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Preparation method of feed additive calcium beta-hydroxy-beta-methylbutyrate

A technology of calcium methylbutyrate and feed additives, which is applied in the preparation of carboxylate, carboxylate, and organic compounds, etc. It can solve the problem of decreased feed intake, digestive disorders, and drug resistance of original microorganisms in piglets, etc. problem, to achieve the effect of stable and reliable product quality, simple preparation process and easy promotion

Active Publication Date: 2014-04-02
CHANGSHA POWERLIFE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Early weaning of piglets is an important measure to improve reproductive efficiency and production level in modern farming, but early weaning can easily lead to reduced feed intake, malnutrition, decreased immunity, growth stagnation, digestive disorders and diarrhea, and even Dead pigs, serious consequences such as increased morbidity and mortality
Adding antibiotics to feed can effectively improve the growth performance of piglets and control the occurrence of diseases, but the abuse of antibiotics can easily lead to the development of drug resistance of the original microorganisms, the decline of the animal's own immunity, and the drug residues are harmful to human health

Method used

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  • Preparation method of feed additive calcium beta-hydroxy-beta-methylbutyrate
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  • Preparation method of feed additive calcium beta-hydroxy-beta-methylbutyrate

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Embodiment 1

[0016] The preparation method of the feed additive β-hydroxyl-β-methylbutyrate calcium of the present embodiment may further comprise the steps:

[0017] 1) Preparation of peracetic acid: 100ml of glacial acetic acid, 10ml of 10% sulfuric acid solution, 300ml of 30%H 2 o 2 Add it into the reaction vessel, control the reaction temperature at 45°C, and react for 10 minutes. After the reaction, it will be distilled under reduced pressure, and the fraction at 60°C will be collected to obtain 125ml of peracetic acid aqueous solution;

[0018] 2) Preparation of β-hydroxy-β-methylbutyric acid: In a reaction vessel, mix 125ml of peracetic acid aqueous solution obtained in step 1) with 62.5ml of diacetone alcohol, add 100ml of methyl acetate as a solvent, and control the temperature at 30 ℃ reaction, after reacting for 1 hour, the mixture was transferred to a distillation device, and the fraction at 70 ℃ was collected by distillation to obtain methyl acetate, and the residue after dis...

Embodiment 2

[0021] The preparation method of the feed additive β-hydroxyl-β-methylbutyrate calcium of the present embodiment may further comprise the steps:

[0022] 1) Preparation of peracetic acid: mix 200ml glacial acetic acid, 20ml 10% sulfuric acid solution, 650ml 30%H 2 o 2 Add it into the reaction vessel, control the reaction temperature at 50°C, and react for 15 minutes. After the reaction, it will be distilled under reduced pressure, and the fraction at 60°C will be collected to obtain 252.5ml of peracetic acid aqueous solution;

[0023] 2) Preparation of β-hydroxy-β-methylbutyric acid: In a reaction vessel, mix 252.5ml of peracetic acid aqueous solution obtained in step 1) with 125ml of diacetone alcohol, add 200ml of methyl acetate as a solvent, and control the temperature at 35 ℃ reaction, after 1.2 hours of reaction, the mixture was transferred to a distillation device, and the fraction at 70 ℃ was collected by distillation to obtain methyl acetate, and the residue after dis...

Embodiment 3

[0026] The preparation method of the feed additive β-hydroxyl-β-methylbutyrate calcium of the present embodiment may further comprise the steps:

[0027] 1) Preparation of peracetic acid: mix 150ml glacial acetic acid, 15ml 10% sulfuric acid solution, 500ml 30%H 2 o 2 Add it into the reaction vessel, control the reaction temperature at 55°C, and react for 20 minutes. After the reaction, it will be distilled under reduced pressure, and the fraction at 60°C will be collected to obtain 187ml of peracetic acid aqueous solution;

[0028] 2) Preparation of β-hydroxy-β-methylbutyric acid: In a reaction vessel, mix 187ml of peracetic acid aqueous solution obtained in step 1) with 75ml of diacetone alcohol, add 150ml of methyl acetate as a solvent, and control the temperature at 37°C Reaction, after reacting for 1.5 hours, the mixture was transferred to a distillation device, and the fraction at 70°C was collected by distillation to obtain methyl acetate, and the residue after distill...

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Abstract

The invention provides a preparation method of a feed additive calcium beta-hydroxy-beta-methylbutyrate. The preparation method comprises the following steps: 1) performing reaction on glacial acetic acid, sulfuric acid and H2O2 and performing reduced-pressure distillation after the reaction to obtain a peracetic acid solution; 2) mixing the product obtained in the step 1) and diacetone alcohol, adding methyl acetate serving as a solvent, reacting, and distilling and collecting 70-DEG C fraction after the reaction, wherein the residuum after distillation is a beta-hydroxy-beta methylbutyric acid solution; 3) adding water into the distillation residuum obtained in the step 2), adding a sodium hydroxide solution, adjusting the pH value to be 6.0 to 7.0, separating out calcium beta-hydroxy-beta-methylbutyrate, filtering and drying to obtain the product. The preparation process of the calcium beta-hydroxy-beta-methylbutyrate is simple and avoids environmental pollution. The prepared product has high quality, is stable and reliable, and is convenient to popularize.

Description

technical field [0001] The invention relates to a preparation method of a feed additive capable of improving the immunity of livestock and poultry, in particular to a preparation method of β-hydroxy-β-methylbutyrate calcium. Background technique [0002] Early weaning of piglets is an important measure to improve reproductive efficiency and production level in modern farming, but early weaning can easily lead to reduced feed intake, malnutrition, decreased immunity, growth stagnation, digestive disorders and diarrhea, and even Dead pigs, serious consequences such as increased morbidity and mortality. Adding antibiotics to feed can effectively improve the growth performance of piglets and control the occurrence of diseases, but the abuse of antibiotics can easily lead to the resistance of the original microorganisms, the decline of the animal's own immunity, and the drug residues are harmful to human health. For example, the core hazard of mycotoxins, especially aflatoxins, ...

Claims

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Application Information

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IPC IPC(8): C07C59/01C07C51/41
CPCC07C51/00C07C51/412C07C407/00C07C59/01C07C409/38
Inventor 周应培刘继根杨德军
Owner CHANGSHA POWERLIFE BIOTECH
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