Implementation method of preventing and treating thrombus with black fungus

Abstract

The invention discloses an implementation method of preventing and treating thrombus with black fungus. The implementation method comprises following steps: (1) soaking 500g of the black fungus in cold water; (2) crushing the black fungus through a pulverizer and extracting black fungus polysaccharide from the black fungus in a water-soluble manner or a lipid-soluble manner; (3) feeding experimental rabbits with each experimental black fungus polysaccharide component in equal amount for 2 months in an intragastric administration manner; (4) observing physical indexes of the experimental rabbits in vitro; (5) performing statistical analysis to the physical indexes of the experimental rabbits with results being all represented as (x+ / -S), wherein a t-test method is employed for comparison among groups and a statistical difference exists with P<0.05. The method, by means of the black fungus polysaccharide in the black fungus, can prolong a forming time of New Zealand rabbit specific thrombus and fibrous protein thrombus, reduce in-vitro thrombus length and reduce wet weight and dry weight of the thrombus, can reduce platelet adhesiveness rate and blood viscosity, can significantly reduce a dissolving time of euglobulin, can reduce plasma fibrinogen content, can increase plasmin activity and has significant thrombus forming resistance.

Description

Technical field:

[0001] The invention relates to a realization method of using black fungus to prevent and treat thrombus. Background technique:

[0002] As we all know, the so-called thrombus is that in the heart or blood vessel cavity of a living body, blood coagulates or certain formed components in the blood stick together to form a solid mass. The solid mass formed in this process is called a thrombus. Under physiological conditions, coagulation factors in the blood are continuously activated to produce thrombin, forming a small amount of fibrin, which settles on the intima of the blood vessel, but these small amounts of fibrin are continuously released by the activated fibrinolytic system. Dissolved and activated coagulation factors are continuously swallowed up by the mononuclear phagocyte system. The dynamic balance of the coagulation system and the fibrinolytic system, sometimes under the action of some factors that can promote the coagulation process, breaks the d...

Examples

Embodiment Construction

[0026] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further described below in conjunction with specific illustrations.

[0027] The specific implementation process of the inventive method comprises the following parts:

[0028] 1. Materials and Instruments

[0029] 1. Black fungus for experiment: 3Kg purchased from supermarket, identified as Auricularia auricular fruiting body of Auriculariaceae.

[0030] 2. Male New Zealand white rabbits used in the experiment were purchased from the Animal Center of Shanghai Medical Research Institute. The rabbits were 2 years old, weighed (1.8-2.0) Kg, healthy and had normal body temperature. Animal experiment conditions: temperature (22±2) ℃, humidity 50%~70%, light: 150~200Lx, 12h alternating light and dark, noise <50dB, barrier system temperature, humidity, light, pressure gradient, etc. are equipped with automatic control ...

Technical field:

[0001] The invention relates to a realization method of using black fungus to prevent and treat thrombus. Background technique:

[0002] As we all know, the so-called thrombus is that in the heart or blood vessel cavity of a living body, blood coagulates or certain formed components in the blood stick together to form a solid mass. The solid mass formed in this process is called a thrombus. Under physiological conditions, coagulation factors in the blood are continuously activated to produce thrombin, forming a small amount of fibrin, which settles on the intima of the blood vessel, but these small amounts of fibrin are continuously released by the activated fibrinolytic system. Dissolved and activated coagulation factors are continuously swallowed up by the mononuclear phagocyte system. The dynamic balance of the coagulation system and the fibrinolytic system, sometimes under the action of some factors that can promote the coagulation process, breaks the d...

Examples

Embodiment Construction

[0026] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further described below in conjunction with specific illustrations.

[0027] The specific implementation process of the inventive method comprises the following parts:

[0028] 1. Materials and Instruments

[0029] 1. Black fungus for experiment: 3Kg purchased from supermarket, identified as Auricularia auricular fruiting body of Auriculariaceae.

[0030] 2. Male New Zealand white rabbits used in the experiment were purchased from the Animal Center of Shanghai Medical Research Institute. The rabbits were 2 years old, weighed (1.8-2.0) Kg, healthy and had normal body temperature. Animal experiment conditions: temperature (22±2) ℃, humidity 50%~70%, light: 150~200Lx, 12h alternating light and dark, noise <50dB, barrier system temperature, humidity, light, pressure gradient, etc. are equipped with automatic control ...

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