Preparation method of seven-ingredient heart nourishing and spleen tonifying granules

Abstract

The invention discloses a preparation method of seven-ingredient heart nourishing and spleen tonifying granules. The preparation method comprises the following steps: mixing and grinding fruit of Chinese magnoliavine, mint, cinnamon and platycladi seeds to obtain coarse powder; implementing supercritical carbon dioxide extraction on the coarse powder to obtain a total oil extract, and reserving dregs for later use; mixing the total oil extract with beta-cyclodextrin, and stirring and including to obtain a clathrate compound; mixing the dregs with liquorice, astragalus membranaceus and poria cocos to obtain a mixture, adding water to the mixture, ultrasonically extracting for 2-3 times at normal temperature, mixing extracting solutions, decompressing and concentrating, and drying in a vacuum environment to obtain a dry extract; mixing the dry extract with starch and dextrin, preparing a soft material by taking an ethanol solution as a wetting agent, uniformly mixing the soft material and the clathrate compound, pelleting, straightening and drying to obtain the seven-ingredient heart nourishing and spleen tonifying granules. Pharmacological researches show that the seven-ingredient heart nourishing and spleen tonifying granules have sedative and hypnotic effects, and can enhance mice hypoxia tolerance ability and prolong mice survival time and swinging time.

Description

1. Technical field

[0001] The invention relates to a preparation method of an existing medicine, in particular to a preparation method of Qiwei Yangxin Jianpi Granules. 2. Background technology

[0002] Qiwei Yangxin Jianpi Capsule is a prescription donated by Dr. Zhang Xutong, a descendant of Cui Guoyin, a Chinese-American and imperial physician of the Qing Dynasty. It was listed as a national torch science and technology project in 2003, and was later approved by Anhui University and Anhui Guozheng Pharmaceutical Co., Ltd. After 12 years of research, it was successfully developed and marketed in 2004. The prescription is composed of seven traditional Chinese medicines of schisandra, licorice, astragalus, poria cocos, peppermint, boziren and cinnamon. In the prescription, Schisandra chinensis calms the mind and is used in the largest amount in the prescription. It is aimed at the main syndrome, so it is the monarch drug; Astragalus and licorice function to invigorate the s...

Examples

Embodiment 1

[0013] 1) Mix and grind 45 parts by mass of schisandra, 32 parts by mass of mint, 35 parts by mass of cinnamon and 25 parts by mass of Baiziren, and pass through a 24-mesh sieve to obtain a coarse powder (no more than 40% can pass through a 65-mesh sieve);

[0014] 2) The coarse powder obtained in step 1) is subjected to supercritical carbon dioxide extraction to obtain the total oil extract, and the dregs are used for later use; the process parameters of supercritical carbon dioxide extraction are: extraction time 90min, extraction temperature 40°C, CO 2 The flow rate is 18L / h, the separation pressure is 5MPa, and the separation temperature is 40°C;

[0015] 3) Mix the total oil extract obtained in step 2) and β-cyclodextrin at a mass ratio of 1:10 and stir to form an inclusion compound. The inclusion temperature is 65°C and the inclusion time is 1.5 hours;

[0016] 4) Mix the dregs obtained in step 2) with 15 parts by mass of licorice, 15 parts by mass of astragalus, and 12 ...

Embodiment 2

[0019] 1) Mix and grind 45 parts by mass of schisandra, 32 parts by mass of mint, 35 parts by mass of cinnamon and 25 parts by mass of Baiziren, and pass through a 24-mesh sieve to obtain a coarse powder (no more than 40% can pass through a 65-mesh sieve);

[0020] 2) The coarse powder obtained in step 1) is subjected to supercritical carbon dioxide extraction to obtain the total oil extract, and the dregs are used for later use; the process parameters of supercritical carbon dioxide extraction are: extraction time 95min, extraction temperature 45°C, CO 2 The flow rate is 20L / h, the separation pressure is 5MPa, and the separation temperature is 40°C;

[0021] 3) Mix the total oil extract obtained in step 2) and β-cyclodextrin at a mass ratio of 1:11 and stir to form an inclusion compound. The inclusion temperature is 70°C and the inclusion time is 2 hours;

[0022] 4) Mix the dregs obtained in step 2) with 15 parts by mass of licorice, 15 parts by mass of astragalus, and 12 pa...

Embodiment 3

[0025] 1) Mix and grind 45 parts by mass of schisandra, 32 parts by mass of mint, 35 parts by mass of cinnamon and 25 parts by mass of Baiziren, and pass through a 24-mesh sieve to obtain a coarse powder (no more than 40% can pass through a 65-mesh sieve);

[0026] 2) The coarse powder obtained in step 1) is subjected to supercritical carbon dioxide extraction to obtain the total oil extract, and the dregs are used for later use; the process parameters of supercritical carbon dioxide extraction are: extraction time 100min, extraction temperature 50°C, CO 2 The flow rate is 22L / h, the separation pressure is 5MPa, and the separation temperature is 40°C;

[0027] 3) Mix the total oil extract obtained in step 2) and β-cyclodextrin at a mass ratio of 1:12 and stir to form an inclusion complex. The inclusion temperature is 75°C and the inclusion time is 2 hours;

[0028] 4) Mix the dregs obtained in step 2) with 15 parts by mass of licorice, 15 parts by mass of astragalus and 12 par...

1. Technical field

[0001] The invention relates to a preparation method of an existing medicine, in particular to a preparation method of Qiwei Yangxin Jianpi Granules. 2. Background technology

[0002] Qiwei Yangxin Jianpi Capsule is a prescription donated by Dr. Zhang Xutong, a descendant of Cui Guoyin, a Chinese-American and imperial physician of the Qing Dynasty. It was listed as a national torch science and technology project in 2003, and was later approved by Anhui University and Anhui Guozheng Pharmaceutical Co., Ltd. After 12 years of research, it was successfully developed and marketed in 2004. The prescription is composed of seven traditional Chinese medicines of schisandra, licorice, astragalus, poria cocos, peppermint, boziren and cinnamon. In the prescription, Schisandra chinensis calms the mind and is used in the largest amount in the prescription. It is aimed at the main syndrome, so it is the monarch drug; Astragalus and licorice function to invigorate the s...

Examples

Embodiment 1

[0013] 1) Mix and grind 45 parts by mass of schisandra, 32 parts by mass of mint, 35 parts by mass of cinnamon and 25 parts by mass of Baiziren, and pass through a 24-mesh sieve to obtain a coarse powder (no more than 40% can pass through a 65-mesh sieve);

[0014] 2) The coarse powder obtained in step 1) is subjected to supercritical carbon dioxide extraction to obtain the total oil extract, and the dregs are used for later use; the process parameters of supercritical carbon dioxide extraction are: extraction time 90min, extraction temperature 40°C, CO 2 The flow rate is 18L / h, the separation pressure is 5MPa, and the separation temperature is 40°C;

[0015] 3) Mix the total oil extract obtained in step 2) and β-cyclodextrin at a mass ratio of 1:10 and stir to form an inclusion compound. The inclusion temperature is 65°C and the inclusion time is 1.5 hours;

[0016] 4) Mix the dregs obtained in step 2) with 15 parts by mass of licorice, 15 parts by mass of astragalus, and 12 ...

Embodiment 2

[0019] 1) Mix and grind 45 parts by mass of schisandra, 32 parts by mass of mint, 35 parts by mass of cinnamon and 25 parts by mass of Baiziren, and pass through a 24-mesh sieve to obtain a coarse powder (no more than 40% can pass through a 65-mesh sieve);

[0020] 2) The coarse powder obtained in step 1) is subjected to supercritical carbon dioxide extraction to obtain the total oil extract, and the dregs are used for later use; the process parameters of supercritical carbon dioxide extraction are: extraction time 95min, extraction temperature 45°C, CO 2 The flow rate is 20L / h, the separation pressure is 5MPa, and the separation temperature is 40°C;

[0021] 3) Mix the total oil extract obtained in step 2) and β-cyclodextrin at a mass ratio of 1:11 and stir to form an inclusion compound. The inclusion temperature is 70°C and the inclusion time is 2 hours;

[0022] 4) Mix the dregs obtained in step 2) with 15 parts by mass of licorice, 15 parts by mass of astragalus, and 12 pa...

Embodiment 3

[0025] 1) Mix and grind 45 parts by mass of schisandra, 32 parts by mass of mint, 35 parts by mass of cinnamon and 25 parts by mass of Baiziren, and pass through a 24-mesh sieve to obtain a coarse powder (no more than 40% can pass through a 65-mesh sieve);

[0026] 2) The coarse powder obtained in step 1) is subjected to supercritical carbon dioxide extraction to obtain the total oil extract, and the dregs are used for later use; the process parameters of supercritical carbon dioxide extraction are: extraction time 100min, extraction temperature 50°C, CO 2 The flow rate is 22L / h, the separation pressure is 5MPa, and the separation temperature is 40°C;

[0027] 3) Mix the total oil extract obtained in step 2) and β-cyclodextrin at a mass ratio of 1:12 and stir to form an inclusion complex. The inclusion temperature is 75°C and the inclusion time is 2 hours;

[0028] 4) Mix the dregs obtained in step 2) with 15 parts by mass of licorice, 15 parts by mass of astragalus and 12 par...

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