71 results about "Muscle damage" patented technology

The invention discloses an application of NSUN2 in muscle injury repair. Research finds that the number of activated muscle stem cells of a CTX model mouse can be remarkably increased and proliferation of the muscle stem cells can be promoted by mediating NSUN2 overexpression through AAV, and the overexpression of the NSUN2 not only improves the activation level of the muscle stem cells, but also enhances the self-renewal capacity of the muscle stem cells; in addition, overexpression of NSUN2 also significantly increases the area of muscle fibers of CTX model mice and reduces the weight of muscle atrophy. Overexpression of the NSUN2 promotes muscle fiber repair and muscle mass recovery by promoting proliferation and activation of muscle stem cells, so that healing of muscle injury is promoted, and the NSUN2 has a treatment effect on the disease. Therefore, the invention provides a new method for the treatment of muscle injury, and a new way is possibly opened up for the treatment of other muscle-related diseases.

The invention belongs to the technical field of biomedicine, and particularly relates to an alpha-cyperone bionic nano preparation as well as a preparation method and application thereof, the alpha-cyperone bionic nano preparation is prepared from a polylactic acid-glycolic acid copolymer, alpha-cyperone, a bionic membrane and follicle-stimulating hormone polypeptide, the biomimetic membrane is characterized in that alpha-cyperone is loaded on a polylactic acid-glycolic acid copolymer, the biomimetic membrane is biologically camouflaged on the outer layer, then the biomimetic membrane is modified by follicle-stimulating hormone polypeptide, and the amino acid sequence of the follicle-stimulating hormone polypeptide is as shown in SEQ ID NO.1. According to the alpha-cyperone bionic nano preparation disclosed by the invention, the alpha-cyperone is loaded by utilizing the polylactic acid-glycolic acid copolymer, so that the alpha-cyperone is easily dissolved in water, and the blood circulation half-life period is prolonged and the targeting capability of an ovary part is improved through biological camouflage of the bionic membrane; the modification of the follicle-stimulating hormone polypeptide further improves the targeting ability to granulosa cells, and liver and kidney toxicity and muscle injury are not found in the experiment process.

The invention provides injectable self-healing conductive hydrogel and a preparation method and application thereof, and the preparation method comprises the following steps: (1) mixing a polyvinylpyrrolidone solution with a GLU solution to obtain a mixed solution; and (2) adding MXenes into the mixed solution obtained in the step (1), and then adjusting the pH value to be neutral to obtain the injectable self-healing conductive hydrogel. The injectable self-healing conductive hydrogel prepared by the invention can be conveniently implanted into different parts and irregular muscle injury areas of a human body, is filled in a cavity, and is expected to become an ideal candidate material for muscle injury treatment.

The utility model discloses a novel protein marker diagnostic kit for detecting the muscle injury degree, which comprises a detection kit for detecting the muscle injury degree and a dustproof cover assembled above the detection kit, the detection kit is provided with a detection port for dropping blood of a patient and a display port for displaying a diagnosis result, a reagent card for evaluating the muscle injury degree by detecting the concentration of a specific protein marker in the blood is arranged in the detection kit, and the detection end of the reagent card is located below the detection port. The display end of the reagent card is positioned below the display opening; a positioning opening for positioning the dustproof cover is formed above the detection kit, and a positioning block matched with the positioning opening is arranged in the dustproof cover. According to the utility model, the muscle injury degree of a patient can be detected by quickly reading the novel protein marker in the blood, so that an accurate diagnosis and treatment basis is provided for the treatment of the patient, the detection time of the patient is shortened, and the treatment cost is reduced.

The invention discloses preparation and application of modified hydrolyzed whey protein peptide for promoting muscle cell protein synthesis, and belongs to the field of sports nutrition and health. The preparation method comprises the following steps: carrying out enzymolysis on whey protein powder, carrying out lactic acid modification, and carrying out spray drying to obtain the modified hydrolyzed whey protein peptide. The modified hydrolyzed whey protein peptide is applied to products such as functional foods, medicines and health-care products, effectively improves the glutamine level of a human body, promotes synthesis of muscle cell protein, improves muscle endurance, repairs muscle injury after exercise and promotes recovery after exercise, and is a high-quality nutrition supplement source for exercise and fitness people.

The present invention provides a polypeptide and a use thereof for promoting muscle hyperplasia and improving athletic performance, since the polypeptide provided by the present invention has activity for regulating the performance of proteins such as p-AMPK, AKT, mTOR and the like in a muscle hyperplasia pathway, by administering an effective amount of the polypeptide provided by the present invention or a composition containing the polypeptide to an individual, the activity of the polypeptide is improved, and the activity of the polypeptide is improved. The muscle hyperplasia and the muscle strength of the individual can be promoted, so that the effects of preventing or treating diseases related to muscle damage and improving the exercise performance can be achieved.

The present invention relates to novel use of a cathepsin L inhibitor Z-Phe-Tyr-CHO (C26H26N2O5), wherein the cathepsin L inhibitor Z-Phe-Tyr-CHO inhibits cancer progression and cachexia and muscle damage that are caused by cancer, and thus can be effectively used for preventing, ameliorating or treating cachexia and muscle loss, while having anticancer activity.

Treatments of neuromuscular conditions, activity-induced muscle damage, metabolic myopathies, and movement disorders with compositions comprising 2-((5-fluoropyridin-3-yl)methyl)-6-(2-(2,2,2-trifluoroethoxy)pyrimidin-5-yl)pyridazin-3(2H)-one (Compound 1), as well as solid forms of Compound 1, and pharmaceutical compositions of Compound 1, and kits of Compound 1, are described herein.

The present disclosure provides a plug-and-play functional electrical stimulation system and method. The system includes a main controller connected to at least two series-connected electrical stimulators via a bus; the main controller is configured to receive and execute motion task files, and coordinate the output logic timing of the multi-channel electrical stimulators via the bus; the motion task files are composed of control parameters set based on the patient's degree of muscle damage; the control parameters include: the number of different states of a customizable state machine corresponding to the functional training task, the trigger conditions required for state transitions, and the functional electrical stimulation output parameters for each state.

The present invention relates to the technical field of biomaterial preparation, and in particular to an adhesive hydrogel with anti-inflammatory, antioxidant and pro-angiogenic capabilities and its application. The adhesive hydrogel of the present invention comprises an anti-adhesion layer, an adhesion layer and an inner layer arranged in sequence; the anti-adhesion layer and the adhesion layer are respectively formed by cross-linking ACG solutions of different pH values; the inner layer uses methacrylate whey protein as a base material and is loaded with EGCG@DEX‑PBAP. The adhesive hydrogel can be used for the repair of skin damage, muscle damage, nerve damage, and myocardial damage tissue.

The present invention relates to a composition for strengthening muscle strength or preventing, ameliorating or treating muscle loss, comprising a Lilium lancifolium extract as an active ingredient. Specifically, when C2C12 cells were pre-treated with a Lilium lancifolium extract, and then treated with H2O2, dexamethasone, or TNF-α, muscle damage was alleviated and muscle loss was inhibited, and the muscle mass and grip strength decreased by dexamethasone administration in a muscle atrophy mouse model were increased upon administration of the Lilium lancifolium extract. Therefore, the composition can be effectively used as a health functional food, medicine or feed additive for strengthening muscle strength or preventing, ameliorating or treating muscle loss.

The invention discloses application of poplatin in preparation of a medicine for treating muscle injury. The research finds that the poplatin has the effects of promoting mouse myoblast differentiation and promoting mouse muscle regeneration under various pathological conditions such as acute injury, obesity, diabetes mellitus and hereditary dystrophy.

The invention discloses compound protein powder for improving muscle injury and application of the compound protein powder, and belongs to the field of health-care products. The compound protein powder for improving the muscle injury contains a composition for improving the muscle injury, and the composition consists of brown algae extract, sour cherry extract, cardiomyopeptide and bovine ligament elastin peptide freeze-dried powder. The brown algae extract, the sour cherry extract, the cardiomyopeptide and the bovine ligament elastin peptide freeze-dried powder are compounded for use, so that an excellent muscle injury improvement effect is achieved.

1. Name of the product in this design: Walking Assistive Rehabilitation Device. 2. Purpose of this design: It is used in a walking rehabilitation device, which is a wearable functional neurostimulation instrument used for lower limb rehabilitation and recovery of muscles damaged by motor neurons. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1. 5. Other circumstances requiring explanation: The human lower limb model is a supporting element and is not part of the content for which protection is sought.

The present application relates to the technical field of waist posture recognition, in particular to a human waist posture recognition and force state evaluation method and system based on an inertial sensor, comprising the following steps: collecting original motion data in real time through an inertial measurement unit worn on the L4-L5 segment of the human waist, wherein the original motion data comprises three-axis acceleration data and three-axis angular velocity data; using a Kalman filtering algorithm to filter noise and calibrate the coordinate system of the original motion data, to obtain standard waist motion characteristic data. The present application realizes accurate and continuous recognition of the waist posture in daily scenarios, completes quantitative evaluation of the force on the lumbar vertebrae and prediction of the damage risk, has high detection accuracy and strong scene adaptability, and is portable and easy to use, which can provide a comprehensive basis for the user to manage the health of the waist and effectively prevent lumbar muscle damage.

The present disclosure provides a composition for preventing or minimizing motor-induced muscle injury (EIMD) in a subject in need thereof, comprising Lactobacillus paracasei PS23 and a carrier thereof. The present disclosure also provides a method for preventing or minimizing muscle injury caused by movement by administering the composition.

The utility model discloses a muscle retractor which comprises a retractor head and a retractor handle, the tail portion of the retractor head is connected with the retractor handle, the head portion of the retractor head is of an arc-shaped structure, a semi-arc structure used for preventing muscle injury is arranged on the retractor head, and the retractor head and the retractor handle are both made of high-temperature-resistant and high-pressure-resistant materials. According to the technical scheme, the structural design is reasonable, the retractor head is made of the carbon fiber composite material, the performance is excellent and even superior to that of a metal material, and the retractor head is not prone to deformation under the action of force in the operation process. The head end of the draw hook head is designed to be arc-shaped, and the draw hook head is provided with a semi-arc structure for preventing muscle injury, so that the contact area with the muscle is increased, the pressure of the draw hook on the muscle is reduced, and the injury to the muscle is reduced as much as possible. The draw hook handle is made of silica gel materials, so that the draw hook can be directly fixed on a surgical drape through the existing hemostatic forceps, the two hands of an operator are liberated, the draw hook head and the draw hook handle can be disinfected together with a common surgical instrument and can be reused, and the practicability is good.

Disclosed herein are α7 integrin modulatory agents and methods of using such to treat muscular disorders, disease, degeneration, and / or muscular dystrophy. The methods include administering an effective amount of an α7 integrin modulatory agent to the subject with a muscular disorder, disease, degeneration, and / or dystrophy, wherein the α7 integrin modulatory agent increases α7 integrin expression or activity as compared to α7 integrin expression or activity prior to treatment, thereby treating the subject. Also disclosed are methods of enhancing muscle regeneration, repair, or maintenance in a subject and methods of enhancing α7 integrin expression by use of the disclosed α7 integrin modulatory agents. Methods of preventing or reducing muscle injury or damage in a subject are also disclosed.

The application discloses a planning navigation system for lower limb fracture reduction surgery. The system comprises a medical image processing module for segmenting a proximal bone and a distal bone from a lower limb fracture image and reconstructing a three-dimensional surface model of a broken bone; a surgery planning module for point cloud sampling on the three-dimensional surface model of the broken bone to obtain a corresponding point cloud model; extracting a fracture section from the point cloud model; obtaining a coordinate transformation matrix of an initial position of the distal bone and a target position of the distal bone after reduction by point cloud registration on the fracture section; performing fracture reduction path planning based on the coordinate transformation matrix, the fracture reduction path planning being used for guiding translation and rotation of the distal bone to obtain the target position of the distal bone under the condition that the proximal bone is fixed; and a navigation module for visually displaying a surgery process based on the fracture reduction path planning. The application can improve reduction accuracy, reduce reduction force and reduce soft tissue damage such as muscle damage at a fracture of a patient.

In a first aspect, the present invention is related to lactic acid or a pharmaceutically acceptable salt thereof for use in the prevention and / or treatment of a musculoskeletal injury in a subject. In a second aspect, the present invention is related to an injectable composition for use in the treatment of a musculoskeletal injury in a subject characterized in that it comprises lactic acid or a pharmaceutically acceptable salt thereof and a suitable solvent. In a preferred embodiment, the musculoskeletal injury is selected from the group consisting of tendon injury, joint injury, cartilage injury and muscle injury.

Disclosed are: a composition containing a human urine concentrate; a method for producing the same; a cell population; a human urine collection system; a muscle differentiation promoter; and a muscle damage therapeutic agent. The muscle differentiation promoter and the muscle damage therapeutic agent contain a nucleic acid that promotes the expression of serglycin or serglycin core protein.

The invention discloses a lactobacillus rhamnosus CQFP202457 and application of the lactobacillus rhamnosus CQFP202457 and ellagic acid in relieving exercise fatigue, and belongs to the technical field of microorganisms. The preservation number of the lactobacillus rhamnosus CQFP202457 is CGMCC (China General Microbiological Culture Collection Center) No. 29784. The composition provided by the invention contains ellagic acid and lactobacillus rhamnosus CQFP202457, and can significantly prolong the exercise exhaustion time, reduce the content of fatigue-related metabolites in serum, improve the total antioxidant ability of serum, liver and skeletal muscle and the antioxidant enzyme gene expression level, and improve the exercise-induced liver and skeletal muscle tissue damage. The strain and the composition thereof provided by the invention can be used as exercise synbiotics for preparing products for relieving exercise-induced fatigue, improving exercise performance, reducing exercise-induced oxidative stress or relieving exercise-induced muscle injury.

The invention discloses a medicine for treating arthritis, rheumatic bone pain and acute muscle injury and a preparation method thereof. The medicine is prepared from the following components in parts by weight: 5-10 parts of agilawood, 1-10 parts of resina liquidamberis, 1-8 parts of pseudo-ginseng, 1-8 parts of garden balsam stem, 5-15 parts of fructus cnidii, 5-10 parts of cicada slough, 10-20 parts of frankincense, 10-20 parts of mentholum and 5-15 parts of resina draconis. The traditional Chinese medicinal materials adopted in the prescription do not cause drug resistance and have no side effect.

The present application relates to a kind of cervical vertebra intelligent rehabilitation appliance based on electromyogram-pressure feedback, comprising: support structure unit, electromyogram signal acquisition unit, pressure signal acquisition unit, pneumatic traction unit and control unit;Support structure unit includes mandibular support, back neck support, inner lining and adjustable fixing band, mandibular support is connected with back neck support, inner lining is set to the inner side of mandibular support and back neck support, one end of adjustable fixing band is connected with back neck support;Electromyogram signal acquisition unit is set to the inner lining of back neck support inner side and the site of user neck contact, for gathering the electromyogram signal of the neck of wearer;Pressure signal acquisition unit is used to gather the pressure distribution signal in the process of wearing;Pneumatic traction unit is used to apply adjustable traction to user neck;Control unit is connected with electromyogram signal acquisition unit, pressure signal acquisition unit, pneumatic traction unit respectively.The present application realizes personalized, adaptive intelligent rehabilitation, and can effectively avoid excessive traction and muscle damage.

The invention belongs to the field of food, and particularly relates to two sea cucumber peptides with activity of enhancing exercise ability as well as a preparation method and application of the sea cucumber peptides. Meanwhile, the sea cucumber peptide sequences with the exercise enhancing ability are obtained through screening by adopting peptidomics analysis and molecular docking methods, and comprise FPGGY and PGSPF. Experiments prove that the two sea cucumber peptides can be used for regulating energy metabolism (improving hepatic glycogen, muscle glycogen and ATP (adenosine triphosphate) reserve and maintaining serum glucose level), relieving muscle injury (reducing serum creatine kinase, lactic acid and uric acid content), enhancing antioxidant ability (improving SOD (superoxide dismutase) activity) and promoting skeletal muscle development (improving flatfish muscle and tibia anterior muscle visceral coefficient); the exhaustive swimming time of mice suffering from exercise fatigue is obviously prolonged, the exercise tolerance is effectively enhanced, and the exercise fatigue is relieved. The invention provides a basis for development of sea cucumber resources in the field of sports nutrition, and has important social and economic values.

1. The name of this design product: sports protective pad. 2. Purpose of this product design: to reduce muscle damage caused by exercise. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The invention relates to the technical field of microRNA (Ribonucleic Acid) medicines, in particular to an application of hsa-miR-16-5p in preparation of a medicine for treating muscle injury. The invention discloses that the hsa-miR-16-5p has the function of inhibiting the expression of the Tgfbr3 gene, and the repair of muscle injury can be realized; the function of inhibiting fibroblast / adipogenic progenitor cell adipodifferentiation is also achieved, then muscle fat infiltration and muscle fat degeneration are inhibited, and the effect of further promoting muscle injury repair is achieved. As a microRNA drug, the microRNA drug can be used in muscle injury repair, muscle fat infiltration or muscle fatty degeneration can be effectively inhibited, and meanwhile, promotion of muscle injury repair is realized by regulating and controlling a signal channel in which Tgfbr3 participates. According to the technical scheme, the technical problem that RNA drugs capable of effectively treating muscle injuries are lacked in the prior art can be solved, and the RNA drugs have ideal application and popularization prospects.

The invention relates to application of liquiritigenin in preparation of a medicine for relieving muscle injury caused by exercise fatigue, in particular to application of liquiritigenin in preparation of a medicine for relieving muscle injury caused by exercise fatigue, specifically, liquiritigenin inhibits expression of Caspase 3 by up-regulating the proportion of PI3K / Akt protein so as to inhibit muscle cell apoptosis; meanwhile, liquiritigenin reduces expression of inflammatory factors by up-regulating the proportion of PI3K / Akt protein, so that muscle injury caused by exercise fatigue is relieved; specifically, the liquiritigenin can further prolong the exhaustive exercise time of the mouse, enhance the endurance and improve the exercise ability of the mouse on the basis of improving the endurance of the mouse.

The utility model discloses a traction and stretching exercise machine based on sports human science, and relates to the technical field of sports equipment. The traction and stretching exercise machine based on sports human science includes a fixed support plate, an adjustment structure and a stretching structure. A sliding support plate is provided on one side of the fixed support plate. The adjustment structure includes a sliding plate, a spring, a clamping plate, a second spring and a clamping block. The sliding plate is slidably connected inside the fixed support plate. The sliding plate is fixedly connected to the sliding support plate. The clamping plate is slidably connected inside the fixed support plate. The spring is fixedly connected between the clamping plate and the sliding plate. The second spring is fixedly connected to the top of the clamping block. Moving the clamping plate to different positions can change the stretching degree of the spring, thereby changing the pulling force required for the sliding support plate to move to the farthest point. The pulling force can be adjusted according to the conditions of different users through the adjustment device, which solves the problem that the pulling force required for stretching is too large due to the inconvenience of adjusting the device, which may cause muscle damage to the user.

The invention is suitable for the technical field of spine correction, and particularly relates to a spine correction process monitoring method and device, and the method comprises the steps: obtaining basic information; wherein the basic information comprises information reflecting the position of the spine of the user in a standing state, information reflecting the moving track of the spine of the user in a moving state and information reflecting the fatigue degree of muscles of the user; obtaining initial correction information based on the basic information; acquiring monitoring information; obtaining a real-time control instruction and a correction control scheme based on the monitoring information and the initial correction information; wherein the real-time control instruction and the correction control scheme are used for controlling the spine correction process monitoring device. According to the spine correction process monitoring method and device provided by the embodiment of the invention, the problem that a traditional brace cannot track the spine state and the muscle fatigue degree of the user in real time and cannot adjust the correction scheme in time, so that the correction effect is poor or muscle injury and fatigue accumulation are possibly caused can be solved.