(Compound) rhodiola rosea tablet candy based on hot pulping system and preparation method of (compound) rhodiola rosea tablet candy

Abstract

According to the (compound) rhodiola rosea tablet candy based on the hot pulping system and the preparation method of the (compound) rhodiola rosea tablet candy based on the hot pulping system, the hot pulping system is used for completely separating effective medicinal components from non-medicinal components such as fiber lignin in plant medicinal and edible traditional Chinese medicinal materials through the procedures of slicing, feeding, steaming, rubbing and separating, high-concentration hot pulping and pulp-residue separation; the medicine residues which can only become solid wastes in the prior art can be completely turned into useful light industrial materials; the environment-friendly ecological effect is very prominent. Meanwhile, obtaining of very fine medicinal and edible traditional Chinese medicine extracts and further processing of functional special dietary food become very simple, and the economical efficiency is greatly improved.

Description

Technical Field

[0001] The present disclosure relates to the field of extraction of effective ingredients of functional foods, and in particular to a (compound) Rhodiola rosea tablet candy based on a hot refining system and a preparation method thereof, and belongs to the field of biomedicine. Background Art

[0002] In the 1930s, Asplund of Sunds developed the first hot refiner in the papermaking industry. Through high-speed rotating grinding discs and heat, wood or other plant fiber raw materials were refined into fibers, so that plant fibers and non-fibrous materials were effectively separated, which made a qualitative leap in mechanical papermaking technology. Entering the 20th century, the latest series of hot refiners have greatly improved the separation quality of fibers and resin glue. The hot refiner has a compact structure, strong power, simple operation and maintenance, and a wider range of applications. For example, the invented high-concentration pulping machine uses a dynamic grinding disc and a static grinding disc to form a grinding zone. The fiber raw material is continuously pushed into the grinding zone by a strong feeding device. In the grinding zone, it is subjected to the strong mechanical action of the grinding disc and the mutual friction between fibers. It is repeatedly crushed, dissociated, torn, and filamented, and finally obtains a pulp with a certain degree of freeness. The high-concentration pulping machine can use a variety of papermaking raw materials that were originally unusable, such as shrubs and branches, to produce high-quality paper.

[0003] While the current Chinese patent medicine manufacturing industry has generated huge economic and social benefits, it has also brought major problems to the ecosystem and sustainable development, mainly reflected in the waste of Chinese medicinal materials with medicinal and edible properties, such as the amount of solid waste, which accounts for more than 70% of the total solid waste of Chinese medicinal materials with medicinal and edible properties. In addition to containing a large amount of biomass such as cellulose, hemicellulose and lignin, these solid wastes of Chinese medicinal materials with medicinal and edible properties also contain a large amount of effective medicinal ingredients such as polysaccharides, polypeptides, nucleic acids, vitamins, etc. Traditional methods of handling solid waste generated during the processing of Chinese medicinal materials with medicinal and edible properties, such as landfill, composting, preparation of fermentation matrix, incineration and other extensive methods, have caused a huge waste of biomass resources.

[0004] During the reigns of Emperor Daoguang, Emperor Xianfeng and Emperor Tongzhi of the Qing Dynasty, in a small rural town on the Yangtze River in Changzhou, Jiangsu (now Xinbei District, Changzhou City), now called Menghe Town, famous doctors gathered, business flourished, experience matured, and academic thoughts gradually formed. There were more than a dozen drugstores in Menghe Town, a town with hundreds of households, which shows the prosperity of medical affairs at that time. The most representative doctors in Menghe were the four masters Fei, Ma, Chao and Ding. The four masters of Menghe made outstanding contributions to the development of traditional Chinese medicine with their profound academic attainments and rich clinical experience.

[0005] Among them, Ma Peizhi (1820-1903) was a famous doctor in the Qing Dynasty. His courtesy name was Wenzhi, and he used his courtesy name as his name. He was born in Menghe Town, Wujin, Jiangsu Province. He was a representative figure of the Menghe School of Medicine and was known as the "No. 1 Saint in Jiangnan". He was the great-grandfather of Ma Wanli, a famous modern calligraphy, painting and seal carving artist and art educator. His ancestors had been practicing medicine for generations since the Ming Dynasty, Ma Yuanpan. Peizhi followed his grandfather, the famous doctor Ma Shengsan, to learn medicine for 16 years since he was a child, and learned everything from him. Later, he learned from doctors such as Wang Jiufeng and Fei Boxiong and integrated them. His experience in treating patients for Yu Yue, a famous scholar in the late Qing Dynasty, made him famous as a doctor. He was also summoned to the palace to serve as an imperial physician to diagnose Cixi. Cixi praised him for his "fine pulse theory" and wrote a plaque with the words "Must keep the essence" by hand, and granted him a third-rank official title, making him famous all over the world. Among the four major families in Menghe, Chao Weifang and Ding Ganren, representatives of the Chao and Ding families, both studied under Ma Peizhi; Deng Xingbo, a famous doctor in the late Qing Dynasty, was also a student of Ma. Ma had profound attainments and achievements in all branches of TCM. His works include "Ma's Medical Cases", "Ma's Complete Collection of Surgical Symptoms and Treatments" (also known as "Complete Collection of Surgery"), "Medical Strategies", "Surgery Inheritance Collection", and "Surgery Collection".

[0006] Ma's academic research is extensive and sophisticated. He is familiar with classics and has also learned from various schools of thought. He is good at making changes. He is not bound by established methods when treating patients. He once said: "People's illnesses are related to life and death. It is not possible to stick to one or two books to treat diseases. When treating patients, we must study the fortune of the year, the weather, the land, the endowment, the preferences, yin and yang, the temperament, the deficiency and excess, the cold and heat, the qi, the blood, the meridians and internal organs, and the tongue and pulse for close examination, so as to be able to help." He also said: "There is no permanent disease, no permanent medicine, and we must not be bound by established methods and not be flexible." He has high attainments and excellent curative effects in all branches of traditional Chinese medicine, and he is a famous doctor in the Qing Dynasty. We adhere to his handed-down prescriptions for in-depth secondary development. Summary of the invention

[0007] In view of this, the present disclosure provides a (compound) Rhodiola rosea tablet candy based on a hot pulping system and a preparation method thereof. The present disclosure not only obtains the full extraction rate of the effective ingredients of the Chinese medicinal materials with medicinal and edible properties, but also realizes the complete separation of the fiber, lignin and other substances in the Chinese medicinal materials with medicinal and edible properties from the medicinal ingredients, and the solid waste such as the residue of the Chinese medicinal materials with medicinal and edible properties becomes a useful light industrial material that can be turned into papermaking or wood boards, etc.; the very fine Chinese medicinal materials with medicinal and edible properties extract obtained by the present disclosure can be further prepared into functional special dietary foods that can improve the ability to resist hypoxia and altitude sickness and quickly replenish physical energy.

[0008] In a first aspect of the present disclosure, the present disclosure provides a hot refining system for extracting effective ingredients from Chinese medicinal materials with medicinal and edible properties, which comprises the following steps: S101 Place Chinese medicinal materials with medicinal and edible properties such as rhodiola rosea, tortoise shell, antler, Radix Rehmanniae, ginseng, dried ginger, jujube, liquorice, Rhizoma Anemarrhenae, cypress seed, Polygala tenuifolia, Atractylodes macrocephala, and Poria cocos into a special soaking barrel, add twice the amount of water, heat to 75°C, and soak for 45 minutes to obtain a medicinal material mixture; S102 The medicinal material mixture obtained in S101 is fed into the steaming pipe through a forced feeding motor, and high-temperature steam is introduced into the steaming pipe to maintain the temperature at 105-165°C (for example: 105°C, 125°C, 145°C, 165°C); S103: starting the mechanical kneading function in the steaming pipe at a speed of 100-1500 rpm (for example, 100, 300, 500, 700, 900, 1100, 1300, 1500 rpm) to obtain mixed medicinal material fines; S104: The mixed medicinal material fine material after mechanical kneading is fed into a high-concentration pulping machine through a forced feeding motor, the motor is started, the speed is controlled at 500-1500 rpm (for example: 500, 750, 1000, 1250, 1500 rpm), and the pulping time is maintained for 30-75 minutes (profit: 30, 45, 60, 75 minutes), and a mixed medicinal material high-concentration pulp is obtained; S105: The mixed medicinal material high-concentration slurry obtained in S104 is sent to a press dewatering machine through a forced feeding motor for pulp-residue separation, and the medicinal residue is recycled. The obtained coarse high-concentration slurry is filtered twice using a plate and frame filter to obtain a fine mixed high-concentration slurry; S106 Add the finely mixed high-concentration slurry obtained in S105 to a vacuum concentration pot, slowly heat to 65-75°C (e.g. 65, 70, 75°C), start the pressure reducing valve, and continue until the slurry in the pot becomes a dry solid; S107 The dried solid obtained in S106 is added to a low-temperature freezing grinder and crushed through an 80-mesh sieve to obtain fine medicinal powder.

[0009] In a second aspect of the present disclosure, the present disclosure provides a fine medicinal powder prepared by the hot refining system of the first aspect; In some optional embodiments of the present disclosure, the fine drug powder contained in the (compound) Rhodiola rosea tablet candy contains, by weight: 12 parts of Rhodiola rosea, 3 parts of tortoise shell, 2 parts of antlers, 10 parts of Radix Rehmanniae, 12 parts of ginseng, 5 parts of dried ginger, 3 parts of jujube, 6 parts of liquorice, 5 parts of Rhizoma Anemarrhenae, 5 parts of Semen Platycladi, 5 parts of Polygala tenuifolia, 5 parts of Atractylodes macrocephala, and 5 parts of Poria.

[0010] In a third aspect of the present disclosure, the present disclosure provides a method for preparing a (compound) Rhodiola rosea tablet candy, comprising the following steps: S201 firstly grind menthol and pass it through an 80-mesh sieve to obtain menthol powder; S202: adding the donkey-hide gelatin powder, prickly pear cactus powder, xylitol, the fine powder obtained in S107, and the menthol powder obtained in S201 into a mixing barrel, stirring for 0.5 hours with a mixer, and passing through an 80-mesh sieve to obtain a mixed powder; S203: feeding the mixed drug powder obtained in S202 into a granulation, drying and granulation machine, adding about 5% of 55% ethanol, starting the machine, and finally obtaining uniform drug particles; S204 The drug granules obtained in S203 are fed into a tablet press to be tableted, and tablets meeting the requirements are compressed. After passing the quality inspection, the tablets are packaged to obtain the (compound) Rhodiola rosea tablet candies.

[0011] The (compound) Rhodiola rosea tablet candy disclosed in the present invention comprises a new pharmaceutical composition, and the composition ratio is calculated by weight: 12-15 parts of Rhodiola rosea, 3-5 parts of tortoise shell, 2-5 parts of deer antler, 10-15 parts of Rehmannia glutinosa, 12-15 parts of ginseng, 5-7 parts of dried ginger, 3-5 parts of jujube, 6-9 parts of liquorice, 5-7 parts of Anemarrhena asphodeloides, 5-7 parts of Platycladus orientalis, 5-7 parts of Polygala tenuifolia, 5-8 parts of Atractylodes macrocephala, 5-7 parts of Poria, 2-4 parts of donkey-hide gelatin powder, 4-8 parts of prickly pear cactus powder, 1-1.5 parts of menthol, and 15-25 parts of xylitol.

[0012] In an optional embodiment of the present disclosure, the new drug combination of (compound) Rhodiola rosea tablet candy is calculated by weight: 12 parts of Rhodiola rosea, 3 parts of tortoise shell, 2 parts of antlers, 10 parts of Radix Rehmanniae, 12 parts of ginseng, 5 parts of dried ginger, 3 parts of jujube, 6 parts of liquorice, 5 parts of Rhizoma Anemarrhenae, 5 parts of Platycladus Semen, 5 parts of Polygala Tenuifolia, 5 parts of Atractylodes macrocephala, 5 parts of Poria, 2 parts of donkey-hide gelatin powder, 4 parts of prickly pear cactus powder, 1 part of menthol, and 15 parts of xylitol.

[0013] The present invention utilizes a hot pulping system to extract effective ingredients from Chinese medicinal materials with medicinal and edible properties, and achieves complete separation of medicinal ingredients from non-medicinal ingredients (such as fiber and lignin) in Chinese medicinal materials with medicinal and edible properties, and the drug residues can be completely transformed into useful light industrial materials; the environmental protection and ecological effects are very prominent. It is also very simple to extract very fine liquid medicines to further process Chinese medicinal and edible preparations, and the economic efficiency is greatly improved.

[0014] The compressed candy prepared by the present disclosure has significant advantages over conventional dosage forms: .

[0015] At the same time, the present invention obtains a new drug composition, which is chemically carried out on the basis of the secret recipe of the original Menghe medical school, and for the group of people who travel long distances and plateaus, a unique functional special dietary food that can quickly replenish physical energy, relieve deep fatigue, and improve the ability to resist hypoxia and altitude sickness will be obtained. It can be seen that the preparation method disclosed in the present invention is unique and novel, and has huge technical and economic costs, as well as environmental advantages over traditional preparation processes. DETAILED DESCRIPTION Example

[0016] The present disclosure is further described in detail below with reference to the embodiments: S001 Send the Chinese medicinal materials with medicinal and edible properties such as Rhodiola rosea, tortoise shell, antler, Radix Rehmanniae, ginseng, dried ginger, jujube, liquorice, Rhizoma Anemarrhenae, cypress seed, Polygala tenuifolia, Atractylodes macrocephala, Poria cocos into the hot refining system, add 8 times the total weight of pure water to the mixed medicinal materials before refining, and finally perform pulp-residue separation to remove the residue and obtain fine medicinal pulp; S002 Add the finely mixed high-concentration slurry obtained in S001 into a vacuum concentration pot, slowly heat to 70°C, open the pressure reducing valve, and continue until the slurry in the pot becomes a dry solid; S003 Add the dry solid obtained in S002 into a low-temperature freezing mill and grind it through an 80-mesh sieve to obtain fine powder; S004 Crush menthol and pass through an 80-mesh sieve to obtain menthol powder; S005 Add donkey hide gelatin powder, prickly pear cactus powder, xylitol, the fine powder obtained in S003, and the menthol powder obtained in S004 into a mixing barrel, start a mixer to stir for 0.5 hours, and pass through an 80-mesh sieve to obtain a mixed powder; S006 Feed the mixed drug powder obtained in S005 into a granulation, drying and granulation machine, add an appropriate amount of 55% ethanol, start the machine, and finally obtain uniform drug particles; S007 The drug granules obtained in S006 are fed into a tablet press to be compressed into tablets that meet the requirements. After passing the quality inspection, the tablets are packaged to obtain the (compound) Rhodiola rosea compressed tablet candies.

[0017] The hot pulping system in this embodiment is based on the present disclosure and is composed of non-standard equipment including a forging crusher, a rotary kneading wire separator, a high-concentration hot pulping machine, a screw pulp-residue separator, etc., and is professionally used for the extraction of effective ingredients of Chinese medicinal materials with medicinal and edible homology containing plant fiber and lignin, and the separation of non-medicinal ingredients.

[0018] In this embodiment, the hot refining system described in the present disclosure includes processes such as slicing, loading, steaming, kneading and separating, high-concentration hot refining, and pulp-residue separation of plant-based Chinese medicinal materials with medicinal and edible properties, forming a set of efficient and continuous production line for extracting effective ingredients from Chinese herbal medicines.

[0019] It is to be understood that the above embodiments are merely exemplary embodiments used to illustrate the principles of the present disclosure, but the present disclosure is not limited thereto. For those of ordinary skill in the art, various modifications and improvements can be made without departing from the spirit and substance of the present disclosure, and these modifications and improvements are also considered to be within the scope of protection of the present disclosure.

Claims

1. Mixed medicinal materials such as rhodiola rosea, tortoise shell, antler, radix rehmanniae, ginseng, dried ginger, jujube, licorice, rhizoma anemarrhenae, cypress seed, polygala root, atractylodes macrocephala, and poria are sent into the hot pulping machine system for pulping through a forced feeding motor. The coarse high-concentration slurry is first obtained and then filtered by a plate and frame filter to obtain a fine mixed high-concentration slurry. The high-concentration slurry is then dried and crushed to obtain fine powder.

2. A (compound) Rhodiola rosea tablet candy and a preparation method thereof, characterized in that: It includes the following steps: S201 firstly grind menthol and sieve through 80 mesh to obtain menthol powder; S202 Add donkey hide gelatin powder, prickly pear cactus powder, xylitol, the fine powder according to claim 1, and the menthol powder obtained in S201 into a mixing barrel, start a mixer to stir for 0.5 hours, and pass through an 80-mesh sieve to obtain a mixed powder; S203: feeding the mixed drug powder obtained in S202 into a granulation, drying and granulation machine, adding about 5% of 55% ethanol, starting the machine, and finally obtaining uniform drug particles; S204 The drug granules obtained in S203 are fed into a tablet press to be tableted, and tablets meeting the requirements are compressed. After passing the quality inspection, the tablets are packaged to obtain the (compound) Rhodiola rosea tablet candies.

3. The (compound) Rhodiola rosea tablet candy according to claim 2, characterized in that: The novel pharmaceutical composition comprises the following components in parts by weight: 12-15 parts of Rhodiola rosea, 3-5 parts of tortoise shell, 2-5 parts of deer antler, 10-15 parts of Rehmannia glutinosa, 12-15 parts of ginseng, 5-7 parts of dried ginger, 3-5 parts of jujube, 6-9 parts of liquorice, 5-7 parts of Anemarrhena asphodeloides, 5-7 parts of Platycladus orientalis, 5-7 parts of Polygala tenuifolia, 5-8 parts of Atractylodes macrocephala, 5-7 parts of Poria, 2-4 parts of donkey-hide gelatin powder, 4-8 parts of prickly pear cactus powder, 1-1.5 parts of menthol, and 15-25 parts of xylitol.