Method of using beta-hydroxy-beta-methylbutyrate for the treatment of cancer
a technology of beta-hydroxybeta-methylbutyrate and cancer, which is applied in the direction of drug compositions, immunological disorders, metabolism disorders, etc., can solve the problems of no reports on the effect of hmb in modulating type 1 and type 2 cytokine production, and no disclosure of the use of hmb to affect cytokine imbalance, so as to increase the relative levels or production of type 1
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[0033]We now turn to the first embodiment of the present invention. Conditions included within the first embodiment of the present invention include allergy, asthma, solid tumors, cancers including advanced ovarian cancer and melanoma, kidney tumors, and stress, including psychological stress after a burn injury, surgical stress and pre-surgical stress. The methods are especially useful in treating allergy, asthma, or both.
[0034]With respect to allergy and asthma, elevated levels of IL-4, a type 2 cytokine, have been associated with the promotion or aggravation of allergy and asthma. Therefore, the first embodiment of the present invention, which is directed to a method of treating an individual having a condition comprising administering to the individual an amount of HMB effective to modulate or otherwise cause an increase in type 1 cytokine levels without a corresponding increase in type 2 cytokine levels, can treat individuals suffering from the symptoms of allergy and asthma be...
examples
[0073]The following examples illustrate specific embodiments of the methods of the present invention, including some nutritional and other product forms suitable for use therein. The examples are given solely for the purpose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention.
[0074]The nutritional compositions described below are representative examples of nutritional products suitable for use in the methods of the present invention. Each may be prepared by conventional methods of making nutritional emulsion, some examples of which are described in U.S. Patent Publication 20050215640A1, which description is incorporated herein by reference.
Liquid Nutritional #1 (Weight Gain Formula)
[0075]
AmtAmtIngredient(kg)Ingredient(kg)Water316Vitamin DEK premix0.04Ultratrace / trace min.0.06Carrageenan0.03premixPotassium chloride0.072Soy lecithin0.6Na citrate2.89Sodi...
working example i
[0080]A 28-year old individual who suffers from seasonal allergies in the spring is given 0.25-1 g of HMB (Nutritional Liquid #5) four times a week for a year. The symptoms of seasonal allergies are reduced the following spring.
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