A traditional Chinese medicine capable of decreasing blood sugar and benefiting kidney

Abstract

The invention relates to a kind of Chinese traditional medicine that can decrease the saccharide content and tonify kidney with the total lignanoid extracts from arctii. The content of the total lignanoid extracts from the arctii is 50-89%, the content of the main active ingredient (arctiin) is more than 30%. Using the valid total lignanoid as the material, the producers can prepare different per oral preparations. The advantages of the invention includes: 1. the invention can decrease the blood sugar substantially, it can prevent the damage to kidney because of hyperglycemia, it can even treat the early kidney damage; 2. the preparing method is safe and simple.

Description

Technical field:

[0001] The invention relates to a traditional Chinese medicine for treating diabetic nephropathy, in particular to a traditional Chinese medicine with hypoglycemic and kidney-reinforcing effects which is prepared from the total lignan glycoside extract of arctium fruit. Background technique:

[0002] Diabetic nephropathy is the most common complication of diabetes and one of the leading causes of death in diabetic patients. With the development of the economy and the improvement of people's living standards, the number of diabetic patients in our country is increasing year by year. In the near future, diabetic nephropathy, a complication of diabetes, will become one of the most important causes of end-stage renal failure in our country. There is no ideal Chinese and Western medicine at present. Invention content:

[0003] The object of the present invention is to provide a kind of traditional Chinese medicine with hypoglycemic and kidney-reinforcing effec...

Examples

Embodiment 1

[0018] Example 1: Jiangtang Yishen Capsules

[0019] Recipe: (parts by weight) Arctium lignans 100

[0020] starch 5

[0021] Micronized silica gel 5

[0022] operate:

[0023] (1) Extraction and separation of total lignans of burdock fruit: crush burdock fruit decoction pieces into coarse particles, add 6 times the amount of 60% ethanol to soak overnight, heat and reflux for 1.5 hours, extract the extract, add 6 times the amount of 60% of the dregs % ethanol for 2 extractions, each time for 1.5 hours, extract the extract, combine and filter. Concentrate under reduced pressure until there is no alcohol smell. preprocessed D 101 Macroporous adsorption resin (half the volume of the concentrate), the adsorption rate is 8ml / min, the separation column is rinsed with distilled water, and then the separation column is rinsed with 20% ethanol, desorbed with 6 times the amount of 60% ethanol, and the desorption rate is 6.5ml / min. point. The st...

Embodiment 2

[0025] Embodiment 2: Jiangtang Yishen Dispersible Tablet

[0026] Recipe: (parts by weight): Arctium lignans total 100

[0027] Oligomeric hydroxypropyl cellulose 30~~60

[0028] Starch 100~~120

[0029] Crospovidone XL-10 15~~25

[0030] operate:

[0031] (1) with embodiment 1

[0032] (2) Preparation: The above-mentioned formula materials are pulverized, mixed evenly, passed through a 100-mesh sieve, granulated with 1-2% hydroxypropyl methylcellulose, passed through a 40-mesh sieve, dried at 30-40°C for 3-6 hours, Pass through a 20-mesh sieve to sort the granules, add 1-3% crospovidone XL-10 and starch, mix well, and make tablets, the weight of the tablet is 0.3g / tablet, and the yield is 90-95%.

Embodiment 3

[0033] Example 3: Jiangtang Yishen Granules

[0034] Recipe (parts by weight): burdock fruit total lignans 100

[0035] Galactose 50

[0036] operate:

[0037] (1) with embodiment 1

[0038] (2) Preparation: Mix and pulverize the formula materials, pass through a 100-mesh sieve, mix evenly, directly press into granules, pass through a 20-mesh sieve for granulation, each bag weighs 2.0g, and the yield is 90-95%.

Technical field:

[0001] The invention relates to a traditional Chinese medicine for treating diabetic nephropathy, in particular to a traditional Chinese medicine with hypoglycemic and kidney-reinforcing effects which is prepared from the total lignan glycoside extract of arctium fruit. Background technique:

[0002] Diabetic nephropathy is the most common complication of diabetes and one of the leading causes of death in diabetic patients. With the development of the economy and the improvement of people's living standards, the number of diabetic patients in our country is increasing year by year. In the near future, diabetic nephropathy, a complication of diabetes, will become one of the most important causes of end-stage renal failure in our country. There is no ideal Chinese and Western medicine at present. Invention content:

[0003] The object of the present invention is to provide a kind of traditional Chinese medicine with hypoglycemic and kidney-reinforcing effec...

Examples

Embodiment 1

[0018] Example 1: Jiangtang Yishen Capsules

[0019] Recipe: (parts by weight) Arctium lignans 100

[0020] starch 5

[0021] Micronized silica gel 5

[0022] operate:

[0023] (1) Extraction and separation of total lignans of burdock fruit: crush burdock fruit decoction pieces into coarse particles, add 6 times the amount of 60% ethanol to soak overnight, heat and reflux for 1.5 hours, extract the extract, add 6 times the amount of 60% of the dregs % ethanol for 2 extractions, each time for 1.5 hours, extract the extract, combine and filter. Concentrate under reduced pressure until there is no alcohol smell. preprocessed D 101 Macroporous adsorption resin (half the volume of the concentrate), the adsorption rate is 8ml / min, the separation column is rinsed with distilled water, and then the separation column is rinsed with 20% ethanol, desorbed with 6 times the amount of 60% ethanol, and the desorption rate is 6.5ml / min. point. The st...

Embodiment 2

[0025] Embodiment 2: Jiangtang Yishen Dispersible Tablet

[0026] Recipe: (parts by weight): Arctium lignans total 100

[0027] Oligomeric hydroxypropyl cellulose 30~~60

[0028] Starch 100~~120

[0029] Crospovidone XL-10 15~~25

[0030] operate:

[0031] (1) with embodiment 1

[0032] (2) Preparation: The above-mentioned formula materials are pulverized, mixed evenly, passed through a 100-mesh sieve, granulated with 1-2% hydroxypropyl methylcellulose, passed through a 40-mesh sieve, dried at 30-40°C for 3-6 hours, Pass through a 20-mesh sieve to sort the granules, add 1-3% crospovidone XL-10 and starch, mix well, and make tablets, the weight of the tablet is 0.3g / tablet, and the yield is 90-95%.

Embodiment 3

[0033] Example 3: Jiangtang Yishen Granules

[0034] Recipe (parts by weight): burdock fruit total lignans 100

[0035] Galactose 50

[0036] operate:

[0037] (1) with embodiment 1

[0038] (2) Preparation: Mix and pulverize the formula materials, pass through a 100-mesh sieve, mix evenly, directly press into granules, pass through a 20-mesh sieve for granulation, each bag weighs 2.0g, and the yield is 90-95%.