42 results about "Muscle damage" patented technology

The utility model discloses a novel protein marker diagnostic kit for detecting the muscle injury degree, which comprises a detection kit for detecting the muscle injury degree and a dustproof cover assembled above the detection kit, the detection kit is provided with a detection port for dropping blood of a patient and a display port for displaying a diagnosis result, a reagent card for evaluating the muscle injury degree by detecting the concentration of a specific protein marker in the blood is arranged in the detection kit, and the detection end of the reagent card is located below the detection port. The display end of the reagent card is positioned below the display opening; a positioning opening for positioning the dustproof cover is formed above the detection kit, and a positioning block matched with the positioning opening is arranged in the dustproof cover. According to the utility model, the muscle injury degree of a patient can be detected by quickly reading the novel protein marker in the blood, so that an accurate diagnosis and treatment basis is provided for the treatment of the patient, the detection time of the patient is shortened, and the treatment cost is reduced.

The present invention provides a polypeptide and a use thereof for promoting muscle hyperplasia and improving athletic performance, since the polypeptide provided by the present invention has activity for regulating the performance of proteins such as p-AMPK, AKT, mTOR and the like in a muscle hyperplasia pathway, by administering an effective amount of the polypeptide provided by the present invention or a composition containing the polypeptide to an individual, the activity of the polypeptide is improved, and the activity of the polypeptide is improved. The muscle hyperplasia and the muscle strength of the individual can be promoted, so that the effects of preventing or treating diseases related to muscle damage and improving the exercise performance can be achieved.

The present invention relates to novel use of a cathepsin L inhibitor Z-Phe-Tyr-CHO (C26H26N2O5), wherein the cathepsin L inhibitor Z-Phe-Tyr-CHO inhibits cancer progression and cachexia and muscle damage that are caused by cancer, and thus can be effectively used for preventing, ameliorating or treating cachexia and muscle loss, while having anticancer activity.

Treatments of neuromuscular conditions, activity-induced muscle damage, metabolic myopathies, and movement disorders with compositions comprising 2-((5-fluoropyridin-3-yl)methyl)-6-(2-(2,2,2-trifluoroethoxy)pyrimidin-5-yl)pyridazin-3(2H)-one (Compound 1), as well as solid forms of Compound 1, and pharmaceutical compositions of Compound 1, and kits of Compound 1, are described herein.

The present disclosure provides a plug-and-play functional electrical stimulation system and method. The system includes a main controller connected to at least two series-connected electrical stimulators via a bus; the main controller is configured to receive and execute motion task files, and coordinate the output logic timing of the multi-channel electrical stimulators via the bus; the motion task files are composed of control parameters set based on the patient's degree of muscle damage; the control parameters include: the number of different states of a customizable state machine corresponding to the functional training task, the trigger conditions required for state transitions, and the functional electrical stimulation output parameters for each state.

The present invention relates to a composition for strengthening muscle strength or preventing, ameliorating or treating muscle loss, comprising a Lilium lancifolium extract as an active ingredient. Specifically, when C2C12 cells were pre-treated with a Lilium lancifolium extract, and then treated with H2O2, dexamethasone, or TNF-α, muscle damage was alleviated and muscle loss was inhibited, and the muscle mass and grip strength decreased by dexamethasone administration in a muscle atrophy mouse model were increased upon administration of the Lilium lancifolium extract. Therefore, the composition can be effectively used as a health functional food, medicine or feed additive for strengthening muscle strength or preventing, ameliorating or treating muscle loss.

1. Name of the product in this design: Walking Assistive Rehabilitation Device. 2. Purpose of this design: It is used in a walking rehabilitation device, which is a wearable functional neurostimulation instrument used for lower limb rehabilitation and recovery of muscles damaged by motor neurons. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1. 5. Other circumstances requiring explanation: The human lower limb model is a supporting element and is not part of the content for which protection is sought.

The present application relates to the technical field of waist posture recognition, in particular to a human waist posture recognition and force state evaluation method and system based on an inertial sensor, comprising the following steps: collecting original motion data in real time through an inertial measurement unit worn on the L4-L5 segment of the human waist, wherein the original motion data comprises three-axis acceleration data and three-axis angular velocity data; using a Kalman filtering algorithm to filter noise and calibrate the coordinate system of the original motion data, to obtain standard waist motion characteristic data. The present application realizes accurate and continuous recognition of the waist posture in daily scenarios, completes quantitative evaluation of the force on the lumbar vertebrae and prediction of the damage risk, has high detection accuracy and strong scene adaptability, and is portable and easy to use, which can provide a comprehensive basis for the user to manage the health of the waist and effectively prevent lumbar muscle damage.

The application discloses a planning navigation system for lower limb fracture reduction surgery. The system comprises a medical image processing module for segmenting a proximal bone and a distal bone from a lower limb fracture image and reconstructing a three-dimensional surface model of a broken bone; a surgery planning module for point cloud sampling on the three-dimensional surface model of the broken bone to obtain a corresponding point cloud model; extracting a fracture section from the point cloud model; obtaining a coordinate transformation matrix of an initial position of the distal bone and a target position of the distal bone after reduction by point cloud registration on the fracture section; performing fracture reduction path planning based on the coordinate transformation matrix, the fracture reduction path planning being used for guiding translation and rotation of the distal bone to obtain the target position of the distal bone under the condition that the proximal bone is fixed; and a navigation module for visually displaying a surgery process based on the fracture reduction path planning. The application can improve reduction accuracy, reduce reduction force and reduce soft tissue damage such as muscle damage at a fracture of a patient.

In a first aspect, the present invention is related to lactic acid or a pharmaceutically acceptable salt thereof for use in the prevention and / or treatment of a musculoskeletal injury in a subject. In a second aspect, the present invention is related to an injectable composition for use in the treatment of a musculoskeletal injury in a subject characterized in that it comprises lactic acid or a pharmaceutically acceptable salt thereof and a suitable solvent. In a preferred embodiment, the musculoskeletal injury is selected from the group consisting of tendon injury, joint injury, cartilage injury and muscle injury.

Disclosed are: a composition containing a human urine concentrate; a method for producing the same; a cell population; a human urine collection system; a muscle differentiation promoter; and a muscle damage therapeutic agent. The muscle differentiation promoter and the muscle damage therapeutic agent contain a nucleic acid that promotes the expression of serglycin or serglycin core protein.

The invention discloses a lactobacillus rhamnosus CQFP202457 and application of the lactobacillus rhamnosus CQFP202457 and ellagic acid in relieving exercise fatigue, and belongs to the technical field of microorganisms. The preservation number of the lactobacillus rhamnosus CQFP202457 is CGMCC (China General Microbiological Culture Collection Center) No. 29784. The composition provided by the invention contains ellagic acid and lactobacillus rhamnosus CQFP202457, and can significantly prolong the exercise exhaustion time, reduce the content of fatigue-related metabolites in serum, improve the total antioxidant ability of serum, liver and skeletal muscle and the antioxidant enzyme gene expression level, and improve the exercise-induced liver and skeletal muscle tissue damage. The strain and the composition thereof provided by the invention can be used as exercise synbiotics for preparing products for relieving exercise-induced fatigue, improving exercise performance, reducing exercise-induced oxidative stress or relieving exercise-induced muscle injury.

The invention discloses a medicine for treating arthritis, rheumatic bone pain and acute muscle injury and a preparation method thereof. The medicine is prepared from the following components in parts by weight: 5-10 parts of agilawood, 1-10 parts of resina liquidamberis, 1-8 parts of pseudo-ginseng, 1-8 parts of garden balsam stem, 5-15 parts of fructus cnidii, 5-10 parts of cicada slough, 10-20 parts of frankincense, 10-20 parts of mentholum and 5-15 parts of resina draconis. The traditional Chinese medicinal materials adopted in the prescription do not cause drug resistance and have no side effect.

The present application relates to a kind of cervical vertebra intelligent rehabilitation appliance based on electromyogram-pressure feedback, comprising: support structure unit, electromyogram signal acquisition unit, pressure signal acquisition unit, pneumatic traction unit and control unit;Support structure unit includes mandibular support, back neck support, inner lining and adjustable fixing band, mandibular support is connected with back neck support, inner lining is set to the inner side of mandibular support and back neck support, one end of adjustable fixing band is connected with back neck support;Electromyogram signal acquisition unit is set to the inner lining of back neck support inner side and the site of user neck contact, for gathering the electromyogram signal of the neck of wearer;Pressure signal acquisition unit is used to gather the pressure distribution signal in the process of wearing;Pneumatic traction unit is used to apply adjustable traction to user neck;Control unit is connected with electromyogram signal acquisition unit, pressure signal acquisition unit, pneumatic traction unit respectively.The present application realizes personalized, adaptive intelligent rehabilitation, and can effectively avoid excessive traction and muscle damage.

The invention belongs to the field of food, and particularly relates to two sea cucumber peptides with activity of enhancing exercise ability as well as a preparation method and application of the sea cucumber peptides. Meanwhile, the sea cucumber peptide sequences with the exercise enhancing ability are obtained through screening by adopting peptidomics analysis and molecular docking methods, and comprise FPGGY and PGSPF. Experiments prove that the two sea cucumber peptides can be used for regulating energy metabolism (improving hepatic glycogen, muscle glycogen and ATP (adenosine triphosphate) reserve and maintaining serum glucose level), relieving muscle injury (reducing serum creatine kinase, lactic acid and uric acid content), enhancing antioxidant ability (improving SOD (superoxide dismutase) activity) and promoting skeletal muscle development (improving flatfish muscle and tibia anterior muscle visceral coefficient); the exhaustive swimming time of mice suffering from exercise fatigue is obviously prolonged, the exercise tolerance is effectively enhanced, and the exercise fatigue is relieved. The invention provides a basis for development of sea cucumber resources in the field of sports nutrition, and has important social and economic values.

The invention relates to application of liquiritigenin in preparation of a medicine for relieving muscle injury caused by exercise fatigue, in particular to application of liquiritigenin in preparation of a medicine for relieving muscle injury caused by exercise fatigue, specifically, liquiritigenin inhibits expression of Caspase 3 by up-regulating the proportion of PI3K / Akt protein so as to inhibit muscle cell apoptosis; meanwhile, liquiritigenin reduces expression of inflammatory factors by up-regulating the proportion of PI3K / Akt protein, so that muscle injury caused by exercise fatigue is relieved; specifically, the liquiritigenin can further prolong the exhaustive exercise time of the mouse, enhance the endurance and improve the exercise ability of the mouse on the basis of improving the endurance of the mouse.

A novel protein biomarker for determining the severity of muscle injury, and an obtaining method therefor and a use thereof. The novel protein biomarker comprises at least one of thirty-six proteins. The obtaining method for the novel protein biomarker specifically comprises: establishing experimental rat models with different severities of muscle injury; collecting the plasma of rats in different groups for proteomic detection and performing differential comparison to obtain candidate protein biomarkers; and using the blood of clinical patients with different severities of muscle injury to validate the candidate protein biomarkers and determining diagnostic reference ranges of the candidate protein biomarkers. The use of the proteomic biomarker is: using the novel protein biomarker to make a kit or using the novel protein biomarker for detection to determine the severity of muscle injury by means of mass spectrometry or any other methods. A new basis is provided for the determination of the severity of muscle injury, facilitating quantification of the severity of muscle injury.

This invention discloses the application of ZAK inhibitors in the preparation of drugs for treating EV71 virus infection, relating to the biomedical field. The ZAK inhibitors exert their effects by inhibiting the ZAK-p38 MAPK signaling pathway and by inhibiting the ZAKα-mediated ribosomal toxicity stress response (RSR). The ZAK inhibitor is nilotinib or a pharmaceutically acceptable salt thereof. Cellular and animal experiments of this invention demonstrate that EV71 infection activates the ZAKα-mediated p38 MAPK pathway (RSR), promoting viral replication and leading to multi-organ damage. ZAK inhibitors (such as nilotinib) can inhibit this pathway, reduce the expression of the viral protein VP1, and improve infection-induced renal function damage, metabolic disorders, and muscle damage. Therefore, ZAK inhibitors can be used to prepare anti-EV71 drugs.

The application discloses an enzyme response type composite scaffold for muscle injury repair and a preparation method thereof, and belongs to the technical field of polymer scaffolds. The application takes a decellularized matrix as the scaffold, and combines with MMP-2 responsive nanomicelles loaded with lipoxin LxA4 and SDF-1 alpha, so that precise and long-acting release of drugs at the injury site is realized. Through the synergistic effect of LxA4 and SDF-1 alpha, the inflammatory reaction at the injury site is reduced, and the recruitment and migration of endogenous stem cells are enhanced, so that the repair cycle is shortened. In addition, the composite scaffold of the application also ensures the synchronism of the degradation speed of the scaffold and the tissue regeneration speed, and ensures the effective support of the scaffold in the tissue healing process. The application provides a safer and more effective solution for the treatment of muscle tissue defects, and promotes the application of tissue engineering in clinical practice.

A lateral retractor system for forming a pathway to a patient's intervertebral disc space includes a single dilator and a retractable dual-tapered-blade assembly. The dilator may feature a narrow rectangular body for insertion at an insertion orientation parallel to the fibers of the patient's psoas muscle, at an approximate 45-degree angle to the patient's spine. The retractable dual-tapered-blade assembly consists of only two blade subassemblies, each having a blade bordered by adjustable wings, along with built-in lighting and video capabilities. The dual-tapered-blade assembly may be passed over the single dilator at the insertion orientation and rotated approximately 45-50 degrees to a final rotated orientation parallel to the intervertebral disc space before the two blade subassemblies are retracted away from one another to create the surgical pathway, while simultaneously and continuously assessing for encroachment upon one or more nerve structures within 360-degrees of the instrument. Other embodiments are also disclosed.

The present invention relates to a pharmaceutical composition for preventing or treating muscle atrophy or muscle damage or a composition for promoting muscle differentiation, each composition comprising, as an active ingredient, CU-rich RNA derived from a ChRO1 gene, which is a long non-coding RNA, or an isoform thereof. The composition has the effects of maintaining the chromocenter structure of myocytes, reducing the expression of proteolytic factors, and increasing the expression of muscle activity-related factors, and thus can be more safely and effectively used for the prevention or treatment of muscle atrophy or muscle damage.

The present invention discloses the application of NSUN2 in muscle injury repair. The present invention found that AAV-mediated NSUN2 overexpression can significantly increase the number of activated muscle stem cells in CTX model mice and promote muscle stem cell proliferation. NSUN2 overexpression not only increases the activation level of muscle stem cells but also enhances the self-renewal ability of muscle stem cells. Furthermore, NSUN2 overexpression also significantly increases the area of ​​muscle fibers in CTX model mice and reduces muscle atrophy weight. NSUN2 overexpression promotes the healing of muscle damage by promoting the proliferation and activation of muscle stem cells, promoting muscle fiber repair and muscle mass recovery, and thus has a therapeutic effect on this disease. Therefore, the present invention provides a new method for the treatment of muscle damage and may also open up new avenues for the treatment of other muscle-related diseases.

A lateral retractor system for forming a pathway to a patient's intervertebral disc space includes a single dilator and a retractable dual-tapered-blade assembly. The dilator may feature a narrow rectangular body for insertion at an insertion orientation parallel to the fibers of the patient's psoas muscle, at an approximate 45-degree angle to the patient's spine. The retractable dual-tapered-blade assembly consists of only two blade subassemblies, each having a blade bordered by adjustable wings, along with built-in lighting and video capabilities.The dual-tapered-blade assembly may be passed over the single dilator at the insertion orientation and rotated approximately 45-50 degrees to a final rotated orientation parallel to the intervertebral disc space before the two blade subassemblies are retracted away from one another to create the surgical pathway, while simultaneously and continuously assessing for encroachment upon one or more nerve structures within 360-degrees of the instrument. Other embodiments are also disclosed.

The utility model relates to the technical field of medical instruments, in particular to a tendon obtaining supporting device which comprises a shell, the shell is of a slender body structure with a near end and a far end, the contour of the near end is smaller than that of the far end, the near end is firstly inserted into an incision during insertion, and a notch is formed in the top of the near end. A baffle for sealing the notch is rotationally arranged on the shell, can only rotate outside the shell, and can be pushed by the collector from the interior of the shell to open the notch. In the process that the shell is inserted into the incision and moves towards the deep position of the incision, the baffle and the limiting protruding block are matched with each other, the muscle at the top of the near end is prevented from entering the notch, and the probability that the muscle is injured at the notch when the supporting device is inserted into the incision is reduced; meanwhile, when the collector collects the tendon, the notch avoids the collector, the collector abuts against the baffle, the muscle on the upper portion of the notch is pushed through the baffle, and therefore the probability that the muscle on the upper portion of the notch is injured by the collector is reduced.

The invention provides a preparation method of rice bran protein carnosine, and belongs to the technical field of food. The preparation method comprises the following steps: uniformly mixing rice bran protein and alkaline protease in water, and performing enzymolysis to obtain hydrolysate; carrying out ultrafiltration separation on the hydrolysate to obtain a C4 component; carrying out ion exchange chromatography separation on the C4 component to obtain two rice bran protein carnopotropic peptides, namely F1 and F2 respectively; the mass concentration of the rice bran protein in water is 2-4%; the addition amount of the alkaline protease in the water is 3500-4500 U / g; the molecular weight interval of ultrafiltration separation is lt; 1 KDa. The preparation method disclosed by the invention is simple in step and efficient, has high free radical scavenging capacity, and can relieve skeletal muscle cell atrophy induced by inflammation and muscle differentiation abnormity caused by inflammation so as to resist muscle injury.

An organoleptically acceptable composition containing a ketone body or a ketone body precursor including a hydroxybutyrate ester and a flavouring is provided and gives improved palatability and user adherence to the intended dose regime. The flavouring may be a bitter flavouring and the composition may further contain an adsorbent for the ketone such that on ingestion, the bitterness of the composition may be masked. The composition may be in the form of a solid, gel or liquid and provides increased blood ketone levels and may be used in therapy or in treating muscle impairment or fatigue.

To provide a muscle injury repair-promoting agent, a muscle injury-treating agent, a muscle injury repair-promoting composition and a muscle injury repair-promoting food composition each containing oleic acid, to provide an animal feed containing the muscle injury repair-promoting agent, and to provide a method for treating muscle-injured non-ruminant domestic animals and pet animals.SOLUTION: A muscle injury repair promoter containing oleic acid as an active ingredient is preferably orally ingested 230mg / day to 480mg / day, and an ingestion target may be a human, a non-ruminant livestock, or a pet.SELECTED DRAWING: Figure 2A

To provide a polypeptide and its use for promoting muscle growth and improving exercise performance.SOLUTION: The present invention discloses a polypeptide and its use for promoting muscle growth and improving exercise performance, since the polypeptide disclosed in the present invention has the activity of regulating the expression of proteins such as p-AMPK, AKT, and mTOR in the muscle growth pathway, by administering an effective amount of the polypeptide disclosed in the present invention or a composition containing the polypeptide to an individual, the muscle growth and muscle strength of the individual can be promoted, thereby achieving the effects of preventing or treating muscle damage-related diseases and improving exercise performance.SELECTED DRAWING: Figure 1

Provided herein are compositions for preventing or treating muscle conditions such as muscle damage, injury, or atrophy. In some embodiments, the compositions comprise a prostaglandin E2 (PGE2) compound and a myotoxin. In some embodiments, the muscle damage, injury, or atrophy is the result of a nerve injury, a surgical procedure, or a traumatic injury. Methods of promoting muscle regeneration and methods of increasing muscle mass are also provided herein.

The current disclosure describes use of a histone deacetylase (HDAC) inhibitor, SR-4370 and analogs thereof, for the treatment of muscle-related disorders, such as Duchenne Muscular Dystrophy. Treatments disclosed herein can provide one or more of muscle regeneration, an increase in muscle strength, the healing of a muscle injury, an increase of the homogeneity of the diameter of a muscle fiber, and a decrease in muscle necrosis.