Degradable high-molecular drug-loading fibrous membrane used for repairing scars

Abstract

The invention discloses a degradable high-molecular drug-loading fibrous membrane used for repairing scars. According to the invention, 0.01 to 5 parts of a scar repairing medicine by net weight are dissolved and dispersed in 100 parts of a biodegradable high-molecular material solution by weight, such that a mixed system is obtained. The mixed system is transferred into a spray liquid storing device. Through the altering of electrostatic spinning parameters, a haphazardly or directionally arranged target fibrous membrane is obtained. The electrostatic spun membrane provided by the invention has high porosity and good permeability, such that side-effects caused by poor permeability of a sealed membrane can be solved. The substrate material of the membrane is degradable high molecules. According to the invention, the medicine is sealed in the fibers, such that the stability of the structure of the medicine can be ensured; also, the medicine can be slowly released under the controlling of the degradation of the high-molecular material, such that the effect duration of the medicine is longer than that of traditional scar-repairing preparations or ointments. Further, the membrane can be cut into any required shape according to the dimension of a scar. Therefore, the membrane is easy to be customized and utilized.

Description

technical field

[0001] The invention relates to medical rehabilitation materials, in particular to the technical field of degradable polymer drug-loaded fiber membrane for scar repair and its preparation method. Background technique

[0002] Scar is a normal process of human skin injury (such as trauma, burn, surgical incision, infection, etc.) repair. The main reason for its formation is the excessive deposition of collagen in the dermis and subcutaneous tissue. Scar formation not only affects the appearance, but is often accompanied by symptoms such as itching and pain after the wound heals; if the scar occurs in the joint or grows across the joint, it will further affect its normal physiological function.

[0003] There are nine types of scars in theory, but five types are common: atrophic scars, contracture scars, hypertrophic scars, keloids, and malignant changes of scars. Atrophic scars and contracture scars have little impact on the appearance and normal physiologic...

Examples

Embodiment 1

[0020] Dissolve 10 parts by mass of polylactic acid with an average molecular weight of 140000 in a mixed solution of 50 parts of dichloromethane and 50 parts of N, N-dimethylformamide, stir to make it fully dissolved; then add 5 parts by mass of polylactic acid The dexamethasone is added into the solution, stirred to dissolve and mix evenly, and the drug / polymer composite system is obtained. Transfer the mixed solution to the syringe reservoir, keep the voltage at 20KV, the receiving distance is 15cm, the ambient temperature is 25°C, the solution pushing speed is 2mL / h, collect it with a flat receiving device, and electrospin for 4 hours to obtain a random array. Cloth degradable polymer drug-loaded fiber membrane.

Embodiment 2

[0022] This example is basically the same as Example 1, except that the added degradable polymer is 15 parts by mass of polyε-caprolactone with an average molecular weight of 80,000.

Embodiment 3

[0024] This example is basically the same as Example 1, except that the added degradable polymer is 15 parts by mass of a copolymer of polylactic acid and polyglycolic acid with an average molecular weight of 80,000.

technical field

[0001] The invention relates to medical rehabilitation materials, in particular to the technical field of degradable polymer drug-loaded fiber membrane for scar repair and its preparation method. Background technique

[0002] Scar is a normal process of human skin injury (such as trauma, burn, surgical incision, infection, etc.) repair. The main reason for its formation is the excessive deposition of collagen in the dermis and subcutaneous tissue. Scar formation not only affects the appearance, but is often accompanied by symptoms such as itching and pain after the wound heals; if the scar occurs in the joint or grows across the joint, it will further affect its normal physiological function.

[0003] There are nine types of scars in theory, but five types are common: atrophic scars, contracture scars, hypertrophic scars, keloids, and malignant changes of scars. Atrophic scars and contracture scars have little impact on the appearance and normal physiologic...

Examples

Embodiment 1

[0020] Dissolve 10 parts by mass of polylactic acid with an average molecular weight of 140000 in a mixed solution of 50 parts of dichloromethane and 50 parts of N, N-dimethylformamide, stir to make it fully dissolved; then add 5 parts by mass of polylactic acid The dexamethasone is added into the solution, stirred to dissolve and mix evenly, and the drug / polymer composite system is obtained. Transfer the mixed solution to the syringe reservoir, keep the voltage at 20KV, the receiving distance is 15cm, the ambient temperature is 25°C, the solution pushing speed is 2mL / h, collect it with a flat receiving device, and electrospin for 4 hours to obtain a random array. Cloth degradable polymer drug-loaded fiber membrane.

Embodiment 2

[0022] This example is basically the same as Example 1, except that the added degradable polymer is 15 parts by mass of polyε-caprolactone with an average molecular weight of 80,000.

Embodiment 3

[0024] This example is basically the same as Example 1, except that the added degradable polymer is 15 parts by mass of a copolymer of polylactic acid and polyglycolic acid with an average molecular weight of 80,000.