Hypericum attenuatum extraction and its application for preparing medicine for treating cardiac diseases

Abstract

The invention discloses a hypericum attenuatum extract and application, relating to an extract and application, which solves the problems that severe side effect exists in the prior western medicamentfor treating heart disease and report on hypericum attenuatum is used for treating heart disease do not exist. The hypericum attenuatum extract of the invention is extracted from hypericum attenuatumand the extracting procedures are as follows: firstly, hypericum attenuatum is refluxed, and secondly, the hypericum attenuatum extract can be obtained after concentration, upper sample, elution anddehydration. The hyperium attenuatum extract of the invention can be used for curing heart disease. The extract of the invention without toxic and side effects can obviously inhibit arrhythmia and hasoutstanding dose-effect relationship.

Description

technical field

[0001] The invention relates to an extract and its application in preparing medicine for treating heart disease. Background technique

[0002] Arrhythmia in modern medicine belongs to the category of "palpitations and palpitations" in Chinese medicine, and is one of the common and frequently-occurring diseases of cardiovascular diseases. Arrhythmia can cause abnormal blood circulation. When arrhythmia occurs, the contraction program of atrium and ventricle changes, which can reduce cardiac output by about 30%, causing symptoms such as weak heart, chest tightness, and weakness in patients, and aggravating heart disease. Severe arrhythmias can cause sinus arrest, sinoatrial block, and bradycardia, resulting in tachycardia syndrome. Arrhythmia can also lead to sudden death. According to clinical statistics, arrhythmia is the most common cause of sudden death, among which ventricular tachycardia, ventricular fibrillation and conduction block have the highest inc...

Examples

specific Embodiment approach 1

[0018] Specific embodiment one: the hypericum arginata extract of the present embodiment is extracted from Hypericum adenocarpi, and extraction is carried out according to the following steps: 1. Get the dried product of Hypericum adenocarpi and pulverize it into a coarse powder , use ethanol purification to remove impurities, and filter the extract; 2. Concentrate the extract under reduced pressure at a temperature lower than 80°C to a clear paste with a relative density of 1.10 to 1.40, and load it on a macroporous resin column. Load the sample at a ratio of 1:4 to 8 in the mass ratio of the clear cream to the resin, then elute with ethanol with a mass concentration of 30% to 90% and a volume 2 to 5 times the volume of the macroporous resin column, and collect the eluate Under the condition of lower than 60°C, it is dried under reduced pressure until the moisture content is less than 5%, and then crushed into fine powder; namely, hypericum arvensis extract is obtained.

specific Embodiment approach 2

[0019] Embodiment 2: The difference between this embodiment and Embodiment 1 is that in the second step of extraction, the extract is concentrated under reduced pressure at 60-75° C. to a clear paste with a relative density of 1.20-1.30. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0020] Embodiment 3: The difference between this embodiment and Embodiment 1 is that in the second step of extraction, the extract is concentrated under reduced pressure at 70° C. to a clear paste with a relative density of 1.25. Other steps and parameters are the same as those in Embodiment 1.

technical field

[0001] The invention relates to an extract and its application in preparing medicine for treating heart disease. Background technique

[0002] Arrhythmia in modern medicine belongs to the category of "palpitations and palpitations" in Chinese medicine, and is one of the common and frequently-occurring diseases of cardiovascular diseases. Arrhythmia can cause abnormal blood circulation. When arrhythmia occurs, the contraction program of atrium and ventricle changes, which can reduce cardiac output by about 30%, causing symptoms such as weak heart, chest tightness, and weakness in patients, and aggravating heart disease. Severe arrhythmias can cause sinus arrest, sinoatrial block, and bradycardia, resulting in tachycardia syndrome. Arrhythmia can also lead to sudden death. According to clinical statistics, arrhythmia is the most common cause of sudden death, among which ventricular tachycardia, ventricular fibrillation and conduction block have the highest inc...

Examples

specific Embodiment approach 1

[0018] Specific embodiment one: the hypericum arginata extract of the present embodiment is extracted from Hypericum adenocarpi, and extraction is carried out according to the following steps: 1. Get the dried product of Hypericum adenocarpi and pulverize it into a coarse powder , use ethanol purification to remove impurities, and filter the extract; 2. Concentrate the extract under reduced pressure at a temperature lower than 80°C to a clear paste with a relative density of 1.10 to 1.40, and load it on a macroporous resin column. Load the sample at a ratio of 1:4 to 8 in the mass ratio of the clear cream to the resin, then elute with ethanol with a mass concentration of 30% to 90% and a volume 2 to 5 times the volume of the macroporous resin column, and collect the eluate Under the condition of lower than 60°C, it is dried under reduced pressure until the moisture content is less than 5%, and then crushed into fine powder; namely, hypericum arvensis extract is obtained.

specific Embodiment approach 2

[0019] Embodiment 2: The difference between this embodiment and Embodiment 1 is that in the second step of extraction, the extract is concentrated under reduced pressure at 60-75° C. to a clear paste with a relative density of 1.20-1.30. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0020] Embodiment 3: The difference between this embodiment and Embodiment 1 is that in the second step of extraction, the extract is concentrated under reduced pressure at 70° C. to a clear paste with a relative density of 1.25. Other steps and parameters are the same as those in Embodiment 1.

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