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Improved method of administering beta-hydroxy-beta-methylbutyrate (hmb)

A methylbutyric acid, drug delivery technology, applied in botany equipment and methods, drug combination, active ingredients of anhydride/acid/halide, etc., can solve problems such as uneliminated AKT phosphorylation

Active Publication Date: 2012-10-31
TSI PHARMA (JIANGYIN) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As expected, incubation of HMB with rapamycin (mTORc1 inhibitor) abolished the increase in mTORc1 signaling but not AKT phosphorylation (+188%)

Method used

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  • Improved method of administering beta-hydroxy-beta-methylbutyrate (hmb)
  • Improved method of administering beta-hydroxy-beta-methylbutyrate (hmb)
  • Improved method of administering beta-hydroxy-beta-methylbutyrate (hmb)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: Comparing the Absorption of HMB-Acid Gels and CaHMB in Capsule Form

[0050] Materials and methods

[0051] human subjects

[0052] In Study 1, four male and four female college-age subjects were studied. In Study 2, four additional male and four female college-age subjects were studied. The protocols for both studies were approved by the Iowa State University (Iowa State University) IRB, and each subject gave informed consent to participate in the study. Due to the nature of the treatments described, neither subjects nor investigators were blinded.

[0053] treat

[0054] Subjects in both study groups received the same treatment. The three treatments were administered to each subject in random order with at least one week washout period between treatments. The treatments were supplied by Metabolic Technologies, Inc. (MTI, Ames, IA) and were prepared with food grade ingredients. Subjects were administered 1 gram of CaHMB or an equivalent amount of ...

Embodiment 2

[0093] In this example, the effects of administration of HMB-acid gel and administration of HMB calcium on muscle damage after eccentric exercise were compared. As shown in Example 1, peak plasma HMB levels and HMB clearance were increased with HMB free acid gel compared to CaHMB (13). This example demonstrates that the faster response of HMB administered as a free acid gel before or after extreme exercise protects muscles from injury better than HMB administered as HMB calcium salt.

[0094] Effects of HMB and exercise on markers of muscle damage and inflammatory factors:

[0095] Intense exercise such as resistance training or maximal effort exercise results in increased leakage of the enzyme creatine phosphokinase (CPK) from muscle cells (21; 31). Human studies have demonstrated that HMB calcium supplementation reduces muscle damage after intense exercise as measured by elevated plasma CPK (14; 22; 26; 33). A study of muscle damage after a long 20 km run in a college stud...

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Abstract

A method of administering beta-hydroxy-beta-methylbutyric acid (HMB) is described, and specifically administering HMB-acid to a person such that the administration of free acid HMB results in an increase in effectiveness of HMB over administration of free acid HMB results in an increase in effectiveness of HMB over administration of other forms of HMB, including a calcium salt HMB composition is described. Administration of HMB-acid results in an increase in the peak level of HMB in plasma compared with administration of a similar dose of a calcium salt HMB composition. Administration of HMB-acid results in a faster time to reach peak plasma levels of HMB relative to administration of a similar dosage of a calcium salt HMB composition.

Description

[0001] This application claims priority to US Patent Application Serial No. 61 / 287,857, filed December 18, 2009, which is incorporated herein by reference in its entirety. field of invention [0002] The present invention relates generally to more efficient and effective delivery systems for β-hydroxy-β-methylbutyrate (HMB), and more particularly to the administration of HMB free acid, which results in similar doses of HMB as administered The calcium salt (CaHMB) form is a more efficient and effective form of HMB administration. Background of the invention [0003] HMB has been found to be useful in a variety of application settings. Specifically, in US Pat. No. 5,360,613 (Nissen), HMB is described as useful for lowering blood levels of total cholesterol and low-density lipoprotein cholesterol. In US Patent 5,348,979 (Nissen et al.), HMB is described as being useful for promoting nitrogen retention in humans. US Patent 5,028,440 (Nissen) discusses the usefulness of HMB to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/00A61K31/19
CPCA61K31/19A61P3/00A61P3/02A61P3/04A61P3/06A61P21/00A61P25/00A61P25/18A61P25/22A61P37/00A61P37/02
Inventor J·拉特马克J·富勒S·拜尔S·尼森N·阿布莱德
Owner TSI PHARMA (JIANGYIN) CO LTD
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