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315 results about "Particle analysis" patented technology
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Particle analysis is a general description of some property we would like to find out about a particle or series of particles. Particles generally refer to solid material that is small in size that requires different instrumentation to characterize different properties.
Microfluidic particle-analysis systems
ActiveUS7312085B2Bioreactor/fermenter combinationsBiological substance pretreatmentsReady to useMixed group
The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and / or detection of particles, such as cells and / or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and / or analysis of particles, such as cells, viruses, organelles, beads, and / or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement / positioning, retention / localization, treatment, measurement, release, and / or output of particles. Furthermore, these mechanisms may be combined in any suitable order and / or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and / or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and / or homogeneous particle sets, among others, in series and / or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and / or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and / or may be more informative than comparable macrofluidic assays.
Owner:STANDARD BIOTOOLS INC
Microfluidic particle-analysis systems
InactiveUS20100120077A1Bioreactor/fermenter combinationsBiological substance pretreatmentsAssayMixed group
The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and / or detection of particles, such as cells and / or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and / or analysis of particles, such as cells, viruses, organelles, beads, and / or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement / positioning, retention / localization, treatment, measurement, release, and / or output of particles. Furthermore, these mechanisms may be combined in any suitable order and / or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and / or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and / or homogeneous particle sets, among others, in series and / or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and / or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and / or may be more informative than comparable macrofluidic assays.
Owner:STANDARD BIOTOOLS INC
Multiple Flow Channel Particle Analysis System
ActiveUS20120307244A1Investigating moving fluids/granular solidsScattering properties measurementsComputational physicsParticle analysis
A microfluidic multiple channel particle analysis system (1) which allows particles (2) from a plurality of particle sources (3) to be independently simultaneously entrained in a corresponding plurality of fluid streams (4) for analysis and sorting into particle subpopulations (5) based upon one or more particle characteristics (6).
Owner:CYTONOMEST
Microfluidic particle-analysis systems
InactiveUS7452726B2Bioreactor/fermenter combinationsBiological substance pretreatmentsMixed groupScale down
The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and / or detection of particles, such as cells and / or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and / or analysis of particles, such as cells, viruses, organelles, beads, and / or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement / positioning, retention / localization, treatment, measurement, release, and / or output of particles. Furthermore, these mechanisms may be combined in any suitable order and / or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and / or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and / or homogeneous particle sets, among others, in series and / or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and / or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and / or may be more informative than comparable macrofluidic assays.
Owner:FLUIDIGM CORP
Particle analyzing system and methodology
InactiveUS7338168B2Improve performanceEffectively scaledTelevision system detailsGeometric image transformationImage transferDisplay device
An imaging system, methodology, and various applications are provided to facilitate optical imaging performance. The system contains a sensor having one or more receptors and an image transfer medium to scale the sensor and receptors in accordance with resolvable characteristics of the medium, and as defined with certain ratios. A computer, memory, and / or display associated with the sensor provides storage and / or display of information relating to output from the receptors to produce and / or process an image, wherein a plurality of illumination sources can also be utilized in conjunction with the image transfer medium. The image transfer medium can be configured as a k-space filter that correlates receptor size to a diffraction-limited spot associated with the image transfer medium, wherein the receptor size can be unit-mapped within a certain ratio to the size of the diffraction-limited spot.
Owner:PIXEL MATCHED HLDG
Microfluidic particle-analysis systems
InactiveUS8658418B2Bioreactor/fermenter combinationsBiological substance pretreatmentsAssayMixed group
Owner:STANDARD BIOTOOLS INC
Flowcell systems and methods for particle analysis in blood samples
ActiveUS20140273067A1Decrease in flowpath sizeKeep activeBioreactor/fermenter combinationsImage enhancementParticle imagingImaging analysis
The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. In some aspects the system comprises an analyzer which may be a visual analyzer. In one aspect, this disclosure relates to a particle imaging system comprising a flowcell through which a sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis of samples. Other compositions, methods and features of this disclosure are disclosed herein.
Owner:IRIS INT
Alternative detector configuration and mode of operation of a time delay integration particle analyzer
InactiveUS6947128B2Spectrum generation using refracting elementsAcquiring/recognising microscopic objectsOperation mode3d space
Light from an object moving through an imaging system is collected, dispersed, and imaged onto a time delay integration (TDI) detector that is inclined relative to an axis of motion of the object, producing a pixilated output signal. In one embodiment, the movement of the image object over the TDI detector is asynchronous with the movement of the output signal producing an output signal that is a composite of the image of the object at varying focal point along the focal plane. In another embodiment, light from the object is periodically incident on the inclined TDI detector, producing a plurality of spaced apart images and corresponding output signals that propagate across the TDI detector. The inclined plane enables images of FISH probes or other components within an object to be produced at different focal points, so that the 3D spatial relationship between the FISH probes or components can be resolved.
Owner:AMNIS CORP
Stabilized Optical System for Flow Cytometry
A particle analyzer that includes optical waveguides, a support, and a detector. The optical waveguides direct spatially separated beams from a source of radiation to produce measuring beams in a sample flow measuring area. The support maintains each of the optical waveguides in a fixed relative position with respect to each other and maintains the positioning of the measuring beams within the measuring area. The detector senses light produced from the measuring beams interacting with a particle flowing through the measuring area. At least one of the support and the detector can be coupled to the core stream sample system. The coupling can use an optical waveguide device configured to convey optical radiation arising from sample interaction to the detector. In another example, a particle analyzer comprises an optical system configured to be fixedly coupled to a sample system and configured to direct beams along independent beam paths from a source of radiation to produce measuring beam spots in a sample flow measuring area of the sample system and a detection system configured to sense radiation delivered from the sample flow measuring area.
Owner:BECKMAN COULTER INC
Autofocus systems and methods for particle analysis in blood samples
ActiveUS20140273068A1Quality improvementHigh level of discriminationBioreactor/fermenter combinationsImage enhancementStream flowImaging data
Particles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. A contrast pattern for autofocusing is provided on the flowcell, for example at an edge of a rear illumination opening. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and / or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Blood cell images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.
Owner:IRIS INT
Sheath fluid systems and methods for particle analysis in blood samples
ActiveUS20140315238A1Increase contrastImproves particle/cell alignmentBioreactor/fermenter combinationsBiological substance pretreatmentsAqueous solutionFluid system
Aspects and embodiments of the instant disclosure provide a particle and / or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and / or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and / or a buffer.
Owner:IRIS INT
Non-Linear Histogram Segmentation for Particle Analysis
ActiveUS20100111400A1Increase differentiationImprove segmentationImage analysisCharacter and pattern recognitionHistogramContour line
Systems and methods for non-linear histogram segmentation for particle analysis are provided. In one embodiment, a method for analyzing particles comprises creating an initial two-dimensional histogram based on two selected parameters of the particles, filtering the initial two-dimensional histogram to generate a filtered two-dimensional image, detecting a plurality of seed populations in the filtered two-dimensional image, generating one or more linear contour lines, each having a plurality of contour points, to separate the detected seed populations, and adjusting the contour points in at least one of the linear contour lines to separate the detected seed populations.
Owner:BECKMAN COULTER INC
Forward-scattering signal inspection device and method, cell or particle analyzer
ActiveCN101498646ALow costKeep the advantage of miniaturizationIndividual particle analysisBiological testingForward scatterFlow cell
The invention discloses a forward scattering optical signal detecting device used by a flow cell analyzer or a particle analyzer, a forward scattering optical signal detecting method and a cell or particle analyzer provided with the device. The forward scattering optical signal detecting device comprises a detecting unit and a collecting unit, wherein the detecting unit is provided with a plurality of subsidiary detecting units arranged in a one-dimensional position and used for detecting the forward scattering optical signals; the collecting unit used for collecting forward scattering optical signals and focusing the forward scattering optical signals on the detecting unit; and the optical signals detected by the subsidiary detecting units in different positions or intervals are used as the optical signals with different scattering angles. The invention can reduce the system cost and keep the miniaturized advantage, is easy to debug and can feely select the collected optical signals with different scattering angles so as to more precisely distinguish all subgroups in cells or particles to be detected.
Owner:SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
System and method for monitoring birefringent particles in a fluid
ActiveUS20120127298A1Improve accuracyHigh sensitivityMaterial analysis by optical meansColor television detailsCross polarizationImage system
An imaging system with an imaging mechanism which includes polarization analyzers, which may be crossed polarization analyzers, positioned to provide birefringence images of particles in the fluid passing through the flow chamber. Captured images are of high resolution and may be used in comparison to known images of a library of images. The system and related method enhance the accuracy and sensitivity of particle monitoring by utilizing birefringence imaging combined with particle analysis and the detection of each particle's characteristic features, such as crystalline features. The system includes a scatter detector used to trigger backlighting of the flow chamber and capture images of particles therein.
Owner:YOKOGAWA FLUID IMAGING TECH INC
Particle analyzer of sheath-flow impedance method
ActiveCN101173887AGuaranteed validityImprove the isolation effectIndividual particle analysisMaterial impedanceLiquid wasteEngineering
The invention puts forward a sheath flow impedance particle analyzer, comprising a counting cell, a counting circuit, a latter sheath partition cell and a liquid waste partition cell; wherein, the counting cell comprises a former cell and a latter cell; the former cell comprises a particle suspension liquid inlet and a former sheath liquid inlet; the latter cell comprises a latter sheath liquid inlet and a liquid waste outlet; a hole is arranged between the former cell and the latter cell which are connected with the counting circuit through electrode; the latter sheath liquid stored in the latter sheath partition cell can automatically and continuously flow into the latter cell under the gravitation and the internal negative pressure in the latter cell; the latter sheath partition cell can make the internal liquid passageway, which connects the inlet and the outlet of the latter sheath partition cell, insulated by the air; the liquid waste partition cell can make the internal liquid passageway insulated, which connects the inlet and the outlet of the liquid waste partition cell. The invention has the advantages of preventing the reflowing of the sample liquid in the process of detecting, reducing the signal noise effectively, increasing the detecting sensitivity of the particle and avoiding the electromagnet noise introduced to the counting cell from the latter sheath partition cell or the liquid waste partition cell.
Owner:SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD +1
Method of monitoring macrostickies in a recycling and paper or tissue making process involving recycled pulp
ActiveUS20120258547A1Maximize processing efficiencyReduce quality problemsCellulosic pulp after-treatmentWaste product additionImaging analysisFluorescence
A challenge in using recycled material in the papermaking process is the presence of hydrophobic organics with adhesive properties commonly known as “stickies.” Hydrophobic agglomerates can result in spots or defects in the final paper product or deposit on papermaking equipment resulting in poor runnability and downtime. Technologies for monitoring and controlling microstickies exist. However, a need exists for a technique to rapidly determine the size and content of macrostickies (diameter>100 microns) in recycled pulp process streams. The present invention is a device and method to perform real-time macrostickies and / or any visible hydrophobic particle analysis in an aqueous medium. Using the present invention, furnish quality can be monitored and treatment performance can be monitored and controlled. The technique is based on fluorescence image analysis to identify and count sticky particles as well as measure their size.
Owner:ECOLAB USA INC
Method and device for particle analysis using thermophoresis
ActiveUS20110084218A1High initial setup costsNanoparticle analysisPhotometryTemperature controlElectricity
Owner:NANOTEMPER TECH GMBH
Particle measurement device and measurement method thereof
The invention provides a particle measurement device and a particle measurement method, and belongs to the technical field of particle measurement. The device comprises a body for supporting, a charge adapter for performing charge adapting operation on particles to be measured, a charge collector for supplying charges to the charge adapter, a charged particle receiver for collecting charge quantity carried by the charged particles, a charge leading-out assembly for leading out the received charges, a charge measurement assembly for measuring the charge quantity, and a particle analysis assembly for making the measured charges correspond to the particle condition. The particle measurement method comprises the following steps of: charging the particles, collecting the charged particles carrying charges, leading out the charges carried by the charged particles, measuring the led-out charge quantity carried by the charged particles, and analyzing the condition of the particles according to the measured charge quantity. Compared with the prior art, the device and the method can identify the number and granularity of the particles more effectively.
Owner:上海杰远环保科技有限公司
Particle analyzing apparatus and particle imaging method
A particle analyzing apparatus, comprising: a flow cell which forms a specimen flow including particles; first and second light sources; an irradiation optical system which applies lights emitted from the first and second light sources so that the lights are applied to the specimen flow; a detector which detects forward scattered light, the forward scattered light being emitted from the first light and scattered by the particle in the specimen flow, and generates a signal according to the detected scattered light; a light blocking member disposed between the flow cell and the detector; a controller which obtains characteristic parameters of the particle based on the signal from the detector; and an imaging device which captures an image of the particle in the specimen flow using the light from the second light source is disclosed. Particle imaging method is also disclosed.
Owner:SYSMEX CORP
Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples
ActiveUS20140329265A1Efficiently provideBioreactor/fermenter combinationsBiological substance pretreatmentsUrine sampleImaging data
The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. A particle imaging system or analyzer can include a flowcell through which a urine sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis. A contrast pattern for autofocusing is provided on the flowcell. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and / or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Cell or particle images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.
Owner:IRIS INT
Particle analysis assay for biomolecular quantification
InactiveUS20060127942A1Increase speedMicrobiological testing/measurementMaterial analysisAssayBinding site
Owner:UNIV OF UTAH RES FOUND
Dynamic range extension systems and methods for particle analysis in blood samples
ActiveUS20140273076A1Easy to moveDecrease in flowpath sizeImage enhancementBioreactor/fermenter combinationsParticle physicsParticle counter
For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.
Owner:IRIS INT
Method and particle analyzer for determining a broad particle size distribution
ActiveUS20120274760A1Scattering properties measurementsColor television detailsParticle physicsBright field image
A method and a particle analyzer are provided for determining a particle size distribution of a liquid sample including particles of a lower size range, particles of an intermediate size range, and particles of an upper size range. A dark-field image frame is captured in which the particles of the lower size range and the particles of the intermediate size range are resolved, and a bright-field image frame is captured in which the particles of the intermediate size range and the particles of the upper size range are resolved. Absolute sizes of the particles of the intermediate size range and the particles of the upper size range are determined from the bright-field image frame. Calibrated sizes of the particles of the lower size range are determined from the dark-field image frame by using the particles of the intermediate size range as internal calibration standards.
Owner:PROTEINSIMPLE
Apparatus for analyzing particles in urine and method thereof
ActiveCN101173888AMaterial analysis by optical meansBiological particle analysisFluorescenceRed Cell
An apparatus, intended for use in analyzing particles in urine is disclosed, that comprising: a sample distribution section for distributing urine samples to a first aliquot and a second aliquot; a first specimen preparing section for preparing a first specimen for measuring urinary particles, containing at least erythrocytes, by mixing a first stain reagent and the first aliquot; a second specimen preparing section for preparing a second specimen for measuring bacteria by mixing a second stain reagent and the second aliquot; and an optical detecting section comprising a light source for irradiating a light to a specimen being supplied, a scattered light receiving element for detecting scattered light emitted from the specimen, and a fluorescence receiving element for detecting fluorescence emitted from the specimen. A method intended for use in analyzing particles in urine is also disclosed.
Owner:SYSMEX CORP
Particle detector and particle analyzer employing the same
A particle detector includes first and second cells, the first cell supplying a liquid containing particles to the second cell; electrodes respectively provided in the first cell and the second cell; a plurality of shafts; and clamp members engaged with the respective shafts; the first cell and the second cell being arranged in alignment with each other; the shafts extending through the first cell and the second cell along the alignment of the first cell and the second cell; the clamp members clamping the first cell and the second cell along the alignment.
Owner:SYSMEX CORP
Systems and methods for determining specific gravity and minerological properties of a particle
InactiveUS20150020588A1Well formedMaterial analysis by observing immersed bodiesSpecific gravity using flow propertiesChemical physicsParticulate material
A system includes a particulate material sample that contains a fluid medium and a plurality of particles dispersed in the fluid medium. The system further includes a particle analysis apparatus having a sample cell and sample delivery means for delivering the particulate material sample to the sample cell, wherein the particle analysis apparatus is adapted to obtain particle information on at least one particle in that particulate material sample while the at least one particle is in the sample cell. Furthermore, the system also includes fluid manipulation means for manipulating movement of the fluid medium while the particle analysis apparatus is obtaining the particle information on the at least one particle, and a data processing apparatus that is adapted to determine a specific gravity of the at least one particle based on the obtained particle information.
Owner:NAT OILWELL VARCO LP
Method for additive adhesion force particle analysis and apparatus thereof
InactiveUS6508104B1Material analysis using sonic/ultrasonic/infrasonic wavesComponent separationAdhesion forceEngineering
A method including: sonicating a liquid suspension of first particles; and analyzing the liquid phase for second particles. An apparatus including: a sonicator adapted to sonicate a liquid suspension of first particles; and a first analyzer adapted to analyze the sonicated liquid phase for second particles. The method and apparatus can be used to analyze the adhesion force relationships between the main or host first particles and guest or surface additive second particles.
Owner:XEROX CORP
Particle analyzer and particle analysis method
ActiveCN101435764AEasy to identifyAdd dimensionIndividual particle analysisParticle flowFeature extraction
The invention discloses a particle analyzer and a particle analysis method. The analyzer comprises a flow chamber through which a sample liquid containing particles flows, a drive unit which is used for driving the sample liquid to flow through the flow chamber, a light irradiation unit which is used for emitting specific spectra to the particles in the flow chamber, a magnification imaging unit and a feature extraction analysis unit, wherein the magnification imaging unit acquires particle images formed under the specific spectra, magnifies and then outputs the images to the feature extraction analysis unit; and the feature extraction analysis unit extracts image features, identifies and classifies the particles according to the features. The analysis method comprises the steps of driving the sample liquid containing the particles to flow through the flow chamber, emitting the specific spectra to the particles in the flow chamber, acquiring the particle images formed under the specific spectra, magnifying the images, extracting the image features, identifying and classifying the particles according to the features. Clinical diseases needing to depend on images for analysis can be accurately judged through the invention.
Owner:BEIJING SHEN MINDRAY MEDICAL ELECTRONICS TECH RES INST +1
Structure for particle immobilization and apparatus for particle analysis
InactiveUS20130099143A1Reduce background noiseReduce crosstalk noiseAnalysis by electrical excitationPhotoelectric discharge tubesComputational physicsBackground noise
A structure 14 for particle immobilization has a plurality of holding holes 9 for holding respective test particles in order to detect light emitted from a substance which indicates the presence of a component for constructing each of the test particles, and the structure 14 for particle immobilization comprises a flat plate substrate 15, and a holding unit 20 which is arranged on the substrate 15 and which is formed with the plurality of holding holes 9. In this configuration, a light shielding film 19 which reduces light noise is provided for the substrate 15 or the holding unit 20 in order that the light noise such as the background noise and the crosstalk noise can be reduced, and a large number of test particles can be optically observed highly sensitively and highly accurately.
Owner:TOSOH CORP
Flowcell systems and methods for particle analysis in blood samples
ActiveUS9322752B2Small sizeKeep activeImage enhancementImage analysisParticle imagingImage resolution
Owner:IRIS INT
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