Chromatographic column with high separation efficiency

Abstract

The utility model provides a chromatographic column with high separation efficiency, which comprises a chromatographic tube, and a separation flange is arranged at the lower part of a screening groove. According to the chromatographic column with the high separation efficiency, the sample injection needle can be accurately and stably inserted into the chromatographic column through guiding of the sample injection needle, deviation or shaking in the sample injection process is avoided, and therefore accurate introduction of a sample is ensured, the experiment accuracy can be kept, experiment errors caused by misoperation can be reduced, and the separation efficiency of the chromatographic column is improved. Through the insertion of the sample injection needle, an introduced sample enters the liquid inlet pipeline through the material pushing piston, the amount of the sample entering the chromatographic column can be accurately controlled through the material pushing piston, and the sample can be ensured not to leak in the sample injection process through the tight connection between the material pushing piston and the liquid inlet pipeline; the sealing performance is favorable for keeping the purity of a sample and preventing external impurities or air from entering to influence the accuracy of chromatographic analysis, thereby being favorable for improving the separation effect of the chromatographic column.

Description

Technical Field

[0001] The utility model relates to the technical field of liquid chromatography, in particular to a chromatographic column with high separation efficiency. Background Art

[0002] A chromatographic column is a device used to separate various compounds in a mixture in chemical analysis; chromatographic columns are mainly divided into two types: liquid phase and gas phase. Liquid chromatographic columns inject sample-carrying liquid into the column and use the difference in affinity of the solution to the various compound components in the sample to separate them. On the other hand, gas chromatographic columns inject sample-carrying gas into the column and use the interaction between the gas and the target compound in the column to separate them. In addition, chromatographic columns can also be divided into analytical and preparative types according to their use. Analytical chromatographic columns are mainly used for qualitative and quantitative analysis of samples, while preparative chromatographic columns are mainly used for large-scale preparation of high-purity single compounds.

[0003] However, in the prior art, deviations or shaking are prone to occur during the sample injection process, and the accurate introduction of the sample cannot be ensured. Experimental errors may occur due to improper operation, and external impurities or air may easily enter, thereby affecting the accuracy of chromatographic analysis and reducing the separation effect of the chromatographic column. At the same time, during the analysis process, the chromatographic column may overheat due to the thermal effect of the sample or other reasons. Excessive temperature may cause the material in the chromatographic column to denature or be damaged, and even affect the separation effect, while also reducing the separation efficiency. Utility Model Content

[0004] In view of the above-mentioned defects or shortcomings in the prior art, the present application aims to provide a chromatographic column with high separation efficiency, comprising a chromatographic tube, a sampling cap is provided at the upper part of the chromatographic tube, a sampling needle guide is provided inside the sampling cap, a sampling pad is provided at the lower part of the sampling needle guide, a pushing piston is provided at the lower part of the sampling pad, a liquid inlet pipe is provided at the lower part of the pushing piston, heaters are provided at the left and right ends of the liquid inlet pipe, a coolant inlet is provided at the upper part of the heater, a sieve plate is provided at the lower part of the liquid inlet pipe, a sieve trough is provided at the lower part of the sieve plate, a separation flange is provided at the lower part of the sieve trough, and a separation hole is provided inside the separation flange.

[0005] Preferably, the injection cap is installed above the chromatographic tube, the injection needle guide is installed on the inner wall of the injection cap, and the injection pad is installed below the injection needle guide.

[0006] Preferably, the pushing piston is installed below the injection pad, and the liquid inlet pipeline is connected below the pushing piston.

[0007] Preferably, the heater is symmetrically installed at both ends of the side of the liquid inlet pipe, and the coolant inlet is opened above the heater.

[0008] Preferably, the sieve plate is installed below the liquid inlet pipe, the sieve trough is opened below the sieve plate, the separation flange is installed below the sieve trough, and the separation hole is opened on the inner wall of the separation flange. Beneficial Effects

[0009] 1. The chromatographic column with high separation efficiency is installed above the chromatographic tube through an injection cap. The injection needle guide and injection pad arranged in the injection cap ensure that the injection needle can be accurately and stably inserted into the chromatographic column through the injection needle guide, avoiding deviation or shaking during the injection process, thereby ensuring the accurate introduction of the sample, which not only helps to maintain the accuracy of the experiment, but also can reduce the experimental error caused by improper operation. Through the insertion of the injection needle, the introduced sample enters the liquid inlet pipeline through the push piston, and the amount of sample entering the chromatographic column can be accurately controlled by the push piston. The tight connection between the push piston and the liquid inlet pipeline can ensure that the sample will not leak during the injection process. This sealing performance helps to maintain the purity of the sample, prevents external impurities or air from entering, thereby affecting the accuracy of chromatographic analysis, and further helps to improve the separation effect of the chromatographic column.

[0010] 2. The chromatographic column with high separation efficiency is installed with a heater. When the sample enters the chromatographic column, the temperature of the sample is increased by heating of the heater. When the temperature of the sample is increased by heating of the heater, the thermal motion of its molecules is intensified, the volatility is enhanced, and the separation effect is improved. Therefore, the separation efficiency of the chromatographic column can be significantly improved by the heater, and the separation of volatiles can be accelerated, the interference of impurities can be reduced, and the analysis results can be more accurate. In the analysis process, the chromatographic column can be prevented from being overheated due to the thermal effect of the sample or other reasons. Excessive temperature may cause the material in the chromatographic column to denature and be damaged, and even affect the separation effect. Therefore, the coolant can be introduced in time through the coolant inlet to reduce the temperature of the chromatographic column and avoid the occurrence of overheating. The coolant enters the chromatographic column through the coolant inlet, and the temperature of the chromatographic column can be adjusted to keep it within an appropriate range to optimize the separation effect. The coolant inlet helps to improve the stability of the analysis. The stable temperature environment can reduce the analysis error caused by temperature changes, and make the analysis results more accurate and reliable. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] Other features, objects and advantages of the present application will become more apparent by reading the detailed description of non-limiting embodiments made with reference to the following drawings:

[0012] Figure 1 This is a schematic diagram of the front cross-sectional structure of the utility model;

[0013] Figure 2 This is a schematic diagram of the front view structure of the utility model;

[0014] Figure 3 It is a right side structural schematic diagram of the utility model.

[0015] In the figure: 1. chromatographic tube; 2. injection cap; 3. injection needle guide; 4. injection pad; 5. push piston; 6. liquid inlet pipe; 7. heater; 8. coolant inlet; 9. sieve plate; 10. sieve trough; 11. separation flange; 12. separation hole. DETAILED DESCRIPTION

[0016] The present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It is to be understood that the specific embodiments described herein are only used to explain the relevant utility model, rather than to limit the utility model. It is also necessary to explain that, for ease of description, only the parts related to the utility model are shown in the accompanying drawings.

[0017] The accompanying drawings in the embodiments of the present invention: different types of section lines in the drawings are not marked according to national standards, nor do they impose any requirements on the materials of the components. Instead, they are used to distinguish the cross-sectional views of the components in the drawings.

[0018] See also Figure 1-3 A chromatographic column with high separation efficiency comprises a chromatographic tube 1, a sampling cap 2 is arranged on the upper part of the chromatographic tube 1, a sampling needle guide 3 is arranged inside the sampling cap 2, a sampling pad 4 is arranged at the lower part of the sampling needle guide 3, a pushing piston 5 is arranged at the lower part of the sampling pad 4, a liquid inlet pipe 6 is arranged at the lower part of the pushing piston 5, heaters 7 are arranged at the left and right ends of the liquid inlet pipe 6, a coolant inlet 8 is arranged at the upper part of the heater 7, a sieve plate 9 is arranged at the lower part of the liquid inlet pipe 6, a sieve groove 10 is arranged at the lower part of the sieve plate 9, a separation flange 11 is arranged at the lower part of the sieve groove 10, and a separation hole 12 is arranged inside the separation flange 11.

[0019] The injection cap 2 is installed above the chromatographic tube 1 , the injection needle guide 3 is installed on the inner wall of the injection cap 2 , and the injection pad 4 is installed below the injection needle guide 3 .

[0020] The pushing piston 5 is installed below the sample injection pad 4 , and the liquid inlet pipe 6 is connected below the pushing piston 5 .

[0021] The heater 7 is symmetrically installed at both ends of the side of the liquid inlet pipe 6 , and the coolant inlet 8 is opened above the heater 7 .

[0022] The sieve plate 9 is installed below the liquid inlet pipe 6 , the sieve trough 10 is opened below the sieve plate 9 , the separation flange 11 is installed below the sieve trough 10 , and the separation hole 12 is opened on the inner wall of the separation flange 11 .

[0023] When in use, the injection cap 2 is installed on the top of the chromatographic tube 1, and the injection needle guide 3 and injection pad 4 are arranged in the injection cap 2. The injection needle guide 3 ensures that the injection needle can be accurately and stably inserted into the chromatographic column to avoid deviation or shaking during the injection process, thereby ensuring the accurate introduction of the sample, which not only helps to maintain the accuracy of the experiment, but also can reduce the experimental error caused by improper operation. Through the insertion of the injection needle, the introduced sample enters the liquid inlet pipe 6 through the pushing piston 5, and the amount of sample entering the chromatographic column can be accurately controlled by the pushing piston 5. The tight connection between the pushing piston 5 and the liquid inlet pipe 6 can ensure that the sample will not leak during the injection process. This sealing performance helps to maintain the purity of the sample, prevents external impurities or air from entering, thereby affecting the accuracy of chromatographic analysis, and further helps to improve the separation effect of the chromatographic column. Through the installation of the heater 7, when the sample amount enters the chromatographic column, the heater 7 is used to control the amount of sample entering the chromatographic column. The heating increases the temperature of the sample. When the sample is heated by the heater 7, its molecular thermal motion intensifies and its volatility increases, thereby improving the separation effect. Therefore, the heater 7 can significantly improve the separation efficiency of the chromatographic column, while accelerating the separation of volatiles and reducing the interference of impurities, making the analysis result more accurate. In the analysis process, the chromatographic column is prevented from overheating due to the thermal effect of the sample or other reasons. Excessive temperature may cause the material in the chromatographic column to denature and damage, and even affect the separation effect. Therefore, the coolant can be introduced in time through the coolant inlet 8 to reduce the temperature of the chromatographic column and avoid overheating. The coolant enters the chromatographic column through the coolant inlet 8, and can adjust the temperature of the chromatographic column to keep it within an appropriate range to optimize the separation effect. The coolant inlet 8 helps to improve the stability of the analysis. The stable temperature environment can reduce the analysis error caused by temperature changes, making the analysis result more accurate and reliable.

[0024] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present application will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0025] The above description is only a preferred embodiment of the present application and an explanation of the technical principles used. Those skilled in the art should understand that the scope of the utility model involved in the present application is not limited to the technical solution formed by a specific combination of the above technical features, but should also cover other technical solutions formed by any combination of the above technical features or their equivalent features without departing from the concept of the utility model. For example, the above features are replaced with the technical features with similar functions disclosed in the present application (but not limited to) by each other to form a technical solution.

Claims

1. A chromatographic column with high separation efficiency, comprising a chromatographic tube (1), characterized in that: The chromatographic tube (1) is provided with an injection cap (2) at the top, an injection needle guide (3) is provided inside the injection cap (2), an injection pad (4) is provided at the bottom of the injection needle guide (3), a push piston (5) is provided at the bottom of the injection pad (4), a liquid inlet pipe (6) is provided at the bottom of the push piston (5), heaters (7) are provided at the left and right ends of the liquid inlet pipe (6), a coolant inlet (8) is provided at the top of the heater (7), a sieve plate (9) is provided at the bottom of the liquid inlet pipe (6), a sieve groove (10) is provided at the bottom of the sieve plate (9), a separation flange (11) is provided at the bottom of the sieve groove (10), and a separation hole (12) is provided inside the separation flange (11).

2. A chromatographic column with high separation efficiency according to claim 1, characterized in that: The injection cap (2) is installed above the chromatographic tube (1), the injection needle guide (3) is installed on the inner wall of the injection cap (2), and the injection pad (4) is installed below the injection needle guide (3).

3. A chromatographic column with high separation efficiency according to claim 1, characterized in that: The pushing piston (5) is installed below the sample injection pad (4), and the liquid inlet pipeline (6) is connected below the pushing piston (5).

4. A chromatographic column with high separation efficiency according to claim 1, characterized in that: The heater (7) is symmetrically mounted on both ends of the side of the liquid inlet pipe (6), and the coolant inlet (8) is opened above the heater (7).

5. A chromatographic column with high separation efficiency according to claim 1, characterized in that: The sieve plate (9) is installed below the liquid inlet pipe (6), the sieve trough (10) is opened below the sieve plate (9), the separation flange (11) is installed below the sieve trough (10), and the separation hole (12) is opened on the inner wall of the separation flange (11).

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