30 results about "Muscle damage" patented technology

The present invention provides a polypeptide and a use thereof for promoting muscle hyperplasia and improving athletic performance, since the polypeptide provided by the present invention has activity for regulating the performance of proteins such as p-AMPK, AKT, mTOR and the like in a muscle hyperplasia pathway, by administering an effective amount of the polypeptide provided by the present invention or a composition containing the polypeptide to an individual, the activity of the polypeptide is improved, and the activity of the polypeptide is improved. The muscle hyperplasia and the muscle strength of the individual can be promoted, so that the effects of preventing or treating diseases related to muscle damage and improving the exercise performance can be achieved.

The present invention relates to novel use of a cathepsin L inhibitor Z-Phe-Tyr-CHO (C26H26N2O5), wherein the cathepsin L inhibitor Z-Phe-Tyr-CHO inhibits cancer progression and cachexia and muscle damage that are caused by cancer, and thus can be effectively used for preventing, ameliorating or treating cachexia and muscle loss, while having anticancer activity.

Treatments of neuromuscular conditions, activity-induced muscle damage, metabolic myopathies, and movement disorders with compositions comprising 2-((5-fluoropyridin-3-yl)methyl)-6-(2-(2,2,2-trifluoroethoxy)pyrimidin-5-yl)pyridazin-3(2H)-one (Compound 1), as well as solid forms of Compound 1, and pharmaceutical compositions of Compound 1, and kits of Compound 1, are described herein.

1. Name of the product in this design: Walking Assistive Rehabilitation Device. 2. Purpose of this design: It is used in a walking rehabilitation device, which is a wearable functional neurostimulation instrument used for lower limb rehabilitation and recovery of muscles damaged by motor neurons. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1. 5. Other circumstances requiring explanation: The human lower limb model is a supporting element and is not part of the content for which protection is sought.

The present application relates to the technical field of waist posture recognition, in particular to a human waist posture recognition and force state evaluation method and system based on an inertial sensor, comprising the following steps: collecting original motion data in real time through an inertial measurement unit worn on the L4-L5 segment of the human waist, wherein the original motion data comprises three-axis acceleration data and three-axis angular velocity data; using a Kalman filtering algorithm to filter noise and calibrate the coordinate system of the original motion data, to obtain standard waist motion characteristic data. The present application realizes accurate and continuous recognition of the waist posture in daily scenarios, completes quantitative evaluation of the force on the lumbar vertebrae and prediction of the damage risk, has high detection accuracy and strong scene adaptability, and is portable and easy to use, which can provide a comprehensive basis for the user to manage the health of the waist and effectively prevent lumbar muscle damage.

The application discloses a planning navigation system for lower limb fracture reduction surgery. The system comprises a medical image processing module for segmenting a proximal bone and a distal bone from a lower limb fracture image and reconstructing a three-dimensional surface model of a broken bone; a surgery planning module for point cloud sampling on the three-dimensional surface model of the broken bone to obtain a corresponding point cloud model; extracting a fracture section from the point cloud model; obtaining a coordinate transformation matrix of an initial position of the distal bone and a target position of the distal bone after reduction by point cloud registration on the fracture section; performing fracture reduction path planning based on the coordinate transformation matrix, the fracture reduction path planning being used for guiding translation and rotation of the distal bone to obtain the target position of the distal bone under the condition that the proximal bone is fixed; and a navigation module for visually displaying a surgery process based on the fracture reduction path planning. The application can improve reduction accuracy, reduce reduction force and reduce soft tissue damage such as muscle damage at a fracture of a patient.

The invention discloses a lactobacillus rhamnosus CQFP202457 and application of the lactobacillus rhamnosus CQFP202457 and ellagic acid in relieving exercise fatigue, and belongs to the technical field of microorganisms. The preservation number of the lactobacillus rhamnosus CQFP202457 is CGMCC (China General Microbiological Culture Collection Center) No. 29784. The composition provided by the invention contains ellagic acid and lactobacillus rhamnosus CQFP202457, and can significantly prolong the exercise exhaustion time, reduce the content of fatigue-related metabolites in serum, improve the total antioxidant ability of serum, liver and skeletal muscle and the antioxidant enzyme gene expression level, and improve the exercise-induced liver and skeletal muscle tissue damage. The strain and the composition thereof provided by the invention can be used as exercise synbiotics for preparing products for relieving exercise-induced fatigue, improving exercise performance, reducing exercise-induced oxidative stress or relieving exercise-induced muscle injury.

The invention discloses a medicine for treating arthritis, rheumatic bone pain and acute muscle injury and a preparation method thereof. The medicine is prepared from the following components in parts by weight: 5-10 parts of agilawood, 1-10 parts of resina liquidamberis, 1-8 parts of pseudo-ginseng, 1-8 parts of garden balsam stem, 5-15 parts of fructus cnidii, 5-10 parts of cicada slough, 10-20 parts of frankincense, 10-20 parts of mentholum and 5-15 parts of resina draconis. The traditional Chinese medicinal materials adopted in the prescription do not cause drug resistance and have no side effect.

The present application relates to a kind of cervical vertebra intelligent rehabilitation appliance based on electromyogram-pressure feedback, comprising: support structure unit, electromyogram signal acquisition unit, pressure signal acquisition unit, pneumatic traction unit and control unit;Support structure unit includes mandibular support, back neck support, inner lining and adjustable fixing band, mandibular support is connected with back neck support, inner lining is set to the inner side of mandibular support and back neck support, one end of adjustable fixing band is connected with back neck support;Electromyogram signal acquisition unit is set to the inner lining of back neck support inner side and the site of user neck contact, for gathering the electromyogram signal of the neck of wearer;Pressure signal acquisition unit is used to gather the pressure distribution signal in the process of wearing;Pneumatic traction unit is used to apply adjustable traction to user neck;Control unit is connected with electromyogram signal acquisition unit, pressure signal acquisition unit, pneumatic traction unit respectively.The present application realizes personalized, adaptive intelligent rehabilitation, and can effectively avoid excessive traction and muscle damage.

The invention belongs to the field of food, and particularly relates to two sea cucumber peptides with activity of enhancing exercise ability as well as a preparation method and application of the sea cucumber peptides. Meanwhile, the sea cucumber peptide sequences with the exercise enhancing ability are obtained through screening by adopting peptidomics analysis and molecular docking methods, and comprise FPGGY and PGSPF. Experiments prove that the two sea cucumber peptides can be used for regulating energy metabolism (improving hepatic glycogen, muscle glycogen and ATP (adenosine triphosphate) reserve and maintaining serum glucose level), relieving muscle injury (reducing serum creatine kinase, lactic acid and uric acid content), enhancing antioxidant ability (improving SOD (superoxide dismutase) activity) and promoting skeletal muscle development (improving flatfish muscle and tibia anterior muscle visceral coefficient); the exhaustive swimming time of mice suffering from exercise fatigue is obviously prolonged, the exercise tolerance is effectively enhanced, and the exercise fatigue is relieved. The invention provides a basis for development of sea cucumber resources in the field of sports nutrition, and has important social and economic values.

A novel protein biomarker for determining the severity of muscle injury, and an obtaining method therefor and a use thereof. The novel protein biomarker comprises at least one of thirty-six proteins. The obtaining method for the novel protein biomarker specifically comprises: establishing experimental rat models with different severities of muscle injury; collecting the plasma of rats in different groups for proteomic detection and performing differential comparison to obtain candidate protein biomarkers; and using the blood of clinical patients with different severities of muscle injury to validate the candidate protein biomarkers and determining diagnostic reference ranges of the candidate protein biomarkers. The use of the proteomic biomarker is: using the novel protein biomarker to make a kit or using the novel protein biomarker for detection to determine the severity of muscle injury by means of mass spectrometry or any other methods. A new basis is provided for the determination of the severity of muscle injury, facilitating quantification of the severity of muscle injury.

This invention discloses the application of ZAK inhibitors in the preparation of drugs for treating EV71 virus infection, relating to the biomedical field. The ZAK inhibitors exert their effects by inhibiting the ZAK-p38 MAPK signaling pathway and by inhibiting the ZAKα-mediated ribosomal toxicity stress response (RSR). The ZAK inhibitor is nilotinib or a pharmaceutically acceptable salt thereof. Cellular and animal experiments of this invention demonstrate that EV71 infection activates the ZAKα-mediated p38 MAPK pathway (RSR), promoting viral replication and leading to multi-organ damage. ZAK inhibitors (such as nilotinib) can inhibit this pathway, reduce the expression of the viral protein VP1, and improve infection-induced renal function damage, metabolic disorders, and muscle damage. Therefore, ZAK inhibitors can be used to prepare anti-EV71 drugs.

A lateral retractor system for forming a pathway to a patient's intervertebral disc space includes a single dilator and a retractable dual-tapered-blade assembly. The dilator may feature a narrow rectangular body for insertion at an insertion orientation parallel to the fibers of the patient's psoas muscle, at an approximate 45-degree angle to the patient's spine. The retractable dual-tapered-blade assembly consists of only two blade subassemblies, each having a blade bordered by adjustable wings, along with built-in lighting and video capabilities. The dual-tapered-blade assembly may be passed over the single dilator at the insertion orientation and rotated approximately 45-50 degrees to a final rotated orientation parallel to the intervertebral disc space before the two blade subassemblies are retracted away from one another to create the surgical pathway, while simultaneously and continuously assessing for encroachment upon one or more nerve structures within 360-degrees of the instrument. Other embodiments are also disclosed.

The present invention relates to a pharmaceutical composition for preventing or treating muscle atrophy or muscle damage or a composition for promoting muscle differentiation, each composition comprising, as an active ingredient, CU-rich RNA derived from a ChRO1 gene, which is a long non-coding RNA, or an isoform thereof. The composition has the effects of maintaining the chromocenter structure of myocytes, reducing the expression of proteolytic factors, and increasing the expression of muscle activity-related factors, and thus can be more safely and effectively used for the prevention or treatment of muscle atrophy or muscle damage.

A lateral retractor system for forming a pathway to a patient's intervertebral disc space includes a single dilator and a retractable dual-tapered-blade assembly. The dilator may feature a narrow rectangular body for insertion at an insertion orientation parallel to the fibers of the patient's psoas muscle, at an approximate 45-degree angle to the patient's spine. The retractable dual-tapered-blade assembly consists of only two blade subassemblies, each having a blade bordered by adjustable wings, along with built-in lighting and video capabilities.The dual-tapered-blade assembly may be passed over the single dilator at the insertion orientation and rotated approximately 45-50 degrees to a final rotated orientation parallel to the intervertebral disc space before the two blade subassemblies are retracted away from one another to create the surgical pathway, while simultaneously and continuously assessing for encroachment upon one or more nerve structures within 360-degrees of the instrument. Other embodiments are also disclosed.

An organoleptically acceptable composition containing a ketone body or a ketone body precursor including a hydroxybutyrate ester and a flavouring is provided and gives improved palatability and user adherence to the intended dose regime. The flavouring may be a bitter flavouring and the composition may further contain an adsorbent for the ketone such that on ingestion, the bitterness of the composition may be masked. The composition may be in the form of a solid, gel or liquid and provides increased blood ketone levels and may be used in therapy or in treating muscle impairment or fatigue.

To provide a muscle injury repair-promoting agent, a muscle injury-treating agent, a muscle injury repair-promoting composition and a muscle injury repair-promoting food composition each containing oleic acid, to provide an animal feed containing the muscle injury repair-promoting agent, and to provide a method for treating muscle-injured non-ruminant domestic animals and pet animals.SOLUTION: A muscle injury repair promoter containing oleic acid as an active ingredient is preferably orally ingested 230mg / day to 480mg / day, and an ingestion target may be a human, a non-ruminant livestock, or a pet.SELECTED DRAWING: Figure 2A

To provide a polypeptide and its use for promoting muscle growth and improving exercise performance.SOLUTION: The present invention discloses a polypeptide and its use for promoting muscle growth and improving exercise performance, since the polypeptide disclosed in the present invention has the activity of regulating the expression of proteins such as p-AMPK, AKT, and mTOR in the muscle growth pathway, by administering an effective amount of the polypeptide disclosed in the present invention or a composition containing the polypeptide to an individual, the muscle growth and muscle strength of the individual can be promoted, thereby achieving the effects of preventing or treating muscle damage-related diseases and improving exercise performance.SELECTED DRAWING: Figure 1

Provided herein are compositions for preventing or treating muscle conditions such as muscle damage, injury, or atrophy. In some embodiments, the compositions comprise a prostaglandin E2 (PGE2) compound and a myotoxin. In some embodiments, the muscle damage, injury, or atrophy is the result of a nerve injury, a surgical procedure, or a traumatic injury. Methods of promoting muscle regeneration and methods of increasing muscle mass are also provided herein.

The current disclosure describes use of a histone deacetylase (HDAC) inhibitor, SR-4370 and analogs thereof, for the treatment of muscle-related disorders, such as Duchenne Muscular Dystrophy. Treatments disclosed herein can provide one or more of muscle regeneration, an increase in muscle strength, the healing of a muscle injury, an increase of the homogeneity of the diameter of a muscle fiber, and a decrease in muscle necrosis.

This invention provides an injectable self-healing conductive hydrogel, its preparation method, and its application. The preparation method includes the following steps: (1) mixing a polyvinylpyrrolidone solution with a GLU solution to obtain a mixed solution; (2) adding MXenes to the mixed solution obtained in step (1), and then adjusting the pH to neutral to obtain the injectable self-healing conductive hydrogel. The injectable self-healing conductive hydrogel prepared by this invention can be easily implanted into different parts of the human body and irregular muscle injury areas to fill cavities, and it is expected to become an ideal candidate material for the treatment of muscle injuries.

This utility model relates to the field of exercise device technology, and in particular to an exercise device for relieving muscle injury. It includes a support base with placement slots at both ends of the top of the support base. A massage mechanism is installed within the placement slots, and the bottom of the massage mechanism is fixed within the placement slots by a support frame. A first slot is formed in the middle of one side of the support base, with its top extending through the top of the support base. A support shaft is installed near the opening of the first slot. A second slot is formed in the middle of the other side of the support base, with its bottom extending through the bottom of the support base. A strip plate is installed within the top of the second slot. In use, this exercise device for relieving muscle injury allows multiple support bases to be placed side-by-side through the correspondence between the support shaft and multiple limiting slots, ensuring stability. This allows for the placement and assembly of the support bases according to the extent and location of muscle injury in the leg, thus better relieving muscle damage.

The present invention relates to a composition comprising a recombinant KAI1 protein that promotes muscle differentiation and exhibits muscle damage protection and muscle regeneration effects. Recombinant KAI1 has been found to increase the expression of genes and proteins of myogenic regulatory factors through activation of Akt / AMPK signaling pathways in myoblasts, promote myotube formation, induce differentiation from stem cells into myoblasts, improve muscle strength and muscular endurance in in vitro and in vivo muscular atrophy models through muscle damage recovery, and exhibit muscle damage protection and muscle regeneration ability, and thus is provided as a composition for muscle differentiation or as a composition for treating muscle damage, muscular atrophy, and sarcopenia.

This utility model relates to the field of stretching device technology and discloses a stretching device for sports and fitness, including a base plate. A tensioning assembly is disposed within the inner cavity of the base plate. A height adjustment assembly is fixedly connected to the top of the base plate. A stretching assembly is fixedly connected to one side of the tensioning assembly. The tensioning assembly includes a fixed seat, one side of which is fixedly connected to the base plate. A fixed plate is fixedly connected to one side of the fixed seat. A rotating handle is disposed within the inner cavity of one side of the fixed plate. A threaded tube is fixedly connected to one side of the rotating handle. Through the tensioning assembly, the rotating handle drives the threaded tube to rotate, causing the moving block to move. Combined with the elasticity of a spring, the force exerted by the tensioning plate on the stretching assembly can be precisely adjusted, achieving multi-level control of the stretching intensity to meet the different stretching strength needs of exercisers. Simultaneously, the buffering effect of the spring prevents sudden changes in stretching intensity from causing muscle damage.

This invention discloses a heat-inactivated Lactobacillus rhamnosus. rhamnosus This invention relates to strain CQFP202442 and its application in alleviating exercise-induced fatigue, belonging to the field of microbial technology. The preservation number of this heat-inactivated strain is CGMCC No. 29612. This invention demonstrates that this heat-inactivated strain can significantly prolong the time to exhaustion during running in mice and reduce the degree of muscle damage; it can increase the levels of T-AOC, CAT, GSH, and GLU in mouse serum, as well as the relative mRNA expression levels of SOD1, SOD2, and CAT in mouse muscle tissue; simultaneously, it can upregulate the relative expression levels of related mRNAs in muscle tissue; and downregulate the levels of LDH, BUN, and CRE in mouse serum. The heat-inactivated strain of this invention can effectively alleviate exercise-induced fatigue through a dual mechanism of regulating oxidative stress and myofibrillary protection, exhibiting high safety and good stability.

The present application provides an injectable self-healing conductive hydrogel, a method for preparing same, and use thereof. The method comprises: (1) mixing a polyvinylpyrrolidone solution with a GLU solution to give a mixed solution; and (2) adding MXenes to the mixed solution obtained in step (1), and then adjusting the pH to neutral to give the injectable self-healing conductive hydrogel. The injectable self-healing conductive hydrogel prepared according to the present application can be conveniently implanted into irregular muscle injury regions at different parts of a human body and fill cavities. The injectable self-healing conductive hydrogel is expected to become an ideal candidate material for the treatment of muscle injuries.

The invention belongs to the technical field of traditional Chinese medicine compositions or functional foods, and particularly relates to an anti-fatigue traditional Chinese medicine composition and a preparation method and application thereof. The anti-fatigue traditional Chinese medicine composition comprises the following raw materials: red ginseng, American ginseng, sun-dried ginseng, Chinese wolfberry, honey, xylitol and starch. The preparation method comprises the steps of low-temperature drying of ginseng, superfine grinding, decoction and concentration of wolfberry, dissolution and mixing of auxiliary materials, granulation, drying and the like. Through scientific compatibility of various ginsengs and combination of an optimized process, synergistic interaction of effects of various traditional Chinese medicines can be realized, the ginseng health-care food has remarkable effects of resisting fatigue, enhancing immunity and regulating body metabolism, meanwhile, can protect visceral organs and muscle injury induced by movement, and is high in dissolution rate and absorption rate of active ingredients, fresh and sweet in taste, convenient to eat, stable in quality and free of toxic and side effects. And the product is suitable for various sub-health people to eat, and has good safety, practicability and industrial popularization prospects.

This invention discloses a method for analyzing neck muscle impact injuries based on dummy experimental data, relating to the fields of biomechanical engineering and safety protection technology. The method includes the following steps: using neck motion trajectory parameters collected during dummy impact testing as boundary conditions for musculoskeletal model simulation; importing a pre-defined neck musculoskeletal model into the OpenSim platform, and geometrically scaling the model according to standardized dummy dimensions to obtain cervical joint angles, cervical joint loads, and the activation and force distribution of each muscle; and conducting an impact-induced muscle injury risk assessment based on the extracted peak muscle force, muscle activation sequence, and unit mass muscle energy absorption rate. This invention solves the problem that traditional methods cannot quantify deep muscle injuries under controllable conditions, providing a highly reliable engineering analysis tool for automotive safety design and protective equipment optimization.

The invention provides a plant fermentation composition for improving exercise tolerance, and belongs to the field of non-alcoholic beverages. The beverage comprises the following components: fermented roxburgh rose juice, a fermented radix astragali extract, an angelica sinensis extract, a lucid ganoderma extract, a ginseng extract and a black tea extract. The fermented radix astragali seu hedysari extract is obtained by performing aerobic fermentation on radix astragali seu hedysari through bacillus subtilis, sterilizing and filtering; the fermented roxburgh rose juice is obtained by pulping new roxburgh rose, filtering, fermenting with lactobacillus plantarum, filtering and taking filtrate. According to the composition disclosed by the invention, through a multi-target-point synergistic effect, the energy metabolism efficiency is remarkably optimized, and motor glycogen depletion and lactic acid accumulation are delayed; meanwhile, the activity of an organism antioxidant enzyme system is enhanced, and damage of oxidative stress to skeletal muscles is relieved; and inflammatory response induced by motion can be inhibited, and muscle injury repair is accelerated. The comprehensive performance is that the exercise endurance is obviously improved, the exhaustion time is prolonged, and the composition has an exact effect on improving the exercise performance.

The present invention relates to novel use of a cathepsin L inhibitor Z-Phe-Tyr-CHO (C26H26N2O5), wherein the cathepsin L inhibitor Z-Phe-Tyr-CHO inhibits cancer progression and cachexia and muscle damage that are caused by cancer, and thus can be effectively used for preventing, ameliorating or treating cachexia and muscle loss, while having anticancer activity.