The invention provides a medical balloon and a preparation method of the medical balloon. The medical balloon comprises an inner layer and an outer layer, wherein the outer layer at least partially covers the inner layer, the inner layer has a first friction coefficient, the outer layer has a second friction coefficient, and the second friction coefficient is greater than the first friction coefficient. For the medical balloon, the falling problem of a stent is solved by changing the physical attribute of the surface of the balloon, the passing outer diameter of the balloon is not increased, processing and forming are also convenient, meanwhile, the frictional resistance suffered by the stent is relatively high, falling seldom occurs, and the breakdown resistance is good. Particularly, theinner layer of the medical balloon is made of a first material, the outer layer is made of a second material, the hardness of the second material is smaller than the hardness of the first material, the lower the hardness is, the higher the friction coefficient is, therefore, the outer layer formed by the material with relatively low hardness is beneficial for improving the frictional resistance between the balloon and the stent, thus the falling problem of the stent can be avoided, in addition, the structure is simple, and the processing is convenient.