Method and apparatus for analyzing body fluids
a body fluid and method technology, applied in water supply installation, instruments, transportation and packaging, etc., can solve the problems of difficult to accurately discriminate between and quantify rbcs and wbcs, and achieve the effect of improving the accuracy of auto-particle recognition and analysis
Active Publication Date: 2010-10-26
IRIS INT
View PDF13 Cites 9 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Benefits of technology
The patent describes a method and system for improving the accuracy of identifying and analyzing particles in a specimen. This is achieved by treating a portion of the specimen to alter a subgroup of particles, and then measuring the number of particles in both the treated and untreated portions of the specimen. By subtracting the number of particles in the treated portion from the number of particles in the untreated portion, a "difference count" is obtained, which indicates which particles were altered by the treatment. This method and system can help to more accurately identify and analyze particles in a specimen, which can be useful in various fields such as medical diagnostics or environmental monitoring.
Problems solved by technology
The problem is that for some APR systems, it can be difficult to accurately discriminate between and quantify RBCs and WBCs.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0014]The system and method described herein enhances classification accuracy for particles that can be difficult to differentiate between, especially in automated particle analyzer systems. The enhanced system and method can be employed using Auto-Particle Recognition (APR) techniques employing a particle analyzer having an imaging system 2 and a processor 4, as schematically illustrated in FIG. 1.
[0015]Imaging System and Processor
[0016]Imaging system 2 is used to produce images of fields of view of a sample containing the particles of interest. Imaging system 2 is preferably a well known flow microscope, such as those described in U.S. Pat. Nos. 4,338,024, 4,393,466, 4,538,299 and 4,612,614, which are all hereby incorporated herein by reference. Such a system includes a flow cell 10, a microscope 12, and a camera 14, as shown in FIG. 1. Specimen fluid containing the particles of interest is passed through an examination area of the flow cell 10, whereby images of the particles are...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
| Property | Measurement | Unit |
|---|---|---|
| imaging | aaaaa | aaaaa |
| color | aaaaa | aaaaa |
| size | aaaaa | aaaaa |
Login to View More
Abstract
A system and method for analyzing a specimen containing particles that can be difficult to differentiate. The system and method determines a first collective count of a selected group of particles in the specimen, treats at least a portion of the specimen to alter a subgroup of the selected group of particles, determines a second collective count of any of the selected group of particles in the treated portion of the specimen, and subtracts the second collective count from the first collective count to determine a differentiation count for the subgroup of particles altered by the treating of the specimen. The system and method is described with the example of determining concentrations of red and white blood cells in a specimen (e.g. spinal fluid), using auto-particle recognition techniques, without attempting to distinguish and count red versus white blood cells co-existing in the same specimen portion.
Description
RELATED APPLICATION[0001]This application claims the benefit of U.S. Provisional Application Ser. No. 60 / 653,752 filed on Feb. 17, 2005, the content of which is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]The present invention relates generally to methods and systems for analyzing particles in a sample and more particularly for identifying and quantifying the particles in the sample.BACKGROUND OF THE INVENTION[0003]Methods and apparatuses for processing images of particles in a fluid sample are well known. For example, U.S. Pat. Nos. 4,338,024, 4,393,466, 4,667,335 and 4,612,614 describe apparatuses for analyzing biological particles. Such biological particle analysis apparatuses can automatically—i.e., without human intervention—determine characteristics such as color, size, and brightness of particles in a fluid sample. Moreover, based on the determined characteristics, these apparatuses can categorize each particle into one of many classes and cal...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & AuthorityPatents(United States)
IPC IPC(8): G06K9/46C12Q1/00E03B1/00G06K9/00
CPCG01N15/1459G01N15/1463G01N2015/0069G01N2015/0073G01N2015/008G01N2015/1486Y10T137/0352G01N2015/011G01N2015/012G01N2015/016G01N15/1433
InventorTURNER, RICHARD H.CHAPOULAUD, ERIC
OwnerIRIS INT