlet B32, and a discrete phase flow channel liquid inlet 33. The multiple flow channels merge into a mixing flow channel 35, and then are discharged through a mixing flow channel liquid outlet 36. The discharged liquid enters a liquid flow recovery device 26, and the fluid recovery device 26 is connected to an exhaust gas recovery bottle 27 through a pipeline;

[0042] The temperature control device includes a temperature control stirring kettle 9 and temperature control boxes A13, B14 and C15, and the intermediate containers include intermediate containers A10, B11 and C12;

[0043] The injection pump A1 is connected to a temperature-controlled stirring kettle 9 through an injection pipe, and the temperature-controlled stirring kettle 9 is connected to a continuous phase flow channel liquid inlet 29 of the microfluidic chip 23;

[0044] The injection pump B2 is connected to the intermediate container A10 through an injection pipeline. The intermediate container A10 is arranged in the temperature control box A13. The outlet of the intermediate container A10 is connected to the flow dividing device 20. The flow dividing device 20 divides the fluid into two paths, which are respectively connected to the continuous phase flow channel liquid inlet A30 and the continuous phase flow channel liquid inlet B32;

[0045] The injection pump C3 is connected to an intermediate container B11 through an injection pipeline. The intermediate container B11 is arranged in a temperature control box B14. The outlet of the intermediate container B11 is connected to the liquid inlet 31 of the gas phase flow channel.

[0046] The injection pump D4 is connected to an intermediate container C12 through an injection pipeline. The intermediate container C12 is arranged in a temperature control box C15. The outlet of the intermediate container C15 is connected to the liquid inlet 33 of the discrete phase flow channel.

[0047] The above-mentioned official roads connected in pairs are all provided with valves, namely valve A5, valve B6, valve C7, valve D8, valve E16, valve F17, valve G18, valve H19;

[0048] The microfluidic chip 23 is mounted on the base 25 via the clamping plate 24. The Raman spectrometer 21 and the infrared imaging temperature measuring device 22 are arranged as shown in the attached figure. Figure 1 and attached Figure 5 As shown;

[0049] In the microfluidic chip 23, a micro-machined structure 34 is provided at the intersection of the fluid channels, as shown in the attached Figure 3 As shown, the specific structure of the micro-machined structure 34 is shown in the attached Figure 4 As shown, it includes a structural body and a rectangular through hole arranged on the structural body.

[0050] The specific research process is:

[0051] The first step is to start the injection pump A1 and open the valve A5 at the same time to allow the fluid in the pipeline to enter the temperature-controlled stirring kettle 9, and then start the temperature-controlled stirring kettle 9 to allow the fluid to be evenly mixed with the solid particles pre-filled in the temperature-controlled stirring kettle 9;

[0052] The second step is to start the syringe pump B2, the syringe pump C3, and the syringe pump D4, and at the same time open the valve B6, the valve C7, and the valve D8 to allow the preset sample fluid to enter the intermediate container A10, the intermediate container B11, and the intermediate container C12, and set the temperature control box A13, the temperature control box B14, and the temperature control box C15 to the specified temperature;

[0053] The third step is to open valves E16, F17, G18 and H19, pass the heated fluid into the microfluidic chip 23, and turn on the Raman spectrometer 21 and the infrared imaging temperature measuring device 22 to realize the flow-mass transfer-heat transfer-reaction-erosion-precipitation process of the multiphase foam microfluid;

[0054] The fourth step is to cycle through steps one to three in sequence, and after detecting that the bubble size in the microfluidic chip 23 has not changed by image analysis, stop the multiphase microfluid flow simulation experiment, turn off all injection pumps, close all valves, and discharge the fluid.

[0055] In this specification, each embodiment is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part.

[0056] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A visualized microfluidic experimental device for multiphase fluid flow-mass transfer-heat transfer coupling process, characterized in that: include: Multiphase fluid generation and injection unit, microfluidics unit, and data acquisition unit; The multiphase fluid generation and injection unit comprises an injection pump, an intermediate container and a temperature control device which are connected in sequence through an injection pipeline, and a plurality of the injection pump, the intermediate container, the temperature control device and the flow dividing device are provided; The microfluidic unit includes a microfluidic chip and a micro-machined structure arranged in the microfluidic chip; the liquid inlet of the microfluidic chip is connected to the end of the injection pipe; The data acquisition unit comprises an observation and imaging device and a computer connected to the observation and imaging device and the multi-spectral imaging device.

2. A visualized microfluidic experimental device for multiphase fluid flow-mass transfer-heat transfer coupling process according to claim 1, characterized in that: The temperature control device comprises a temperature control stirring kettle and a temperature control box, and the intermediate container is arranged in the temperature control box.

3. A visualized microfluidic experimental device for multiphase fluid flow-mass transfer-heat transfer coupling process according to claim 1, characterized in that: It also includes a flow dividing device, the inlet end of which is connected to the end of the injection pipe, and the outlet end of which is connected to the liquid inlet of the microfluidic chip.

4. A visualized microfluidic experimental device for multiphase fluid flow-mass transfer-heat transfer coupling process according to claim 1, characterized in that: Also included is a valve, which is disposed on the injection pipeline.

5. A visualized microfluidic test device for multiphase fluid flow-mass transfer-heat transfer coupling process according to claim 1, characterized in that: It also includes a microfluidic chip fixing device, which includes a base and a clamping plate, and the microfluidic chip is detachably mounted on the clamping plate.

6. A visualized microfluidic test device for multiphase fluid flow-mass transfer-heat transfer coupling process according to claim 1, characterized in that: It also includes a recovery unit, which includes a liquid recovery device and an exhaust gas treatment device connected in sequence, and the liquid recovery device is connected to the liquid outlet of the microfluidic chip.

7. A visualized microfluidic test device for multiphase fluid flow-mass transfer-heat transfer coupling process according to claim 1, characterized in that: The micro-machined structure is arranged at the junction of the micro-fluidic channels in the micro-fluidic chip.

8. The visualized microfluidic test device for multiphase fluid flow-mass transfer-heat transfer coupling process according to claim 1, characterized in that: The micro-machined structure includes a structural body and a through hole arranged on the structural body.

9. A visualized microfluidic experimental device for multiphase fluid flow-mass transfer-heat transfer coupling process according to claim 1, characterized in that: The observation and imaging device comprises a Raman spectrometer and an infrared imaging temperature measuring device.

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