Method of using beta-hydroxy-beta-methylbutyrate to reduce the risk of infection in an elderly individual

a technology of beta-hydroxy-beta-methylbutyrate and elderly individuals, applied in the field of methods, can solve the problems of no reports on the effect of hmb in modulating type 1 and type 2 cytokine production, and no disclosure of the use of hmb to affect cytokine imbalance, so as to increase the relative levels or production of type 1

Inactive Publication Date: 2012-07-12
ABBOTT LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0016]The present invention is based upon the discovery that peripheral blood mononuclear cells (PBMC) stimulated with the T cell stimulus CD3 / CD28 and simultaneously exposed to HMB exhibit a shift in type 1 and type 2 cytokine production, favoring type 1 cytokine production. The shift occurs as HMB exposure increases the production of type 1 cytokines such as interferon-γ (IFNγ), interleukin 12 (IL-12), and interleukin 2 (IL-2), without a corresponding increase in the production of type 2 cytokines such as interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 10 (IL-10), and interleukin 13 (IL-13).

Problems solved by technology

Both are associated with an imbalance in the relative levels of type-1 and type-2 cytokines in the body.
To date, however, there have been no reports on the effect of HMB in modulating type 1 and type 2 cytokine production nor any disclosure of the use of HMB to affect cytokine imbalance in treating conditions responsive thereto, including allergies and asthma.

Method used

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  • Method of using beta-hydroxy-beta-methylbutyrate to reduce the risk of infection in an elderly individual
  • Method of using beta-hydroxy-beta-methylbutyrate to reduce the risk of infection in an elderly individual
  • Method of using beta-hydroxy-beta-methylbutyrate to reduce the risk of infection in an elderly individual

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embodiments

[0033]We now turn to the first embodiment of the present invention. Conditions included within the first embodiment of the present invention include allergy, asthma, solid tumors, cancers including advanced ovarian cancer and melanoma, kidney tumors, and stress, including psychological stress after a burn injury, surgical stress and pre-surgical stress. The methods are especially useful in treating allergy, asthma, or both.

[0034]With respect to allergy and asthma, elevated levels of IL-4, a type 2 cytokine, have been associated with the promotion or aggravation of allergy and asthma. Therefore, the first embodiment of the present invention, which is directed to a method of treating an individual having a condition comprising administering to the individual an amount of HMB effective to modulate or otherwise cause an increase in type 1 cytokine levels without a corresponding increase in type 2 cytokine levels, can treat individuals suffering from the symptoms of allergy and asthma be...

examples

[0073]The following examples illustrate specific embodiments of the methods of the present invention, including some nutritional and other product forms suitable for use therein. The examples are given solely for the purpose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention.

[0074]The nutritional compositions described below are representative examples of nutritional products suitable for use in the methods of the present invention. Each may be prepared by conventional methods of making nutritional emulsion, some examples of which are described in U.S. Patent Publication 20050215640A1, which description is incorporated herein by reference.

Liquid Nutritional #1 (Weight Gain Formula)AmtAmtIngredient(kg)Ingredient(kg)Water316Vitamin DEK premix0.04Ultratrace / trace min.0.06Carrageenan0.03premixPotassium chloride0.072Soy lecithin0.6Na citrate2.89Sodium cas...

working example i

[0075]A 28-year old individual who suffers from seasonal allergies in the spring is given 0.25-1 g of HMB (Nutritional Liquid #5) four times a week for a year. The symptoms of seasonal allergies are reduced the following spring.

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Abstract

Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.

Description

[0001]This application is a divisional of U.S. application Ser. No. 11 / 641,978 filed Dec. 19, 2006, which claims the benefit of U.S. Provisional Patent Application 60 / 752,253 filed Dec. 19, 2005, the entire disclosures of which are incorporated herein by reference.TECHNICAL FIELD[0002]The present invention relates to a method of treating individuals with β-hydroxy-β-methylbutyrate (HMB) to modulate cytokine production.BACKGROUND OF THE INVENTION[0003]Allergies and asthma in the industrialized world have increased in prevalence and severity over recent years. Asthma is now, in fact, the most common chronic illness among children.[0004]Much is known about the pathogenesis of allergies and asthma. Both are immune-based diseases. Both are associated with an imbalance in the relative levels of type-1 and type-2 cytokines in the body. It has been observed that individuals with allergies or asthma have a higher relative ratio of type 2 to type1 cytokines. It is believed that this skewed ra...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/19A61P25/00A61P11/00A61P31/00A23L29/206A23L33/00A23L33/15
CPCA61K31/19Y10S514/826A23L1/30A23L1/296Y10S514/885A23L33/40A23L33/10A61P11/00A61P11/06A61P17/00A61P25/00A61P3/02A61P31/00A61P35/00A61P37/00A61P37/02A61P37/08A61P43/00
Inventor THOMAS, DEBRA L.MUKERJI, PRADIP
Owner ABBOTT LAB INC
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