58 results about "Muscle damage" patented technology

The utility model discloses a novel protein marker diagnostic kit for detecting the muscle injury degree, which comprises a detection kit for detecting the muscle injury degree and a dustproof cover assembled above the detection kit, the detection kit is provided with a detection port for dropping blood of a patient and a display port for displaying a diagnosis result, a reagent card for evaluating the muscle injury degree by detecting the concentration of a specific protein marker in the blood is arranged in the detection kit, and the detection end of the reagent card is located below the detection port. The display end of the reagent card is positioned below the display opening; a positioning opening for positioning the dustproof cover is formed above the detection kit, and a positioning block matched with the positioning opening is arranged in the dustproof cover. According to the utility model, the muscle injury degree of a patient can be detected by quickly reading the novel protein marker in the blood, so that an accurate diagnosis and treatment basis is provided for the treatment of the patient, the detection time of the patient is shortened, and the treatment cost is reduced.

The invention discloses preparation and application of modified hydrolyzed whey protein peptide for promoting muscle cell protein synthesis, and belongs to the field of sports nutrition and health. The preparation method comprises the following steps: carrying out enzymolysis on whey protein powder, carrying out lactic acid modification, and carrying out spray drying to obtain the modified hydrolyzed whey protein peptide. The modified hydrolyzed whey protein peptide is applied to products such as functional foods, medicines and health-care products, effectively improves the glutamine level of a human body, promotes synthesis of muscle cell protein, improves muscle endurance, repairs muscle injury after exercise and promotes recovery after exercise, and is a high-quality nutrition supplement source for exercise and fitness people.

The present invention provides a polypeptide and a use thereof for promoting muscle hyperplasia and improving athletic performance, since the polypeptide provided by the present invention has activity for regulating the performance of proteins such as p-AMPK, AKT, mTOR and the like in a muscle hyperplasia pathway, by administering an effective amount of the polypeptide provided by the present invention or a composition containing the polypeptide to an individual, the activity of the polypeptide is improved, and the activity of the polypeptide is improved. The muscle hyperplasia and the muscle strength of the individual can be promoted, so that the effects of preventing or treating diseases related to muscle damage and improving the exercise performance can be achieved.

The present invention relates to novel use of a cathepsin L inhibitor Z-Phe-Tyr-CHO (C26H26N2O5), wherein the cathepsin L inhibitor Z-Phe-Tyr-CHO inhibits cancer progression and cachexia and muscle damage that are caused by cancer, and thus can be effectively used for preventing, ameliorating or treating cachexia and muscle loss, while having anticancer activity.

Treatments of neuromuscular conditions, activity-induced muscle damage, metabolic myopathies, and movement disorders with compositions comprising 2-((5-fluoropyridin-3-yl)methyl)-6-(2-(2,2,2-trifluoroethoxy)pyrimidin-5-yl)pyridazin-3(2H)-one (Compound 1), as well as solid forms of Compound 1, and pharmaceutical compositions of Compound 1, and kits of Compound 1, are described herein.

The present disclosure provides a plug-and-play functional electrical stimulation system and method. The system includes a main controller connected to at least two series-connected electrical stimulators via a bus; the main controller is configured to receive and execute motion task files, and coordinate the output logic timing of the multi-channel electrical stimulators via the bus; the motion task files are composed of control parameters set based on the patient's degree of muscle damage; the control parameters include: the number of different states of a customizable state machine corresponding to the functional training task, the trigger conditions required for state transitions, and the functional electrical stimulation output parameters for each state.

The present invention relates to a composition for strengthening muscle strength or preventing, ameliorating or treating muscle loss, comprising a Lilium lancifolium extract as an active ingredient. Specifically, when C2C12 cells were pre-treated with a Lilium lancifolium extract, and then treated with H2O2, dexamethasone, or TNF-α, muscle damage was alleviated and muscle loss was inhibited, and the muscle mass and grip strength decreased by dexamethasone administration in a muscle atrophy mouse model were increased upon administration of the Lilium lancifolium extract. Therefore, the composition can be effectively used as a health functional food, medicine or feed additive for strengthening muscle strength or preventing, ameliorating or treating muscle loss.

The invention discloses application of poplatin in preparation of a medicine for treating muscle injury. The research finds that the poplatin has the effects of promoting mouse myoblast differentiation and promoting mouse muscle regeneration under various pathological conditions such as acute injury, obesity, diabetes mellitus and hereditary dystrophy.

1. Name of the product in this design: Walking Assistive Rehabilitation Device. 2. Purpose of this design: It is used in a walking rehabilitation device, which is a wearable functional neurostimulation instrument used for lower limb rehabilitation and recovery of muscles damaged by motor neurons. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1. 5. Other circumstances requiring explanation: The human lower limb model is a supporting element and is not part of the content for which protection is sought.

The present application relates to the technical field of waist posture recognition, in particular to a human waist posture recognition and force state evaluation method and system based on an inertial sensor, comprising the following steps: collecting original motion data in real time through an inertial measurement unit worn on the L4-L5 segment of the human waist, wherein the original motion data comprises three-axis acceleration data and three-axis angular velocity data; using a Kalman filtering algorithm to filter noise and calibrate the coordinate system of the original motion data, to obtain standard waist motion characteristic data. The present application realizes accurate and continuous recognition of the waist posture in daily scenarios, completes quantitative evaluation of the force on the lumbar vertebrae and prediction of the damage risk, has high detection accuracy and strong scene adaptability, and is portable and easy to use, which can provide a comprehensive basis for the user to manage the health of the waist and effectively prevent lumbar muscle damage.

The present disclosure provides a composition for preventing or minimizing motor-induced muscle injury (EIMD) in a subject in need thereof, comprising Lactobacillus paracasei PS23 and a carrier thereof. The present disclosure also provides a method for preventing or minimizing muscle injury caused by movement by administering the composition.

The application discloses a planning navigation system for lower limb fracture reduction surgery. The system comprises a medical image processing module for segmenting a proximal bone and a distal bone from a lower limb fracture image and reconstructing a three-dimensional surface model of a broken bone; a surgery planning module for point cloud sampling on the three-dimensional surface model of the broken bone to obtain a corresponding point cloud model; extracting a fracture section from the point cloud model; obtaining a coordinate transformation matrix of an initial position of the distal bone and a target position of the distal bone after reduction by point cloud registration on the fracture section; performing fracture reduction path planning based on the coordinate transformation matrix, the fracture reduction path planning being used for guiding translation and rotation of the distal bone to obtain the target position of the distal bone under the condition that the proximal bone is fixed; and a navigation module for visually displaying a surgery process based on the fracture reduction path planning. The application can improve reduction accuracy, reduce reduction force and reduce soft tissue damage such as muscle damage at a fracture of a patient.

In a first aspect, the present invention is related to lactic acid or a pharmaceutically acceptable salt thereof for use in the prevention and / or treatment of a musculoskeletal injury in a subject. In a second aspect, the present invention is related to an injectable composition for use in the treatment of a musculoskeletal injury in a subject characterized in that it comprises lactic acid or a pharmaceutically acceptable salt thereof and a suitable solvent. In a preferred embodiment, the musculoskeletal injury is selected from the group consisting of tendon injury, joint injury, cartilage injury and muscle injury.

Disclosed are: a composition containing a human urine concentrate; a method for producing the same; a cell population; a human urine collection system; a muscle differentiation promoter; and a muscle damage therapeutic agent. The muscle differentiation promoter and the muscle damage therapeutic agent contain a nucleic acid that promotes the expression of serglycin or serglycin core protein.

The invention discloses a lactobacillus rhamnosus CQFP202457 and application of the lactobacillus rhamnosus CQFP202457 and ellagic acid in relieving exercise fatigue, and belongs to the technical field of microorganisms. The preservation number of the lactobacillus rhamnosus CQFP202457 is CGMCC (China General Microbiological Culture Collection Center) No. 29784. The composition provided by the invention contains ellagic acid and lactobacillus rhamnosus CQFP202457, and can significantly prolong the exercise exhaustion time, reduce the content of fatigue-related metabolites in serum, improve the total antioxidant ability of serum, liver and skeletal muscle and the antioxidant enzyme gene expression level, and improve the exercise-induced liver and skeletal muscle tissue damage. The strain and the composition thereof provided by the invention can be used as exercise synbiotics for preparing products for relieving exercise-induced fatigue, improving exercise performance, reducing exercise-induced oxidative stress or relieving exercise-induced muscle injury.

The invention discloses a medicine for treating arthritis, rheumatic bone pain and acute muscle injury and a preparation method thereof. The medicine is prepared from the following components in parts by weight: 5-10 parts of agilawood, 1-10 parts of resina liquidamberis, 1-8 parts of pseudo-ginseng, 1-8 parts of garden balsam stem, 5-15 parts of fructus cnidii, 5-10 parts of cicada slough, 10-20 parts of frankincense, 10-20 parts of mentholum and 5-15 parts of resina draconis. The traditional Chinese medicinal materials adopted in the prescription do not cause drug resistance and have no side effect.

The present application relates to a kind of cervical vertebra intelligent rehabilitation appliance based on electromyogram-pressure feedback, comprising: support structure unit, electromyogram signal acquisition unit, pressure signal acquisition unit, pneumatic traction unit and control unit;Support structure unit includes mandibular support, back neck support, inner lining and adjustable fixing band, mandibular support is connected with back neck support, inner lining is set to the inner side of mandibular support and back neck support, one end of adjustable fixing band is connected with back neck support;Electromyogram signal acquisition unit is set to the inner lining of back neck support inner side and the site of user neck contact, for gathering the electromyogram signal of the neck of wearer;Pressure signal acquisition unit is used to gather the pressure distribution signal in the process of wearing;Pneumatic traction unit is used to apply adjustable traction to user neck;Control unit is connected with electromyogram signal acquisition unit, pressure signal acquisition unit, pneumatic traction unit respectively.The present application realizes personalized, adaptive intelligent rehabilitation, and can effectively avoid excessive traction and muscle damage.

The invention belongs to the field of food, and particularly relates to two sea cucumber peptides with activity of enhancing exercise ability as well as a preparation method and application of the sea cucumber peptides. Meanwhile, the sea cucumber peptide sequences with the exercise enhancing ability are obtained through screening by adopting peptidomics analysis and molecular docking methods, and comprise FPGGY and PGSPF. Experiments prove that the two sea cucumber peptides can be used for regulating energy metabolism (improving hepatic glycogen, muscle glycogen and ATP (adenosine triphosphate) reserve and maintaining serum glucose level), relieving muscle injury (reducing serum creatine kinase, lactic acid and uric acid content), enhancing antioxidant ability (improving SOD (superoxide dismutase) activity) and promoting skeletal muscle development (improving flatfish muscle and tibia anterior muscle visceral coefficient); the exhaustive swimming time of mice suffering from exercise fatigue is obviously prolonged, the exercise tolerance is effectively enhanced, and the exercise fatigue is relieved. The invention provides a basis for development of sea cucumber resources in the field of sports nutrition, and has important social and economic values.

1. The name of this design product: sports protective pad. 2. Purpose of this product design: to reduce muscle damage caused by exercise. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The invention relates to the technical field of microRNA (Ribonucleic Acid) medicines, in particular to an application of hsa-miR-16-5p in preparation of a medicine for treating muscle injury. The invention discloses that the hsa-miR-16-5p has the function of inhibiting the expression of the Tgfbr3 gene, and the repair of muscle injury can be realized; the function of inhibiting fibroblast / adipogenic progenitor cell adipodifferentiation is also achieved, then muscle fat infiltration and muscle fat degeneration are inhibited, and the effect of further promoting muscle injury repair is achieved. As a microRNA drug, the microRNA drug can be used in muscle injury repair, muscle fat infiltration or muscle fatty degeneration can be effectively inhibited, and meanwhile, promotion of muscle injury repair is realized by regulating and controlling a signal channel in which Tgfbr3 participates. According to the technical scheme, the technical problem that RNA drugs capable of effectively treating muscle injuries are lacked in the prior art can be solved, and the RNA drugs have ideal application and popularization prospects.

The invention relates to application of liquiritigenin in preparation of a medicine for relieving muscle injury caused by exercise fatigue, in particular to application of liquiritigenin in preparation of a medicine for relieving muscle injury caused by exercise fatigue, specifically, liquiritigenin inhibits expression of Caspase 3 by up-regulating the proportion of PI3K / Akt protein so as to inhibit muscle cell apoptosis; meanwhile, liquiritigenin reduces expression of inflammatory factors by up-regulating the proportion of PI3K / Akt protein, so that muscle injury caused by exercise fatigue is relieved; specifically, the liquiritigenin can further prolong the exhaustive exercise time of the mouse, enhance the endurance and improve the exercise ability of the mouse on the basis of improving the endurance of the mouse.

A novel protein biomarker for determining the severity of muscle injury, and an obtaining method therefor and a use thereof. The novel protein biomarker comprises at least one of thirty-six proteins. The obtaining method for the novel protein biomarker specifically comprises: establishing experimental rat models with different severities of muscle injury; collecting the plasma of rats in different groups for proteomic detection and performing differential comparison to obtain candidate protein biomarkers; and using the blood of clinical patients with different severities of muscle injury to validate the candidate protein biomarkers and determining diagnostic reference ranges of the candidate protein biomarkers. The use of the proteomic biomarker is: using the novel protein biomarker to make a kit or using the novel protein biomarker for detection to determine the severity of muscle injury by means of mass spectrometry or any other methods. A new basis is provided for the determination of the severity of muscle injury, facilitating quantification of the severity of muscle injury.

This invention discloses the application of ZAK inhibitors in the preparation of drugs for treating EV71 virus infection, relating to the biomedical field. The ZAK inhibitors exert their effects by inhibiting the ZAK-p38 MAPK signaling pathway and by inhibiting the ZAKα-mediated ribosomal toxicity stress response (RSR). The ZAK inhibitor is nilotinib or a pharmaceutically acceptable salt thereof. Cellular and animal experiments of this invention demonstrate that EV71 infection activates the ZAKα-mediated p38 MAPK pathway (RSR), promoting viral replication and leading to multi-organ damage. ZAK inhibitors (such as nilotinib) can inhibit this pathway, reduce the expression of the viral protein VP1, and improve infection-induced renal function damage, metabolic disorders, and muscle damage. Therefore, ZAK inhibitors can be used to prepare anti-EV71 drugs.

The utility model discloses a pair of close-fitting sport pants with knee-protecting and leg-repairing functions, which comprises a sport pants body forming a side splicing type pants body structure, a knee-protecting structure for protecting knees and a leg-repairing structure for modifying shanks, the knee-protecting structure is arranged in the middle of one side of the sport pants body, and the leg-repairing structure is arranged in the middle of the other side of the sport pants body. The sports pants have the advantages that the sports pants body is designed in a side splicing curve mode, the thighs of a user can be lengthened in the visual sense aspect, the sports pants are dynamic and fashionable in vision, the kneecap structures are arranged to be matched with the leg repairing structures, the structure is simple, and the sports pants are convenient to use. The kneecap structure and the leg repairing structure can protect the knees of a user and modify and protect the shanks of the user at the same time, muscle injury or deformation of the shanks of the user in the exercising process is avoided, and the kneecap structure and the leg repairing structure both adopt a built-in dispensing technology, so that the kneecap structure and the leg repairing structure are attractive, free of stitch exposure, low in production difficulty, low in processing cost and convenient to popularize and use.

The application discloses an enzyme response type composite scaffold for muscle injury repair and a preparation method thereof, and belongs to the technical field of polymer scaffolds. The application takes a decellularized matrix as the scaffold, and combines with MMP-2 responsive nanomicelles loaded with lipoxin LxA4 and SDF-1 alpha, so that precise and long-acting release of drugs at the injury site is realized. Through the synergistic effect of LxA4 and SDF-1 alpha, the inflammatory reaction at the injury site is reduced, and the recruitment and migration of endogenous stem cells are enhanced, so that the repair cycle is shortened. In addition, the composite scaffold of the application also ensures the synchronism of the degradation speed of the scaffold and the tissue regeneration speed, and ensures the effective support of the scaffold in the tissue healing process. The application provides a safer and more effective solution for the treatment of muscle tissue defects, and promotes the application of tissue engineering in clinical practice.

A lateral retractor system for forming a pathway to a patient's intervertebral disc space includes a single dilator and a retractable dual-tapered-blade assembly. The dilator may feature a narrow rectangular body for insertion at an insertion orientation parallel to the fibers of the patient's psoas muscle, at an approximate 45-degree angle to the patient's spine. The retractable dual-tapered-blade assembly consists of only two blade subassemblies, each having a blade bordered by adjustable wings, along with built-in lighting and video capabilities. The dual-tapered-blade assembly may be passed over the single dilator at the insertion orientation and rotated approximately 45-50 degrees to a final rotated orientation parallel to the intervertebral disc space before the two blade subassemblies are retracted away from one another to create the surgical pathway, while simultaneously and continuously assessing for encroachment upon one or more nerve structures within 360-degrees of the instrument. Other embodiments are also disclosed.

The present invention relates to a pharmaceutical composition for preventing or treating muscle atrophy or muscle damage or a composition for promoting muscle differentiation, each composition comprising, as an active ingredient, CU-rich RNA derived from a ChRO1 gene, which is a long non-coding RNA, or an isoform thereof. The composition has the effects of maintaining the chromocenter structure of myocytes, reducing the expression of proteolytic factors, and increasing the expression of muscle activity-related factors, and thus can be more safely and effectively used for the prevention or treatment of muscle atrophy or muscle damage.

The present invention discloses the application of NSUN2 in muscle injury repair. The present invention found that AAV-mediated NSUN2 overexpression can significantly increase the number of activated muscle stem cells in CTX model mice and promote muscle stem cell proliferation. NSUN2 overexpression not only increases the activation level of muscle stem cells but also enhances the self-renewal ability of muscle stem cells. Furthermore, NSUN2 overexpression also significantly increases the area of ​​muscle fibers in CTX model mice and reduces muscle atrophy weight. NSUN2 overexpression promotes the healing of muscle damage by promoting the proliferation and activation of muscle stem cells, promoting muscle fiber repair and muscle mass recovery, and thus has a therapeutic effect on this disease. Therefore, the present invention provides a new method for the treatment of muscle damage and may also open up new avenues for the treatment of other muscle-related diseases.

A lateral retractor system for forming a pathway to a patient's intervertebral disc space includes a single dilator and a retractable dual-tapered-blade assembly. The dilator may feature a narrow rectangular body for insertion at an insertion orientation parallel to the fibers of the patient's psoas muscle, at an approximate 45-degree angle to the patient's spine. The retractable dual-tapered-blade assembly consists of only two blade subassemblies, each having a blade bordered by adjustable wings, along with built-in lighting and video capabilities.The dual-tapered-blade assembly may be passed over the single dilator at the insertion orientation and rotated approximately 45-50 degrees to a final rotated orientation parallel to the intervertebral disc space before the two blade subassemblies are retracted away from one another to create the surgical pathway, while simultaneously and continuously assessing for encroachment upon one or more nerve structures within 360-degrees of the instrument. Other embodiments are also disclosed.

The present invention provides an application of botulinum toxin type A in the preparation of a drug for reducing local muscle damage to limbs after bites by Agkistrodon acutus, and relates to the technical field of snake venom bite drugs. This application confirms the application effect of botulinum toxin type A in the treatment of local muscle damage to limbs after bites by Agkistrodon acutus through research, and on this basis explores the research and development and clinical transformation of botulinum toxin type A drugs. Specifically, this application is obtained by applying a botulinum toxin type A preparation to the biting muscle tissue of an animal model of Agkistrodon acutus bite for four weeks. Compared with the animal model of Agkistrodon acutus bite, the botulinum toxin type A can effectively reduce the circumference of the animal limbs and the level of muscle damage markers in the serum after treatment, and in the analysis of the degree of pathological damage, the degree of apoptosis of muscle tissue cells, and the degree of inflammatory damage to muscle tissue, the effect improvement is statistically significant.