46 results about "Beta hydroxy beta methylbutyrate" patented technology

A method of administering beta-hydroxy-beta-methylbutyric acid (HMB) is described, and specifically administering HMB-acid to a person such that the administration of free acid HMB results in an increase in effectiveness of HMB over administration of other forms of HMB, including a calcium salt HMB composition is described. Administration of HMB-acid results in an increase in the peak level of HMB in plasma compared with administration of a similar dose of a calcium salt HMB composition. Administration of HMB-acid results in a faster time to reach peak plasma levels of HMB relative to administration of a similar dosage of a calcium salt HMB composition.

The present invention relates to the compositions that enhance post-exercise recovery processes to increase both strength and muscle mass, replace glycogen stores, and prevent inflammation, resulting in the prevention and / or reduction of delayed onset muscle soreness. Additionally, it provides a feeling of muscle relaxation as well as a feeling of mental tranquility immediately following exercise. The composition consists of any or all high-glycemic sugars and / or polysaccharides (e.g., sucrose, glucose, maltodextrin), all essential amino acids and beta-hydroxy-beta-methylbutyrate and can include other amino acids sources (e.g. whey protein), performance enhancing agents (e.g., caffeine, L-glutamate), anti-inflammatory agents (e.g., ginger, boswellia, curcumen), antioxidants (vitamin C, vitamin E, selenium, polyphenols,), insulin-mimicking agents (cinnamon, Banaba), analgesics (e.g. aspirin, ibuprofen, naproxen, acetaminophen), and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.

Disdosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, induding an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disdosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.

The invention provides a preparation method of a feed additive calcium beta-hydroxy-beta-methylbutyrate. The preparation method comprises the following steps: 1) performing reaction on glacial acetic acid, sulfuric acid and H2O2 and performing reduced-pressure distillation after the reaction to obtain a peracetic acid solution; 2) mixing the product obtained in the step 1) and diacetone alcohol, adding methyl acetate serving as a solvent, reacting, and distilling and collecting 70-DEG C fraction after the reaction, wherein the residuum after distillation is a beta-hydroxy-beta methylbutyric acid solution; 3) adding water into the distillation residuum obtained in the step 2), adding a sodium hydroxide solution, adjusting the pH value to be 6.0 to 7.0, separating out calcium beta-hydroxy-beta-methylbutyrate, filtering and drying to obtain the product. The preparation process of the calcium beta-hydroxy-beta-methylbutyrate is simple and avoids environmental pollution. The prepared product has high quality, is stable and reliable, and is convenient to popularize.

The present invention provides a full-nutrient food formula containing short peptides for populations with muscle attenuation syndromes. The formula food with a special medical use is prepared from the food-derived short peptides as a main raw material, contains concentrate extracts of traditional medibly and edibly homogenous Chinese herbal medicines of coix seeds, semen ziziphi spinosae, mulberries, apricot kernels, white hyacinth beans, licorice, etc., and then combines calcium beta-hydroxy-beta-methylbutyrate, creatine, oligosaccharides, various vitamins and minerals to form the compound formula. The formula can be used to prepare powdery or granular or liquid food. The food prepared according to the formula can provide high-quality proteins, vitamins and minerals required for the populations with the muscle attenuation syndromes in time, does not increase liver and kidney burdens, and at the same time, can significantly increase muscle strength and LBM, increase protein synthesis,prevent muscle loss and atrophy, inhibit muscle protein degradation, and protect muscle tissues. The provided formula food containing the short peptides with the special medical use is suitable for the populations with the muscle attenuation syndromes.

A nutritional composition comprises fat, protein and carbohydrate such that the fat provides from about 60 to about 90% of the total calories of the composition, the protein provides from about 10 to about 30% of the total calories of the composition, and the carbohydrate provides from about 0.1 to about 15% of the total calories of the composition, and the composition comprises from about 0.01 to about 10 wt % beta-hydroxy-beta-methylbutyrate (HMB). A method of achieving or sustaining metabolic ketosis in an individual comprises administering the nutritional composition to the individual. A method of maintaining lean body mass and muscle strength in an individual during dietary ketosis comprises administering the nutritional composition to the individual.

The invention provides a composition for meeting requirement for controlling body weight through sports, and a preparation method of the composition. The formula of the composition consists of the following components in parts by weight: 10-48 parts of protein powder, 1-21 parts of mixed fat powder, 6-39 parts of saccharide, 0.05-1 part of a potato extract, 0.05-3 parts of creatine, 0.05-3 parts of glutamine, 0.06-3 parts of calcium beta-hydroxy-beta-methylbutyrate, 0.01-2 parts of L-carnitine, 0.05-1 part of taurine, 0.01-3 parts of a vitamin premix, 0.5-4 parts of a mineral and trace elementpremix and 0.01-3 parts of a food additive. The composition is obtained in a mixing manner. The composition can provide high-quality protein, promote growth of muscle, strengthen the force of the muscle and enable athletes to scientifically and reasonably reduce body weight.

Disclosed are nutritional compositions comprising a peroxide-treated aseptic package and a nutritional liquid contained therein, wherein the nutritional liquid comprises beta-hydroxy-beta-methylbutyrate (HMB) and at least one of fat, carbohydrate, and protein. The HMB provides a buffering effect in the nutritional liquid to thus minimize an acidic pH shift that is prevalent in aseptically sterilized packages, and thus helps maintain product stability over time.

Disclosed are methods for enhancing neural function in an individual, such as an older adult. The methods include administering nutritional compositions comprising HMB to the individual. The nutritional compositions provide benefits for individuals that have or may be at risk of having cognitive decline, cognitive impairment, and neural dysfunction, typically resulting from cognitive diseases associated with neurodegenerative diseases.

Disclosed are nutritional compositions comprising a plastic package and a nutritional liquid contained therein, wherein the nutritional liquid comprises beta-hydroxy-beta-methylbutyrate (HMB) and at least one of fat, protein, and carbohydrate. It has been found that HMB provides a buffering effect in the nutritional liquid to thus minimize an acidic pH shift that is more prevalent in plastic packages, and thus help maintain product stability over time.

The invention relates to a feed additive for improving the growth performance of intrauterine growth retardation piglets, and an application thereof, and belongs to the field of feeds. The feed additive comprises, by weight, 15-30 parts of N-carbamoylglutamic acid, 15-30 parts of soybean lecithin, 5-15 parts of leucine, 5-15 parts of tributyrin, 5-15 parts of calcium beta-hydroxy-beta-methylbutyrate, 5-15 parts of a complex enzyme-microecological preparation, 5-15 parts of vitamin E, 2-8 parts of folic acid and 2-8 parts of choline, and the complex enzyme-microecological preparation includes a complex enzyme preparation and a microbial agent. The feed additive can promote the growth of animals, and especially can improve the growth performance of the intrauterine growth retardation piglets; and the feed additive can be applied to the feeds in order to regulate the body immunity level of the intrauterine growth retardation piglets improve the muscle growth, enhance the functions of internal organs and promote the healthy growth of the gastrointestinal tract.

The invention provides a formula of short-peptide foods for special dietary uses for crowds lying in a bed for a long term and crowds having sarcopenia to eat. According to the foods, food-derived short peptides are used as main raw materials, conventional medicinal and edible dual-purpose Chinese herbal medicine concentration extracts of coix seeds, spina date seeds, mulberries, apricot kernels,white hyacinth beans, licorice roots and the like are added, then calcium beta-hydroxy-beta-methylbutyrate (HMB), creatine, oligosaccharide, multivitamins and minerals are used for assistance, and a composite formula is formed. Through adoption of the food formula, powdery foods, or granular foods or liquid foods can be made. The food made by the formula disclosed by the invention not only can timely complement high-quality protein, vitamins and minerals, which are needed by middle-aged and old people, the crowds lying in a bed for a long term, and the crowds having sarcopenia, and the burdenof the liver and the kidney is not increased; and besides, the muscle strength and the LBM can be notably improved, protein synthesis can be promoted, running off of the muscle can be avoided, amyotrophy is avoided, the degradation of muscle protein is restrained, and the muscular tissue is protected. The short-peptide foods for special dietary uses, provided by the invention, are suitable for themiddle-aged and old people, the crowds lying in a bed for a long term, and the crowds having sarcopenia to eat.

The invention discloses a solid beverage for treating diabetes and a prerparation method thereof. The solid beverage comprises germinant brown rice flour, small molecular peptide, cyclocarya paliurusextract, phylloporia ribis fermented mycelium, corn stigma extract, mulberry leaf extract, tartary buckwheat extract, lecithin, poria cocos extract, ampelopsis grossedentata leaf powder, calcium beta-hydroxy-beta-methylbutyrate, L-carnitine, magnesium oxide, vitamin C, taurine, zinc gluconate, niacin, vitamin E, pantothenic acid, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin A, folic acid, vitamin D3, and additives. The beverage has the effect of inhibiting the rise of blood sugar, can help diabetic patients get rid of the problem of insulin injection, can gradually replace insulin,and help the patient get rid of dependence on the insulin and western medicines, thereby avoiding the side effects of the insulin.

Disclosed are nutritional emulsions comprising fat, protein, and carbohydrate, including from about 0.01% to about 5% by weight of an oil having hydrophobic off-notes that is process-encapsulated by an emulsifying agent having a melt point above about 25 C, and maltodextrin having a DE of about 10 or less, wherein the weight ratio of the emulsifying agent to the process-encapsulated oil is at least about 1:15 and the weight ratio of the maltodextrin to the process-encapsulated oil is at least about 1:2. The nutritional emulsions effectively mask off-notes commonly associated with certain oils, e.g., polyunsaturated fatty acids, soy oil, beta-hydroxy-beta-methylbutyrate oils.

The invention relates to an all-nutrition solid beverage for tumor patients and a preparation method thereof. The solid beverage is prepared from raw materials comprising the following components in percentage by weight: 9.5-20% of plant fat powder, 19-30% of maltodextrin, 9-12.5% of collagen peptide powder, 9-12.5% of soybean peptide powder, 2-4.5% of calcium beta-hydroxy-beta-methylbutyrate, 7-13% of concentrated whey protein powder, 7-13% of soybean isolate protein powder, 5-7.2% of water-soluble dietary fibers, 2-5% of medium chain triglyceride, 0.8-2% of multivitamins, 2-5% of compound minerals, 0.1-0.5% of taurine, and 0.4-1.2% of edible yeast powder. The solid beverage is comprehensive in nutrition, and can effectively improve the symptoms of body wasting, malnutrition, limb weakness and the like of the tumor patients.

The invention provides a whole nutrient formula food for tumors. The whole nutrient formula food is prepared from calcium beta-hydroxy-beta-methylbutyrate, a broccoli seed extract, carbohydrate, protein, fat microcapsule powder, dietary fibers, a mineral compound, a vitamin compound, immunity nutrients and appropriate auxiliary materials. The energy density of the whole nutrient formula food is greater than 1.2kcal / mL, and the whole nutrient formula food can provide comprehensive reasonable nutrient support for patients during perioperative periods, radiotherapy or chemotherapy periods and advanced-stage palliative treatment, synergistically exert effects in the respects of enhancing immunity, controlling inflammation disease development and adjusting and controlling tumor development, caneffectively protect the barriering functions of the gastrointestinal tract mucosa of tumor patients during the period of receiving treatment, and can relieve side effects during treatment course.

Disclosed are shelf stable nutritional products including beta-hydroxy-beta-methylbutyrate (HMB) and an oxidatively active species such as iron or copper. The HMB restricts the capacity of the oxidative species to catalyze the oxidation of nutrients such as fatty acids and vitamins thereby imparting both nutritional benefits and sensory benefits to the nutritional products.

The present invention provides a composition comprising HMB and methods of using HMB to mitigate loss of lean body mass, increase fat free mass, improve muscular performance, increase body fat loss and decrease body fat percentage in individuals undergoing intermittent fasting.

The invention provides energy gum for recovering physical fitness after movement and a preparation method of the energy gum. The functional components of the energy gum consist of pure water, cane sugar, levulose, maltodextrin, L-leucine, L-isoleucine, L-valine, whey protein hydrolysates, separated whey protein, micellar casein, a red jujube extract, calcium beta-hydroxy-beta-methylbutyrate, concentrated apple juice, composite vitamins and composite electrolyte. The capacity of organisms for resisting oxygen deficit and quickly decomposing lactic acids can be effectively strengthened, the weariness time is shortened, the recovery of physical fitness can be accelerated, and finally the movement capacity is improved.

The invention discloses a method for preparing and purifying calcium beta-hydroxy-beta-methylbutyrate. The method comprises the following steps: performing haloform reaction by taking sodium hypochlorite as a reaction raw material and diacetone alcohol as a solvent, then performing acidification and ethyl acetate extraction, salifying beta-hydroxy-beta-methyl butyric acid in an ethyl acetate extract and calcium hydroxide and purifying through a cryogenic kettle and a plate and frame filter press to prepare the calcium beta-hydroxy-beta-methylbutyrate. The method disclosed by the invention hasthe advantages of being simple in production process, safe, non-toxic, cheap, convenient to recover and high in crystal purity and yield; meanwhile, a large number of impurities are removed through plate and frame separation, so that the product content is improved, the efficacy is improved, and the labor cost is reduced.

Disclosed is the combination of beta-hydroxy-beta-methylbutryate, arginine, and glutamine for use in a method of treating a diabetic ulcer in a diabetic individual having at least one of: (a) a serum albumin level of less than or equal to 4.0 g / dL, and / or (b) an Ankle-Brachial Index of less than 1.0. 9. Also disclosed is the use of the combination of beta-hydroxy-beta-methylbutryate, arginine, and glutamine for the manufacture of a medicament for use in the treatment of a diabetic ulcer in a diabetic individual having at least one of: (a) a serum albumin level of less than or equal to 4.0 g / dL, and / or (b) an Ankle-Brachial Index of less than 1.0. In certain embodiments, the combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine are orally administered via a nutritional composition.

The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to modulate autophagy and lipophagy. HMB is also administered to treat, prevent, inhibit, slow or reduce autophagy-mediated conditions or diseases.

Liquids, substantially clear liquids and foodstuffs are described that contain free acid HMB. The liquids, substantially clear liquids and foodstuffs are substantially free of crude fat and may contain soluble proteins, carbohydrates, vitamins, minerals, amino acids, flavorings and other components. The products are shelf-stable and are substantially free of separation, gelation, sedimentation and coagulation.

The invention discloses nutritive formula goat milk powder capable of strengthening constitutions and improving sleep. The nutritive formula goat milk powder consists of the following components in parts by weight of 80-100 parts of goat milk powder, 0.05-0.2 part of casein phosphopeptides, 0.01-0.05 part of taurine, 0.5-3 parts of euphausia superba oil powder, 0.1-1 part of calcium beta-hydroxy-beta-methylbutyrate, 1-5 parts of calcium-ferrum-zinc-magnesium composite minerals, 0.01-0.1 part of composite vitamins and 0.5-5 parts of plant extracts. The nutritive formula goat milk powder not only can complement nutrient substances of protein, fat, vitamins, minerals and the like which are necessary daily, but also can strengthen the constitutions, improve sleep quality and prevent four-high symptoms of high blood pressure, high blood lipid, high blood sugar and high uric acid.

Disclosed are nutritional compositions, and methods of using and making the nutritional compositions, that include calcium beta-hydroxy-beta-methylbutyrate and protein. The calcium beta-hydroxy-beta-methylbutyrate is in sequestered or ion-exchanged form to reduce the interaction of the calcium with the protein in the nutritional composition and improve the overall stability of the nutritional composition.