Quantitative subpackaging device for suspension and efficient sterilization process of quantitative subpackaging device

Abstract

The invention relates to the technical field of production and filling, and discloses a suspension quantitative subpackaging device and an efficient sterilization process thereof.The suspension quantitative subpackaging device comprises a bottom plate, a fixing assembly is arranged in the bottom plate and used for fixing a tank body, the bottom of the tank body abuts against the top of the bottom plate, a feeding port is formed in one side of the top of the tank body, and a discharging port is formed in the other side of the top of the tank body; a flow controller is arranged on one side of the bottom plate, conveying pipes are fixedly connected to the output end and the input end of the flow controller, the end, away from the flow controller, of one conveying pipe is fixedly connected to the interior of the tank body, and a flow dividing disc is fixedly connected to the end, away from the flow controller, of the other conveying pipe. The stirring blades can be driven to rotate by starting the first motor, the suspension can be stirred and mixed through rotation of the stirring blades, the uniformity of liquid in the split charging process is ensured, the clamping plates can be driven to move by starting the second motor to fix the tank body, and the situation that the liquid separation process is affected due to the fact that the tank body deviates on the top of the bottom plate is prevented.

Description

Technical Field

[0001] The invention relates to the technical field of production and filling, in particular to a suspension quantitative filling device and a high-efficiency sterilization process thereof. Background Art

[0002] In the production and filling process of cell therapy products, the traditional method is to manually dispense liquids into containers one by one. Manual filling is inefficient and time-consuming, and the long-term exposure of liquids increases the risk of contamination, which cannot meet the needs of large-scale packaging. To solve these problems, a new type of high-pressure sterilized suspension quantitative dispensing device has emerged in recent years, which can improve the efficiency, accuracy and safety of dispensing.

[0003] The existing new high-pressure sterilized suspension quantitative filling device usually fills the liquid into different containers through a filling head, and uses a quantitative pump to accurately control the liquid delivery amount to ensure the consistency of each filling volume. However, this type of device lacks an effective stirring structure, which makes the suspension easy to precipitate during the static process, thereby affecting the uniformity of the liquid during the filling process and failing to ensure the consistency of the suspension components in each container.

[0004] Based on the above defects, the present invention develops a device suitable for quantitative and uniform packaging of solutions, and is equipped with a sterilization procedure. It is particularly suitable for quantitative packaging of sterile liquid medicines and suspensions, and can ensure uniform quality of packaged samples and controllable packaging volume. Summary of the invention

[0005] In view of the deficiencies of the prior art, the present invention provides a suspension quantitative filling device and an efficient sterilization process thereof, which solves the problem in the prior art that the uniformity of the liquid during the filling process cannot be ensured due to the lack of a stirring structure.

[0006] To achieve the above objectives, the present invention is implemented through the following technical solutions: a suspension quantitative filling device and its efficient sterilization process, including a bottom plate, characterized in that: a fixing component is arranged inside the bottom plate, the fixing component is used to fix the tank body, the bottom of the tank body abuts against the top of the bottom plate, a feed port is arranged on one side of the top of the tank body, a flow controller is arranged on one side of the bottom plate, the output end and the input end of the flow controller are fixedly connected to a delivery pipe, one end of the delivery pipe away from the flow controller is fixedly connected to the inside of the tank body, and the other end of the delivery pipe away from the flow controller is fixedly connected to the inside of the tank body. One end of the device is fixedly connected to a diverter plate, a plurality of evenly distributed diverter tubes are fixedly connected to the bottom of the diverter plate, a syringe is fixedly connected to the bottom of the diverter tube, a support plate is arranged at the bottom of the diverter tube, a plurality of evenly distributed liquid separation bottles are fixedly connected to the top of the support plate, a motor 1 is fixedly connected to the top of the tank body, a gear 1 is fixedly connected to the driving end of the motor 1, a rotating shaft is rotatably connected to the left and right sides of the inside of the tank body, a gear 2 is fixedly connected to the outer periphery of the rotating shaft, the gear 2 is meshingly connected to the gear 1, and a plurality of evenly distributed stirring blades are fixedly connected to the outer periphery of the rotating shaft.

[0007] Preferably, the fixing component includes Motor 2, which is fixedly connected to the inside of the base plate, and the driving end of Motor 2 is fixedly connected to a rotating plate, and the top of the rotating plate is rotatably connected to a plurality of evenly distributed connecting plates, and the side of the connecting plate away from the rotating plate is rotatably connected to a slide plate, and the top of the slide plate is fixedly connected to a splint.

[0008] Preferably, a rubber pad is fixedly connected to one side of the clamping plate.

[0009] Preferably, a plurality of evenly distributed sliding grooves are provided inside the bottom plate, and the outer periphery of the sliding plate is slidably connected to the sliding grooves inside the bottom plate.

[0010] Preferably, a slide plate is fixedly connected to one side of the support plate, and a movable frame is slidably connected inside the slide plate.

[0011] Preferably, a telescopic rod is fixedly connected to the rear side of the slide plate, and a telescopic end of the telescopic rod is fixedly connected to the rear side of the moving frame.

[0012] Preferably, the outer periphery of the diverter pipe is fixedly connected to the inside of the movable frame, and the telescopic end of the telescopic rod is slidably connected to the inside of the slide plate.

[0013] Preferably, the flow controller is a peristaltic pump.

[0014] An efficient sterilization process for a suspension comprises the following steps:

[0015] S1. Preparation and loading of suspension: loading the pre-prepared suspension into the tank through the feed port, and fixing the tank to ensure its stability;

[0016] S2. High-pressure sterilization: sterilization is performed using a high-pressure steam sterilizer, which is equipped with a temperature control system, a pressure control system and a stirring device. The temperature of the sterilizer is set to 121°C and the pressure is set to 1.2 bar during sterilization, and the stirring device is continuously operated at a speed of 300 rpm; after reaching the temperature and pressure, the sterilization process is performed for 20 minutes, and the temperature and pressure are monitored in real time by the monitoring system of the sterilizer to ensure the stability of the sterilization process; after the sterilization is completed, the pressure is slowly reduced and cooled to room temperature, and the stirring device continues to operate during the cooling process, and the stirring is stopped after the pressure drops to normal pressure, and the subpackaging operation is prepared; the sterilizer and the outside of the tank are disinfected before and after sterilization to ensure the sterility of the equipment;

[0017] S3. Filling process: After sterilization is completed, start the flow controller to control the flow of the suspension, deliver the sterilized suspension to the diversion plate through the delivery tube, and quantitatively fill multiple liquid separation bottles through the diversion tube and the syringe. Keep the stirring device running during the filling process to ensure the fluidity and uniformity of the suspension.

[0018] Preferably, the method further comprises the following steps:

[0019] S4. Equipment cleaning and disinfection: Before the suspension is loaded into the tank, the bottom plate, tank, delivery tube, diverter plate, diverter tube, syringe and dispensing bottle shall be thoroughly cleaned and disinfected, and sterile air drying equipment shall be used to ensure that all parts in contact with the suspension are in a sterile state;

[0020] S5. Sterilization after filling: After filling, the liquid-dispensing bottle is sterilized for the second time. The outside of the liquid-dispensing bottle is sterilized by high pressure sterilization, ultraviolet sterilization or irradiation sterilization to ensure the sterility of the product. Finally, the liquid-dispensing bottle is packaged and labeled.

[0021] Working principle: Place the tank body on the top of the bottom plate, start motor 2 to drive the rotating plate to rotate, the rotating plate can drive the connecting plate to rotate by rotation, the connecting plate can drive the slide plate to move by rotation, the slide plate can drive the splint to move by movement, the splint can fix the tank body by movement to ensure its stability and prevent the tank body from shifting, thereby affecting the liquid separation process, place the liquid to be separated inside the tank body through the feed port, start motor 1 to drive gear 1 to rotate, gear 1 can drive gear 2 to rotate by rotation, gear 2 can drive the rotating shaft to rotate by rotation, the rotating shaft can drive the stirring blade to rotate by rotation, the stirring blade can stir and mix the suspension by rotation to ensure the uniformity of the liquid during the filling process, while maintaining its fluidity to avoid blockage during the filling process, at the same time, the flow controller controls the flow of the liquid and transports it to the diverter plate through the delivery pipe, and then flows into the diverter bottle from the bottom of the diverter plate through the diverter pipe and the syringe, at this time the telescopic rod drives the mobile frame to move to complete quantitative liquid separation for all diverter bottles.

[0022] The present invention provides a suspension quantitative packaging device and an efficient sterilization process thereof. The device has the following beneficial effects:

[0023] 1. The present invention starts motor 1 to rotate gear 1, gear 1 drives gear 2, gear 2 rotates the rotating shaft, the rotating shaft drives the stirring blades, and the stirring blades can stir and mix the suspension by rotating to ensure the uniformity of the liquid during the packaging process, while maintaining its fluidity and avoiding blockage during the packaging process.

[0024] 2. The present invention starts the second motor to rotate the rotating plate, which in turn drives the connecting plate to rotate. The rotation of the connecting plate moves the sliding plate, and the movement of the sliding plate pushes the clamping plate to move. The clamping plate moves to fix the tank body to ensure its stability and prevent the tank body from shifting on the top of the bottom plate, thereby affecting the liquid separation process.

[0025] 3. The present invention ensures the uniformity of the suspension by using a stirring device during the sterilization process, thereby avoiding insufficient local sterilization caused by uneven heating of the liquid during high-pressure sterilization and ensuring the thoroughness of sterilization. Secondly, the cooperation between the flow controller and the diverter disk realizes accurate quantitative packaging, ensures the consistency of the amount of suspension in each liquid separation bottle, improves production efficiency and reduces human operation errors. At the same time, the secondary sterilization step further ensures the sterility of the product after packaging, improves the safety and quality stability of the product, and the overall process has the advantages of high automation, good sterilization effect, and high packaging accuracy, and is particularly suitable for suspension packaging that needs to be processed in a sterile environment. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 A perspective view of the present invention;

[0027] Figure 2 It is a structural schematic diagram of the tank body of the present invention;

[0028] Figure 3 It is a structural schematic diagram of the bottom plate of the present invention;

[0029] Figure 4 It is a structural schematic diagram of the splint of the present invention;

[0030] Figure 5 It is a structural schematic diagram of the support plate of the present invention;

[0031] Figure 6 It is a process flow chart of the present invention.

[0032] Among them, 1. bottom plate; 2. tank body; 3. feed port; 4. flow controller; 5. conveying pipe; 6. diverter plate; 7. diverter tube; 8. syringe; 9. support plate; 10. liquid separation bottle; 11. motor 1; 12. gear 1; 13. gear 2; 14. rotating shaft; 15. stirring blade; 16. motor 2; 17. rotating plate; 18. connecting plate; 19. sliding plate; 20. clamping plate; 21. rubber pad; 22. slide plate; 23. movable frame; 24. telescopic rod. DETAILED DESCRIPTION

[0033] The following will be combined with the drawings in the specification of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0034] Please refer to the attached Figure 1 , Figure 2 and Figure 5The embodiment of the present invention provides a novel high-pressure sterilization suspension quantitative filling device, comprising a bottom plate 1, a tank body 2 bottom abutting against the top of the bottom plate 1, a feed port 3 is arranged on one side of the top of the tank body 2, a flow controller 4 is arranged on one side of the bottom plate 1, and a delivery pipe 5 is fixedly connected to the output end and the input end of the flow controller 4, one end of the delivery pipe 5 away from the flow controller 4 is fixedly connected to the inside of the tank body 2, and the other end of the delivery pipe 5 away from the flow controller 4 is fixedly connected to a diverter plate 6, and a plurality of evenly distributed diverters are fixedly connected to the bottom of the diverter plate 6. Flow tube 7, a syringe 8 is fixedly connected to the bottom of the shunt tube 7, a support plate 9 is arranged at the bottom of the shunt tube 7, a plurality of evenly distributed liquid separation bottles 10 are fixedly connected to the top of the support plate 9, a motor 11 is fixedly connected to the top of the tank body 2, a gear 12 is fixedly connected to the driving end of the motor 11, a rotating shaft 14 is rotatably connected to the left and right sides of the inside of the tank body 2, a gear 2 13 is fixedly connected to the outer periphery of the rotating shaft 14, the gear 2 13 is meshed with the gear 12, and a plurality of evenly distributed stirring blades 15 are fixedly connected to the outer periphery of the rotating shaft 14. The bottom plate 1 is used to place the tank body 2, the tank body 2 is used to contain the suspension, the feed port 3 is used to place the suspension inside the tank body 2, the flow controller 4 is used to pump the inside of the tank body 2 into the diverter plate 6, the delivery pipe 5 is used to fix the flow route of the suspension, the diverter plate 6 is used to divert the suspension, the diverter pipe 7 can transport the diverted suspension, the syringe 8 is used to inject the suspension into the liquid separation bottle 10, the support plate 9 is used to fix the liquid separation bottle 10, the liquid separation bottle 10 is used to store the suspension, the motor 11 is used to drive the gear 12 to rotate, the gear 12 can drive the gear 2 13 to rotate by rotation, the gear 2 13 can drive the rotating shaft 14 to rotate by rotation, the rotating shaft 14 can drive the stirring blade 15 to rotate by rotation, the stirring blade 15 can stir the suspension by rotation, ensure the uniformity of the liquid during the filling process, while maintaining its fluidity, and avoid blockage during the filling process.

[0035] Please refer to the attached Figure 1 , Figure 3 and Figure 4 A fixing assembly is provided inside the bottom plate 1, and the fixing assembly is used to fix the tank body 2. The fixing assembly includes a second motor 16, and the second motor 16 is fixedly connected inside the bottom plate 1. The driving end of the second motor 16 is fixedly connected to a rotating plate 17, and the top of the rotating plate 17 is rotatably connected to a plurality of evenly distributed connecting plates 18, and the side of the connecting plate 18 away from the rotating plate 17 is rotatably connected to a slide plate 19, and the top of the slide plate 19 is fixedly connected to a clamping plate 20. The second motor 16 is used to drive the rotating plate 17 to rotate, and the rotating plate 17 can drive the connecting plate 18 to rotate by rotating, and the connecting plate 18 can drive the slide plate 19 to move by rotating, and the slide plate 19 can drive the clamping plate 20 to move by moving, and the clamping plate 20 is used to fix the tank body 2.

[0036] Please refer to the attached Figure 1 , Figure 3 and Figure 5 A rubber pad 21 is fixedly connected to one side of the clamping plate 20, a plurality of evenly distributed slide grooves are provided inside the bottom plate 1, the outer periphery of the slide plate 19 is slidably connected to the slide groove inside the bottom plate 1, a slide groove plate 22 is fixedly connected to one side of the support plate 9, a mobile frame 23 is slidably connected inside the slide groove plate 22, a telescopic rod 24 is fixedly connected to the rear side of the slide groove plate 22, the telescopic end of the telescopic rod 24 is fixedly connected to the rear side of the mobile frame 23, the outer periphery of the shunt pipe 7 is fixedly connected to the inside of the mobile frame 23, the telescopic end of the telescopic rod 24 is slidably connected to the inside of the slide groove plate 22, and the flow controller 4 is a peristaltic pump. The rubber pad 21 is used to prevent the clamping plate 20 from damaging the shape of the tank body 2, the slide groove plate 22 is used to fix the mobile frame 23, the mobile frame 23 is used to fix the shunt pipe 7, and the telescopic rod 24 is used to drive the mobile frame 23 to move.

[0037] Example 1: Standard high pressure steam sterilization + automated quantitative packaging

[0038] Process steps:

[0039] Suspension preparation: A suspension containing 10% solids was prepared in a volume of 20 liters.

[0040] Suspension filtration: Filter the suspension using a 0.22 μm filter to remove impurities.

[0041] Equipment cleaning and preparation before sterilization: Clean the equipment and rinse with sterile water, dry it and prepare for sterilization.

[0042] High-pressure steam sterilization: sterilization is carried out using a high-pressure steam sterilizer, which is equipped with a temperature control system, a pressure control system and a stirring device. The temperature of the sterilizer is set to 121°C, the pressure is set to 1.2 bar, and the stirring device runs continuously at a speed of 300 rpm during sterilization; after reaching the temperature and pressure, sterilization is carried out for 20 minutes, and the temperature and pressure are monitored in real time through the monitoring system of the sterilizer to ensure the stability of the sterilization process; after sterilization is completed, the pressure is slowly reduced and cooled to room temperature, and the stirring device continues to run during the cooling process, and the stirring is stopped after the pressure drops to normal pressure, and the packaging operation is prepared; the sterilizer and the outside of the tank are disinfected before and after sterilization to ensure the sterility of the equipment.

[0043] Cooling and depressurization: After sterilization is completed, slowly depressurize and cool to room temperature.

[0044] Quantitative filling: Start the automated quantitative filling device and fill into 30 ml sterile bottles. The flow controller adjusts the flow rate to 50 ml / min and the stirring speed to 200 rpm.

[0045] Post-packaging processing: The sterile bottles after packaging are sterilized again (121°C, 15 minutes), and then packaged and labeled.

[0046] Process parameters:

[0047] Sterilization temperature: 121℃

[0048] Sterilization time: 20 minutes

[0049] Stirring speed: 300rpm (during sterilization), 200rpm (during packaging)

[0050] Packing volume: 30ml

[0051] Example 2: Long-term high-pressure steam sterilization at a lower temperature + manual packaging

[0052] Process steps:

[0053] Suspension preparation: A suspension containing 20% ​​solids was prepared in a volume of 15 liters.

[0054] Suspension filtration: Use a 0.45 μm filter to filter and remove large particles.

[0055] Equipment cleaning and preparation before sterilization: After cleaning the equipment, treat it with disinfectant and finally rinse it with sterile water.

[0056] High-pressure steam sterilization: The sterilization temperature was set at 115°C, the sterilization time was 40 minutes, the stirring speed was 250 rpm, and the pressure was maintained at 1.0 bar.

[0057] Cooling and depressurization: After sterilization is completed, slowly reduce the pressure to normal pressure and cool to room temperature.

[0058] Manual filling: Manual filling into 50ml sterile bottles, the filling volume is controlled by the operator.

[0059] Post-packaging processing: No secondary sterilization is performed, and packaging and labeling are carried out directly.

[0060] Process parameters:

[0061] Sterilization temperature: 115℃

[0062] Sterilization time: 40 minutes

[0063] Stirring speed: 250rpm (during sterilization)

[0064] Packing volume: 50ml

[0065] Example 3: Ultra-high temperature rapid sterilization + automated packaging + secondary ultraviolet sterilization

[0066] Process steps:

[0067] Suspension preparation: A suspension containing 15% solids was prepared in a volume of 25 liters.

[0068] Suspension filtration: Use a 0.22 μm filter to filter and remove tiny particle impurities.

[0069] Equipment cleaning and preparation before sterilization: Rinse the equipment with sterile water and dry it in preparation for sterilization.

[0070] High-pressure steam sterilization: The sterilization temperature was set at 130°C, the sterilization time was 10 minutes, the stirring speed was 350 rpm, and the pressure was maintained at 1.5 bar.

[0071] Cooling and depressurization: Rapidly reduce the pressure to normal pressure and cool to room temperature.

[0072] Quantitative filling: Start the automated quantitative filling device and fill into 20 ml sterile bottles. The flow controller adjusts the flow rate to 60 ml / min and the stirring speed to 250 rpm.

[0073] Post-packaging processing: After packaging, the products are sterilized by ultraviolet light (UV-C 254nm, 20 minutes), and then packaged and labeled.

[0074] Process parameters:

[0075] Sterilization temperature: 130℃

[0076] Sterilization time: 10 minutes

[0077] Stirring speed: 350rpm (during sterilization), 250rpm (during packaging)

[0078] Packing volume: 20ml

[0079] Comparative Example 1: High-pressure steam sterilization without stirring

[0080] Process steps:

[0081] Autoclave (121°C, 20 minutes) without stirring.

[0082] Results: The topical suspension was heated unevenly, resulting in poor sterilization, leading to contamination of some samples.

[0083] Comparative Example 2: Normal Temperature and Low Pressure Sterilization

[0084] Process steps:

[0085] The suspension was treated in a normal pressure sterilizer at 100°C for 60 minutes, and no secondary sterilization was performed after packaging.

[0086] Result: The sterilization time was too long, the active ingredients of the suspension were destroyed, and the sterilization effect was incomplete.

[0087] Comparative Example 3: No secondary sterilization

[0088] Process steps:

[0089] Sterilize at 121℃ for 20 minutes. After packaging, do not perform secondary sterilization but directly package.

[0090] Result: The post-packaging operating environment caused some contamination outside the bottle and the sterility of the final product could not be guaranteed.

[0091] Comparative experimental design:

[0092] In order to verify the effects of different sterilization processes, the following experiments were designed:

[0093] The three embodiments and three comparative examples were produced in the same batch and compared by the following indicators:

[0094] Sterility of suspension after sterilization (microbial residues)

[0095] Sterility inside and outside the bottle after filling

[0096] Suspension uniformity (change in solid content)

[0097] Packaging accuracy (amount per bottle)

[0098] Experimental data table:

[0099]

[0100] According to the table: Examples 1 and 3 have excellent sterilization effects, filling accuracy, and external sterility of the bottles, and good uniformity, indicating that high-pressure sterilization combined with stirring function and secondary sterilization can ensure the sterility and uniformity of the suspension.

[0101] In the comparative examples, especially in the process without stirring and secondary sterilization, the sterility inside and outside the bottle was significantly reduced, which verified the importance of stirring and secondary sterilization in this process.

[0102] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A highly efficient sterilization quantitative dispensing device for suspensions, comprising a bottom plate (1), characterized in that: A fixing component is arranged inside the bottom plate (1), and the fixing component is used to fix the tank body (2). The bottom of the tank body (2) abuts against the top of the bottom plate (1). A feed port (3) is arranged on one side of the top of the tank body (2). A flow controller (4) is arranged on one side of the bottom plate (1). The output end and the input end of the flow controller (4) are both fixedly connected to a delivery pipe (5). One end of one of the delivery pipes (5) away from the flow controller (4) is fixedly connected to the inside of the tank body (2), and the other end of the delivery pipe (5) away from the flow controller (4) is fixedly connected to a diverter plate (6). The bottom of the diverter plate (6) is fixedly connected to a plurality of evenly distributed diverter pipes ( 7), a syringe (8) is fixedly connected to the bottom of the shunt tube (7), a support plate (9) is arranged at the bottom of the shunt tube (7), a plurality of evenly distributed liquid separation bottles (10) are fixedly connected to the top of the support plate (9), a motor 1 (11) is fixedly connected to the top of the tank body (2), a gear 1 (12) is fixedly connected to the driving end of the motor 1 (11), a rotating shaft (14) is rotatably connected to both the left and right sides of the tank body (2), a gear 2 (13) is fixedly connected to the outer periphery of the rotating shaft (14), the gear 2 (13) is meshingly connected to the gear 1 (12), and a plurality of evenly distributed stirring blades (15) are fixedly connected to the outer periphery of the rotating shaft (14).

2. The highly efficient sterilization quantitative packaging device for suspension according to claim 1, characterized in that: The fixing assembly comprises a second motor (16), the second motor (16) being fixedly connected inside the bottom plate (1), the driving end of the second motor (16) being fixedly connected to a rotating plate (17), the top of the rotating plate (17) being rotatably connected to a plurality of evenly distributed connecting plates (18), the side of the connecting plate (18) away from the rotating plate (17) being rotatably connected to a sliding plate (19), the top of the sliding plate (19) being fixedly connected to a clamping plate (20).

3. The highly efficient sterilization quantitative packaging device for suspension according to claim 1, characterized in that: A rubber pad (21) is fixedly connected to one side of the clamping plate (20).

4. The highly efficient sterilization quantitative packaging device for suspension according to claim 1, characterized in that: A plurality of evenly distributed sliding grooves are provided inside the bottom plate (1), and the outer periphery of the sliding plate (19) is slidably connected to the sliding grooves inside the bottom plate (1).

5. The highly efficient sterilization quantitative dispensing device for suspension according to claim 1, characterized in that: A slide plate (22) is fixedly connected to one side of the support plate (9), and a moving frame (23) is slidably connected inside the slide plate (22).

6. The highly efficient sterilization quantitative dispensing device for suspension according to claim 1, characterized in that: A telescopic rod (24) is fixedly connected to the rear side of the slide plate (22), and a telescopic end of the telescopic rod (24) is fixedly connected to the rear side of the moving frame (23).

7. The highly efficient sterilization quantitative packaging device for suspension according to claim 1, characterized in that: The outer periphery of the diverter pipe (7) is fixedly connected to the inside of the moving frame (23), and the telescopic end of the telescopic rod (24) is slidably connected to the inside of the slide plate (22).

8. The highly efficient sterilization quantitative dispensing device for suspension according to claim 1, characterized in that: The flow controller (4) is a peristaltic pump.

9. A high-efficiency sterilization process for suspensions, according to the high-efficiency sterilization quantitative filling device for suspensions according to claims 1-8, characterized in that: The following steps are involved: S1. Preparation and loading of suspension: loading the pre-prepared suspension into the tank through the feed port, and fixing the tank to ensure its stability; S2. High-pressure sterilization: sterilization is performed using a high-pressure steam sterilizer, which is equipped with a temperature control system, a pressure control system and a stirring device. The temperature of the sterilizer is set to 121°C and the pressure is set to 1.2 bar during sterilization, and the stirring device is continuously operated at a speed of 300 rpm; after reaching the temperature and pressure, the sterilization process is performed for 20 minutes, and the temperature and pressure are monitored in real time by the monitoring system of the sterilizer to ensure the stability of the sterilization process; after the sterilization is completed, the pressure is slowly reduced and cooled to room temperature, and the stirring device continues to operate during the cooling process, and the stirring is stopped after the pressure drops to normal pressure, and the subpackaging operation is prepared; the sterilizer and the outside of the tank are disinfected before and after sterilization to ensure the sterility of the equipment; S3. Filling process: After sterilization is completed, start the flow controller to control the flow of the suspension, deliver the sterilized suspension to the diversion plate through the delivery tube, and quantitatively fill multiple liquid separation bottles through the diversion tube and the syringe. Keep the stirring device running during the filling process to ensure the fluidity and uniformity of the suspension.

10. A high-efficiency sterilization process for a suspension according to claim 9, characterized in that: The following steps are also included: S4. Equipment cleaning and disinfection: Before the suspension is loaded into the tank, the bottom plate, tank, delivery tube, diverter plate, diverter tube, syringe and dispensing bottle shall be thoroughly cleaned and disinfected, and sterile air drying equipment shall be used to ensure that all parts in contact with the suspension are in a sterile state; S5. Sterilization after filling: After filling, the liquid-dispensing bottle is sterilized for the second time. The outside of the liquid-dispensing bottle is sterilized by high pressure sterilization, ultraviolet sterilization or irradiation sterilization to ensure the sterility of the product. Finally, the liquid-dispensing bottle is packaged and labeled.

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